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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Synaptotagmin XII

Srg1, Syt XII
involved in Ca(2+)-dependent exocytosis of secretory vesicles [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: ACID, CAN, Spt16, Spt6, Histone
Papers on Srg1
Transcriptome profiling of postharvest strawberry fruit in response to exogenous auxin and abscisic acid.
New
Luo et al., Hangzhou, China. In Planta, Jan 2016
In contrast, exogenous ABA induced genes related to fruit softening, and genes involved in signaling pathways including SKP1, HSPs, CK2, and SRG1.
Identification of Mutant Versions of the Spt16 Histone Chaperone That Are Defective for Transcription-Coupled Nucleosome Occupancy in Saccharomyces cerevisiae.
Martens et al., Pittsburgh, United States. In G3 (bethesda), 2012
We have previously shown, consistent with this function, that Spt16 facilitates repression of the Saccharomyces cerevisiae SER3 gene by maintaining nucleosome occupancy over the promoter of this gene as a consequence of intergenic transcription of SRG1 noncoding DNA.
The Paf1 complex represses SER3 transcription in Saccharomyces cerevisiae by facilitating intergenic transcription-dependent nucleosome occupancy of the SER3 promoter.
Martens et al., Pittsburgh, United States. In Eukaryot Cell, 2011
Previous studies have shown that repression of the Saccharomyces cerevisiae SER3 gene is dependent on transcription of SRG1 from noncoding DNA initiating within the intergenic region 5' of SER3 and extending across the SER3 promoter region.
Identification of histone mutants that are defective for transcription-coupled nucleosome occupancy.
Martens et al., Pittsburgh, United States. In Mol Cell Biol, 2011
Our previous studies of Saccharomyces cerevisiae described a gene repression mechanism where the transcription of intergenic noncoding DNA (ncDNA) (SRG1) assembles nucleosomes across the promoter of the adjacent SER3 gene that interfere with the binding of transcription factors.
Transcription regulation by the noncoding RNA SRG1 requires Spt2-dependent chromatin deposition in the wake of RNA polymerase II.
Nourani et al., Québec, Canada. In Mol Cell Biol, 2011
This gene is repressed by a transcription interference mechanism involving the transcription of an adjacent intergenic region, SRG1, that leads to the production of a noncoding RNA (ncRNA).
Inactivation of expression of two genes in Saccharomyces cerevisiae with the external guide sequence methodology.
Altman et al., New Haven, United States. In Rna, 2011
The TOP2 and SRG1 genes can be inhibited by ∼30% with EGSs in vivo.
Intergenic transcription causes repression by directing nucleosome assembly.
Martens et al., Pittsburgh, United States. In Genes Dev, 2011
We previously identified a regulatory system in Saccharomyces cerevisiae whereby transcription of intergenic ncDNA (SRG1) represses transcription of an adjacent protein-coding gene (SER3) through transcription interference.
Synaptotagmin-12, a synaptic vesicle phosphoprotein that modulates spontaneous neurotransmitter release.
GeneRIF
Südhof et al., Dallas, United States. In J Cell Biol, 2007
Studies of the orthologous gene in rat have shown that spontaneous synaptic-vesicle exocytosis is selectively modulated by synaptotagmin 12.
Cytoplasmic decay of intergenic transcripts in Saccharomyces cerevisiae.
Parker et al., Tucson, United States. In Mol Cell Biol, 2007
In this work, we examine the degradation pathway of the RNA SRG1, which is produced from an intergenic region and contributes to the regulation of the SER3 gene by promoter occlusion during SRG1 transcription.
Regulation of an intergenic transcript controls adjacent gene transcription in Saccharomyces cerevisiae.
Winston et al., Boston, United States. In Genes Dev, 2005
We have previously shown that in Saccharomyces cerevisiae, expression of an intergenic transcript, SRG1, represses the transcription of the adjacent gene, SER3, by transcription interference.
Intergenic transcription is required to repress the Saccharomyces cerevisiae SER3 gene.
Impact
Winston et al., Boston, United States. In Nature, 2004
We now show that the regulatory region of this gene is highly transcribed under these conditions and produces a non-protein-coding RNA (SRG1).
Comparative analysis of tandem C2 domains from the mammalian synaptotagmin family.
Davletov et al., Cambridge, United Kingdom. In Biochem J, 2004
All tested isoforms, except Syt XII and Syt XIII, bound the target SNARE heterodimer comprising syntaxin 1 and SNAP-25 (25 kDa synaptosome-associated protein).
Mechanism of the SDS-resistant synaptotagmin clustering mediated by the cysteine cluster at the interface between the transmembrane and spacer domains.
Mikoshiba et al., Wako, Japan. In J Biol Chem, 2001
fatty-acylated) cysteine (Cys) cluster (Cys-74, Cys-75, Cys-77, Cys-79, and Cys-82) at the interface between the transmembrane and spacer domains of Syt I. We also show that the number of Cys residues at the interface between the transmembrane and spacer domains determines the SDS- resistant oligomerizing capacity of each synaptotagmin isoform: Syt II, which contains seven Cys residues, showed the strongest SDS-resistant oligomerizing activity in the synaptotagmin family, whereas Syt XII, which has no Cys residues, did not form any SDS-resistant oligomers.
Brain glucose utilization in mice with a targeted mutation in the thyroid hormone alpha or beta receptor gene.
Nunez et al., Bethesda, United States. In Proc Natl Acad Sci U S A, 2001
Inasmuch as local cerebral glucose utilization is closely related to local synaptic activity, we also examined which thyroid hormone receptor is involved in the expression of synaptotagmin-related gene 1 (Srg1), a TH-positively regulated gene involved in the formation and function of synapses [Thompson, C. C. (1996) J. Neurosci.
Neuronal expression of synaptotagmin-related gene 1 is regulated by thyroid hormone during cerebellar development.
Thompson et al., Baltimore, United States. In J Neurosci, 2001
In a screen for genes regulated by TH in the rat cerebellum, we recently identified a novel gene, synaptotagmin-related gene 1 (Srg1).
Thyroid hormone action in neural development.
Review
Potter et al., Baltimore, United States. In Cereb Cortex, 2000
Recently identified thyroid hormone-responsive genes include synaptotagmin-related gene 1 (Srg1), a putative mediator of synaptic structure and/or activity, and hairless, a transcriptional cofactor that may influence the expression of other thyroid hormone-responsive genes.
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