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Sterol regulatory element binding transcription factor 2

SREBP-2, Sterol Regulatory Element Binding Protein 2
This gene encodes a ubiquitously expressed transcription factor that controls cholesterol homeostasis by stimulating transcription of sterol-regulated genes. The encoded protein contains a basic helix-loop-helix-leucine zipper (bHLH-Zip) domain. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, Sterol Regulatory Element Binding Protein 1, V1a, LDL receptor, HAD
Papers using SREBP-2 antibodies
Statin use is associated with improved prostate cancer survival: is it time for a clinical trial?
Agoulnik Irina, In PLoS ONE, 2009
... was from Novus Biologicals, LLC (Littleton, CO, USA) and antibody for Sterol regulatory element-binding protein 2 (SREBP2 (Clone IgG-1C6)) was from BD Biosciences (Franklin Lakes, NJ, USA) ...
Determination of LDL- and scavenger-receptor activity in adherent and non-adherent cultured cells with a new single-step fluorometric assay.
Hansen Immo A., In PLoS ONE, 1995
... The IgG-1C6 mouse anti-SREBP-2 primary antibody [20] was obtained from BD Biosciences (North Ryde, NSW, AU) ...
Papers on SREBP-2
SREBP2 activation induces hepatic long-chain acyl-CoA synthetase 1 expression in vivo and in vitro through a SRE motif of ACSL1 C-promoter.
Liu et al., Palo Alto, United States. In J Biol Chem, Feb 2016
Decreases in Acsl1 expression strongly correlated with reductions in hepatic SREBP2 mRNA level and mSREBP2 protein abundance.
De-ubiquitylase inhibition reveals LXR-independent transcriptional regulation of the E3 ubiquitin ligase IDOL and lipoprotein uptake.
Zelcer et al., Amsterdam, Netherlands. In J Biol Chem, Jan 2016
Importantly, this occurred in the absence of changes in the mRNA levels of the LDLR or other SREBP2-regulated genes, in line with this phenotype being a post-transcriptional event.
Increase of circulating cholesterol in vitamin D deficiency is linked to reduced vitamin D receptor activity via the Insig-2/SREBP-2 pathway.
Sun et al., Harbin, China. In Mol Nutr Food Res, Jan 2016
Under vitamin D deficiency, the transcriptional activity of vitamin D receptor (VDR) was decreased, leading to the down-regulation of insulin-induced gene-2 (Insig-2) expression and thus its inhibitory role on sterol regulatory element-binding protein 2 activation; 3-hydroxy-3-methylglutaryl-coenzyme A reductase expression was accordingly increased.
Camphene, a Plant Derived Monoterpene, Exerts Its Hypolipidemic Action by Affecting SREBP-1 and MTP Expression.
Hadzopoulou-Cladaras et al., Thessaloníki, Greece. In Plos One, Dec 2015
To evaluate the mode of action of camphene, we examined its effects on the expression of SREBP-1, which affects TG biosynthesis and SREBP-2, which mostly affects sterol synthesis.
Hypercholesterolemia, low density lipoprotein receptor and proprotein convertase subtilisin/kexin-type 9.
Zhang et al., Edmonton, Canada. In J Biomed Res, Sep 2015
The expression of LDLR is regulated at the transcriptional level via the sterol regulatory element binding protein 2 (SREBP-2) and at the posttranslational levels mainly through proprotein convertase subtilisin/kexin-type 9 (PCSK9) and inducible degrader of the LDLR (IDOL).
Treatment with PPARα Agonist Clofibrate Inhibits the Transcription and Activation of SREBPs and Reduces Triglyceride and Cholesterol Levels in Liver of Broiler Chickens.
He et al., Taiyuan, China. In Ppar Res, 2014
We observed that PPARα agonist clofibrate decreases the mRNA and protein levels of LXRα and the mRNA and both precursor and nuclear protein levels of SREBP1 and SREBP2 as well as the mRNA levels of the SREBP1 (FASN and GPAM) and SREBP2 (HMGCR and LDLR) target genes in the liver of treated broiler chickens compared to control group, whereas the mRNA level of INSIG2, which inhibits SREBP activation, was increased in the liver of treated broiler chickens compared to control group.
PCSK9 and LDLR degradation: regulatory mechanisms in circulation and in cells.
Lagace, Ottawa, Canada. In Curr Opin Lipidol, 2014
Recent findings have identified hepatocyte nuclear factor-1α as a key transcriptional regulator that cooperates with sterol regulatory element-binding protein-2 to control PCSK9 expression in hepatocytes in response to nutritional and hormonal inputs, as well as acute inflammation.
Cholesterol biosynthesis and ER stress in peroxisome deficiency.
Kovacs et al., New York City, United States. In Biochimie, 2014
Pex2(-/-) mice were unable to maintain normal cholesterol homeostasis despite activation of SREBP-2, the master transcriptional regulator of cholesterol biosynthesis, and increased protein levels and activities of cholesterol biosynthetic enzymes.
Targeting the proprotein convertase subtilisin/kexin type 9 for the treatment of dyslipidemia and atherosclerosis.
Laufs et al., Homburg, Germany. In J Am Coll Cardiol, 2013
Low intracellular cholesterol levels in response to statin treatment activate the sterol regulatory element-binding protein-2 (SREBP-2), resulting in coexpression of LDLR and PCSK9.
DNA methylation analysis in nonalcoholic fatty liver disease suggests distinct disease-specific and remodeling signatures after bariatric surgery.
Hampe et al., Kiel, Germany. In Cell Metab, 2013
Transcription factor binding sites at NAFLD-specific CpG sites were >1,000-fold enriched for ZNF274, PGC1A, and SREBP2.
An SREBP-responsive microRNA operon contributes to a regulatory loop for intracellular lipid homeostasis.
Osborne et al., Orlando, United States. In Cell Metab, 2013
Here, we have uncovered a polycistrionic microRNA (miRNA) locus that is activated directly by SREBP-2.
[Progress of Niemann-Pick type C1 Like 1 on cholesterol metabolism].
Wang et al., Guangzhou, China. In Sheng Li Xue Bao, 2013
Polyunsaturated fatty acids down-regulates NPC1L1 expression by the way of sterol regulatory element binding protein 2 (SREBP2).
ER stress contributes to renal proximal tubule injury by increasing SREBP-2-mediated lipid accumulation and apoptotic cell death.
Austin et al., Hamilton, Canada. In Am J Physiol Renal Physiol, 2012
Endoplasmic reticulum stress-induced SREBP-2 activation contributes to renal proximal tubule cell injury by dysregulating lipid homeostasis.
The impact of severe LDL receptor mutations on SREBP-pathway regulation in homozygous familial hypercholesterolemia (FH).
Schaefer et al., Marburg an der Lahn, Germany. In Gene, 2012
Impact of a severe familial hypercholesterolemia (FH) causing LDLR mutation (FH p.W556R) on the SREBP pathway in primary FH fibroblasts.
β-amyloid inhibits protein prenylation and induces cholesterol sequestration by impairing SREBP-2 cleavage.
Posse de Chaves et al., Edmonton, Canada. In J Neurosci, 2012
SREBP-2 is directly linked as a target of amyloid-beta protein in cholesterol homeostasis impairment.
Increased hepatic synthesis and dysregulation of cholesterol metabolism is associated with the severity of nonalcoholic fatty liver disease.
Sanyal et al., Richmond, United States. In Cell Metab, 2012
NAFLD was associated with increased SREBP-2 maturation, HMG CoA reductase (HMGCR) expression and decreased phosphorylation of HMGCR.
Association of sterol regulatory element-binding transcription factor gene polymorphisms with ischaemic stroke.
Liu et al., Changsha, China. In J Int Med Res, 2011
The SREBF1c 54G>C and SREBPF2 1784G>C genotypes were assessed using restriction fragment length polymorphism analysis in 446 Han Chinese ischaemic stroke patients and 355 Han Chinese control subjects without cerebrovascular disease.
Early dengue virus protein synthesis induces extensive rearrangement of the endoplasmic reticulum independent of the UPR and SREBP-2 pathway.
Harris et al., Berkeley, United States. In Plos One, 2011
Enlargement of the endoplasmic reticulum is independent of the SREBP-2 activation.
A conserved SREBP-1/phosphatidylcholine feedback circuit regulates lipogenesis in metazoans.
Näär et al., United States. In Cell, 2011
Distinct from negative regulation of SREBP-2 by cholesterol, our data suggest a feedback mechanism whereby maturation of nuclear, transcriptionally active SREBP-1 is controlled by levels of PC.
Genome-wide localization of SREBP-2 in hepatic chromatin predicts a role in autophagy.
Osborne et al., Irvine, United States. In Cell Metab, 2011
SREBP-2 directly activates autophagy genes during cell-sterol depletion, conditions known to induce both autophagy and nuclear SREBP-2 levels.
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