PCSK9 and LDLR degradation: regulatory mechanisms in circulation and in cells.
Ottawa, Canada. In Curr Opin Lipidol, 2014
Recent findings have identified hepatocyte nuclear factor-1α as a key transcriptional regulator that cooperates with sterol regulatory element-binding protein-2 to control PCSK9 expression in hepatocytes in response to nutritional and hormonal inputs, as well as acute inflammation.
Cholesterol biosynthesis and ER stress in peroxisome deficiency.
New York City, United States. In Biochimie, 2014
Pex2(-/-) mice were unable to maintain normal cholesterol homeostasis despite activation of SREBP-2, the master transcriptional regulator of cholesterol biosynthesis, and increased protein levels and activities of cholesterol biosynthetic enzymes.