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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

V-src sarcoma

Src, c-Src, pp60c-src
This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: V1a, CAN, Akt, EGFR, ERK
Papers using Src antibodies
Myosin IIA modulates T cell receptor transport and CasL phosphorylation during early immunological synapse formation
Dustin Michael L. et al., In Frontiers in Immunology, 2011
... Affinity purified polyclonal antibodies against phospho-Src (Cell Signaling Technology – cat#6943) and ...
Direct detection of guidance receptor activity during border cell migration.
Rappoport Joshua Z., In PLoS ONE, 2009
... Anti-Bek (C-8) and anti-clathrin monoclonal antibodies, Anti-Bek (C-8) monoclonal antibody anti-cortactin, anti-Src (SRC 2), anti-Bek (H80) and anti-Bek (C-17) polyclonal antibodies were from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...
Mechanism of platelet functional changes and effects of anti-platelet agents on in vivo hemostasis under different gravity conditions
Dai Kesheng et al., In International Journal of Molecular Sciences, 2009
... Anti-phospho-Src family (pTyr416) rabbit polyclonal antibody was from Cell Signaling Technology (Beverly, MA, USA) ...
A novel small molecule inhibitor of FAK decreases growth of human pancreatic cancer
Rondé Philippe et al., In Journal of Oncology, 2008
... Anti-Src Ab was from Biomol International ...
aP2-Cre-mediated inactivation of acetyl-CoA carboxylase 1 causes growth retardation and reduced lipid accumulation in adipose tissues.
Appanna Vasu D., In PLoS ONE, 2008
... Antibodies against acetyl-CoA carboxylase1, p-ACC1S79, AMP-activated kinase (AMPK), p-AMPKT172, cortactin, p-SrcY416, and Src were purchased from Cell Signaling Technologies (Beverly, MA) ...
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Papers on Src
Resolution of site-specific conformational heterogeneity in proline-rich molecular recognition by Src homology 3 domains.
Thielges et al., In J Am Chem Soc, Feb 2016
Here we combine the inherent temporal resolution of infrared (IR) spectroscopy with the spatial resolution afforded by selective incorporation of carbon-deuterium (C-D) bonds, which provide frequency-resolved absorptions within a protein IR spectrum, to characterize the molecular recognition of the Src homology 3 (SH3) domain of the yeast protein Sho1 with its cognate proline-rich (PR) sequence of Pbs2.
Inflammation-Induced CCR7 Oligomers Form Scaffolds to Integrate Distinct Signaling Pathways for Efficient Cell Migration.
Legler et al., Kreuzlingen, Switzerland. In Immunity, Feb 2016
Here, we showed that different inflammatory stimuli provoked oligomerization of the chemokine receptor CCR7, enabling human dendritic cells and T cell subpopulations to process guidance cues not only through classical G protein-dependent signaling but also by integrating an oligomer-dependent Src kinase signaling pathway.
A 4-midable Connection: CCR7 Tetramers Link GPCR to Src Kinase Signaling.
Werth et al., Hannover, Germany. In Immunity, Feb 2016
(2016) report that inflammatory cues can induce tetramers of the chemokine receptor CCR7 that serve as scaffolds integrating G protein with Src kinase signaling.
Desipramine targets astrocytes to attenuate synaptic plasticity via modulation of the ephrinA3/EphA4 signalling.
Di Benedetto et al., München, Germany. In Neuropharmacology, Feb 2016
The co-administration of DMI with the Src inhibitor SU6656, which blocks EphA4 forward signalling, could partially reverse the LTP attenuation, further supporting the targeting of the ephrinA3/EphA4 pathway by DMI.
The transport mechanism of integrin αvβ3 receptor targeting nanoparticles in Caco-2 cells.
Huang et al., Chengdu, China. In Int J Pharm, Feb 2016
Our results showed FQS peptide mediated multiple endocytosis pathways and could activate integrin αvβ3 receptor by interacting with FAK and Src-family kinases to induce receptor-mediated endocytosis of the NPs.
Integrins Form an Expanding Diffusional Barrier that Coordinates Phagocytosis.
Grinstein et al., Toronto, Canada. In Cell, Feb 2016
Phagocytosis is initiated by lateral clustering of receptors, which in turn activates Src-family kinases (SFKs).
The Neutrophil Btk Signalosome Regulates Integrin Activation during Sterile Inflammation.
Zarbock et al., Münster, Germany. In Immunity, Feb 2016
The Src family kinase Hck, Wiskott-Aldrich-syndrome protein, and phospholipase Cγ2 were also involved in this pathway required for fMLF-triggered Mac-1 activation and neutrophil recruitment.
The role of the Src Homology-2 domain containing protein B (SHB) in β cells.
Åkerblom et al., Uppsala, Sweden. In J Mol Endocrinol, Jan 2016
This review will describe the SH2-domain signaling protein Src Homology-2 domain containing protein B (SHB) and its role in various physiological processes relating in particular to glucose homeostasis and β cell function.
Mucin 1-mediated chemo-resistance in lung cancer cells.
Yoon et al., Seoul, South Korea. In Oncogenesis, Dec 2015
The c-SRC protein, an activator of MUC1-C, was also overexpressed in A549/PTX.
Regulation of N-Formyl Peptide Receptor Signaling and Trafficking by Arrestin-Src Kinase Interaction.
Prossnitz et al., Albuquerque, United States. In Plos One, Dec 2015
It was later revealed that arrestins also mediate GPCR internalization and recruit a number of signaling proteins including, but not limited to, Src family kinases, ERK1/2, and JNK3.
Caldecrin: A pancreas-derived hypocalcemic factor, regulates osteoclast formation and function.
Tomomura et al., Sakado, Japan. In World J Biol Chem, Dec 2015
Caldecrin also suppressed the bone resorption activity of mature osteoclasts by preventing RANKL-stimulated Src activation, calcium entry, and actin ring formation.
Tumour exosome integrins determine organotropic metastasis.
Lyden et al., New York City, United States. In Nature, Dec 2015
We demonstrate that exosome integrin uptake by resident cells activates Src phosphorylation and pro-inflammatory S100 gene expression.
MyelStones: the executive roles of myelin basic protein in myelin assembly and destabilization in multiple sclerosis.
Harauz et al., Guelph, Canada. In Biochem J, Dec 2015
A central segment of these proteins is pivotal in membrane-anchoring and SH3 domain (Src homology 3) interaction.
Bone antiresorptive agents in the treatment of bone metastases associated with solid tumours or multiple myeloma.
Clézardin et al., Athens, Greece. In Bonekey Rep, 2014
Inhibitors of cathepsin K, Src and activin A are under clinical investigation as potential anti-osteolytics.
Profile of nintedanib in the treatment of solid tumors: the evidence to date.
Schwarz et al., South Bend, United States. In Onco Targets Ther, 2014
Nintedanib (formally known as BIBF 1120) is a triple angiokinase inhibitor of VEGF, fibroblast growth factor, platelet-derived growth factor signaling with lesser activity against RET, Flt-3, and Src.
Involvement of c-Src tyrosine kinase upstream of class I phosphatidylinositol (PI) 3-kinases in Salmonella Enteritidis Rck protein-mediated invasion.
Velge et al., Tours, France. In J Biol Chem, 2012
Involvement of c-Src tyrosine kinase upstream of class I phosphatidylinositol (PI) 3-kinases in Salmonella Enteritidis Rck protein-mediated invasion.
Anoxia-induced NMDA receptor activation opens pannexin channels via Src family kinases.
Thompson et al., Calgary, Canada. In J Neurosci, 2012
Activation of NMDA receptors during anoxia/ischemia recruits Src family kinases to open Panx1, leading to sustained neuronal depolarizations.
cSrc is necessary for epididymal development and is incorporated into sperm during epididymal transit.
Visconti et al., Amherst Center, United States. In Dev Biol, 2012
cSrc is essential for cauda epididymal development.
Src-dependent autophagic degradation of Ret in FAK-signalling-defective cancer cells.
Frame et al., Edinburgh, United Kingdom. In Embo Rep, 2012
Src is a general mediator of selective autophagic targeting of adhesion-linked kinases, and Ret a second FAK-binding tyrosine kinase degraded through autophagy in cancer cells under adhesion stress.
A Src family kinase-Shp2 axis controls RUNX1 activity in megakaryocyte and T-lymphocyte differentiation.
Cantor et al., Boston, United States. In Genes Dev, 2012
These findings link SFK and Shp2 signaling pathways to the regulation of RUNX1 activity in hematopoiesis via control of RUNX1 multiprotein complex assembly.
More papers using Src antibodies
Pharmacokinetics and metabolism of the putative cancer chemopreventive agent cyanidin-3-glucoside in mice
Luo Jia et al., In Molecular Cancer, 2008
... Anti-Neu/Her2/ErbB2 (monoclonal), FAK, cSrc, JNK and phospho-Src (Tyr216) antibodies and Protein A/G beads were purchased from Santa Cruz Biotechnology (San Diego, CA) ...
Mechanism of dietary salt-mediated increase in intravascular production of TGF-ss1.
Means Robert E., In PLoS ONE, 2007
... anti-glyceraldehyde-3-phosphate-dehydrogenase (GAPDH) (Fitzgerald Laboratories), mouse anti-α-tubulin (GeneTex, DM1A) and rabbit antibodies toward Fyn, Lyn and c-Src (Santa Cruz Biotechnology) also were purchased ...
HGF-independent Potentiation of EGFR Action by c-Met
Siegfried Jill M. et al., In Oncogene, 2007
... Rabbit anti-c-Met (C-28), mouse anti-c-Src (B-12) and mouse anti-pY99 were purchased from Santa Cruz Biotechnology (Santa Cruz, CA) ...
Calmodulin dynamically regulates the trafficking of the metabotropic glutamate receptor mGluR5
Ferguson Stephen SG et al., In Molecular Brain, 2007
... kinase (Thr202/Tyr402), p44/44 MAP kinase, phospho-Pyk2 (Tyr402) antibody, phospho-Pyk2 (Tyr457), Pyk2, phosphor-Src (Tyr 416) and Src antibodies were all obtained from Cell Signaling Technology ...
Endocytosis machinery is required for beta1-adrenergic receptor-induced hypertrophy in neonatal rat cardiac myocytes.
Jin Dong-Yan, In PLoS ONE, 2007
... Anti-β-arrestin 1 goat polyclonal, anti-β-arrestin 2 mouse monoclonal and anti-c-Src rabbit polyclonal antibodies were from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...
IQGAP2 inactivation through aberrant promoter methylation and promotion of invasion in gastric cancer cells
Jiang Bo et al., In Molecular Cancer, 2007
... (137 F5), phospho-ERK1/2 (Thr202/Tyr204), p38 MAPK, phospho-p38 MAPK (Thr180/Tyr186), SAPK/JNK, phospho-SAPK/JNK (Thr183/Tyr185), Lyn (C13F9), Src, and phospho-Src (TYR416) antibodies were purchased from Cell Signaling Technology (Danvers, MA) ...
Nonviral delivery of synthetic siRNAs in vivo
Buday Laszlo, In PLoS ONE, 2006
... p53, phospho-FoxO3a (Thr32), FoxO3a, phospho-SAPK/JNK (Thr183/Tyr185), SAPK/JNK, phospho-p38 MAPK (Thr180/Tyr182), p38 MAPK, phospho-p44/42 MAPK (Thr202/Try204), phosho-Src (Try416) were from Cell Signaling Technology (Beverly, MA, USA); ...
Capping of actin filaments by vinculin activated by the Shigella IpaA carboxyl-terminal domain.
Finlay B. Brett, In PLoS Pathogens, 2006
... The anti-Src monoclonal antibody clone 327 was purchased from Oncogene Science (Uniondale, NY), and the anti-Src polyclonal antibody N16 was from Santa Cruz Biotechnology.
Transactivation of the epidermal growth factor receptor by formylpeptide receptor exacerbates the malignant behavior of human glioblastoma cells.
Campbell Moray, In PLoS ONE, 2006
... Rabbit polyclonal phospho-Src family Tyr416 antibody was obtained from Cell Signaling Technology, MA ...
A molecular switch that controls cell spreading and retraction
Du Xiaoping et al., In The Journal of Cell Biology, 2006
... inhibitors H-1152 and Y-27632, and calpain inhibitor MDL 28170 were obtained from Calbiochem; and an anti–c-Src polyclonal antibody was obtained from Santa Cruz Biotechnology, Inc ...
Mitochondrial membrane permeabilization in cell death.
Blanke Steven R., In PLoS Pathogens, 2006
... Cruz Biotechnology; h) rabbit polyclonal against c-Src (from Santa Cruz), and phosphospecific rabbit polyclonal against c-Src phosphorylated at Tyr416 (Cell Signaling Technology, Danvers, MA); i) ...
Activation of proMMP-2 and Src by HHV8 vGPCR in human pulmonary arterial endothelial cells.
Ouchi Toru, In PLoS ONE, 2006
... Rabbit polyclonal antibodies specific for c-Src with tyrosine 416 phosphorylated (or other SFK members with equivalent sites phosphorylated) and specific for I-κBα were purchased from Cell Signaling Technology (Beverly, MA) ...
Transactivation of Src, PDGF receptor, and Akt is involved in IL-1beta-induced ICAM-1 expression in A549 cells.
Schneider Guenter, In PLoS ONE, 2006
... Antibodies against p65, pan-IκBα, phosphatidylinositol 3-kinase (PI-3K) p85 and c-Src were obtained from Santa Cruz Biotechnology (Santa Cruz, CA) ...
CellProfiler: image analysis software for identifying and quantifying cell phenotypes
Ridley Anne J. et al., In Open Biology, 2005
... (DM1A clone, Sigma), rabbit polyclonals Pak1, p-Pak1(Ser199/204), p-Src(Tyr416), p-Paxilin(Tyr118) and GEF-H1 (Cell Signaling), mouse monoclonal Src and acetylated-tubulin (Upstate), mouse anti-human active β1 integrin 9G10 (AbCam), mouse anti-human β1 (clone ...
TGF-β and the Smad signaling pathway support transcriptomic reprogramming during epithelial-mesenchymal cell transition
Schiemann William P et al., In Breast Cancer Research, 2004
... integrin, or mutant c-Src retroviral supernatants produced by EcoPac2 retroviral packaging cells (Clontech, San Diego, CA, USA), ...
Signal transduction for protease-activated receptor-2-triggered prostaglandin E2 formation in human lung epithelial cells
Inagaki Chiyoko et al., In Respiratory Research, 2004
... (specific for Tyr1173) were from Santa Cruz Biotechnology, Inc., (Santa Cruz, CA, USA); anti-Src and anti-phospho-Src (specific for Tyr416) antibodies were from Cell Signaling Technology, INC (Danvers, MA, ...
PTP-1B is an essential positive regulator of platelet integrin signaling
Shattil Sanford J. et al., In The Journal of Cell Biology, 2003
... Antibodies to Csk (C-20) and the COOH terminus of c-Src (B-12) were obtained from Santa Cruz Biotechnology, Inc ...
ADP-ribosylation factor 6 regulates tumor cell invasion through the activation of the MEK/ERK signaling pathway
Keen James, In PLoS ONE, 2003
... α-adaptin, γ-adaptin, clathrin heavy chain, GM130, ILK, paxillin clone 349 (BD Transduction), paxillin clone H114, Src, GFP (Santa Cruz Biotechnology), α-actinin, actopaxin (Sigma), Src ...
Helical Packing Patterns in Membrane and Soluble Proteins
Askari Amir et al., In Biochemistry, 2003
... -ATPase and EGFR from Upstate Biotechnology (Lake Placid, NY); ERK 1/2, Src (sc-8056), phosphotyrosine, PY99 (sc-7020), goat anti-rabbit IgG-bound horseradish peroxidase (HRP), and goat anti-mouse IgG-bound HRP from Santa Cruz Biotechnology (Santa Cruz, CA); caveolin-1 (610059), ...
A renaissance for SRC
McNiven Mark A. et al., In The Journal of Cell Biology, 2003
... The phospho-Src family antibody pY416 was from Cell Signaling Technology, the monoclonal vinculin ...
The weight of leptin in immunity.
Ferreira Sérgio Teixeira, In PLoS ONE, 2003
... Antibodies against p-Src family Tyr416 (2101L) and p-Src family Tyr 527 (2105L) were from Cell Signaling Technology (Danvers, MA, USA) ...
Coordinate signaling by Src and p38 kinases in the induction of cortical cataracts
Fisher P. B. et al., In Oncogene, 2003
... The following reagents were obtained from the indicated providers: anti-c-Src and anti-IκBα (Santa Cruz Biotechnology, CA), anti-HA (Covance Research ...
The neurite outgrowth multiadaptor RhoGAP, NOMA-GAP, regulates neurite extension through SHP2 and Cdc42
Birchmeier Walter et al., In The Journal of Cell Biology, 2002
... pSrcBridge was generated by subcloning nonmyristoylated (G2E) active (Y416F Y527F) chicken Src into the second multiple cloning site of pBridge (CLONTECH Laboratories, Inc.) ...
Partitioning of lipid-modified monomeric GFPs into membrane microdomains of live cells
Öbrink Björn et al., In The Journal of Cell Biology, 2001
... Other mouse mAbs used were anti-CD56 (T199; Dako), anti-Src (B-12; Santa Cruz Biotechnology, Inc.), anti–α3-integrin (clone 42; ...
Palmitoylation supports assembly and function of integrin–tetraspanin complexes
Hemler Martin E. et al., In The Journal of Cell Biology, 2001
... Antibodies to FAK, fyn, Src, and p130Cas were obtained from Santa Cruz Biotechnology, Inc., and anti-GFP was ...
Integrin α2β1 mediates outside-in regulation of platelet spreading on collagen through activation of Src kinases and PLCγ2
Watson Steve P. et al., In The Journal of Cell Biology, 2001
... Anti–phospho-Src family (Tyr416) pAb was from New England Biolabs, Inc ...
Expanding the role of NHERF, a PDZ-domain containing protein adapter, to growth regulation
Arpin Monique et al., In Breast Cancer Research, 2000
... Pan c-Src antibody (Ab-1) was obtained from Oncogene Science (Cambridge, MA, USA), and Matrigel was obtained from Becton Dickinson Co ...
Two dimensional non equilibrium pH gel electrophoresis mapping of cytosolic protein changes caused by dietary protein depletion in mouse liver
Gray Nicola K. et al., In Biochemical Journal, 2000
... HRP-conjugated goat anti-mouse IgG, anti-GAPDH (glyceraldehyde-3-phosphate dehydrogenase) and anti-G3BP [Ras GAP (GTPase-activating protein) SH3 (Src homology 3) domain-binding protein] antibodies were from Thermo Scientific, Abcam and Becton Dickinson ...
Beta-arrestin- and c-Src-dependent degradation of G-protein-coupled receptor kinase 2.
Buday Laszlo, In PLoS ONE, 2000
... Antibodies against c-Src and phospho-Src (Tyr-416) were purchased from Cell Signaling Technology (Danvers, MA, USA) ...
The EphA4 receptor regulates dendritic spine remodeling by affecting β1-integrin signaling pathways
Pasquale Elena B. et al., In The Journal of Cell Biology, 1999
... The phosphospecific antibodies to Crk tyrosine 221, Cas tyrosine 165, and Src tyrosine 416 were obtained from Cell Signaling.
Chronic myeloid leukemia
Combs Colin K et al., In Journal of Neuroinflammation, 1998
... The anti-Lyn antibody, anti-Src, anti-α-tubulin antibodies, FITC and Texas Red conjugated secondary antibodies, and horseradish peroxidase conjugated secondary antibodies were purchased from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...
Phosphorylation and regulation of Raf by Akt (protein kinase B)
Kholodenko Boris N et al., In Molecular Systems Biology, 1998
... Millipore); mouse anti-phospho-ERK1/2 (T202/185 and Y204/187), anti-phospho-AKT1 (S473) (587F11) (both from Cell Signaling), anti-α-tubulin (DM1A), anti-Src (GD11) (both from Millipore), anti-Ras (BD Biosciences), anti-glyceraldehyde-3-phosphate dehydrogenase (GAPDH) (6C5) ...
Specific SHP-2 partitioning in raft domains triggers integrin-mediated signaling via Rho activation
Mañes Santos et al., In The Journal of Cell Biology, 1998
... Antibodies used included the following: anti–SHP-2, -caveolin-1, -FAK, and anti-pan Src (Santa Cruz Biotechnology); anti-β1 integrin (Chemicon International); ...
Focal adhesion kinase promotes phospholipase C-gamma1 activity
Huttenlocher Anna et al., In The Journal of Cell Biology, 1998
... (clone M-300; Santa Cruz Biotechnology, Inc.), anti-pY31 paxillin, anti-pY397 FAK (Invitrogen), anti-pY410 p130Cas, and anti-pY416 Src (Cell Signaling Technology) ...
Autocrine CSF-1R activation promotes Src-dependent disruption of mammary epithelial architecture
Brugge Joan S. et al., In The Journal of Cell Biology, 1998
... from Chemicon; E-cadherin, β-catenin, α-catenin, and p120ctn from BD Transduction Labs; Ki-67 from Zymed Laboratories; phospho-Src(Y416) from New England Biolabs, Inc.; and cleaved caspase-3 ...
Multi-ligand interactions with receptor-like protein tyrosine phosphatase beta: implications for intercellular signaling
Katsoris Panagiotis et al., In Molecular Cancer, 1997
... (Thr202/Tyr204), as well as monoclonal antibodies against Src (36D10) were purchased from Cell Signaling Technology ...
Nicotinic acetylcholine receptor is internalized via a Rac-dependent, dynamin-independent endocytic pathway
Barrantes Francisco J. et al., In The Journal of Cell Biology, 1996
... Anti-EEA1, Rac1, phospho-Src antibodies, and SA-phycoerythrin (PE) were purchased from BD Biosciences.
Peptidase inhibitors improve recovery of substance P and calcitonin gene-related peptide release from rat spinal cord slices
Hingtgen Cynthia M et al., In Molecular Pain, 1995
... 1:500 titer, Cell Signaling Technologies; SFK: rabbit polyclonal primary antibody, 1:500 titer, Cell Signaling Technologies; c-Src: mouse monoclonal primary antibody, 1:500 titer, Santa Cruz Biotechnology; Fyn: mouse monoclonal primary ...
Gelsolin-actin interaction and actin polymerization in human neutrophils
Chellaiah Meenakshi A et al., In BMC Cell Biology, 1989
... Antibodies to PI3-kinase and Src were purchased from Santa Cruz Biotechnology, Inc (Santa Cruz, CA) ...
Expression of cellular-yes protein in mammalian tissues
Milgram Sharon L. et al., In The Journal of Cell Biology, 1989
... sources: mouse anti-Yes and mouse anti-ezrin from Transduction Laboratories; rabbit anti-Yes from Upstate Biotechnology, mouse anti-Src from Santa Cruz Biotechnology, and rat anti-ZO-1 and ...
Src family kinases participate in the regulation of encephalomyocarditis virus-induced cyclooxygenase-2 expression by macrophages
Corbett John A. et al., In The Journal of General Virology, 1987
... rabbit anti-STAT1 antiserum from Santa Cruz Biotechnology, mouse monoclonal anti-Src (clone GD11) from Upstate, rabbit anti-phospho-Src (Y416) from Cell Signaling Technology and mouse anti-GAPDH ...
Changes in protein phosphorylation in Rous sarcoma virus-transformed chicken embryo cells.
Fujita Donald J et al., In BMC Biochemistry, 1980
... α-Src phosphotyrosine 419 antibody was from Cell Signaling.
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
Sharma Rajendra K et al., In Molecular Cancer, 1975
... , anti-phospho-Src (Tyr527], and anti-phospho-Src (Tyr416] were purchased from Cell Signaling, USA ...
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.
Monleon Daniel, In PLoS ONE, 1975
... Rabbit polyclonal antibody against total c-Src (2108) and rabbit polyclonal antibody against Y416 c-Src (2101) were from Cell Signaling Technology (Boston, EEUU) ...
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