Inhibitory leukocyte immunoglobulin-like receptors: Immune checkpoint proteins and tumor sustaining factors.
Dallas, United States. In Cell Cycle, Feb 2016
Inhibitory leukocyte immunoglobulin-like receptors (LILRBs 1-5) transduce signals via intracellular immunoreceptor tyrosine-based inhibitory motifs (ITIMs) that recruit protein tyrosine phosphatase non-receptor type 6 (PTPN6 or SHP-1), protein tyrosine phosphatase non-receptor type 11 (PTPN11 or SHP-2), or Src homology 2 domain-containing inositol phosphatase (SHIP), leading to negative regulation of immune cell activation.
Inhibitory leukocyte immunoglobulin-like receptors in cancer development.
More papers using
Shanghai, China. In Sci China Life Sci, Dec 2015
Inhibitory leukocyte immunoglobulin-like receptors (LILRB1-5) signal through immunoreceptor tyrosine-based inhibitory motifs (ITIMs) in their intracellular domains and recruit phosphatases protein tyrosine phosphatase, non-receptor type 6 (PTPN6, SHP-1), protein tyrosine phosphatase, non-receptor type 6 (PTPN6, SHP-2), or Src homology 2 domain containing inositol phosphatase (SHIP) to negatively regulate immune cell activation.
IQGAP2 inactivation through aberrant promoter methylation and promotion of invasion in gastric cancer cells
In Molecular Cancer, 2007
... (137 F5), phospho-ERK1/2 (Thr202/Tyr204), p38 MAPK, phospho-p38 MAPK (Thr180/Tyr186), SAPK/JNK, phospho-SAPK/JNK (Thr183/Tyr185), Lyn (C13F9), Src, and phospho-Src (TYR416) antibodies were purchased from Cell Signaling Technology (Danvers, MA) ... Nonviral delivery of synthetic siRNAs in vivo
In PLoS ONE, 2006
... p53, phospho-FoxO3a (Thr32), FoxO3a, phospho-SAPK/JNK (Thr183/Tyr185), SAPK/JNK, phospho-p38 MAPK (Thr180/Tyr182), p38 MAPK, phospho-p44/42 MAPK (Thr202/Try204), phosho-Src (Try416) were from Cell Signaling Technology (Beverly, MA, USA); ... ADP-ribosylation factor 6 regulates tumor cell invasion through the activation of the MEK/ERK signaling pathway
In PLoS ONE, 2003
... α-adaptin, γ-adaptin, clathrin heavy chain, GM130, ILK, paxillin clone 349 (BD Transduction), paxillin clone H114, Src, GFP (Santa Cruz Biotechnology), α-actinin, actopaxin (Sigma), Src ... Chronic myeloid leukemia
In Journal of Neuroinflammation, 1998
... The anti-Lyn antibody, anti-Src, anti-α-tubulin antibodies, FITC and Texas Red conjugated secondary antibodies, and horseradish peroxidase conjugated secondary antibodies were purchased from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...