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Nuclear receptor coactivator 1

SRC-1, steroid receptor coactivator-1
The protein encoded by this gene acts as a transcriptional coactivator for steroid and nuclear hormone receptors. It is a member of the p160/steroid receptor coactivator (SRC) family and like other family members has histone acetyltransferase activity and contains a nuclear localization signal, as well as bHLH and PAS domains. The product of this gene binds nuclear receptors directly and stimulates the transcriptional activities in a hormone-dependent fashion. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Src, CAN, AIB1, CBP, ACID
Papers using SRC-1 antibodies
Association of the heat shock protein hsp90 with steroid hormone receptors and tyrosine kinase oncogene products
Puca Giovanni A. et al., In The Journal of Cell Biology, 1985
... (aa 5–20), to Nurr77 (aa 4–23), to TFIIB (aa 299–316), and to steroid receptor cofactor-1 (SRC-1) were from Santa Cruz Biotechnology Inc. ...
Papers on SRC-1
Dose-dependent regulation of steroid receptor coactivator-1 and steroid receptors by testosterone propionate in the hippocampus of adult male mice.
Zhang et al., Chongqing, China. In J Steroid Biochem Mol Biol, Feb 2016
Steroid receptor coactivator-1 (SRC-1) is present in the hippocampus of several species, and its expression is regulated by development and aging, as well as by orchidectomy and aromatase inhibitor letrozole administration, while ovariectomy only transiently downregulated hippocampal SRC-1.
Androgen Receptor Coactivators in Regulation of Growth and Differentiation in Prostate Cancer.
Culig, Innsbruck, Austria. In J Cell Physiol, Feb 2016
The p160 group of coactivators, SRC-1, -2, and -3 not only potentiate the activation of the AR, but are also implicated in potentiation of function of insulin-like growth factor-I and activation of the Akt pathway.
Control of heterochromatin localization and silencing by the nuclear membrane protein Lem2.
Braun et al., Martinsried, Germany. In Genes Dev, Feb 2016
Chromatin association and tethering of centromeres to the periphery are mediated by the N-terminal LEM (LAP2-Emerin-MAN1) domain of Lem2, whereas telomere anchoring and heterochromatin silencing require exclusively its conserved C-terminal MSC (MAN1-Src1 C-terminal) domain.
Interaction of steroid receptor coactivators and estrogen receptors in the human placenta.
An et al., Miryang, South Korea. In J Mol Endocrinol, Feb 2016
In addition, SRC family including SRC-1, SRC-2, and SRC-3 was expressed in the human placenta, and the levels of SRC-1, SRC-2, and SRC-3 were increased in the placenta at the late stage of gestation.
Moving Beyond the Androgen Receptor (AR): Targeting AR-Interacting Proteins to Treat Prostate Cancer.
Mitsiades et al., Houston, United States. In Horm Cancer, Feb 2016
In this review, we discuss the preclinical research that has been done, as well as clinical trials for prostate cancer, on inhibiting several important families of AR-interacting proteins, including chaperones (such as heat shock protein 90 (HSP90) and FKBP52), pioneer factors (including forkhead box protein A1 (FOXA1) and GATA-2), and AR transcriptional coregulators such as the p160 steroid receptor coactivators (SRCs) SRC-1, SRC-2, SRC-3, as well as lysine deacetylases (KDACs) and lysine acetyltransferases (KATs).
The effects of bufadienolides on HER2 overexpressing breast cancer cells.
Yuan et al., Dalian, China. In Tumour Biol, Jan 2016
Our results showed that arenobufagin and bufalin could significantly inhibit the proliferation and survival of HER2 overexpressing breast cancer cells, along with the declination of SRC-1, SRC-3, nuclear transcription factor E2F1, phosphorylated AKT, and ERK.
Implications of a peroxisome proliferator-activated receptor alpha (PPARα) ligand clofibrate in breast cancer.
Sharma-Walia et al., North Chicago, United States. In Oncotarget, Dec 2015
High level of coactivators steroid receptor coactivator-1 (SRC-1) and histone acetylase CBP-300 (CREB binding protein-300) were observed in the nuclear complexes of clofibrate treated breast cancer cells.
Characterization of a Steroid Receptor Coactivator Small Molecule Stimulator that Overstimulates Cancer Cells and Leads to Cell Stress and Death.
O'Malley et al., Houston, United States. In Cancer Cell, Sep 2015
By integrating growth pathways on which cancer cells rely, steroid receptor coactivators (SRC-1, SRC-2, and SRC-3) represent emerging targets in cancer therapeutics.
The p160/steroid receptor coactivator family: potent arbiters of uterine physiology and dysfunction.
Lydon et al., Houston, United States. In Biol Reprod, 2014
The p160/steroid receptor coactivator (SRC) family comprises three pleiotropic coregulators (SRC-1, SRC-2, and SRC-3; otherwise known as NCOA1, NCOA2, and NCOA3, respectively), which modulate a wide spectrum of physiological responses and clinicopathologies.
Steroid receptor coactivators: servants and masters for control of systems metabolism.
O'Malley et al., Houston, United States. In Trends Endocrinol Metab, 2014
The steroid receptor coactivator (SRC) family is composed of three homologous members (SRC-1, SRC-2, and SRC-3), which are uniquely important for mediating steroid hormone and mitogenic actions.
Coactivator recruitment of AhR/ARNT1.
Shibasaki et al., Tokyo, Japan. In Int J Mol Sci, 2013
In this review, we focus on our recent findings related to the recruitment of steroid receptor coactivator 1 (SRC1/NCoA1) by the estrogen receptor-α (ERα) and by the arylhydrocarbon receptor/arylhydrocarbon receptor nuclear translocator 1 (AhR/ARNT1) complex.
A new isoform of steroid receptor coactivator-1 is crucial for pathogenic progression of endometriosis.
O'Malley et al., Houston, United States. In Nat Med, 2012
A previously unidentified 70-kDa SRC-1 proteolytic isoform is highly elevated both in the endometriotic tissue of mice with endometriosis and in endometriotic stromal cells biopsied from patients with endometriosis.
Steroid receptor coactivator-interacting protein (SIP) inhibits caspase-independent apoptosis by preventing apoptosis-inducing factor (AIF) from being released from mitochondria.
Shang et al., Beijing, China. In J Biol Chem, 2012
Our data demonstrate that SIP is a novel regulator in caspase-independent and AIF-mediated apoptosis.
Estradiol increases cell growth in human astrocytoma cell lines through ERα activation and its interaction with SRC-1 and SRC-3 coactivators.
Camacho-Arroyo et al., Mexico. In Biochim Biophys Acta, 2012
Results demonstrate that estradiol induces growth of human astrocytoma cell lines through ERalpha and its interaction with SRC-1 and SRC-3 and also suggest differential roles of ERalpha on cell growth depending on astrocytoma grade.
A SNP in steroid receptor coactivator-1 disrupts a GSK3β phosphorylation site and is associated with altered tamoxifen response in bone.
Oesterreich et al., Houston, United States. In Mol Endocrinol, 2012
We have identified a functional genetic variant of SRC-1 with decreased activity, resulting, at least in part, from the loss of a GSK3beta phosphorylation site, which was also associated with decreased bone mineral density in tamoxifen-treated women.
[Effects of daidzein on steroid receptor coactivator-1 expression in MC3T3-E1 cells and the mechanism].
Gao et al., Shanghai, China. In Zhong Xi Yi Jie He Xue Bao, 2011
Daidzein increases protein level of SRC-1 in cultured osteoblasts.
Role of the ubiquitin-like protein Hub1 in splice-site usage and alternative splicing.
Jentsch et al., Martinsried, Germany. In Nature, 2011
Here we report that alternative splicing of Saccharomyces cerevisiae SRC1 pre-mRNA is promoted by the conserved ubiquitin-like protein Hub1.
The coactivator SRC-1 is an essential coordinator of hepatic glucose production.
O'Malley et al., Houston, United States. In Cell Metab, 2011
SRC-1 acts as a critical mediator of glucose homeostasis in the liver by adjusting the transcriptional activity of key genes involved in the hepatic glucose production machinery.
The transcriptional coregulators TIF2 and SRC-1 regulate energy homeostasis by modulating mitochondrial respiration in skeletal muscles.
Metzger et al., Illkirch-Graffenstaden, France. In Cell Metab, 2010
SRC-1 and TIF2 can modulate the expression of the uncoupling protein 3 in an antagonistic manner and that enhanced SRC-1 levels in TIF2-deficient myofibers are critically involved in the metabolic changes of TIF2(i)skm-/- mice.
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