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Mediator complex subunit 21

Srb7, Med21, Srb7p, hSRB7, SURB7
The Mediator is a multiprotein coactivator that is required by DNA-binding transcription factors for transcriptional activation of polymerase II (see MIM 180660)-transcribed genes. MED21 is a Mediator subunit predicted to reside in the middle module and appears to be a core subunit found in nearly all Mediator preparations (summary by Sato et al., 2004 [PubMed 15175163]).[supplied by OMIM, Nov 2010] (from NCBI)
Top mentioned proteins: POLYMERASE, CAN, MED6, Med7, Tup1
Papers on Srb7
Characterization of the influence of mediator complex in HIV-1 transcription.
Esté et al., Badalona, Spain. In J Biol Chem, 2014
Knockdown of 9 out of 28 human MED proteins significantly impaired viral replication without affecting cell viability, including MED6, MED7, MED11, MED14, MED21, MED26, MED27, MED28, and MED30.
The function of the Mediator complex in plant immunity.
Mou et al., Gainesville, United States. In Plant Signal Behav, 2013
Here, we review current understanding of the role of five functionally characterized Mediator subunits (MED8, MED15, MED16, MED21 and MED25) in plant immunity.
Role of Mediator in regulating Pol II elongation and nucleosome displacement in Saccharomyces cerevisiae.
Gross et al., Shreveport, United States. In Genetics, 2012
We find that ewe (expression without heat shock element) mutations in conserved Mediator subunits Med7, Med14, Med19, and Med21-all located within or adjacent to the middle module-severely diminish heat-shock-induced expression of the Hsf1-regulated HSP82 gene.
The transcriptional coactivator DRIP/mediator complex is involved in vitamin D receptor function and regulates keratinocyte proliferation and differentiation.
Bikle et al., San Francisco, United States. In J Invest Dermatol, 2010
Blocking MED1/MED21 expression caused hyperproliferation of keratinocytes
HISTONE MONOUBIQUITINATION1 interacts with a subunit of the mediator complex and regulates defense against necrotrophic fungal pathogens in Arabidopsis.
Mengiste et al., West Lafayette, United States. In Plant Cell, 2009
HUB1 interacts with MED21, a subunit of the Arabidopsis Mediator, a conserved complex that regulates RNA polymerase II.
Gal11p dosage-compensates transcriptional activator deletions via Taf14p.
Lehming et al., Singapore, Singapore. In J Mol Biol, 2007
We have further shown that the suppression of a GAL4 deletion by high levels of Gal11p required Taf14p, and that over-expression of Gal11p recruited Taf14p to the GAL1 promoter together with Tbp1p, Swi2p and Srb7p.
Functional and physical interactions within the middle domain of the yeast mediator.
Ronne et al., Umeå, Sweden. In Mol Genet Genomics, 2006
Med21 (Srb7) is a small essential subunit of the middle domain of the Mediator, which is conserved in all eukaryotes.
A conserved mediator hinge revealed in the structure of the MED7.MED21 (Med7.Srb7) heterodimer.
Cramer et al., München, Germany. In J Biol Chem, 2005
Co-expressed yeast MED21 and MED7 in E. coli to determine structure.
hSrb7, an essential human Mediator component, acts as a coactivator for the thyroid hormone receptor.
Aranda et al., Madrid, Spain. In Mol Cell Endocrinol, 2004
We describe a novel functional interaction of the nuclear thyroid receptor (TR), with a human Mediator component (hSrb7), and a human TFIIH component (hMo15).
Recruitment of Tup1-Ssn6 by yeast hypoxic genes and chromatin-independent exclusion of TATA binding protein.
Zitomer et al., Albany, United States. In Eukaryot Cell, 2003
The mediator factor Srb7 has been shown to interact with Tup1 and to play a role in repression at several regulons, but we found that significant levels of repression remained in srb7 mutants even when the chromatin-dependent repression mechanism was eliminated.
Characterization of mutations that are synthetic lethal with pol3-13, a mutated allele of DNA polymerase delta in Saccharomyces cerevisiae.
Heude et al., Orsay, France. In Curr Genet, 2003
Other mutations were identified in genes involved in repair and genome stability (MET18/ MMS19), in the control of origin-firing and/or transcription (ABF1, SRB7), in the S/G2 checkpoint (RAD53), in the Ras-cAMP signal transduction pathway (MKS1), in nuclear pore metabolism (SEH1), in protein degradation (DOC1) and in folding (YDJ1).
Expression profile of genes from 12p in testicular germ cell tumors of adolescents and adults associated with i(12p) and amplification at 12p11.2-p12.1.
Shipley et al., United Kingdom. In Oncogene, 2003
High-level overexpression of BCAT1 was specific to nonseminomas and overexpression of genes such as CMAS, EKI1, KRAS2, SURB7 and various ESTs correlated with their amplification.
Srb7p is a physical and physiological target of Tup1p.
Lehming et al., Köln, Germany. In Embo J, 2001
We demonstrate that the essential holoenzyme component Srb7p is a physiologically relevant target of the global repressor Tup1p in Saccharomyces cerevisiae.
Genomics of the human genes encoding four TAFII subunits of TFIID, the three subunits of TFIIA, as well as CDK8 and SURB7.
Purrello et al., Catania, Italy. In Somat Cell Mol Genet, 1999
By in situ chromosomal hybridization, and by somatic cell and radiation hybrid analysis, we have determined the genomic position of the human genes encoding four TAFII subunits of TFIID (TAFII150, TAFII105, TAFII68, TAFII18), the three subunits of TFIIA (TFIIA35 and TFIIA19, both encoded by the same gene, and TFIIA12), CDK8, and SURB7.
A mammalian SRB protein associated with an RNA polymerase II holoenzyme.
Young et al., Cambridge, United States. In Nature, 1996
We have now isolated a human homologue of the yeast SRB7 gene and used antibodies against human SRB7 protein to purify and characterize a mammalian RNA polymerase II holoenzyme containing the general transcription factors TFIIE and TFIIH.
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