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SRB5 Srb5p

Srb5, Med18, p28b
MED18 is a component of the Mediator complex, which is a coactivator for DNA-binding factors that activate transcription via RNA polymerase II (Sato et al., 2003 [PubMed 12584197]).[supplied by OMIM, Oct 2008] (from NCBI)
Top mentioned proteins: POLYMERASE, ACID, CAN, PCNA, TBP
Papers on Srb5
Identification and characterisation of the IL-27 p28 subunits in fish: Cloning and comparative expression analysis of two p28 paralogues in Atlantic salmon Salmo salar.
Wang et al., Aberdeen, United Kingdom. In Fish Shellfish Immunol, 2014
Two p28 paralogues (p28a and p28b) sharing 72% aa identity have been identified and characterised in Atlantic salmon.
Mediator MED18 subunit plays a negative role in transcription via the CDK/cyclin module.
Ohkuma et al., Toyama, Japan. In Genes Cells, 2014
The Mediator complex (Mediator) is conserved among eukaryotes and is comprised of head, middle, tail and CDK/cyclin modules.
MED18 interaction with distinct transcription factors regulates multiple plant functions.
Mengiste et al., West Lafayette, United States. In Nat Commun, 2013
Here we show that Arabidopsis MED18 is a multifunctional protein regulating plant immunity, flowering time and responses to hormones through interactions with distinct transcription factors.
Rare variant testing of imputed data: an analysis pipeline typified.
Becker et al., Bonn, Germany. In Hum Hered, 2013
In addition, we highlight several suggestive rare variant association findings for follow-up studies, including genomic regions overlapping MCPH1, MED18 and NOTCH3.
Srb5/Med18-mediated termination of transcription is dependent on gene looping.
Ansari et al., Detroit, United States. In J Biol Chem, 2013
We have earlier demonstrated the involvement of Mediator subunit Srb5/Med18 in the termination of transcription for a subset of genes in yeast.
Mediator subunit18 controls flowering time and floral organ identity in Arabidopsis.
Oppenheimer et al., Gainesville, United States. In Plos One, 2012
Here we show that in Arabidopsis thaliana, MEDIATOR SUBUNIT 18 (MED18) affects flowering time and floral organ formation through FLOWERING LOCUS C (FLC) and AGAMOUS (AG).
Novel role for mediator complex subunit Srb5/Med18 in termination of transcription.
GeneRIF
Ansari et al., Detroit, United States. In J Biol Chem, 2011
Mediator subunit Srb5/Med18 is required for proper termination of transcription of a subset of genes in budding yeast.
Transcriptome dynamics and molecular cross-talk between bovine oocyte and its companion cumulus cells.
Tesfaye et al., Bonn, Germany. In Bmc Genomics, 2010
Of these, 320 and 246 are over expressed in CCs+OO and CCs-OO, respectively.While oocyte specific transcripts include those involved in transcription (IRF6, POU5F1, MYF5, MED18), translation (EIF2AK1, EIF4ENIF1) and CCs specific ones include those involved in carbohydrate metabolism (HYAL1, PFKL, PYGL, MPI), protein metabolic processes (IHH, APOA1, PLOD1), steroid biosynthetic process (APOA1, CYP11A1, HSD3B1, HSD3B7).
Mediator subunits and histone methyltransferase Set2 contribute to Ino2-dependent transcriptional activation of phospholipid biosynthesis in the yeast Saccharomyces cerevisiae.
Schüller et al., Greifswald, Germany. In Mol Genet Genomics, 2010
We used a set of 15 strains each defective for one of the non essential subunits of yeast mediator complex and identified med2, med3, med15, med18 and med19 as impaired for inositol biosynthesis.
The involvement of the Schizosaccharomyces pombe sep9/spt8 gene in the regulation of septum cleavage.
Sipiczki et al., Debrecen, Hungary. In Fems Yeast Res, 2009
sep9-307 is synthetically lethal with mutations in the cell separation genes sep11/med18(+) and sep15/med8(+), which encode subunits of the general transcription factor mediator.
[The functional interaction of an RNA polymerase II Rpb11 subunit with the Med18 subunit (Srb5) of the Saccharomyces cerevisiae mediator complex].
Shpakovskiĭ et al., In Bioorg Khim, 2009
The SRB5 gene encoding the Med18 (Srb5) subunit of the mediator complex of the Saccharomyces cerevisiae transcription apparatus was identified in the C-terminal region of the yeast RNA polymerase II Rpb11 subunit as a multicopy suppressor of the Leu111Ala (L111A) point mutation.
Structure-system correlation identifies a gene regulatory Mediator submodule.
Cramer et al., München, Germany. In Genes Dev, 2008
Med8C forms a conserved alpha-helix that tethers Med18/20 to the Mediator.
Structure and TBP binding of the Mediator head subcomplex Med8-Med18-Med20.
GeneRIF
Cramer et al., München, Germany. In Nat Struct Mol Biol, 2006
Our results and published data support a positive role of the Med8/18/20 subcomplex in initiation-complex formation and suggest that the Mediator head contains a multipartite TBP-binding site that can be modulated by transcriptional activators.
Plasma proteomic analysis of the acute phase response of rainbow trout (Oncorhynchus mykiss) to intraperitoneal inflammation and LPS injection.
Lumsden et al., Guelph, Canada. In Dev Comp Immunol, 2005
We have constructed a plasma protein panel of eight increased or induced proteins (p9.5, p10.5, p24a, p24b, p24c, p25a, p36 and p37), one decreased (p16) and two that are unaltered (p28a, p28b) in rainbow trout following inflammation or injection with LPS/FIA.
A multiprotein mediator of transcriptional activation and its interaction with the C-terminal repeat domain of RNA polymerase II.
Impact
Kornberg et al., Stanford, United States. In Cell, 1994
The mediator comprised some 20 polypeptides, including the three subunits of TFIIF and other polypeptides cross-reactive with antisera against GAL11, SUG1, SRB2, SRB4, SRB5, and SRB6 proteins.
A multisubunit complex associated with the RNA polymerase II CTD and TATA-binding protein in yeast.
Impact
Young et al., Cambridge, United States. In Cell, 1993
The isolation and characterization of extragenic suppressors of S. cerevisiae RNA polymerase II CTD truncation mutations led us to identify SRB2, SRB4, SRB5, and SRB6 as genes involved in CTD function in vivo.
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