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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

SRB4 Srb4p

Srb4, med17
The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: POLYMERASE, TBP, MED12, CHIP, Srb5
Papers on Srb4
Deposition of 5-Methylcytosine on Enhancer RNAs Enables the Coactivator Function of PGC-1α.
New
Walsh et al., New York City, United States. In Cell Rep, Feb 2016
Interactions of methylated PGC-1α[K779me] with the Spt-Ada-Gcn5-acetyltransferase (SAGA) complex, the Mediator members MED1 and MED17, and the NOP2/Sun RNA methytransferase 7 (NSUN7) reinforce transcription, and are concomitant with the m(5)C mark on enhancer RNAs (eRNAs).
Distinct but milder phenotypes with choreiform movements in siblings with compound heterozygous mutations in the transcription preinitiation mediator complex subunit 17 (MED17).
New
Matsumoto et al., Nagano, Japan. In Brain Dev, Jan 2016
Whole exome sequencing (WES) revealed compound heterozygous mutations in MED17 gene in both siblings: c.1013-5A>G and c.1484T>G mutations transmitted from their father and mother, respectively.
Somatic MED12 mutations in prostate cancer and uterine leiomyomas promote tumorigenesis through distinct mechanisms.
New
Vahteristo et al., Helsinki, Finland. In Prostate, Jan 2016
Instead, the L1224F mutation was shown to affect interactions between MED12 and other Mediator components (MED1, MED13, MED13L, MED14, MED15, MED17, and MED24).
Mediator independently orchestrates multiple steps of preinitiation complex assembly in vivo.
New
Soutourina et al., Gif-sur-Yvette, France. In Nucleic Acids Res, Nov 2015
Med17 is an essential and central component of the Mediator head module.
Human mediator MED17 subunit plays essential roles in gene regulation by associating with the transcription and DNA repair machineries.
New
Ohkuma et al., Toyama, Japan. In Genes Cells, Mar 2015
We studied the human head module subunit MED17 (hMED17).
Homozygous missense mutation in MED25 segregates with syndromic intellectual disability in a large consanguineous family.
New
Santos et al., Campina Grande, Brazil. In J Med Genet, Feb 2015
Deleterious mutations in MED12, MED17 and MED23 have already been associated with ID.
Genome-wide association of mediator and RNA polymerase II in wild-type and mediator mutant yeast.
Morse et al., Albany, United States. In Mol Cell Biol, 2015
We also show that recruitment of tail module subunits to active gene promoters continues genome-wide when Mediator integrity is compromised in med17 temperature-sensitive (ts) yeast, demonstrating the modular nature of the Mediator complex in vivo.
Mouse DRG Cell Line with Properties of Nociceptors.
Nassar et al., Sheffield, United Kingdom. In Plos One, 2014
Using immunocytochemistry, RT-PCR and calcium microfluorimetry, we demonstrate that the cell line MED17.11
Mediator links transcription and DNA repair by facilitating Rad2/XPG recruitment.
Soutourina et al., Gif-sur-Yvette, France. In Genes Dev, 2014
We identified a functional contact between the Med17 Mediator subunit and Rad2/XPG, the 3' endonuclease involved in nucleotide excision DNA repair.
Distribution and in situ abundance of sulfate-reducing bacteria in diverse marine hydrocarbon seep sediments.
Knittel et al., Bremen, Germany. In Environ Microbiol, 2012
Two other uncultured groups, SEEP-SRB3 and SEEP-SRB4, were preferentially detected in surface sediments from mud volcanoes.
Med5(Nut1) and Med17(Srb4) are direct targets of mediator histone H4 tail interactions.
GeneRIF
Myers et al., United States. In Plos One, 2011
Data show that Med17(Srb4) are direct targets of mediator histone H4 tail interactions.
Direct interaction of RNA polymerase II and mediator required for transcription in vivo.
Impact
GeneRIF
Werner et al., Gif-sur-Yvette, France. In Science, 2011
identifed direct physical interaction between the Rpb3 Pol II subunit and the Mediator subunit, Med17; findings suggest a direct interaction between Mediator and Pol II is generally required for transcription of class II genes in eukaryotes
Mediator and post-recruitment regulation of RNA polymerase II.
GeneRIF
Taatjes et al., Boulder, United States. In Transcription, 2011
Studies indicate that the activation domain of p53 (p53AD) binds directly to the MED17 subunit of Mediator, whereas the p53 C-terminal domain (p53CTD) binds the MED1 subunit.
Infantile cerebral and cerebellar atrophy is associated with a mutation in the MED17 subunit of the transcription preinitiation mediator complex.
GeneRIF
Elpeleg et al., Jerusalem, Israel. In Am J Hum Genet, 2010
the p. L371P mutation in MED17 is a founder mutation in the Caucasus Jewish community and that homozygosity for this mutation is associated with infantile cerebral and cerebellar atrophy with poor myelination.
Mediator complex association with constitutively transcribed genes in yeast.
Morse et al., Albany, United States. In Proc Natl Acad Sci U S A, 2009
Here we have investigated Mediator association with several constitutively transcribed genes in yeast by comparing a yeast strain that harbors a temperature-sensitive mutation in an essential Mediator subunit, Srb4, with its wild-type (WT) counterpart.
Two conserved modules of Schizosaccharomyces pombe Mediator regulate distinct cellular pathways.
Holmberg et al., Stockholm, Sweden. In Nucleic Acids Res, 2008
Biochemical analysis of med8(ts), med17(ts), Deltamed18, Deltamed20 and Deltamed27 alleles revealed a stepwise head domain molecular architecture.
A subunit of the mediator complex regulates vertebrate neuronal development.
GeneRIF
Guo et al., San Francisco, United States. In Proc Natl Acad Sci U S A, 2006
This paper demonstrates a regulatory role of motionless/Med12 in vertebrate neuronal development.
A multiprotein mediator of transcriptional activation and its interaction with the C-terminal repeat domain of RNA polymerase II.
Impact
Kornberg et al., Stanford, United States. In Cell, 1994
The mediator comprised some 20 polypeptides, including the three subunits of TFIIF and other polypeptides cross-reactive with antisera against GAL11, SUG1, SRB2, SRB4, SRB5, and SRB6 proteins.
A multisubunit complex associated with the RNA polymerase II CTD and TATA-binding protein in yeast.
Impact
Young et al., Cambridge, United States. In Cell, 1993
The isolation and characterization of extragenic suppressors of S. cerevisiae RNA polymerase II CTD truncation mutations led us to identify SRB2, SRB4, SRB5, and SRB6 as genes involved in CTD function in vivo.
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