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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Macrophage scavenger receptor 1

SRA, macrophage scavenger receptor, MTRR, methionine synthase reductase, APJ
This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: apelin, V1a, CAN, methylenetetrahydrofolate reductase, HAD
Papers using SRA antibodies
Down-regulation of the forkhead transcription factor Foxp1 is required for monocyte differentiation and macrophage function.
Apte Rajendra S., In PLoS ONE, 2007
... SRA-TGF-ß1 transgenic mice could be discriminated ...
Identification and characterization of vascular calcification-associated factor, a novel gene upregulated during vascular calcification in vitro and in vivo.
Launikonis Bradley, In PLoS ONE, 2004
... Anti-human apelin receptor (APJ) antibody was purchased from Abcam Inc ...
Papers on SRA
Apelin: An Endogenous Peptide Essential for Cardiomyogenic Differentiation of Mesenchymal Stem Cells via Activating Extracellular Signal-Regulated Kinase 1/2 and 5.
Gao et al., Beijing, China. In Cell Biol Int, Feb 2016
UNASSIGNED: Growing evidence has shown that apelin/APJ system functions as a critical mediator of cardiac development as well as cardiovascular function.
Extracellular Vesicles from Trypanosoma brucei Mediate Virulence Factor Transfer and Cause Host Anemia.
Harrington et al., Athens, United States. In Cell, Feb 2016
Trypanosome EVs contain several flagellar proteins that contribute to virulence, and Trypanosoma brucei rhodesiense EVs contain the serum resistance-associated protein (SRA) necessary for human infectivity.
Apelin/APJ signaling in hypoxia-related diseases.
Li et al., Hengyang, China. In Clin Chim Acta, Jan 2016
The regulatory peptide apelin is the endogenous ligand for the orphan G protein-coupled receptor APJ.
Combinatorial Treatment with Apelin-13 Enhances the Therapeutic Efficacy of a Preconditioned Cell-Based Therapy for Peripheral Ischemia.
Hamano et al., Ube, Japan. In Sci Rep, Dec 2015
Interestingly, expression of an apelin receptor, APJ, in PBMNC was increased under hypoxia but not under normoxia.
Genetic variants of the class A scavenger receptor gene are associated with essential hypertension in Chinese.
Huang et al., Wuxi, China. In J Thorac Dis, Nov 2015
BACKGROUND: The class A scavenger receptor, which is encoded by the macrophage scavenger receptor 1 (MSR1) gene, is a pattern recognition receptor (PPR) primarily expressed in macrophages.
ELABELA Is an Endogenous Growth Factor that Sustains hESC Self-Renewal via the PI3K/AKT Pathway.
Reversade et al., Singapore, Singapore. In Cell Stem Cell, Nov 2015
ELABELA (ELA) is a peptide hormone required for heart development that signals via the Apelin Receptor (APLNR, APJ).
Current therapies and mortality in acromegaly.
Poiană et al., Bucureşti, Romania. In J Med Life, Oct 2015
A meta-analysis proved that mortality is much lower in operated patients, even uncured, than the entire group of patients and is similar with the general population in patients with GH<1 μg/ L. For the patients with hypersecreting postoperative remnant tumor, those with low chance of surgical cure or with life-threatening comorbidities, medical therapies are available: somatostatin receptor analogues (SRA), dopamine agonists (DA) and GH receptor antagonists.
Epigenome-wide association of liver methylation patterns and complex metabolic traits in mice.
Pellegrini et al., Los Angeles, United States. In Cell Metab, Jul 2015
Methylation levels were regulated by genetics largely in cis, but we also found evidence of trans regulation, and we demonstrate that genetic variation in the methionine synthase reductase gene Mtrr affects methylation of hundreds of CpGs throughout the genome.
Long Non-Coding RNAs in Endometrial Carcinoma.
Haybaeck et al., Graz, Austria. In Int J Mol Sci, 2014
Other notatble lncRNAs such as HOTAIR, H19 and SRA become up-regulated with increasing EC tumour grade and other features associated with poor prognosis.
Associations of the A66G Methionine Synthase Reductase Polymorphism in Colorectal Cancer: A Systematic Review and Meta-Analysis.
Singh et al., Philippines. In Biomark Cancer, 2014
Inconsistency in the reported associations between the A66G polymorphism in the methionine synthase reductase (MTRR) gene and colorectal cancer (CRC) prompted a meta-analysis, so that we could obtain a more precise estimate.
The Apelin-APJ System in the Evolution of Heart Failure.
Vida-Simiti et al., Cluj-Napoca / Kolozsvár, Romania. In Clujul Med, 2014
The apelin-APJ system is a newly discovered molecular pathway and the RAAS counterbalance is its principal effect.
Identification of androgenic gland microRNA and their target genes to discover sex-related microRNA in the oriental river prawn, Macrobrachium nipponense.
Wu et al., Wuxi, China. In Genet Mol Res, 2014
A total of 8,248, 76,011, and 78,307 target genes were predicted in the EST and SRA sequences provided in the NCBI database, and the androgenic gland transcriptome of M. nipponense, respectively.
APJ receptor A445C gene polymorphism in Turkish patients with coronary artery disease.
Genç et al., Kütahya, Turkey. In Int J Clin Exp Med, 2014
Apelin is a novel endogenous peptide with inotropic and vasodilatory properties and is the ligand for the angiotensin receptor-like 1 (APJ) receptor.
SRA- and SET-domain-containing proteins link RNA polymerase V occupancy to DNA methylation.
Jacobsen et al., Los Angeles, United States. In Nature, 2014
SUVH2 and SUVH9 both contain SRA (SET- and RING-ASSOCIATED) domains capable of binding methylated DNA, suggesting that they function to recruit Pol V through DNA methylation.
The WAVE regulatory complex links diverse receptors to the actin cytoskeleton.
Rosen et al., Dallas, United States. In Cell, 2014
Structural, biochemical, and cellular studies reveal that a sequence motif that defines these ligands binds to a highly conserved interaction surface of the WRC formed by the Sra and Abi subunits.
Centrally administered apelin-13 induces depression-like behavior in mice.
Chen et al., Lanzhou, China. In Brain Res Bull, 2012
Centrally administered apelin-13 elicited depression-like behavior in mice, which was mediated via APJ receptor and kappa-opioid receptor, but not CRF receptor.
Apelin enhances cardiac neovascularization after myocardial infarction by recruiting aplnr+ circulating cells.
Duckers et al., Rotterdam, Netherlands. In Circ Res, 2012
We conclude that apelin functions as a new and potent chemoattractant for circulating cKit+/Flk1+/Aplnr+ cells during early myocardial repair, providing myocardial protection against ischemic damage by improving neovascularization via paracine action.
APJ acts as a dual receptor in cardiac hypertrophy.
Ruiz-Lozano et al., Los Angeles, United States. In Nature, 2012
data indicate that APJ is a bifunctional receptor for both mechanical stretch and the endogenous peptide apelin; by sensing the balance between these stimuli, APJ occupies a pivotal point linking sustained overload to cardiomyocyte hypertrophy
Highly upregulated expression of CD36 and MSR1 in circulating monocytes of patients with acute coronary syndromes.
Plewa et al., Poznań, Poland. In Protein J, 2012
In patients with symptoms of acute coronary syndrome the amount of CD36 and MSR1 mRNA in circulating monocytes, as well as the density of both receptors on the cells surface was significantly higher.
The polymorphisms in methylenetetrahydrofolate reductase, methionine synthase, methionine synthase reductase, and the risk of colorectal cancer.
Yu et al., Chongqing, China. In Int J Biol Sci, 2011
Meta-analysis suggested that MTHFR 677T allele might provide protection against CRC in worldwide populations, while MTRR 66G allele might increase the risk of CRC in Caucasians.
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