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RNA binding protein S1, serine-rich domain

SR protein, RNPS1
This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. This protein contains many serine residues. Two splice variants have been found for this gene; both variants encode the same protein. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, ATPase, SC35, ACID, SRPK1
Papers on SR protein
Multiple protein-protein interactions converging on the Prp38 protein during activation of the human spliceosome.
Wahl et al., Berlin, Germany. In Rna, Feb 2016
Our results show that human Prp38 is an unusual SR protein, whose amino-terminal domain is a multi-interface protein-protein interaction platform that might organize the relative positioning of other proteins during splicing.
Nuclear protein kinase CLK1 uses a non-traditional docking mechanism to select physiological substrates.
Adams et al., San Diego, United States. In Biochem J, Jan 2016
The disordered N-terminus of CLK1 induces oligomerization, a necessary event for targeting its physiological substrates the SR protein (splicing factor containing a C-terminal RS domain) family of splicing factors.
Reduced serine racemase expression in aging rat cerebellum is associated with oxidative DNA stress and hypermethylation in the promoter.
Wu et al., Wenzhou, China. In Brain Res, Jan 2016
The reduction of SR protein level in aging cerebella was evidenced by decreased immunostaining observed in the cell body of granule cells or Purkinje cells.
Transcriptome-Wide Identification of RNA Targets of Arabidopsis SERINE/ARGININE-RICH45 Uncovers the Unexpected Roles of This RNA Binding Protein in RNA Processing.
Reddy et al., Fort Collins, United States. In Plant Cell, Dec 2015
Plant SR45 and its metazoan ortholog RNPS1 are serine/arginine-rich (SR)-like RNA binding proteins that function in splicing/postsplicing events and regulate diverse processes in eukaryotes.
HIV-1 splicing at the major splice donor site is controlled by highly conserved RNA sequence and structural elements.
Das et al., Amsterdam, Netherlands. In J Gen Virol, Oct 2015
Analysis of a large set of HIV-1 sequences revealed that all three regulatory features of the 5'ss region (RNA structure, SR protein binding and sequence complementarity with U1 snRNA) are highly conserved among virus isolates, which supports their importance.
The role of tissue factor isoforms in cancer biology.
Eisenreich et al., Berlin, Germany. In Int J Cancer, Sep 2015
The TF isoform expression is differentially modulated on post-transcriptional level via regulatory factors, such as serine/arginine-rich (SR) proteins, SR protein kinases and micro (mi)RNAs.
Regulation of human adenovirus alternative RNA splicing by the adenoviral L4-33K and L4-22K proteins.
Akusjärvi et al., Uppsala, Sweden. In Int J Mol Sci, 2014
E4-ORF4 is a viral protein that binds the cellular protein phosphatase IIA (PP2A) and controls Serine/Arginine (SR)-rich protein activity by inducing SR protein dephosphorylation.
Emerging functions of SRSF1, splicing factor and oncoprotein, in RNA metabolism and cancer.
Krainer et al., New York City, United States. In Mol Cancer Res, 2014
Serine/Arginine Splicing Factor 1 (SRSF1) is the archetype member of the SR protein family of splicing regulators.
SRp20: an overview of its role in human diseases.
Salvatore et al., Napoli, Italy. In Biochem Biophys Res Commun, 2013
Evidence indicates that SRp20 (SFSR3), the smallest member of the SR protein family, is involved in numerous biological processes.
Regulation of splicing by SR proteins and SR protein-specific kinases.
Fu et al., San Diego, United States. In Chromosoma, 2013
Among a large number of factors implicated in the splicing regulation are the SR protein family of splicing factors and SR protein-specific kinases.
SR proteins collaborate with 7SK and promoter-associated nascent RNA to release paused polymerase.
Fu et al., Wuhan, China. In Cell, 2013
These findings reveal an unanticipated SR protein function, a role for promoter-proximal nascent RNA in gene activation, and an analogous mechanism to HIV Tat/TAR for activating cellular genes.
The cellular EJC interactome reveals higher-order mRNP structure and an EJC-SR protein nexus.
Moore et al., Worcester, United States. In Cell, 2012
In addition to sculpting eukaryotic transcripts by removing introns, pre-mRNA splicing greatly impacts protein composition of the emerging mRNP.
Association between SRBD1 and ELOVL5 gene polymorphisms and primary open-angle glaucoma.
Tsukahara et al., Japan. In Invest Ophthalmol Vis Sci, 2011
SRBD1 gene polymorphism is associated with the development of HTG as well as NTG, including late-onset NTG.
The RNA binding protein RNPS1 alleviates ASF/SF2 depletion-induced genomic instability.
Manley et al., New York City, United States. In Rna, 2007
RNPS1 is able to function together with ASF/SF2 to form ribonucleoprotein complexes on nascent transcripts, and thereby prevent formation of transcriptional R-loops.
Inactivation of the SR protein splicing factor ASF/SF2 results in genomic instability.
Manley et al., New York City, United States. In Cell, 2005
Here we provide evidence that a prototypical SR protein, ASF/SF2, is unexpectedly required for maintenance of genomic stability.
Activation of pre-mRNA splicing by human RNPS1 is regulated by CK2 phosphorylation.
Mayeda et al., Miami, United States. In Mol Cell Biol, 2005
The phosphorylation of RNPS1 at Ser-53 influences the efficiencies of both splicing and translation.
Alternative splicing regulation impacts heart development.
Cooper, Houston, United States. In Cell, 2005
In this issue of Cell, Xu et al. (2005) demonstrate that a heart-specific knockout of one SR protein, ASF/SF2, produces cardiomyopathy and misregulation of specific alternative splicing events during early postnatal development.
Dephosphorylated SRp38 acts as a splicing repressor in response to heat shock.
Manley et al., New York City, United States. In Nature, 2004
SRp38 is an SR protein splicing factor that functions as a general repressor of splicing.
Role of the nonsense-mediated decay factor hUpf3 in the splicing-dependent exon-exon junction complex.
Dreyfuss et al., Philadelphia, United States. In Science, 2001
binds to Upf complexes which bind upstream of mRNA exon-exon junctions
Communication of the position of exon-exon junctions to the mRNA surveillance machinery by the protein RNPS1.
Steitz et al., New Haven, United States. In Science, 2001
has a role in mRNA surveillance (detecting mRNAs with truncated open reading frames and subjecting them to nonsense-mediated mRNA decay (NMD))
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