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Farnesyl-diphosphate farnesyltransferase 1

squalene synthase, Farnesyl-Diphosphate Farnesyltransferase, SQS
This gene encodes a membrane-associated enzyme located at a branch point in the mevalonate pathway. The encoded protein is the first specific enzyme in cholesterol biosynthesis, catalyzing the dimerization of two molecules of farnesyl diphosphate in a two-step reaction to form squalene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, CAN, STEP, V1a, HAD
Papers using squalene synthase antibodies
Over-expression of TsCBF1 gene confers improved drought tolerance in transgenic maize
Supplier
Nguyen Henry T. et al., In Journal of Experimental Botany, 2009
... PCR amplification of SQS in transgenic RNAi lines (lane 1 and ...
Papers on squalene synthase
Jasmonic acid and Methyl dihydrojasmonate enhance saponin biosynthesis as well as expression of functional genes in adventitious roots of Panax notoginseng F.H. Chen.
New
Gao et al., Tianjin, China. In Biotechnol Appl Biochem, Feb 2016
Furthermore, we found that JA and MDJ significantly up-regulated the expression of the geranyl diphosphate synthase (GPS), farnesyl diphosphate synthase (FPS), squalene synthase (SS), squalene epoxidase(SE), dammarenediol synthase (DS), CYP716A47 and CYP716A53v2 (CYP450 enzyme) genes, down-regulated the expression of the cycloartenol synthase (CAS) gene and increased superoxide dismutase (SOD), peroxidase (POD) activity.
Genetic engineering and molecular characterization of yeast strain expressing hybrid human-yeast squalene synthase as a tool for anti-cholesterol drug assessment.
New
Burzynska et al., Warsaw, Poland. In J Appl Microbiol, Feb 2016
AIMS: The main objective of the study is molecular and biological characterization of the human-yeast hybrid squalene synthase, as a promising target for treatment of hypercholesterolemia. METHODS AND RESULTS: The human-yeast hybrid squalene synthase, with 67% amino acids, including the catalytic site derived from human enzyme, was expressed in S. cerevisiae strain deleted of its own squalene synthase gene.
Absolute Configuration of Hydroxysqualene. An Intermediate in Bacterial Hopanoid Biosynthesis.
New
Poulter et al., Salt Lake City, United States. In Org Lett, Feb 2016
In contrast, eukaryotic squalene synthase catalyzes solvolysis of (1R,2R,3R)-PSPP to give (R)-HSQ.
Heterologous biosynthesis of triterpenoid dammarenediol-II in engineered Escherichia coli.
New
Lu et al., Tianjin, China. In Biotechnol Lett, Feb 2016
RESULTS: By the strategy of synthetic biology, dammarenediol-II biosynthetic pathway was reconstituted in E. coli by co-expression of squalene synthase (SS), squalene epoxidase (SE), NADPH-cytochrome P450 reductase (CPR) from Saccharomyces cerevisiae, and SE from Methylococcus capsulatus (McSE), NADPH-cytochrome P450 reductase (CPR) from Arabidopsis thaliana.
Role of Phosphatidic Acid Phosphatase Domain Containing 2 (PPAPDC2) In Squalestatin 1-Mediated Activation of the Constitutive Androstane Receptor in Primary Cultured Rat Hepatocytes.
New
Kocarek et al., Wayne, United States. In Drug Metab Dispos, Jan 2016
UNASSIGNED: Farnesyl pyrophosphate (FPP) is a branch-point intermediate in the mevalonate pathway that is normally converted mainly to squalene by squalene synthase in the first committed step of sterol biosynthesis.
Squalene is lipotoxic to yeast cells defective in lipid droplet biogenesis.
New
Hapala et al., In Biochem Biophys Res Commun, Jan 2016
The hypersensitivity of the lipid droplet-less mutant to terbinafine was alleviated by decreasing squalene accumulation with low doses of squalene synthase inhibitor zaragozic acid.
Cloning, prokaryotic expression and functional analysis of squalene synthase (SQS) in Magnolia officinalis.
New
Huang et al., Beijing, China. In Protein Expr Purif, Jan 2016
Squalene synthase plays a significant role in catalyzing two farnesyl diphosphate molecules to form squalene, the first precursor of triterpenoid, phytosterol, and cholesterol biosynthesis.
Advances in biochemistry and microbial production of squalene and its derivatives.
Review
New
Sohng et al., South Korea. In J Microbiol Biotechnol, Jan 2016
In this study, we first review the biosynthetic routes of squalene and its typical derivatives, particularly the squalene synthase route.
Triglyceride-lowering agents.
Review
Laev et al., Novosibirsk, Russia. In Bioorg Med Chem, 2014
The effects and mechanisms of action of statins, squalene synthase inhibitors, fibrates, PPARα and PPARα/γ agonists, nicotinic acid, omega-3 fatty acids and some other molecular targets were considered.
Therapeutic approaches to drug targets in atherosclerosis.
Review
Sakhare et al., India. In Saudi Pharm J, 2014
However, novel drug targets like endoglin receptor, PPARα, squalene synthase, thyroid hormone analogues, scavenger receptor and thyroid hormone analogues are more powerful to control the process of atherosclerosis.
Incomplete sterols and hopanoids pathways in ciliates: gene loss and acquisition during evolution as a source of biosynthetic genes.
Review
Nusblat et al., Argentina. In Mol Phylogenet Evol, 2014
The pre-squalene pathway, for instance, is largely present in all sequenced ciliates except in Ichthyophthirius multifiliis; although Paramecium tetraurelia lacks the squalene synthase and Oxytricha trifallax the squalene hopene synthase, in addition to the former.
Biological stereoselectivity of atropisomeric natural products and drugs.
Review
Ellestad et al., New York City, United States. In Chirality, 2013
The biological targets include: antiapoptotic proteins; bacteria; microtubules; kinases; vasopressin receptors; a G-protein coupled receptor related to obesity; monocarboxylate transporters; tachykinin NK1 -receptors; cyclooxygenase-1 and squalene synthase.
Exclusion of CTSB and FDFT1 as positional and functional candidate genes for keratolytic winter erythema (KWE).
GeneRIF
Ramsay et al., Johannesburg, South Africa. In J Dermatol Sci, 2012
CTSB and FDFT1 are excluded as candidates for keratolytic winter erythema
Polymorphism in the farnesyl diphosphate farnesyl transferase 1 gene and nonalcoholic fatty liver disease severity.
GeneRIF
Daly et al., In Gastroenterology, 2011
NASH is intimately related to fibrosis progression, the FDFT1 SNP is a good candidate for a link with inflammation and fibrosis.
Genome-wide association study identifies variants associated with histologic features of nonalcoholic Fatty liver disease.
GeneRIF
Nonalcoholic Steatohepatitis Clinical Research Network et al., Indianapolis, United States. In Gastroenterology, 2010
In multivariate models adjusted for age, body mass index, diabetes, waist/hip ratios, and levels of glycated hemoglobin, the NAFLD activity score was associated with the SNP rs2645424 on chromosome 8 in farnesyl diphosphate farnesyl transferase 1 (FDFT1)
Targeting isoprenoid biosynthesis for drug discovery: bench to bedside.
Impact
Oldfield, Urbana, United States. In Acc Chem Res, 2010
The structure of CrtM is similar to that of human squalene synthase (SQS), and some SQS inhibitors (originally developed as cholesterol-lowering drugs) block staphyloxanthin biosynthesis.
Squalene synthase: a critical enzyme in the cholesterol biosynthesis pathway.
Review
GeneRIF
Engert et al., Montréal, Canada. In Clin Genet, 2009
squalene synthase may be involved in the etiology of hypercholesterolemia
Studies of CTNNBL1 and FDFT1 variants and measures of obesity: analyses of quantitative traits and case-control studies in 18,014 Danes.
GeneRIF
Hansen et al., Denmark. In Bmc Med Genet, 2008
FDFT1 rs7001819 showed no association with obesity, neither when analysing quantitative traits nor when performing case-control studies of obesity
A cholesterol biosynthesis inhibitor blocks Staphylococcus aureus virulence.
Impact
Oldfield et al., Taipei, Taiwan. In Science, 2008
We determined the crystal structures of S. aureus dehydrosqualene synthase (CrtM) at 1.58 angstrom resolution, finding structural similarity to human squalene synthase (SQS).
Pharmacogenetic study of statin therapy and cholesterol reduction.
Impact
Ridker et al., Boston, United States. In Jama, 2004
Among the remaining genes, less robust associations were found for squalene synthase and change in total cholesterol, apolipoprotein E and change in LDL cholesterol, and cholesteryl ester transfer protein and change in HDL cholesterol, although none of these met our conservative criteria for purely pharmacogenetic effects.
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