Jasmonic acid and Methyl dihydrojasmonate enhance saponin biosynthesis as well as expression of functional genes in adventitious roots of Panax notoginseng F.H. Chen.
Tianjin, China. In Biotechnol Appl Biochem, Feb 2016
Furthermore, we found that JA and MDJ significantly up-regulated the expression of the geranyl diphosphate synthase (GPS), farnesyl diphosphate synthase (FPS), squalene synthase (SS), squalene epoxidase(SE), dammarenediol synthase (DS), CYP716A47 and CYP716A53v2 (CYP450 enzyme) genes, down-regulated the expression of the cycloartenol synthase (CAS) gene and increased superoxide dismutase (SOD), peroxidase (POD) activity.
Heterologous biosynthesis of triterpenoid dammarenediol-II in engineered Escherichia coli.
Tianjin, China. In Biotechnol Lett, Feb 2016
RESULTS: By the strategy of synthetic biology, dammarenediol-II biosynthetic pathway was reconstituted in E. coli by co-expression of squalene synthase (SS), squalene epoxidase (SE), NADPH-cytochrome P450 reductase (CPR) from Saccharomyces cerevisiae, and SE from Methylococcus capsulatus (McSE), NADPH-cytochrome P450 reductase (CPR) from Arabidopsis thaliana.
Novosibirsk, Russia. In Bioorg Med Chem, 2014
The effects and mechanisms of action of statins, squalene synthase inhibitors, fibrates, PPARα and PPARα/γ agonists, nicotinic acid, omega-3 fatty acids and some other molecular targets were considered.
Therapeutic approaches to drug targets in atherosclerosis.
India. In Saudi Pharm J, 2014
However, novel drug targets like endoglin receptor, PPARα, squalene synthase, thyroid hormone analogues, scavenger receptor and thyroid hormone analogues are more powerful to control the process of atherosclerosis.
Biological stereoselectivity of atropisomeric natural products and drugs.
New York City, United States. In Chirality, 2013
The biological targets include: antiapoptotic proteins; bacteria; microtubules; kinases; vasopressin receptors; a G-protein coupled receptor related to obesity; monocarboxylate transporters; tachykinin NK1 -receptors; cyclooxygenase-1 and squalene synthase.
Pharmacogenetic study of statin therapy and cholesterol reduction.
Boston, United States. In Jama, 2004
Among the remaining genes, less robust associations were found for squalene synthase and change in total cholesterol, apolipoprotein E and change in LDL cholesterol, and cholesteryl ester transfer protein and change in HDL cholesterol, although none of these met our conservative criteria for purely pharmacogenetic effects.