Jasmonic acid and Methyl dihydrojasmonate enhance saponin biosynthesis as well as expression of functional genes in adventitious roots of Panax notoginseng F.H. Chen.
Tianjin, China. In Biotechnol Appl Biochem, Feb 2016
Furthermore, we found that JA and MDJ significantly up-regulated the expression of the geranyl diphosphate synthase (GPS), farnesyl diphosphate synthase (FPS), squalene synthase (SS), squalene epoxidase(SE), dammarenediol synthase (DS), CYP716A47 and CYP716A53v2 (CYP450 enzyme) genes, down-regulated the expression of the cycloartenol synthase (CAS) gene and increased superoxide dismutase (SOD), peroxidase (POD) activity.
Heterologous biosynthesis of triterpenoid dammarenediol-II in engineered Escherichia coli.
Tianjin, China. In Biotechnol Lett, Feb 2016
RESULTS: By the strategy of synthetic biology, dammarenediol-II biosynthetic pathway was reconstituted in E. coli by co-expression of squalene synthase (SS), squalene epoxidase (SE), NADPH-cytochrome P450 reductase (CPR) from Saccharomyces cerevisiae, and SE from Methylococcus capsulatus (McSE), NADPH-cytochrome P450 reductase (CPR) from Arabidopsis thaliana.
Electron Transfer Pathways in Cholesterol Synthesis.
Lexington, United States. In Lipids, Oct 2015
Four enzymes catalyzing five steps in the pathway require electron input: squalene monooxygenase, lanosterol demethylase, sterol 4α-methyl oxidase, and sterol C5-desaturase.
Navigating the Shallows and Rapids of Cholesterol Synthesis Downstream of HMGCR.
Australia. In J Nutr Sci Vitaminol (tokyo), 2014
We also discuss the post-translational regulation of another critical enzyme, squalene monooxygenase (SM), which has its protein levels controlled by cholesterol, and DHCR24, which has its activity affected by sterols and related compounds, as well as via phosphorylation/signalling.
The UPS and downs of cholesterol homeostasis.
Sydney, Australia. In Trends Biochem Sci, 2014
This includes the low-density lipoprotein (LDL) receptor, transcription factors (sterol regulatory element binding proteins and liver X receptors), flux-controlling enzymes in cholesterol synthesis (3-hydroxy-3-methylglutaryl-CoA reductase and squalene monooxygenase), and cholesterol exporters (ATP-binding cassette transporters ABCA1 and ABCG1).
The biology and chemistry of antifungal agents: a review.
Pune, India. In Bioorg Med Chem, 2012
This review addresses the areas such as the underlying mechanisms, eight different targets such as ergosterol synthesis, chitin synthesis, ergosterol disruptors, glucan synthesis, squalene epoxidase, nucleic acid synthesis, protein synthesis, microtubules synthesis.