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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

SPT6 Spt6p

Spt6, ssn20, Spt6p
Top mentioned proteins: Spt4, POLYMERASE, Histone, Spt5, BRG1
Papers on Spt6
The Abundant Histone Chaperones Spt6 and FACT Collaborate to Assemble, Inspect, and Maintain Chromatin Structure in Saccharomyces cerevisiae.
New
Formosa et al., Salt Lake City, United States. In Genetics, Nov 2015
Saccharomyces cerevisiae Spt6 protein is a conserved chromatin factor with several distinct functional domains, including a natively unstructured 30-residue N-terminal region that binds competitively with Spn1 or nucleosomes.
Spt6 Is Essential for rRNA Synthesis by RNA Polymerase I.
New
Schneider et al., Birmingham, United States. In Mol Cell Biol, Jul 2015
Spt6 (suppressor of Ty6) has many roles in transcription initiation and elongation by RNA polymerase (Pol) II.
Histone chaperones in Arabidopsis and rice: genome-wide identification, phylogeny, architecture and transcriptional regulation.
Singla-Pareek et al., In Bmc Plant Biol, 2014
These could be classified into seven different families, namely NAP, CAF1, SPT6, ASF1, HIRA, NASP, and FACT.
Spt6 regulates intragenic and antisense transcription, nucleosome positioning, and histone modifications genome-wide in fission yeast.
Winston et al., Boston, United States. In Mol Cell Biol, 2013
Spt6 is a highly conserved histone chaperone that interacts directly with both RNA polymerase II and histones to regulate gene expression.
Control of transcriptional elongation.
Review
Impact
Lis et al., Ithaca, United States. In Annu Rev Genet, 2012
We then discuss Pol II elongation through the bodies of genes and the roles of FACT and SPT6, factors that allow Pol II to move through nucleosomes.
The histone H3 Lys 27 demethylase JMJD3 regulates gene expression by impacting transcriptional elongation.
Shi et al., Boston, United States. In Genes Dev, 2012
Furthermore, JMJD3 and KIAA1718 also play a role in localizing elongation factors SPT6 and SPT16 to the target genes.
The cellular protein SPT6 is required for efficient replication of human cytomegalovirus.
GeneRIF
Bresnahan et al., Minneapolis, United States. In J Virol, 2012
Abolishing UL69's ability to interact with the SPT6 protein inhibited human cytomegalovirus replication.
Spt6 levels are modulated by PAAF1 and proteasome to regulate the HIV-1 LTR.
GeneRIF
Kiernan et al., Montpellier, France. In Retrovirology, 2011
These results show that intracellular levels of Spt6 are fine-tuned by PAAF1 and proteasome, which is required for HIV-1 transcription and extends to cellular genes implicated in cancer.
Spt6 is required for heterochromatic silencing in the fission yeast Schizosaccharomyces pombe.
Winston et al., Boston, United States. In Mol Cell Biol, 2011
Spt6 is a conserved factor, critically required for several transcription- and chromatin-related processes.
Solution structure of tandem SH2 domains from Spt6 protein and their binding to the phosphorylated RNA polymerase II C-terminal domain.
GeneRIF
Shi et al., Hefei, China. In J Biol Chem, 2011
Spt6 may use the tandem SH2 domain module to sense the phosphorylation level of RNAPII CTD.
High nitrogen insensitive 9 (HNI9)-mediated systemic repression of root NO3- uptake is associated with changes in histone methylation.
Lepetit et al., Montpellier, France. In Proc Natl Acad Sci U S A, 2011
Here, we show that HNI9 encodes Arabidopsis INTERACT WITH SPT6 (AtIWS1), an evolutionary conserved component of the RNA polymerase II complex.
Crystal structures of the S. cerevisiae Spt6 core and C-terminal tandem SH2 domain.
GeneRIF
Hill et al., Salt Lake City, United States. In J Mol Biol, 2011
these findings provide a structural foundation for understanding how Spt6 encodes several distinct functions within a single polypeptide chain.
Histone chaperone Spt6 is required for class switch recombination but not somatic hypermutation.
GeneRIF
Honjo et al., Kyoto, Japan. In Proc Natl Acad Sci U S A, 2011
Knockdown of Spt6 resulted in severe reduction of class switch recombination in the endogenous Ig locus in B cells.
Control of chromatin structure by spt6: different consequences in coding and regulatory regions.
Winston et al., Boston, United States. In Mol Cell Biol, 2011
Spt6 is a highly conserved factor required for normal transcription and chromatin structure.
Intergenic transcription causes repression by directing nucleosome assembly.
Martens et al., Pittsburgh, United States. In Genes Dev, 2011
Repression by SRG1 transcription is dependent on the Spt6 and Spt16 transcription elongation factors.
Structure and biological importance of the Spn1-Spt6 interaction, and its regulatory role in nucleosome binding.
Hill et al., Salt Lake City, United States. In Mol Cell, 2011
Eukaryotic transcription and mRNA processing depend upon the coordinated interactions of many proteins, including Spn1 and Spt6, which are conserved across eukaryotes, are essential for viability, and associate with each other in some of their biologically important contexts.
Deletion of Candida albicans SPT6 is not lethal but results in defective hyphal growth.
Bliss et al., Providence, United States. In Fungal Genet Biol, 2010
A reactive clone contained the 3' end of the C. albicans gene, orf 19.7136, designated SPT6 based on homology to Saccharomyces cerevisiae, where its product functions as a transcription elongation factor.
Transcription elongation factors repress transcription initiation from cryptic sites.
Impact
Winston et al., Boston, United States. In Science, 2003
Here we present studies of Saccharomyces cerevisiae Spt6, a conserved protein implicated in both transcription elongation and chromatin structure.
Evidence that Spt6p controls chromatin structure by a direct interaction with histones.
Impact
Winston et al., Boston, United States. In Science, 1996
Genetic analysis has implicated SPT6, an essential gene of Saccharomyces cerevisiae, in the control of chromatin structure.
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