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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

SPT5 Spt5p

Spt5, hSpt5
Top mentioned proteins: POLYMERASE, Spt4, ACID, CAN, Spt6
Papers on Spt5
Structure of transcribing mammalian RNA polymerase II.
Cramer et al., Göttingen, Germany. In Nature, Feb 2016
This position of upstream DNA allows for binding of the general transcription elongation factor DSIF (SPT4-SPT5) that we localize over the active centre cleft in a conserved position on the clamp domain of Pol II.
The zinc-finger protein SPT4 interacts with SPT5L/KTF1 and modulates transcriptional silencing in Arabidopsis.
Grasser et al., Regensburg, Germany. In Febs Lett, Nov 2015
The Arabidopsis multidomain protein SPT5L/KTF1 (which has similarity to the transcript elongation factor SPT5) associates with RNA polymerase V (RNAPV) and is an accessory factor in RNA-directed DNA methylation.
Suppressor of Ty homolog-5, a novel tumor-specific human telomerase reverse transcriptase promoter-binding protein and activator in colon cancer cells.
Hu et al., Hangzhou, China. In Oncotarget, Nov 2015
In the present study, suppressor of Ty homolog-5 (SPT5), a protein encoded by the SUPT5H gene, was identified as a novel tumor-specific hTERT promoter-binding protein and activator in colon cancer cells.
Elongator and SPT4/SPT5 complexes as proxy to study RNA polymerase II transcript elongation control of plant development.
Grasser et al., Gent, Belgium. In Proteomics, 2014
Elongator and SUPPRESSOR OF Ty4 (SPT4)/SPT5 are transcript elongation factors that contribute to the regulation of mRNA synthesis by RNA polymerase II in the chromatin context.
The transcript elongation factor SPT4/SPT5 is involved in auxin-related gene expression in Arabidopsis.
Grasser et al., Regensburg, Germany. In Nucleic Acids Res, 2014
The heterodimeric complex SPT4/SPT5 is a transcript elongation factor (TEF) that directly interacts with RNA polymerase II (RNAPII) to regulate messenger RNA synthesis in the chromatin context.
CTR9, a component of PAF complex, controls elongation block at the c-Fos locus via signal-dependent regulation of chromatin-bound NELF dissociation.
Yoo et al., South Korea. In Plos One, 2012
Furthermore, association of negative elongation factor, NELF, which is required to proceed to the elongation phase, was significantly reduced by CTR9 depletion, whereas elongation factor SPT5 recruitment was enhanced by CTR9 depletion.
Characterization of amyloid-β precursor protein intracellular domain-associated transcriptional complexes in SH-SY5Y neurocytes.
Lu et al., Hefei, China. In Neurosci Bull, 2012
Following this by mass spectrometry, we identified physically associated proteins, some reported previously and other novel binding partners, CUX1 and SPT5.
The spt5 C-terminal region recruits yeast 3' RNA cleavage factor I.
Cramer et al., München, Germany. In Mol Cell Biol, 2012
Chromatin immunoprecipitation (ChIP) revealed that the Spt5 C-terminal region is required for normal recruitment of pre-mRNA cleavage factor I (CFI) to the 3' ends of Saccharomyces cerevisiae genes.
Mutations in the transcription elongation factor SPT5 disrupt a reporter for dosage compensation in Drosophila.
Kelley et al., Houston, United States. In Plos Genet, 2011
In an unbiased forward genetic screen for new factors required for dosage compensation, we found that mutations in the universally conserved transcription elongation factor Spt5 lower MSL complex dependent expression from the miniwhite reporter gene in vivo.
Mechanism of glycyrrhizic acid inhibition of Kaposi's sarcoma-associated herpesvirus: disruption of CTCF-cohesin-mediated RNA polymerase II pausing and sister chromatid cohesion.
Lieberman et al., Philadelphia, United States. In J Virol, 2011
GA altered the enrichment of the RNAPII pausing complex, along with pausing factors SPT5 and NELF-A, at the intragenic CTCF-cohesin binding sites.
Independent chromatin binding of ARGONAUTE4 and SPT5L/KTF1 mediates transcriptional gene silencing.
Wierzbicki et al., Ann Arbor, United States. In Plos Genet, 2011
We show through chromatin immunoprecipitation (ChIP) that SPT5L/KTF1, a silencing factor and a homolog of SPT5 elongation factors, binds chromatin at loci subject to transcriptional silencing.
The transcription elongation factor Spt5 influences transcription by RNA polymerase I positively and negatively.
Schneider et al., Birmingham, United States. In J Biol Chem, 2011
Spt5p plays both positive and negative roles in transcription by Pol I.
Yeast transcription elongation factor Spt5 associates with RNA polymerase I and RNA polymerase II directly.
Schneider et al., Birmingham, United States. In J Biol Chem, 2011
Spt5 is recruited to the rDNA early in transcription and propose that it plays an important role in ribosomal RNA synthesis through direct binding to the Pol I complex.
Erythropoiesis is regulated by the transcription elongation factor Foggy/Spt5 through gata1 gene regulation.
Wada et al., Yokohama, Japan. In Genes Cells, 2011
the positive function of Foggy/Spt5 is required for gata1 expression during zebrafish embryonic hematopoiesis.
DSIF and RNA polymerase II CTD phosphorylation coordinate the recruitment of Rpd3S to actively transcribed genes.
Robert et al., Montréal, Canada. In Plos Genet, 2010
Data provide evidence implicating the yeast DSIF complex (Spt4/5) and RNA polymerase II phosphorylation by Kin28 and Ctk1 in the recruitment of Rpd3S to active genes.
An effector of RNA-directed DNA methylation in arabidopsis is an ARGONAUTE 4- and RNA-binding protein.
Zhu et al., Riverside, United States. In Cell, 2009
KTF1 has similarity to the transcription elongation factor SPT5 and contains a C-terminal extension rich in GW/WG repeats.
SPT genes: key players in the regulation of transcription, chromatin structure and other cellular processes.
Handa et al., Yokohama, Japan. In J Biochem, 2001
Over the past few years, molecular complexes and cellular functions in which other SPT gene products involve have been discovered through genetic and biochemical studies in yeast and several other organisms: Key regulators of transcription and chromatin structure, such as DSIF, SAGA, and FACT, all contain SPT gene products as essential subunits.
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