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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

SPT4 Spt4p

Spt4, Spt4p, hSpt4
Top mentioned proteins: POLYMERASE, Spt5, Spt6, ACID, CAN
Papers on Spt4
Structure of transcribing mammalian RNA polymerase II.
Cramer et al., Göttingen, Germany. In Nature, Feb 2016
This position of upstream DNA allows for binding of the general transcription elongation factor DSIF (SPT4-SPT5) that we localize over the active centre cleft in a conserved position on the clamp domain of Pol II.
The zinc-finger protein SPT4 interacts with SPT5L/KTF1 and modulates transcriptional silencing in Arabidopsis.
Grasser et al., Regensburg, Germany. In Febs Lett, Nov 2015
The zinc-finger protein SPT4 was found to interact with SPT5L (and SPT5) both in vivo and in vitro.
Elongator and SPT4/SPT5 complexes as proxy to study RNA polymerase II transcript elongation control of plant development.
Grasser et al., Gent, Belgium. In Proteomics, 2014
Elongator and SUPPRESSOR OF Ty4 (SPT4)/SPT5 are transcript elongation factors that contribute to the regulation of mRNA synthesis by RNA polymerase II in the chromatin context.
The transcript elongation factor SPT4/SPT5 is involved in auxin-related gene expression in Arabidopsis.
Grasser et al., Regensburg, Germany. In Nucleic Acids Res, 2014
The heterodimeric complex SPT4/SPT5 is a transcript elongation factor (TEF) that directly interacts with RNA polymerase II (RNAPII) to regulate messenger RNA synthesis in the chromatin context.
Spt4 is selectively required for transcription of extended trinucleotide repeats.
Cheng et al., Taipei, Taiwan. In Cell, 2012
These findings indicate that Supt4h is differentially required for expression of the mutant Htt allele in mouse striatal neurons.
The DSIF subunits Spt4 and Spt5 have distinct roles at various phases of immunoglobulin class switch recombination.
Honjo et al., Kyoto, Japan. In Plos Genet, 2011
our findings indicate that Spt4 and Spt5 have essential functions in the DNA repair phase of immunoglobulin class switch recombination.
The transcription elongation factor Spt5 influences transcription by RNA polymerase I positively and negatively.
Schneider et al., Birmingham, United States. In J Biol Chem, 2011
We have shown previously that Spt4p and Spt5p also influence synthesis of ribosomal RNA by RNA polymerase (Pol) I; however, previous studies only characterized defects in Pol I transcription induced by deletion of SPT4.
DSIF and RNA polymerase II CTD phosphorylation coordinate the recruitment of Rpd3S to actively transcribed genes.
Robert et al., Montréal, Canada. In Plos Genet, 2010
Data provide evidence implicating the yeast DSIF complex (Spt4/5) and RNA polymerase II phosphorylation by Kin28 and Ctk1 in the recruitment of Rpd3S to active genes.
Cotranscriptional recruitment of She2p by RNA pol II elongation factor Spt4-Spt5/DSIF promotes mRNA localization to the yeast bud.
Chartrand et al., Montréal, Canada. In Genes Dev, 2010
She2p interacts in vivo with the elongating forms of RNA polymerase II (pol II) via the transcription elongation factor Spt4-Spt5
Interactions between DSIF (DRB sensitivity inducing factor), NELF (negative elongation factor), and the Drosophila RNA polymerase II transcription elongation complex.
Gilmour et al., United States. In Proc Natl Acad Sci U S A, 2010
analysis of the interactions between DSIF (DRB sensitivity inducing factor), NELF (negative elongation factor), and the Drosophila RNA polymerase II transcription elongation complex
Crystal structure of the human transcription elongation factor DSIF hSpt4 subunit in complex with the hSpt5 dimerization interface.
Wöhrl et al., Bayreuth, Germany. In Biochem J, 2010
crystal structure of hSpt4 in complex with the dimerization region of hSpt5
Core structure of the yeast spt4-spt5 complex: a conserved module for regulation of transcription elongation.
Niu et al., Hefei, China. In Structure, 2008
Structural and evolutionary perspective of Spt4-Spt5 complex and suggests that it is an ancient, core component of the transcription elongation machinery.
The small hSpt4 subunit of the human transcription elongation factor DSIF is a Zn-finger protein with alpha/beta type topology.
Wöhrl et al., Bayreuth, Germany. In Biochem Biophys Res Commun, 2008
Spt4 was purified and characterized.
Yeast screens identify the RNA polymerase II CTD and SPT5 as relevant targets of BRCA1 interaction.
Marks et al., Durham, United States. In Plos One, 2007
These genes delineate a metabolic mRNA pathway that temporally links transcription elongation (SPT4, SPT5, CTK1, DEF1) to nucleopore-mediated mRNA export (ASM4, MLP1, MLP2, NUP2, NUP53, NUP120, NUP133, NUP170, NUP188, POM34) and cytoplasmic mRNA decay at P-bodies (CCR4, DHH1).
Structurally reduced monosaccharide transporters in an evolutionarily conserved red alga.
Oesterhelt et al., Potsdam, Germany. In Biochem J, 2007
SPT1 is a conserved type of sugar/H(+) symporter with 12 predicted transmembrane-spanning domains, whereas SPT2 and SPT4 represent monosaccharide transporters, characterized by only nine hydrophobic domains.
Identification of a regulator of transcription elongation as an accessory factor for the human Mediator coactivator.
Jones et al., New York City, United States. In Proc Natl Acad Sci U S A, 2007
Mass spectrometric analyses identified its two constituent polypeptides as hSpt5 and hSpt4, which also comprise the elongation factor DSIF. Mechanistically, MSA-2/DSIF acts by restricting overall transcription in the pure system, thereby imposing a strong Mediator dependence.
Role for the Ssu72 C-terminal domain phosphatase in RNA polymerase II transcription elongation.
Hampsey et al., United States. In Mol Cell Biol, 2007
Furthermore, deletion of SPT4, which encodes a subunit of the Spt4-Spt5 early elongation complex, also suppresses ssu72-2, whereas the spt5-242 allele is suppressed by rpb2-1001.
Isw1 chromatin remodeling ATPase coordinates transcription elongation and termination by RNA polymerase II.
Mellor et al., Oxford, United Kingdom. In Cell, 2003
The transcription elongation factor Spt4p antagonizes Isw1p and overcomes the Isw1p dependent pausing of RNAPII at the onset of the elongation cycle.
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