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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 04 Dec 2014.

Sprouty homolog 4

Spry4, Sprouty4
SPRY4 is an inhibitor of the receptor-transduced mitogen-activated protein kinase (MAPK) signaling pathway. It is positioned upstream of RAS (see HRAS; MIM 190020) activation and impairs the formation of active GTP-RAS (Leeksma et al., 2002 [PubMed 12027893]).[supplied by OMIM, Mar 2008] (from NCBI)
Top mentioned proteins: Sprouty, Spry2, CAN, DMRT1, HAD
Papers on Spry4
Long noncoding RNAs as putative biomarkers for prostate cancer detection.
New
Perera et al., In J Mol Diagn, 30 Nov 2014
AK024556 (SPRY4-IT1) was highly up-regulated in human prostate cancer cell line PC3 but not in LNCaP, and siRNA knockdown of SPRY4-IT1 in PC3 cells inhibited cell proliferation and invasion and increased cell apoptosis.
ETS1 is a genome-wide effector of RAS/ERK signaling in epithelial cells.
New
Hollenhorst et al., Bloomington, United States. In Nucleic Acids Res, 29 Nov 2014
Genome-wide expression analysis showed that ETS1 was required for activation of RAS-regulated cell migration genes, but also identified a surprising role for ETS1 in the repression of genes such as DUSP4, DUSP6 and SPRY4 that provide negative feedback to the RAS/ERK pathway.
The functional characterization of long noncoding RNA SPRY4-IT1 in human melanoma cells.
New
Perera et al., Orlando, United States. In Oncotarget, 15 Nov 2014
Expression of the long noncoding RNA (lncRNA) SPRY4-IT1 is low in normal human melanocytes but high in melanoma cells.
The role of microRNAs and long non-coding RNAs in the pathology, diagnosis, and management of melanoma.
Review
New
Perera et al., Orlando, United States. In Arch Biochem Biophys, Aug 2014
Data are also emerging on the role of long non-coding RNAs (lncRNAs), such as SPRY4-IT1, BANCR, and HOTAIR, in melanomagenesis.
[Congenital hypogonadotropic hypogonadism and Kallmann syndrome in males].
Review
New
Young et al., Cluj-Napoca / Kolozsvár, Romania. In Presse Med, Feb 2014
Mutations in KAL1, FGFR1/FGF8/FGF17, PROK2/PROKR2, NELF, CHD7, HS6ST1, WDR11, SEMA3A, SOX10, IL17RD2, DUSP6, SPRY4, and FLRT3 have been associated with KS but sometimes also with its milder hyposmic/normosmic CHH clinical variant.
The H3K9 methyltransferase G9a is a marker of aggressive ovarian cancer that promotes peritoneal metastasis.
New
Yen et al., Taipei, Taiwan. In Mol Cancer, Dec 2013
Importantly, microarray and quantitative RT-PCR analysis revealed that G9a regulates a cohort of tumor suppressor genes including CDH1, DUSP5, SPRY4, and PPP1R15A in ovarian cancer.
EZH2-mediated epigenetic suppression of long noncoding RNA SPRY4-IT1 promotes NSCLC cell proliferation and metastasis by affecting the epithelial-mesenchymal transition.
New
Wang et al., Nanjing, China. In Cell Death Dis, Dec 2013
In this study, we showed that epigenetic silencing of lncRNA SPRY4 intronic transcript 1 (SPRY4-IT1) occurs in non-small-cell lung cancer (NSCLC) cells through direct transcriptional repression mediated by the Polycomb group protein enhancer of zeste homolog 2 (EZH2).
Reproduction, smell, and neurodevelopmental disorders: genetic defects in different hypogonadotropic hypogonadal syndromes.
Review
New
Beckers et al., Liège, Belgium. In Front Endocrinol (lausanne), Dec 2013
KS is associated with mutations in KAL1, FGFR1/FGF8, FGF17, IL17RD, PROK2/PROKR2, NELF, CHD7, HS6ST1, FLRT3, SPRY4, DUSP6, SEMA3A, NELF, and WDR11 genes that are related to defects in neuronal migration.
High expression of long non-coding RNA SPRY4-IT1 predicts poor prognosis of clear cell renal cell carcinoma.
New
Zheng et al., Shanghai, China. In Int J Clin Exp Pathol, Dec 2013
lncRNAs SPRY4-IT1 has recently been identified to be involved in tumorigenesis of several cancers such as non-small cell lung cancer and esophageal squamous cell carcinoma.
Genetic changes in nonepithelial ovarian cancer.
Review
New
Vergote et al., Leuven, Belgium. In Expert Rev Anticancer Ther, Jul 2013
In the latter, recent genome-wide association studies have identified seven susceptibility loci near KITLG, SPRY4, UKC2, BAK1, DMRT1, TERT and ATF7IP.
A novel SPRY2 and SPRY4 interaction increases tooth agenesis susceptibility.
Alonso et al., Porto, Portugal. In Bull Group Int Rech Sci Stomatol Odontol, 2012
Short Communication selected from the Oral Presentations of the 56th Congress of the Groupèment International pour la Recherche Scientifique en Stomatologie et Odontologie, Peñafiel (Portugal) May 2012.
Sprouty2 and -4 regulate axon outgrowth by hippocampal neurons.
GeneRIF
Klimaschewski et al., Innsbruck, Austria. In Hippocampus, 2012
our results imply that Sprouty2 and -4 are downregulated in the hippocampus during postnatal brain development and that they can act as regulators of developmental axon growth.
Associations between variants in KITLG, SPRY4, BAK1, and DMRT1 and pediatric germ cell tumors.
GeneRIF
Ross et al., Minneapolis, United States. In Genes Chromosomes Cancer, 2012
The SPRY4 (rs4324715) variants were significantly associated with germ cell tumors only in the adolescent age group.
[Carcinoma in situ of the testis: predisposition, evolution and early detection].
Review
Biermann, Rotterdam, Netherlands. In Pathologe, 2011
Recently, genome-wide association studies revealed genetic predispositions linked to six genes (KITL, SPRY4, BAK1, TERT, ATF7IP, DMRT1).
Regulation of tooth number by fine-tuning levels of receptor-tyrosine kinase signaling.
GeneRIF
Klein et al., San Francisco, United States. In Development, 2011
Interestingly, changes in sprouty gene dosage led to a graded change in incisor number, with progressive decreases in sprouty dosage leading to increasing numbers of teeth.
Hindbrain patterning requires fine-tuning of early krox20 transcription by Sprouty 4.
GeneRIF
Charnay et al., Paris, France. In Development, 2011
Hindbrain patterning requires fine-tuning of early krox20 transcription by Sprouty 4.
Sprouty-4 inhibits transformed cell growth, migration and invasion, and epithelial-mesenchymal transition, and is regulated by Wnt7A through PPARgamma in non-small cell lung cancer.
GeneRIF
Winn et al., Aurora, United States. In Mol Cancer Res, 2010
Spry4 is a downstream target of Wnt7A/Fzd 9 signaling and may have efficacy in the treatment of non-small cell lung cancer.
High marks for GWAS.
Impact
Chanock, Bethesda, United States. In Nat Genet, 2009
Two genome-wide association studies for testicular cancer report associations at three new loci, including two candidate genes previously implicated in testicular development, KITLG (ligand for the receptor tyrosine kinase) and SPRY4 (sprouty 4).
Common variation in KITLG and at 5q31.3 predisposes to testicular germ cell cancer.
Impact
GeneRIF
Nathanson et al., Philadelphia, United States. In Nat Genet, 2009
These results demonstrate that common genetic variants affect TGCT risk and implicate KITLG and SPRY4 as genes involved in Testicular germ cell tumors susceptibility.
Sef is a feedback-induced antagonist of Ras/MAPK-mediated FGF signalling.
Impact
Thisse et al., Strasbourg, France. In Nat Cell Biol, 2002
On the basis of similarities in their expression patterns during embryonic development, we have identified five genes that define a synexpression group -- fgf8, fgf3, sprouty2, sprouty4, as well as a novel gene, sef (similar expression to fgf genes).
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