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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 29 Aug 2015.

Sprouty homolog 4

Spry4, Sprouty4
SPRY4 is an inhibitor of the receptor-transduced mitogen-activated protein kinase (MAPK) signaling pathway. It is positioned upstream of RAS (see HRAS; MIM 190020) activation and impairs the formation of active GTP-RAS (Leeksma et al., 2002 [PubMed 12027893]).[supplied by OMIM, Mar 2008] (from NCBI)
Top mentioned proteins: Sprouty, Spry2, CAN, DMRT1, HAD
Papers on Spry4
[Effect of Long Non-coding RNA SPRY4-IT1 on Invasion and Migration of A549 Cells].
New
Li et al., Shijiazhuang, China. In Zhongguo Fei Ai Za Zhi, 20 Sep 2015
Abstract available from the publisher.
Loss of negative regulators amplifies RAS signaling.
New
Impact
Cichowski et al., Boston, United States. In Nat Genet, May 2015
A new study identifies SPRY4 as a tumor suppressor in acute myeloid leukemia and shows that loss of SPRY4 acts as an alternative mechanism to drive RAS signaling.
Cooperative loss of RAS feedback regulation drives myeloid leukemogenesis.
New
Impact
Lowe et al., New York City, United States. In Nat Genet, May 2015
We show that in mice, premalignant myeloid cells harboring a Kras(G12D) allele retained low levels of Ras signaling owing to negative feedback involving Spry4 that prevented transformation.
The role of microRNAs and long non-coding RNAs in the pathology, diagnosis, and management of melanoma.
Review
New
Perera et al., Orlando, United States. In Arch Biochem Biophys, Jan 2015
Data are also emerging on the role of long non-coding RNAs (lncRNAs), such as SPRY4-IT1, BANCR, and HOTAIR, in melanomagenesis.
Decreased long noncoding RNA SPRY4-IT1 contributing to gastric cancer cell metastasis partly via affecting epithelial-mesenchymal transition.
New
Liu et al., Nanjing, China. In J Transl Med, Dec 2014
SPRY4-IT1 (SPRY4 intronic transcript 1), a lncRNA derived from an intron within SPRY4 gene, involves in multiple cancers development.
Increased expression of SPRY4-IT1 predicts poor prognosis and promotes tumor growth and metastasis in bladder cancer.
New
Du et al., Kaifeng, China. In Int J Clin Exp Pathol, Dec 2014
In this study, we focused on lncRNA SPRY4-IT1 and investigated its expression pattern, clinical significance, and biological function in UCB.
Autoregulatory loop between TGF-β1/miR-411-5p/SPRY4 and MAPK pathway in rhabdomyosarcoma modulates proliferation and differentiation.
New
Wang et al., Suzhou, China. In Cell Death Dis, Dec 2014
Using a luciferase reporting system and sequence analysis, the potential target of miR-411-5p was identified as sprouty homolog 4 (SPRY4), which inhibits protein kinase Cα-mediated activation of mitogen-activated protein kinases (MAPKs), especially p38MAPK phosphorylation.
[Congenital hypogonadotropic hypogonadism and Kallmann syndrome in males].
Review
New
Young et al., Cluj-Napoca / Kolozsvár, Romania. In Presse Med, Feb 2014
Mutations in KAL1, FGFR1/FGF8/FGF17, PROK2/PROKR2, NELF, CHD7, HS6ST1, WDR11, SEMA3A, SOX10, IL17RD2, DUSP6, SPRY4, and FLRT3 have been associated with KS but sometimes also with its milder hyposmic/normosmic CHH clinical variant.
Reproduction, smell, and neurodevelopmental disorders: genetic defects in different hypogonadotropic hypogonadal syndromes.
Review
Beckers et al., Liège, Belgium. In Front Endocrinol (lausanne), 2013
KS is associated with mutations in KAL1, FGFR1/FGF8, FGF17, IL17RD, PROK2/PROKR2, NELF, CHD7, HS6ST1, FLRT3, SPRY4, DUSP6, SEMA3A, NELF, and WDR11 genes that are related to defects in neuronal migration.
Functional Epigenetic Analysis of Prostate Carcinoma: A Role for Seryl-tRNA Synthetase?
Kempkensteffen et al., Berlin, Germany. In J Biomark, 2013
In addition, GADD45A and SPRY4 showed a remarkable diminished expression (88% and 74%, resp.).
Genetic changes in nonepithelial ovarian cancer.
Review
Vergote et al., Leuven, Belgium. In Expert Rev Anticancer Ther, 2013
In the latter, recent genome-wide association studies have identified seven susceptibility loci near KITLG, SPRY4, UKC2, BAK1, DMRT1, TERT and ATF7IP.
Sprouty2 and -4 regulate axon outgrowth by hippocampal neurons.
GeneRIF
Klimaschewski et al., Innsbruck, Austria. In Hippocampus, 2012
our results imply that Sprouty2 and -4 are downregulated in the hippocampus during postnatal brain development and that they can act as regulators of developmental axon growth.
Associations between variants in KITLG, SPRY4, BAK1, and DMRT1 and pediatric germ cell tumors.
GeneRIF
Ross et al., Minneapolis, United States. In Genes Chromosomes Cancer, 2012
The SPRY4 (rs4324715) variants were significantly associated with germ cell tumors only in the adolescent age group.
[Carcinoma in situ of the testis: predisposition, evolution and early detection].
Review
Biermann, Rotterdam, Netherlands. In Pathologe, 2011
Recently, genome-wide association studies revealed genetic predispositions linked to six genes (KITL, SPRY4, BAK1, TERT, ATF7IP, DMRT1).
Regulation of tooth number by fine-tuning levels of receptor-tyrosine kinase signaling.
GeneRIF
Klein et al., San Francisco, United States. In Development, 2011
Interestingly, changes in sprouty gene dosage led to a graded change in incisor number, with progressive decreases in sprouty dosage leading to increasing numbers of teeth.
Hindbrain patterning requires fine-tuning of early krox20 transcription by Sprouty 4.
GeneRIF
Charnay et al., Paris, France. In Development, 2011
Hindbrain patterning requires fine-tuning of early krox20 transcription by Sprouty 4.
Sprouty-4 inhibits transformed cell growth, migration and invasion, and epithelial-mesenchymal transition, and is regulated by Wnt7A through PPARgamma in non-small cell lung cancer.
GeneRIF
Winn et al., Aurora, United States. In Mol Cancer Res, 2010
Spry4 is a downstream target of Wnt7A/Fzd 9 signaling and may have efficacy in the treatment of non-small cell lung cancer.
High marks for GWAS.
Impact
Chanock, Bethesda, United States. In Nat Genet, 2009
Two genome-wide association studies for testicular cancer report associations at three new loci, including two candidate genes previously implicated in testicular development, KITLG (ligand for the receptor tyrosine kinase) and SPRY4 (sprouty 4).
Common variation in KITLG and at 5q31.3 predisposes to testicular germ cell cancer.
Impact
GeneRIF
Nathanson et al., Philadelphia, United States. In Nat Genet, 2009
These results demonstrate that common genetic variants affect TGCT risk and implicate KITLG and SPRY4 as genes involved in Testicular germ cell tumors susceptibility.
Sef is a feedback-induced antagonist of Ras/MAPK-mediated FGF signalling.
Impact
Thisse et al., Strasbourg, France. In Nat Cell Biol, 2002
On the basis of similarities in their expression patterns during embryonic development, we have identified five genes that define a synexpression group -- fgf8, fgf3, sprouty2, sprouty4, as well as a novel gene, sef (similar expression to fgf genes).
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