GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 14 Mar 2013.
Sprouty homolog 4
Spry4, Sprouty4
SPRY4 is an inhibitor of the receptor-transduced mitogen-activated protein kinase (MAPK) signaling pathway. It is positioned upstream of RAS (see HRAS; MIM 190020) activation and impairs the formation of active GTP-RAS (Leeksma et al., 2002 [PubMed 12027893]).[supplied by OMIM, Mar 2008] (from
NCBI)
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Papers on
Spry4
Novel genes that mediate nuclear respiratory factor 1-regualted neurite outgrowth in neuroblastoma IMR-32 cells.
New
Tainan City, Taiwan. In Gene, 15 Mar 2013
Fifteen genes, MAPRE3, NPDC1, RAB3IP, TRAPPC3, SMAD5, PIP5K1A, USP10, SPRY4, GTF2F2, NR1D1, SUV39H2, SKA3, RHOA, RAPGEF6, and SMAP1 were selected for biological confirmation.
Differential actions of fibroblast growth factors on intracellular pathways and target gene expression in bovine ovarian granulosa cells.
New
China. In Reproduction, Nov 2012
FGF1 and FGF4 increased levels of mRNA encoding Sprouty family members, SPRY2 and SPRY4, and the orphan nuclear receptors NR4A1 and NR4A3.
Replication of genetic susceptibility loci for testicular germ cell cancer in the Croatian population.
New
Ulm, Germany. In Carcinogenesis, Aug 2012
We analyzed six single-nucleotide polymorphisms [rs2900333 (ATF7IP), rs210138 (BAK1), rs755383 (DMRT1), rs995030 (KITLG), rs4624820 (SPRY4), and rs4635969 (TERT/CLPTM1L)], each representing one of the published susceptibility loci/genes.
High accuracy mutation detection in leukemia on a selected panel of cancer genes.
Leuven, Belgium. In Plos One, 2011
Finally, we re-sequenced a small set of 39 candidate genes and identified recurrent mutations in TET1, SPRY3 and SPRY4.
Keratinocyte growth factor induces gene expression signature associated with suppression of malignant phenotype of cutaneous squamous carcinoma cells.
Turku, Finland. In Plos One, 2011
Gene expression profiling of three cutaneous SCC cell lines treated with KGF for 24 h revealed a specific gene expression signature characterized by upregulation of a set of genes specifically downregulated in SCC cells compared to normal epidermal keratinocytes, including genes with tumor suppressing properties (SPRY4, DUSP4, DUSP6, LRIG1, PHLDA1).
Integrative analysis of somatic mutations altering microRNA targeting in cancer genomes.
Memphis, United States. In Plos One, 2011
Specifically, we identify putative miRNA target sites in the 3'UTRs of BMPR1B, KLK3, and SPRY4 that are disrupted by both somatic and germline mutations and, also, are in linkage disequilibrium blocks with high scoring markers from cancer association studies.
Promoter methylation of candidate genes associated with familial testicular cancer.
Bethesda, United States. In Int J Mol Epidemiol Genet, 2011
We observed increased PDE11A, SPRY4 and BAK1 promoter methylation, and decreased KITLG promoter methylation, in familial TGCT cases versus healthy male family controls.
Analyzing genetic association studies with an extended propensity score approach.
Amman, Jordan. In Stat Appl Genet Mol Biol, 2011
We illustrate this approach in a population-based genetic association study of testicular germ cell tumors and KITLG and SPRY4 susceptibility genes.
[Carcinoma in situ of the testis: predisposition, evolution and early detection].
Review
Rotterdam, Netherlands. In Pathologe, 2011
Recently, genome-wide association studies revealed genetic predispositions linked to six genes (KITL, SPRY4, BAK1, TERT, ATF7IP, DMRT1).
Regulation of tooth number by fine-tuning levels of receptor-tyrosine kinase signaling.
GeneRIF
San Francisco, United States. In Development, 2011
Interestingly, changes in sprouty gene dosage led to a graded change in incisor number, with progressive decreases in sprouty dosage leading to increasing numbers of teeth.
Hindbrain patterning requires fine-tuning of early krox20 transcription by Sprouty 4.
GeneRIF
Paris, France. In Development, 2011
Hindbrain patterning requires fine-tuning of early krox20 transcription by Sprouty 4.
Sprouty4 levels are increased under hypoxic conditions by enhanced mRNA stability and transcription.
GeneRIF
Vienna, Austria. In Biol Chem, 2010
The Spry4 might be involved in the timely restriction of MAPK signals under hypoxic conditions, similar to its role in mitogen-regulated processes.
Sprouty-4 inhibits transformed cell growth, migration and invasion, and epithelial-mesenchymal transition, and is regulated by Wnt7A through PPARgamma in non-small cell lung cancer.
GeneRIF
Aurora, United States. In Mol Cancer Res, 2010
Spry4 is a downstream target of Wnt7A/Fzd 9 signaling and may have efficacy in the treatment of non-small cell lung cancer.
Familial testicular germ cell tumours.
Review
Bethesda, United States. In Best Pract Res Clin Endocrinol Metab, 2010
Moreover, two genome-wide association studies of predominantly sporadic but also familial cases of TGCT have identified three additional susceptibility loci, KITLG, SPRY4 and BAK1.
Familial testicular germ cell tumors in adults: 2010 summary of genetic risk factors and clinical phenotype.
Review
Bethesda, United States. In Endocr Relat Cancer, 2010
Two genomewide association studies of predominantly sporadic but also familial cases of TGCT have implicated the KIT-ligand, SPRY4, and BAK1 genes as TGCT risk modifiers.
Cell adaptation to activated FGFR3 includes Sprouty4 up regulation to inhibit the receptor-mediated ERKs activation from the endoplasmic reticulum.
GeneRIF
Verona, Italy. In Febs Lett, 2009
cell adaptation to activated FGFR3 include Sprouty4 activity, which silences the premature receptor signaling and suppress apoptosis.
Common variation in KITLG and at 5q31.3 predisposes to testicular germ cell cancer.
Impact
GeneRIF
Philadelphia, United States. In Nat Genet, 2009
These results demonstrate that common genetic variants affect TGCT risk and implicate KITLG and SPRY4 as genes involved in Testicular germ cell tumors susceptibility.
High marks for GWAS.
Impact
Bethesda, United States. In Nat Genet, 2009
Two genome-wide association studies for testicular cancer report associations at three new loci, including two candidate genes previously implicated in testicular development, KITLG (ligand for the receptor tyrosine kinase) and SPRY4 (sprouty 4).
FGF signaling network in the gastrointestinal tract (review).
Review
Japan. In Int J Oncol, 2006
FGF18, FGF20 and SPRY4 are potent targets of the canonical WNT signaling pathway in the gastrointestinal tract.
Sef is a feedback-induced antagonist of Ras/MAPK-mediated FGF signalling.
Impact
Strasbourg, France. In Nat Cell Biol, 2002
On the basis of similarities in their expression patterns during embryonic development, we have identified five genes that define a synexpression group -- fgf8, fgf3, sprouty2, sprouty4, as well as a novel gene, sef (similar expression to fgf genes).
