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Sprouty homolog 4

Spry4, Sprouty4
SPRY4 is an inhibitor of the receptor-transduced mitogen-activated protein kinase (MAPK) signaling pathway. It is positioned upstream of RAS (see HRAS; MIM 190020) activation and impairs the formation of active GTP-RAS (Leeksma et al., 2002 [PubMed 12027893]).[supplied by OMIM, Mar 2008] (from NCBI)
Top mentioned proteins: Sprouty, CAN, Spry2, DMRT1, telomerase reverse transcriptase
Papers on Spry4
Identification of genetic risk factors for maxillary lateral incisor agenesis.
New
Alonso et al., Porto, Portugal. In J Dent Res, May 2014
We selected 8 genes-MSX1, PAX9, AXIN2, EDA, SPRY2, TGFA, SPRY4, and WNT10A-and performed one of the largest case-control studies taking into account the number of genes and variants assessed, aiming at the identification of MLIA susceptibility factors.
[Congenital hypogonadotropic hypogonadism and Kallmann syndrome in males].
New
Young et al., Cluj-Napoca / Kolozsvár, Romania. In Presse Med, Feb 2014
Mutations in KAL1, FGFR1/FGF8/FGF17, PROK2/PROKR2, NELF, CHD7, HS6ST1, WDR11, SEMA3A, SOX10, IL17RD2, DUSP6, SPRY4, and FLRT3 have been associated with KS but sometimes also with its milder hyposmic/normosmic CHH clinical variant.
Characterization of DNA damage-induced cellular senescence by ionizing radiation in endothelial cells.
New
Kim et al., In Int J Radiat Biol, Jan 2014
We found that IGFBP5 (insulin-like growth factor binding protein 5), PLAT (plasminogen activator), SNAI2 (snail homolog 2), JAG1 (jagged 1), SPRY4 (Sprouty homolog 4), and CD44 were upregulated, whereas CFB (complement factor B), VCAM1 (vascular cell adhesion molecule 1), AQP1 (aquaporin 1), LOXL1 (lysyl oxidase-like 1), and RBPMS (RNA-binding protein with multiple splicing) were down- regulated in both radiation-damaged and old cells.
Divergence of intracellular signaling pathways and early response genes of two closely related fibroblast growth factors, FGF8 and FGF18, in bovine ovarian granulosa cells.
New
Price et al., China. In Mol Cell Endocrinol, Sep 2013
FGF8 increased abundance of mRNA encoding the FGF-responsive genes SPRY1, SPRY2, SPRY4, NR4A1 and NR4A3 whereas FGF18 did not.
Genetic changes in nonepithelial ovarian cancer.
Review
New
Vergote et al., Leuven, Belgium. In Expert Rev Anticancer Ther, Jul 2013
In the latter, recent genome-wide association studies have identified seven susceptibility loci near KITLG, SPRY4, UKC2, BAK1, DMRT1, TERT and ATF7IP.
Mutations in FGF17, IL17RD, DUSP6, SPRY4, and FLRT3 are identified in individuals with congenital hypogonadotropic hypogonadism.
New
Pitteloud et al., Lausanne, Switzerland. In Am J Hum Genet, Jun 2013
Except for FGF18 and SPRY2, all other genes were found to be mutated in CHH individuals: FGF17 (n = 3 individuals), IL17RD (n = 8), DUSP6 (n = 5), SPRY4 (n = 14), and FLRT3 (n = 3).
Upregulation of long noncoding RNA SPRY4-IT1 modulates proliferation, migration, apoptosis, and network formation in trophoblast cells HTR-8SV/neo.
Sun et al., Nanjing, China. In Plos One, 2012
SPRY4-IT1 has been reported to have extremely high expression in normal placenta tissues.
Sprouty genes regulate proliferation and survival of human embryonic stem cells.
Klein et al., San Francisco, United States. In Sci Rep, 2012
SPRY2 and SPRY4 are the two most highly expressed Sprouty family members in hESCs, suggesting that they may influence self-renewal.
Sprouty2 and -4 regulate axon outgrowth by hippocampal neurons.
GeneRIF
Klimaschewski et al., Innsbruck, Austria. In Hippocampus, 2012
our results imply that Sprouty2 and -4 are downregulated in the hippocampus during postnatal brain development and that they can act as regulators of developmental axon growth.
Associations between variants in KITLG, SPRY4, BAK1, and DMRT1 and pediatric germ cell tumors.
GeneRIF
Ross et al., Minneapolis, United States. In Genes Chromosomes Cancer, 2012
The SPRY4 (rs4324715) variants were significantly associated with germ cell tumors only in the adolescent age group.
[Carcinoma in situ of the testis: predisposition, evolution and early detection].
Review
Biermann, Rotterdam, Netherlands. In Pathologe, 2011
Recently, genome-wide association studies revealed genetic predispositions linked to six genes (KITL, SPRY4, BAK1, TERT, ATF7IP, DMRT1).
Regulation of tooth number by fine-tuning levels of receptor-tyrosine kinase signaling.
GeneRIF
Klein et al., San Francisco, United States. In Development, 2011
Interestingly, changes in sprouty gene dosage led to a graded change in incisor number, with progressive decreases in sprouty dosage leading to increasing numbers of teeth.
Hindbrain patterning requires fine-tuning of early krox20 transcription by Sprouty 4.
GeneRIF
Charnay et al., Paris, France. In Development, 2011
Hindbrain patterning requires fine-tuning of early krox20 transcription by Sprouty 4.
Sprouty-4 inhibits transformed cell growth, migration and invasion, and epithelial-mesenchymal transition, and is regulated by Wnt7A through PPARgamma in non-small cell lung cancer.
GeneRIF
Winn et al., Aurora, United States. In Mol Cancer Res, 2010
Spry4 is a downstream target of Wnt7A/Fzd 9 signaling and may have efficacy in the treatment of non-small cell lung cancer.
Familial testicular germ cell tumours.
Review
Greene et al., Bethesda, United States. In Best Pract Res Clin Endocrinol Metab, 2010
Moreover, two genome-wide association studies of predominantly sporadic but also familial cases of TGCT have identified three additional susceptibility loci, KITLG, SPRY4 and BAK1.
Familial testicular germ cell tumors in adults: 2010 summary of genetic risk factors and clinical phenotype.
Review
Korde et al., Bethesda, United States. In Endocr Relat Cancer, 2010
Two genomewide association studies of predominantly sporadic but also familial cases of TGCT have implicated the KIT-ligand, SPRY4, and BAK1 genes as TGCT risk modifiers.
High marks for GWAS.
Impact
Chanock, Bethesda, United States. In Nat Genet, 2009
Two genome-wide association studies for testicular cancer report associations at three new loci, including two candidate genes previously implicated in testicular development, KITLG (ligand for the receptor tyrosine kinase) and SPRY4 (sprouty 4).
Common variation in KITLG and at 5q31.3 predisposes to testicular germ cell cancer.
Impact
GeneRIF
Nathanson et al., Philadelphia, United States. In Nat Genet, 2009
These results demonstrate that common genetic variants affect TGCT risk and implicate KITLG and SPRY4 as genes involved in Testicular germ cell tumors susceptibility.
FGF signaling network in the gastrointestinal tract (review).
Review
Katoh et al., Japan. In Int J Oncol, 2006
FGF18, FGF20 and SPRY4 are potent targets of the canonical WNT signaling pathway in the gastrointestinal tract.
Sef is a feedback-induced antagonist of Ras/MAPK-mediated FGF signalling.
Impact
Thisse et al., Strasbourg, France. In Nat Cell Biol, 2002
On the basis of similarities in their expression patterns during embryonic development, we have identified five genes that define a synexpression group -- fgf8, fgf3, sprouty2, sprouty4, as well as a novel gene, sef (similar expression to fgf genes).
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