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Sprouty homolog 4

Spry4, Sprouty4
SPRY4 is an inhibitor of the receptor-transduced mitogen-activated protein kinase (MAPK) signaling pathway. It is positioned upstream of RAS (see HRAS; MIM 190020) activation and impairs the formation of active GTP-RAS (Leeksma et al., 2002 [PubMed 12027893]).[supplied by OMIM, Mar 2008] (from NCBI)
Top mentioned proteins: Sprouty, CAN, Spry2, DMRT1, telomerase reverse transcriptase
Papers on Spry4
Etiology and early pathogenesis of malignant testicular germ cell tumors: towards possibilities for preinvasive diagnosis.
New
Looijenga et al., Rotterdam, Netherlands. In Asian J Androl, May 2015
Since 2009, several genome wide association studies (GWAS) have been published, reporting on single-nucleotide polymorphisms (SNPs) with significant associations in or near the genes KITLG, SPRY4, BAK1, DMRT1, TERT, ATF7IP, HPGDS, MAD1L1, RFWD3, TEX14, and PPM1E, likely to be related to TGCT development.
Loss of negative regulators amplifies RAS signaling.
New
Impact
Cichowski et al., Boston, United States. In Nat Genet, May 2015
A new study identifies SPRY4 as a tumor suppressor in acute myeloid leukemia and shows that loss of SPRY4 acts as an alternative mechanism to drive RAS signaling.
Cooperative loss of RAS feedback regulation drives myeloid leukemogenesis.
New
Impact
Lowe et al., New York City, United States. In Nat Genet, May 2015
We show that in mice, premalignant myeloid cells harboring a Kras(G12D) allele retained low levels of Ras signaling owing to negative feedback involving Spry4 that prevented transformation.
Long noncoding RNA SPRY4-IT1 predicts poor patient prognosis and promotes tumorigenesis in gastric cancer.
New
Feng et al., Nanjing, China. In Tumour Biol, May 2015
In this study, we focused on lncRNA SPRY4 intronic transcript 1 (SPRY4-IT1) and investigated its expression pattern, clinical significance, biological function, and molecular mechanism in GC.
The role of microRNAs and long non-coding RNAs in the pathology, diagnosis, and management of melanoma.
Review
New
Perera et al., Orlando, United States. In Arch Biochem Biophys, Jan 2015
Data are also emerging on the role of long non-coding RNAs (lncRNAs), such as SPRY4-IT1, BANCR, and HOTAIR, in melanomagenesis.
The long noncoding RNA SPRY4-IT1 increases the proliferation of human breast cancer cells by upregulating ZNF703 expression.
New
Shu et al., Nanjing, China. In Mol Cancer, Dec 2014
The SPRY4 intronic transcript 1 (SPRY4-IT1) is a 708-bp lncRNA on chromosome 5 with a potential functional role in tumorigenesis.
Increased expression of SPRY4-IT1 predicts poor prognosis and promotes tumor growth and metastasis in bladder cancer.
New
Du et al., Kaifeng, China. In Int J Clin Exp Pathol, Dec 2014
In this study, we focused on lncRNA SPRY4-IT1 and investigated its expression pattern, clinical significance, and biological function in UCB.
A mRNA landscape of bovine embryos after standard and MAPK-inhibited culture conditions: a comparative analysis.
New
Roelen et al., Utrecht, Netherlands. In Bmc Genomics, Dec 2014
Expression of other genes in the MAPK pathway including DUSP4 and SPRY4, or influenced by MAPK inhibition such as IFNT, was down-regulated.
[Congenital hypogonadotropic hypogonadism and Kallmann syndrome in males].
Review
New
Young et al., Cluj-Napoca / Kolozsvár, Romania. In Presse Med, Feb 2014
Mutations in KAL1, FGFR1/FGF8/FGF17, PROK2/PROKR2, NELF, CHD7, HS6ST1, WDR11, SEMA3A, SOX10, IL17RD2, DUSP6, SPRY4, and FLRT3 have been associated with KS but sometimes also with its milder hyposmic/normosmic CHH clinical variant.
Reproduction, smell, and neurodevelopmental disorders: genetic defects in different hypogonadotropic hypogonadal syndromes.
Review
Beckers et al., Liège, Belgium. In Front Endocrinol (lausanne), 2013
KS is associated with mutations in KAL1, FGFR1/FGF8, FGF17, IL17RD, PROK2/PROKR2, NELF, CHD7, HS6ST1, FLRT3, SPRY4, DUSP6, SEMA3A, NELF, and WDR11 genes that are related to defects in neuronal migration.
Genetic changes in nonepithelial ovarian cancer.
Review
Vergote et al., Leuven, Belgium. In Expert Rev Anticancer Ther, 2013
In the latter, recent genome-wide association studies have identified seven susceptibility loci near KITLG, SPRY4, UKC2, BAK1, DMRT1, TERT and ATF7IP.
Sprouty2 and -4 regulate axon outgrowth by hippocampal neurons.
GeneRIF
Klimaschewski et al., Innsbruck, Austria. In Hippocampus, 2012
our results imply that Sprouty2 and -4 are downregulated in the hippocampus during postnatal brain development and that they can act as regulators of developmental axon growth.
Associations between variants in KITLG, SPRY4, BAK1, and DMRT1 and pediatric germ cell tumors.
GeneRIF
Ross et al., Minneapolis, United States. In Genes Chromosomes Cancer, 2012
The SPRY4 (rs4324715) variants were significantly associated with germ cell tumors only in the adolescent age group.
[Carcinoma in situ of the testis: predisposition, evolution and early detection].
Review
Biermann, Rotterdam, Netherlands. In Pathologe, 2011
Recently, genome-wide association studies revealed genetic predispositions linked to six genes (KITL, SPRY4, BAK1, TERT, ATF7IP, DMRT1).
Regulation of tooth number by fine-tuning levels of receptor-tyrosine kinase signaling.
GeneRIF
Klein et al., San Francisco, United States. In Development, 2011
Interestingly, changes in sprouty gene dosage led to a graded change in incisor number, with progressive decreases in sprouty dosage leading to increasing numbers of teeth.
Hindbrain patterning requires fine-tuning of early krox20 transcription by Sprouty 4.
GeneRIF
Charnay et al., Paris, France. In Development, 2011
Hindbrain patterning requires fine-tuning of early krox20 transcription by Sprouty 4.
Sprouty-4 inhibits transformed cell growth, migration and invasion, and epithelial-mesenchymal transition, and is regulated by Wnt7A through PPARgamma in non-small cell lung cancer.
GeneRIF
Winn et al., Aurora, United States. In Mol Cancer Res, 2010
Spry4 is a downstream target of Wnt7A/Fzd 9 signaling and may have efficacy in the treatment of non-small cell lung cancer.
High marks for GWAS.
Impact
Chanock, Bethesda, United States. In Nat Genet, 2009
Two genome-wide association studies for testicular cancer report associations at three new loci, including two candidate genes previously implicated in testicular development, KITLG (ligand for the receptor tyrosine kinase) and SPRY4 (sprouty 4).
Common variation in KITLG and at 5q31.3 predisposes to testicular germ cell cancer.
Impact
GeneRIF
Nathanson et al., Philadelphia, United States. In Nat Genet, 2009
These results demonstrate that common genetic variants affect TGCT risk and implicate KITLG and SPRY4 as genes involved in Testicular germ cell tumors susceptibility.
Sef is a feedback-induced antagonist of Ras/MAPK-mediated FGF signalling.
Impact
Thisse et al., Strasbourg, France. In Nat Cell Biol, 2002
On the basis of similarities in their expression patterns during embryonic development, we have identified five genes that define a synexpression group -- fgf8, fgf3, sprouty2, sprouty4, as well as a novel gene, sef (similar expression to fgf genes).
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