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Sprouty homolog 2

Spry2, Sprouty2, hSpry2
This gene encodes a protein belonging to the sprouty family. The encoded protein contains a carboxyl-terminal cysteine-rich domain essential for the inhibitory activity on receptor tyrosine kinase signaling proteins and is required for growth factor stimulated translocation of the protein to membrane ruffles. In primary dermal endothelial cells this gene is transiently upregulated in response to fibroblast growth factor two. This protein is indirectly involved in the non-cell autonomous inhibitory effect on fibroblast growth factor two signaling. The protein interacts with Cas-Br-M (murine) ectropic retroviral transforming sequence, and can function as a bimodal regulator of epidermal growth factor receptor/mitogen-activated protein kinase signaling. This protein may play a role in alveoli branching during lung development as shown by a similar mouse protein. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Sprouty, ERK, MAPK, V1a, Akt
Papers on Spry2
Upregulation of microRNA‑27b contributes to the migration and invasion of gastric cancer cells via the inhibition of sprouty2‑mediated ERK signaling.
New
Cao et al., Changsha, China. In Mol Med Report, Feb 2016
Luciferase reporter assay data indicated that sprouty2 (SPRY2) is a direct target of miR‑27b, and miR‑27b binds to the 3'‑untranslated region of SPRY2 mRNA.
Spaceflight alters expression of microRNA during T-cell activation.
New
Li et al., San Francisco, United States. In Faseb J, Dec 2015
EGR3, FASLG, BTG2, SPRY2, and TAGAP are biologically confirmed targets and are co-up-regulated with miR-21.
Microarray Analysis of Gene Expression Alteration in Human Middle Ear Epithelial Cells Induced by Asian Sand Dust.
New
Song et al., Seoul, South Korea. In Clin Exp Otorhinolaryngol, Dec 2015
A total of 11 genes including CSF3, DKK1, FOSL1, FST, TERT, MMP13, PTHLH, SPRY2, TGFBR2, THBS1, and TIMP1 acted as main components of pathway associated with 2-fold down regulated genes.
SPROUTY-2 represses the epithelial phenotype of colon carcinoma cells via upregulation of ZEB1 mediated by ETS1 and miR-200/miR-150.
New
Muñoz et al., Madrid, Spain. In Oncogene, Nov 2015
UNASSIGNED: SPROUTY-2 (SPRY2) is a modulator of tyrosine kinase receptor signaling with receptor- and cell type-dependent inhibitory or enhancing effects.
Atypical role of sprouty in colorectal cancer: sprouty repression inhibits epithelial-mesenchymal transition.
New
Khare et al., Columbia, United States. In Oncogene, Nov 2015
UNASSIGNED: Sprouty (SPRY) appears to act as a tumor suppressor in cancer, whereas we demonstrated that SPRY2 functions as a putative oncogene in colorectal cancer (CRC) (Oncogene, 2010, 29: 5241-5253).
Sprouty2 suppresses the inflammatory responses in rheumatoid arthritis fibroblast-like synoviocytes through regulating the Raf/ERK and PTEN/AKT signals.
New
Xu et al., Beijing, China. In Mol Immunol, Oct 2015
Sprouty2 (SPRY2) has been known as a tumor suppressor by preventing both ERK and AKT signaling activations.
13q31.1 microdeletion: A prenatal case report with macrocephaly and macroglossia.
New
Coutton et al., Grenoble, France. In Eur J Med Genet, Oct 2015
We report on a female fetus with macrocephaly and macroglossia harbouring 13q31.1 microdeletion encompassing three genes: SPRY2, NDFIP2 and RBM26.
Atypical role of sprouty in p21 dependent inhibition of cell proliferation in colorectal cancer.
New
Khare et al., United States. In Mol Carcinog, Sep 2015
UNASSIGNED: Sprouty (SPRY) appears to act as a tumor suppressor in cancer, whereas we reported that SPRY2 functions as a putative oncogene in colorectal cancer (CRC) [Oncogene, 2010, 29: 5241-5253].
Carcinogenic mechanisms of endometrial cancer: involvement of genetics and epigenetics.
Review
Aoki et al., Tokyo, Japan. In J Obstet Gynaecol Res, 2014
Possible carcinogenic mechanisms include imbalance between endometrial proliferation by unopposed estrogen and the mismatch repair (MMR) system; hypermethylation of the MMR gene hMLH1; mutation of PTEN, β-catenin and K-ras genes in type I endometrial cancer and of HER-2/neu and p53 genes in type II endometrial cancer; hypermethylation of SPRY2, RASSF1A, RSK4, CHFR and CDH1; and methylation of tumor suppressor microRNAs, including miR-124, miR-126, miR-137, miR-491, miR-129-2 and miR-152.
Nuclear translocation of FGF8 and its implication to induce Sprouty2.
GeneRIF
Nakamura et al., Sendai, Japan. In Dev Growth Differ, 2012
Nuclear FGF8 could function as transcriptional regulator to induce Sprouty2 in the isthmus.
G Protein-regulated inducer of neurite outgrowth (GRIN) modulates Sprouty protein repression of mitogen-activated protein kinase (MAPK) activation by growth factor stimulation.
GeneRIF
Neves et al., New York City, United States. In J Biol Chem, 2012
G Protein-regulated inducer of neurite outgrowth (GRIN) modulates Sprouty protein repression of mitogen-activated protein kinase (MAPK) activation by growth factor stimulation
Spry1 and spry2 are essential for development of the temporomandibular joint.
GeneRIF
Klein et al., Boston, United States. In J Dent Res, 2012
Spry1/Spry2 highly expressed in lateral pterygoid and temporal muscles. combined inactivation of Spry1 and Spry2 results in muscle overgrowth disrupting normal glenoid fossa development. TMJ condyle and disc develop independently of the mandibular fossa.
Intersectin 1 enhances Cbl ubiquitylation of epidermal growth factor receptor through regulation of Sprouty2-Cbl interaction.
GeneRIF
O'Bryan et al., Chicago, United States. In Mol Cell Biol, 2012
ITSN1 binds Pro-rich regions in both Cbl and Spry2, and interaction of ITSN1 with Spry2 disrupts Spry2-Cbl interaction, resulting in enhanced ubiquitylation of the EGFR.
Immunolocalization of sprouty-1 and sprouty-2 in developing rat lung.
GeneRIF
Katyal et al., Pittsburgh, United States. In Pathobiology, 2011
A comparison the distribution of Sprouty-1 and Sprouty-2 proteins by immunohistochemistry in developing and adult rat lung.
Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile.
Impact
Loos et al., Cambridge, United Kingdom. In Nat Genet, 2011
We confirmed a previously established adiposity locus in FTO (P = 3 × 10(-26)) and identified two new loci associated with body fat percentage, one near IRS1 (P = 4 × 10(-11)) and one near SPRY2 (P = 3 × 10(-8)).
Malignant transformation of human skin fibroblasts by two alternative pathways.
Review
Maher et al., East Lansing, United States. In Adv Exp Med Biol, 2010
Loss of expression of p14(ALT) and enhanced expression of SPRY2 gave rise to the MSU-1.1 cell strain.
MicroRNA-21 in cardiovascular disease.
Review
Zhang et al., Newark, United States. In J Cardiovasc Transl Res, 2010
Programmed cell death 4 (PDCD4), phosphatase and tensin homology deleted from chromosome 10 (PTEN), sprouty1 (SPRY1), and sprouty2 (SPRY2) are the current identified target genes of miR-21 that are involved in miR-21-mediated cardiovascular effects.
Ubiquitous SPRY domains and their role in the skeletal type ryanodine receptor.
Review
Dulhunty et al., Canberra, Australia. In Eur Biophys J, 2009
In this article, we review the general characteristics of a range of SPRY domains and discuss evidence that the SPRY2 domain in RyR1 supports interactions with binding partners that contain a structural surface of aligned basic residues.
Molecular recognition of the disordered dihydropyridine receptor II-III loop by a conserved spry domain of the type 1 ryanodine receptor.
Review
Casarotto et al., Canberra, Australia. In Clin Exp Pharmacol Physiol, 2009
Mutations within the A and B regions in the DHPR II-III loop alter the binding affinity to the SPRY2 domain.
Sef is a feedback-induced antagonist of Ras/MAPK-mediated FGF signalling.
Impact
Thisse et al., Strasbourg, France. In Nat Cell Biol, 2002
On the basis of similarities in their expression patterns during embryonic development, we have identified five genes that define a synexpression group -- fgf8, fgf3, sprouty2, sprouty4, as well as a novel gene, sef (similar expression to fgf genes).
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