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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Sprouty homolog 1

Sprouty, Spry1, Sprouty1
Top mentioned proteins: Spry2, ERK, MAPK, CAN, Spry4
Papers on Sprouty
Long noncoding RNA UPAT promotes colon tumorigenesis by inhibiting degradation of UHRF1.
New
Akiyama et al., Tokyo, Japan. In Proc Natl Acad Sci U S A, Feb 2016
Furthermore, we demonstrate that UHRF1 up-regulates Stearoyl-CoA desaturase 1 and Sprouty 4, which are required for the survival of colon tumor cells.
Sprouty4 mediates amphiregulin-induced down-regulation of E-cadherin and cell invasion in human ovarian cancer cells.
New
Leung et al., Vancouver, Canada. In Tumour Biol, Feb 2016
UNASSIGNED: Sprouty (SPRY) proteins are well-characterized factors that inhibit receptor tyrosine kinase (RTK)-mediated activation of cellular signaling pathways.
Sprouty-Related Ena/Vasodilator-Stimulated Phosphoprotein Homology 1-Domain-Containing Protein-2 Critically Regulates Influenza A Virus-Induced Pneumonia.
New
Matsukawa et al., Okayama, Japan. In Crit Care Med, Feb 2016
Raf/MEK/extracellular signal-regulated kinase cascade is one of the key signaling pathways during influenza virus infection, and the Sprouty-related Ena/vasodilator-stimulated phosphoprotein homology 1-domain-containing protein has recently been identified as a negative regulator of Raf-dependent extracellular signal-regulated kinase activation.
A multicentric association study between 39 genes and nonsyndromic cleft lip and palate in a Brazilian population.
New
Gil-da-Silva-Lopes et al., Campinas, Brazil. In J Craniomaxillofac Surg, Jan 2016
RESULTS: Twenty-four SNPs in 16 genes were significantly associated with the etiology of NSCLP, including MSX1, SPRY1, MSX2, PRSS35, TFAP2A, SHH, VAX1, TBX10, WNT11, PAX9, BMP4, JAG2, AXIN2, DVL2, KIF7, and TCBE3.
Fibrosis in the lens. Sprouty regulation of TGFβ-signaling prevents lens EMT leading to cataract.
Review
New
McAvoy et al., Sydney, Australia. In Exp Eye Res, Jan 2016
Intriguingly, recent studies in animal models have shown that EMT and cataract developed when a class of negative-feedback regulators, Sprouty (Spry)1 and Spry2, were conditionally deleted from the lens.
siRNA mediated down-regulation of Sprouty2/4 diminishes ischemic brain injury.
New
Millan et al., Innsbruck, Austria. In Neurosci Lett, Jan 2016
UNASSIGNED: Down-regulation of Sprouty proteins promotes axon regeneration in lesioned nerves and prevents neurodegeneration following excitotoxic brain injury.
The Ras/MAPK pathway and hepatocarcinoma: pathogenesis and therapeutic implications.
Review
New
Stärkel et al., Brussels, Belgium. In Eur J Clin Invest, Jun 2015
Downregulation of several Ras/MAPK pathway inhibitors such as GAPs, RASSF proteins, DUSP1, Sprouty and Spred proteins is largely implicated in the aberrant activation of this pathway in the context of wild-type Ras and Raf genes.
MiR-21: an environmental driver of malignant melanoma?
Review
Melnik, Osnabrück, Germany. In J Transl Med, 2014
MiR-21 is an oncomiR that affects critical target genes of malignant melanoma, resulting in sustained proliferation (PTEN, PI3K, Sprouty, PDCD4, FOXO1, TIPE2, p53, cyclin D1), evasion from apoptosis (FOXO1, FBXO11, APAF1, TIMP3, TIPE2), genetic instability (MSH2, FBXO11, hTERT), increased oxidative stress (FOXO1), angiogenesis (PTEN, HIF1α, TIMP3), invasion and metastasis (APAF1, PTEN, PDCD4, TIMP3).
The developing story of Sprouty and cancer.
Review
Morris et al., Sydney, Australia. In Cancer Metastasis Rev, 2014
Sprouty proteins are evolutionarily conserved modulators of MAPK/ERK pathway.
Mnk kinase pathway: Cellular functions and biological outcomes.
Review
Platanias et al., Houston, United States. In World J Biol Chem, 2014
Several studies have established multiple Mnk protein targets, including PSF, heterogenous nuclear ribonucleoprotein A1, Sprouty 2 and have lead to the identification of distinct biological functions and substrate specificity for the Mnk kinases.
Tissue-specific expression of Sprouty1 in mice protects against high-fat diet-induced fat accumulation, bone loss and metabolic dysfunction.
GeneRIF
Liaw et al., West Scarborough, United States. In Br J Nutr, 2012
investigation of role of Spry1: Overexpression of Spry1 in transgenic mice leads to lower body fat, reduced bone loss, and normal metabolic function (i.e., prevents liver steatosis/glucose intolerance) compared with Spry1-negative transgenic mice.
Sprouty1 is a candidate tumor-suppressor gene in medullary thyroid carcinoma.
GeneRIF
Encinas et al., Lleida, Spain. In Oncogene, 2012
findings identify Spry1 as a candidate tumor-suppressor gene in medullary thyroid carcinoma
Spry1 as a novel regulator of erythropoiesis, EPO/EPOR target, and suppressor of JAK2.
GeneRIF
Wojchowski et al., West Scarborough, United States. In Blood, 2012
Studies implicate Spry1 as a novel regulator of erythropoiesis during anemia, transducer of EPO/EPOR signals, and candidate suppressor of Jak2 activity.
Spry1 and spry2 are essential for development of the temporomandibular joint.
GeneRIF
Klein et al., Boston, United States. In J Dent Res, 2012
Spry1/Spry2 highly expressed in lateral pterygoid and temporal muscles. combined inactivation of Spry1 and Spry2 results in muscle overgrowth disrupting normal glenoid fossa development. TMJ condyle and disc develop independently of the mandibular fossa.
Transcriptional and post-transcriptional regulation of Sprouty1, a receptor tyrosine kinase inhibitor in prostate cancer.
GeneRIF
Kwabi-Addo et al., Washington, D.C., United States. In Prostate Cancer Prostatic Dis, 2011
Spry1 is a target for miR-21-mediated gene silencing.
Regulation of ERK activity duration by Sprouty contributes to dorsoventral patterning.
Impact
Nishida et al., Nagoya, Japan. In Nat Cell Biol, 2009
Distinct modes of ERK activation, sustained or transient, are essential for cell fate decision in cultured cells.
Differential gene expression patterns and interaction networks in BCR-ABL-positive and -negative adult acute lymphoblastic leukemias.
Impact
Sikic et al., Stanford, United States. In J Clin Oncol, 2007
Within the BCR-ABL-positive subgroups, we identified genes overexpressed (PILRB, STS-1, SPRY1) or underexpressed (TSPAN16, ADAMTSL4) in p185BCR-ABL-positive ALL relative to p210BCR-ABL-positive ALL.
A negative feedback signaling network underlies oncogene-induced senescence.
Impact
Cichowski et al., Boston, United States. In Cancer Cell, 2006
This negative feedback program is regulated in part by RasGEFs, Sprouty proteins, RasGAPs, and MKPs.
Mammalian Sprouty4 suppresses Ras-independent ERK activation by binding to Raf1.
Impact
Yoshimura et al., Fukuoka, Japan. In Nat Cell Biol, 2003
Two families of membrane-bound molecules, Sprouty and Sprouty-related EVH1-domain-containing protein (Spred) have been identified and characterized as negative regulators of growth-factor-induced ERK activation.
Sprouty1 and Sprouty2 provide a control mechanism for the Ras/MAPK signalling pathway.
Impact
Nishida et al., Kyoto, Japan. In Nat Cell Biol, 2002
Sprouty (Spry) inhibits signalling by receptor tyrosine kinases; however, the molecular mechanism underlying this function has not been defined.
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