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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Sprouty-related, EVH1 domain containing 2

Spred-2
SPRED2 is a member of the Sprouty (see SPRY1; MIM 602465)/SPRED family of proteins that regulate growth factor-induced activation of the MAP kinase cascade (see MAPK1; MIM 176948) (Nonami et al., 2004 [PubMed 15465815]).[supplied by OMIM, Mar 2008] (from NCBI)
Top mentioned proteins: Sprouty, ERK, SPRED1, MAPK, Raf
Papers on Spred-2
Oxidized low-density lipoprotein is a common risk factor for cardiovascular diseases and gastroenterological cancers via epigenomical regulation of microRNA-210.
New
Juo et al., Taipei, Taiwan. In Oncotarget, Oct 2015
Furthermore, miR-210 can directly inhibit sprouty-related EVH1 domain 2 (SPRED2) expressions, and SPRED2 reduces cell migration via ERK/c-Fos/MMPs pathways.
SPREDs (Sprouty related proteins with EVH1 domain) promote self-renewal and inhibit mesodermal differentiation in murine embryonic stem cells.
New
Bundschu et al., Ulm, Germany. In Dev Dyn, Apr 2015
RESULTS: We generated SPRED1 and SPRED2 overexpressing and SPRED2 knockout murine ES cells to analyze the functions of SPRED proteins in ES cells and during early differentiation.
Negative regulation of TGFβ-induced lens epithelial to mesenchymal transition (EMT) by RTK antagonists.
New
Lovicu et al., Sydney, Australia. In Exp Eye Res, Mar 2015
pLSXG-Spry1, pLSXG-Spry2, pLXSG-Sef, pLSXG-Spred1, pLSXG-Spred2, pLSXG-Spred3), before treating with TGFβ for up to 3 days.
Spred2 modulates the erythroid differentiation induced by imatinib in chronic myeloid leukemia cells.
Wang et al., Beijing, China. In Plos One, 2014
Our previous work has demonstrated that Sprouty-related EVH1 domainprotein2 (Spred2) was involved in imatinib mediated cytotoxicity in CML cells.
The MAPK pathway as an apoptosis enhancer in melanoma.
Meierjohann et al., Würzburg, Germany. In Oncotarget, 2014
The simultaneous knockdown of SPRED1 and SPRED2 mimicked the effects of MEK inhibitor such as PUMA repression and protection from apoptosis.
Spred-2 deficiency exacerbates lipopolysaccharide-induced acute lung inflammation in mice.
Matsukawa et al., Okayama, Japan. In Plos One, 2013
METHODS: Wild-type (WT) mice and Spred-2(-/-) mice were exposed to intratracheal LPS (50 µg in 50 µL PBS) to induce pulmonary inflammation.
Gene expression responses to mechanical stimulation of mesenchymal stem cells seeded on calcium phosphate cement.
Hughes et al., London, United Kingdom. In Tissue Eng Part A, 2013
Mechanical loading resulted in upregulation of Erk1/2 phosphorylation and the gene expression study identified a number of possible genes (SPRY2, RIPK1, SPRED2, SERTAD1, TRIB1, and RAPGEF2) that may regulate this process.
Rheumatoid arthritis in Latin Americans enriched for Amerindian ancestry is associated with loci in chromosomes 1, 12, and 13, and the HLA class II region.
Alarcón-Riquelme et al., Granada, Spain. In Arthritis Rheum, 2013
Previously reported associations were observed in the current study, including PTPN22, SPRED2, STAT4, IRF5, CCL21, and IL2RA, although the significance was relatively moderate.
Evidence for downregulation of the negative regulator SPRED2 in clinical prostate cancer.
Gnanapragasam et al., Cambridge, United Kingdom. In Br J Cancer, 2013
METHODS: A transcriptome bank of microdissected grade-specific primary cancers was constructed and interrogated for transcript expression of prostate cancer genes, known negative signalling regulators as well as SPRED1 and 2. The effect of SPRED2 manipulation was tested in in vitro assays.
Computational approaches for discovery of common immunomodulators in fungal infections: towards broad-spectrum immunotherapeutic interventions.
Murali et al., Blacksburg, United States. In Bmc Microbiol, 2012
These processes contained both immune response-inducing genes such as MALT1, SERPINE1, ICAM1, and IL8, and immune response-repressing genes such as DUSP8, DUSP6, and SPRED2.
Profiling of miRNAs in pediatric asthma: upregulation of miRNA-221 and miRNA-485-3p.
Zhao et al., Nanjing, China. In Mol Med Report, 2012
The sprouty-related protein with an EVH1 domain-2 (Spred-2) protein content was assessed by western blotting.
Spred-2 deficiency exacerbates acetaminophen-induced hepatotoxicity in mice.
GeneRIF
Matsukawa et al., Okayama, Japan. In Clin Immunol, 2012
Spred-2 negatively regulates APAP-hepatotoxicity under the control of Kupffer cells and NK cells.
Tyrosines 303/343/353 within the Sprouty-related domain of Spred2 are essential for its interaction with p85 and inhibitory effect on Ras/ERK activation.
GeneRIF
Wang et al., Yangzhou, China. In Int J Biochem Cell Biol, 2012
Tyrosines 303/343/353 within the Sprouty-related domain of Spred2 are essential for its interaction with the p85 subunit of phosphatidylinositol 3-kinase.
Defining an EPOR- regulated transcriptome for primary progenitors, including Tnfr-sf13c as a novel mediator of EPO- dependent erythroblast formation.
Wojchowski et al., West Scarborough, United States. In Plos One, 2011
For example, not only Socs3 plus Socs2 but also Spred2, Spred1 and Eaf1 were EPO-induced as negative-feedback components.
Regulation of human hepatocellular carcinoma cells by Spred2 and correlative studies on its mechanism.
GeneRIF
Wang et al., Lanzhou, China. In Biochem Biophys Res Commun, 2011
the knockdown of Spred2 markedly enhanced tumor growth in vivo.
Identification of SPRED2 (sprouty-related protein with EVH1 domain 2) as a negative regulator of the hypothalamic-pituitary-adrenal axis.
GeneRIF
Schuh et al., Würzburg, Germany. In J Biol Chem, 2011
Identification of SPRED2 (sprouty-related protein with EVH1 domain 2) as a negative regulator of the hypothalamic-pituitary-adrenal axis.
Sprouty2 and Spred1-2 proteins inhibit the activation of the ERK pathway elicited by cyclopentenone prostanoids.
GeneRIF
Rojas et al., Madrid, Spain. In Plos One, 2010
Sprouty and Spred proteins are negative regulators of the ERK/Elk-1 pathway activation induced not only by growth-factors, but also by reactive lipidic mediators.
Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci.
Impact
Plenge et al., Boston, United States. In Nat Genet, 2010
The associated SNPs are near genes of known immune function, including IL6ST, SPRED2, RBPJ, CCR6, IRF5 and PXK.
Spred is a Sprouty-related suppressor of Ras signalling.
Impact
Yoshimura et al., Fukuoka, Japan. In Nature, 2001
Here we describe two structurally similar tyrosine kinase substrates, Spred-1 and Spred-2.
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