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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

SPO11 Spo11p

Spo11, Rec12, Spo11p
Meiotic recombination and chromosome segregation require the formation of double-strand breaks (DSBs) in paired chromosome homologs. During meiosis in yeast, a meiotic recombination protein is covalently-linked to the 5' end of DSBs and is essential for the formation of DSBs. The protein encoded by this gene is similar in sequence and conserved features to the yeast meiotic recombination protein. The encoded protein belongs to the TOP6A protein family. Several transcript variants encoding different isoforms have been found for this gene, but the full-length nature of only two of them have been described. [provided by RefSeq, Jul 2008] (from NCBI)
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Top mentioned proteins: CAN, Dmc1, Rad50, ACID, Rad51
Papers on Spo11
[Association of SPO11 and GST gene polymorphisms with idiopathic male infertility in ethnic Han Chinese].
New
Gao et al., Zhengzhou, China. In Zhonghua Yi Xue Yi Chuan Xue Za Zhi, Jan 2016
OBJECTIVE: To explore the possible roles of polymorphisms of SPO11 and glutathionine S-transferase (GST) genes in idiopathic male infertility in a ethnic Han Chinese population from Henan.
A surge of late-occurring meiotic double-strand breaks rescues synapsis abnormalities in spermatocytes of mice with hypomorphic expression of SPO11.
New
Barchi et al., Roma, Italy. In Chromosoma, Nov 2015
In mammals, during prophase of meiosis I, homologous chromosomes align and synapse through a recombination-mediated mechanism initiated by the introduction of DNA double-strand breaks (DSBs) by the SPO11 protein.
DNA methylation restrains transposons from adopting a chromatin signature permissive for meiotic recombination.
New
Bourc'his et al., Paris, France. In Genes Dev, Jul 2015
Indeed, H3K4me3 marks gained over transcriptionally active transposons correlate with formation of SPO11-dependent double-strand breaks and recruitment of the DMC1 repair enzyme in Dnmt3L(-/-) meiotic cells, whereas these features are normally exclusive to meiotic recombination hot spots.
MEI4 – a central player in the regulation of meiotic DNA double-strand break formation in the mouse.
New
de Massy et al., Montpellier, France. In J Cell Sci, Jun 2015
Meiotic DSB formation is catalyzed by SPO11 and their repair takes place on meiotic chromosome axes.
Identification of the meiotic toolkit in diatoms and exploration of meiosis-specific SPO11 and RAD51 homologs in the sexual species Pseudo-nitzschia multistriata and Seminavis robusta.
Ferrante et al., Napoli, Italy. In Bmc Genomics, 2014
The two sexual species Pseudo-nitzschia multistriata and Seminavis robusta were used to explore the expression of meiosis-related genes: RAD21, SPO11-2, RAD51-A, RAD51-B and RAD51-C were upregulated during meiosis, whereas other paralogs in these families showed no differential expression patterns, suggesting that they may play a role during vegetative divisions.
Spatio-Temporal Gene Expression Profiling during In Vivo Early Ovarian Folliculogenesis: Integrated Transcriptomic Study and Molecular Signature of Early Follicular Growth.
Mandon-Pepin et al., France. In Plos One, 2014
This set of biomarkers includes known genes such as SPO11 meiotic protein covalently bound to DSB (SPO11), bone morphogenetic protein 15 (BMP15) and WEE1 homolog 2 (S.
Initiation of meiotic recombination: how and where? Conservation and specificities among eukaryotes.
Review
Impact
de Massy, Montpellier, France. In Annu Rev Genet, 2012
DSBs are catalyzed by the evolutionarily conserved SPO11 protein, assisted by several other factors.
Homeostatic control of recombination is implemented progressively in mouse meiosis.
Impact
GeneRIF
Jasin et al., New York City, United States. In Nat Cell Biol, 2012
Mice with greater or fewer copies of the Spo11 gene--with correspondingly greater or fewer numbers of early recombination foci--exhibited relatively invariant crossover numbers.
ATM controls meiotic double-strand-break formation.
Impact
Keeney et al., New York City, United States. In Nature, 2011
In many organisms, developmentally programmed double-strand breaks (DSBs) formed by the SPO11 transesterase initiate meiotic recombination, which promotes pairing and segregation of homologous chromosomes.
Spo11-accessory proteins link double-strand break sites to the chromosome axis in early meiotic recombination.
Impact
GeneRIF
Klein et al., Vienna, Austria. In Cell, 2011
Study shows that Spo11-accessory proteins Rec114, Mer2, and Mei4 stably interact with chromosome axis sequences, upon phosphorylation of Mer2 by S phase Cdk.
An association study of SPO11 gene single nucleotide polymorphisms with idiopathic male infertility in Chinese Han population.
GeneRIF
Tian et al., Xi'an, China. In J Assist Reprod Genet, 2011
SPO11 might has an effect on premorbid functioning, which increase susceptibility for idiopathic male reproduction
Rec10- and Rec12-independent recombination in meiosis of Schizosaccharomyces pombe.
GeneRIF
Kohli et al., Bern, Switzerland. In Yeast, 2011
Reductions in rec10 rec12 double deletion crosses indicate partially redundant functions of Rec10 and Rec12 in the initiation of intrachromosomal recombination.
The expression profile of the major mouse SPO11 isoforms indicates that SPO11beta introduces double strand breaks and suggests that SPO11alpha has an additional role in prophase in both spermatocytes and oocytes.
GeneRIF
Camerini-Otero et al., Bethesda, United States. In Mol Cell Biol, 2010
Data support a role for SPO11alpha in mid- to late prophase, presumably acting as a topoisomerase, that would be conserved in male and female meiocytes.
DNA double strand break repair, chromosome synapsis and transcriptional silencing in meiosis.
Review
Baarends et al., Rotterdam, Netherlands. In Epigenetics, 2010
Chromosome pairing and synapsis during meiotic prophase requires the formation and repair of DNA double-strand breaks (DSBs) by the topoisomerase-like enzyme SPO11.
Detection of SPO11-oligonucleotide complexes from mouse testes.
Review
GeneRIF
Keeney et al., New York City, United States. In Methods Mol Biol, 2008
Detection of the release product, SPO11-oligonucleotide complexes, from mouse testis lysates.
Crossover homeostasis in yeast meiosis.
Impact
Keeney et al., New York City, United States. In Cell, 2006
Recombination initiates with an excess number of double-strand breaks made by Spo11 protein.
The genetics of male infertility: a field of study whose time is now.
Review
Lamb et al., Salt Lake City, United States. In Arch Androl, 2006
Initial reports from human studies have identified several candidate genes, including the protamine genes, SPO11, EIF5A2, USP26, ACT, and others.
Double-stranded DNA breaks and gene functions in recombination and meiosis.
Review
Ma et al., United States. In Cell Res, 2006
Recent studies have suggested that the SPO11 proteins have conserved functions in a number of organisms in generating sites of double-stranded DNA breaks (DSBs) that are thought to be the starting points of homologous recombination.
Endonucleolytic processing of covalent protein-linked DNA double-strand breaks.
Impact
GeneRIF
Keeney et al., New York City, United States. In Nature, 2005
meiotic double-stranded breaks are processed by endonucleolytic cleavage that releases Spo11 attached to an oligonucleotide with a free 3'-OH
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