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Spire homolog 1

Spir-1, Spire1
Spire proteins, such as SPIRE1, are highly conserved between species. They belong to the family of Wiskott-Aldrich homology region-2 (WH2) proteins, which are involved in actin organization (Kerkhoff et al., 2001 [PubMed 11747823]).[supplied by OMIM, Mar 2008] (from NCBI)
Top mentioned proteins: Actin, Fmn2, V1a, Arp2, CsF
Papers on Spir-1
Transcriptional regulation of Annexin A2 promotes starvation-induced autophagy.
Rubinsztein et al., Cambridge, United Kingdom. In Nat Commun, 2014
This process is dependent on the Annexin A2 effectors ARP2 and Spire1.
Enhanced fear expression in Spir-1 actin organizer mutant mice.
Kerkhoff et al., Regensburg, Germany. In Eur J Cell Biol, 2014
The mammalian genome encodes two Spir proteins, namely Spir-1 and Spir-2.
An actin-dependent mechanism for long-range vesicle transport.
Schuh, Cambridge, United Kingdom. In Nat Cell Biol, 2011
Vesicles organize their own actin tracks by recruiting the actin nucleation factors Spire1, Spire2 and Formin-2, which assemble an extensive actin network from the vesicles' surfaces.
Molecular basis of actin nucleation factor cooperativity: crystal structure of the Spir-1 kinase non-catalytic C-lobe domain (KIND)•formin-2 formin SPIR interaction motif (FSI) complex.
Kerkhoff et al., Tübingen, Germany. In J Biol Chem, 2011
analysis of the molecular basis of the Spir1/formin-2 interaction
Spire-type actin nucleators cooperate with Formin-2 to drive asymmetric oocyte division.
Schuh et al., Cambridge, United Kingdom. In Curr Biol, 2011
Spire1 and Spire2 drive two critical steps of asymmetric oocyte division.
Expression patterns of the mouse Spir-2 actin nucleator.
Kerkhoff et al., Regensburg, Germany. In Gene Expr Patterns, 2010
The mammalian genome encodes two spir genes, spir-1 and spir-2.
Two genes on A/J chromosome 18 are associated with susceptibility to Staphylococcus aureus infection by combined microarray and QTL analyses.
Fowler et al., Durham, United States. In Plos Pathog, 2009
18 (March3, Cep120, Chmp1b, Dcp2, Dtwd2, Isoc1, Lman1, Spire1, Tnfaip8, and Seh1l) mapped to the two significant QTL regions and were also identified by the expression array selection strategy.
Identification of a short Spir interaction sequence at the C-terminal end of formin subgroup proteins.
Kerkhoff et al., Regensburg, Germany. In J Biol Chem, 2009
both mammalian Spir proteins, Spir-1 and Spir-2, interact with mammalian Fmn subgroup proteins formin-1 and formin-2
Annexin A2-dependent polymerization of actin mediates endosome biogenesis.
Gruenberg et al., Genève, Switzerland. In Dev Cell, 2009
It also requires the actin nucleation factor Spire1 and involves Arp2/3, which is needed for filament branching.
Analysis of the function of Spire in actin assembly and its synergy with formin and profilin.
Carlier et al., Gif-sur-Yvette, France. In Mol Cell, 2007
The multifunctional character of the WH2 domains allows Spire to sequester four G-actin subunits binding cooperatively in a tight SA(4) complex and to nucleate, sever, and cap filaments at their barbed ends.
Overlapping expression pattern of the actin organizers Spir-1 and formin-2 in the developing mouse nervous system and the adult brain.
Kerkhoff et al., Würzburg, Germany. In Gene Expr Patterns, 2004
By analyzing the expression of the spir-1 gene it was shown that spir-1 and formin-2 have a nearly identical expression pattern during mouse embryogenesis and in the adult brain.
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