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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Spire homolog 1

Spir-1, Spire1
Spire proteins, such as SPIRE1, are highly conserved between species. They belong to the family of Wiskott-Aldrich homology region-2 (WH2) proteins, which are involved in actin organization (Kerkhoff et al., 2001 [PubMed 11747823]).[supplied by OMIM, Mar 2008] (from NCBI)
Papers on Spir-1
Molecular basis of actin nucleation factor cooperativity: crystal structure of the Spir-1 kinase non-catalytic C-lobe domain (KIND)•formin-2 formin SPIR interaction motif (FSI) complex.
Kerkhoff et al., Tübingen, Germany. In J Biol Chem, 2011
analysis of the molecular basis of the Spir1/formin-2 interaction
Spire-type actin nucleators cooperate with Formin-2 to drive asymmetric oocyte division.
Schuh et al., Cambridge, United Kingdom. In Curr Biol, 2011
Spire1 and Spire2 drive two critical steps of asymmetric oocyte division.
Identification of a short Spir interaction sequence at the C-terminal end of formin subgroup proteins.
Kerkhoff et al., Regensburg, Germany. In J Biol Chem, 2009
both mammalian Spir proteins, Spir-1 and Spir-2, interact with mammalian Fmn subgroup proteins formin-1 and formin-2
Analysis of the function of Spire in actin assembly and its synergy with formin and profilin.
Carlier et al., Gif-sur-Yvette, France. In Mol Cell, 2007
The multifunctional character of the WH2 domains allows Spire to sequester four G-actin subunits binding cooperatively in a tight SA(4) complex and to nucleate, sever, and cap filaments at their barbed ends.
Overlapping expression pattern of the actin organizers Spir-1 and formin-2 in the developing mouse nervous system and the adult brain.
Kerkhoff et al., Würzburg, Germany. In Gene Expr Patterns, 2004
By analyzing the expression of the spir-1 gene it was shown that spir-1 and formin-2 have a nearly identical expression pattern during mouse embryogenesis and in the adult brain.
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