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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Spi-B transcription factor

Spi-B
The protein encoded by this gene is a transcriptional activator that binds to the PU-box (5'-GAGGAA-3') and acts as a lymphoid-specific enhancer. Four transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011] (from NCBI)
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Top mentioned proteins: PU.1, CAN, V1a, MUM1, HAD
Papers on Spi-B
Ventromedial hypothalamic lesions downregulate multiple immune signaling pathways in rat pancreatic islets.
New
Kiba, Kure, Japan. In Neurosci Lett, Feb 2016
Real-time polymerase chain reaction also confirmed that gene expressions of RT1 class II, locus Bb (RT1-Bb) was up-regulated and Spi-B transcription factor (Spib) was downregulated at day 3 after the VMH lesions.
Tissue microarray-based study of hepatocellular carcinoma validating SPIB as potential clinical prognostic marker.
New
Lu et al., Taipei, Taiwan. In Acta Histochem, Jan 2016
Currently, the prognostic significance of SPIB protein overexpression in human hepatocellular carcinoma (HCC) is unclear.
Aberrant expression of homeobox gene SIX1 in Hodgkin lymphoma.
New
MacLeod et al., Braunschweig, Germany. In Oncotarget, Dec 2015
Genes encoding the transcription factors GATA2, GATA3, MSX1 and SPIB - all basic lymphoid regulators - were identified as targets of SIX1 in HL.
Epigenetic program and transcription factor circuitry of dendritic cell development.
New
Zenke et al., Aachen, Germany. In Nucleic Acids Res, Dec 2015
The circuitry provides the transcription factor hierarchy that drives the sequel MPP-CDP-cDC/pDC, including Irf4, Irf8, Tcf4, Spib and Stat factors.
RANKL regulates differentiation of microfold cells in mouse nasopharynx-associated lymphoid tissue (NALT).
New
Iida et al., Sapporo, Japan. In Cell Tissue Res, Dec 2015
We have immunohistochemically detected GP2-expressing cells in the FAE of NALT and the simultaneous expression of other intestinal M-cell markers, namely Tnfaip2, CCL9, and Spi-B.
Mucosal Immunosenescence in the Gastrointestinal Tract: A Mini-Review.
Review
Fujihashi et al., Tokyo, Japan. In Gerontology, 2014
In this regard, Spi-B, an essential transcription factor for the functional and structural differentiation of M cells, could be a potent strategy for the induction of effective mucosal immunity in aging.
The Mechanisms of M-cell Differentiation.
Review
Ohno et al., Yokohama, Japan. In Biosci Microbiota Food Health, 2013
We have found that the ets-family transcription factor Spi-B is essential for functional maturation of M cells.
Transcriptional control of dendritic cell differentiation.
Review
Kaisho et al., Suita, Japan. In Curr Top Microbiol Immunol, 2013
We have recently found that an Ets family transcription factor, SPI-B, which is abundantly expressed in pDCs among DC subsets, plays critical roles in functions and late stage development of pDCs.
A genomic regulatory element that directs assembly and function of immune-specific AP-1-IRF complexes.
Impact
Singh et al., San Francisco, United States. In Science, 2012
They are recruited to cis-regulatory Ets-IRF composite elements by PU.1 or Spi-B.
BATF-JUN is critical for IRF4-mediated transcription in T cells.
Impact
Leonard et al., Bethesda, United States. In Nature, 2012
IRF4 binds DNA weakly owing to a carboxy-terminal auto-inhibitory domain, but cooperative binding with factors such as PU.1 or SPIB in B cells increases binding affinity, allowing IRF4 to regulate genes containing ETS-IRF composite elements (EICEs; 5'-GGAAnnGAAA-3').
Peyer's patch M cells derived from Lgr5(+) stem cells require SpiB and are induced by RankL in cultured "miniguts".
GeneRIF
Clevers et al., Utrecht, Netherlands. In Mol Cell Biol, 2012
RankL-induced expression of SpiB is essential for Lgr5 stem cell-derived epithelial precursors to develop into Peyer's patch M cells
The Ets transcription factor Spi-B is essential for the differentiation of intestinal microfold cells.
Impact
GeneRIF
Ohno et al., Japan. In Nat Immunol, 2012
Spi-B is an essential transcription factor that regulates M-cell differentiation.
Exploiting synthetic lethality for the therapy of ABC diffuse large B cell lymphoma.
Impact
GeneRIF
Staudt et al., Bethesda, United States. In Cancer Cell, 2012
Data show that in a cereblon-dependent fashion, lenalidomide downregulates IRF4 and SPIB, transcription factors that together prevent IFNbeta production.
The transcription factor Spi-B regulates human plasmacytoid dendritic cell survival through direct induction of the antiapoptotic gene BCL2-A1.
GeneRIF
Blom et al., Amsterdam, Netherlands. In Blood, 2012
The transcription factor Spi-B regulates human plasmacytoid dendritic cell survival through direct induction of the antiapoptotic gene BCL2-A1.
Association of primary biliary cirrhosis with variants in the CLEC16A, SOCS1, SPIB and SIAE immunomodulatory genes.
GeneRIF
Siminovitch et al., Toronto, Canada. In Genes Immun, 2012
Fine mapping identified 26 single-nucleotide polymorphisms (SNPs) across the CLEC16A-SOCS1 and 11 SNPs across the SPIB locus with significant association to primary biliary cirrhosis.
Progress in the genetics of primary biliary cirrhosis.
Review
Invernizzi et al., Toronto, Canada. In Semin Liver Dis, 2011
MMEL1, SPIB, and CTLA-4.
Transcription factor E2-2 is an essential and specific regulator of plasmacytoid dendritic cell development.
Impact
Reizis et al., New York City, United States. In Cell, 2008
E2-2 directly activated multiple PDC-enriched genes, including transcription factors involved in PDC development (SpiB, Irf8) and function (Irf7).
ETS transcription factors and regulation of immunity.
Review
Gilkeson et al., Charleston, United States. In Arch Immunol Ther Exp (warsz), 2006
Of the 29 recognized ETS factors, nine are known to regulate genes involved in immunity, including Ets1, Ets2, GABP, Fli1, Elf1, MEF, ESE1, PU.1, and SpiB.
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