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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Sphingosine kinase 2

SphK2, sphingosine kinase 2
This gene encodes one of two sphingosine kinase isozymes that catalyze the phosphorylation of sphingosine into sphingosine 1-phosphate. Sphingosine 1-phosphate mediates many cellular processes including migration, proliferation and apoptosis, and also plays a role in several types of cancer by promoting angiogenesis and tumorigenesis. The encoded protein may play a role in breast cancer proliferation and chemoresistance. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011] (from NCBI)
Top mentioned proteins: sphingosine kinase, V1a, HAD, CAN, S1P1
Papers on SphK2
Sphingosine kinase 2 promotes colorectal cancer cell proliferation and invasion by enhancing MYC expression.
Ma et al., Jinzhou, China. In Tumour Biol, Feb 2016
SphK2 is overexpressed in a number of aggressive human carcinomas; however, the expression profile and potential function of SphK2 in CRC are still unknown.
Elevated Nuclear and Cytoplasmic FTY720-Phosphate in Mouse Embryonic Fibroblasts Suggests the Potential for Multiple Mechanisms in FTY720-Induced Neural Tube Defects.
Gelineau-van Waes et al., Omaha, United States. In Toxicol Sci, Jan 2016
Sphingosine kinases (Sphk1, Sphk2) phosphorylate FTY720 in vivo to form the bioactive metabolite FTY720-1-phosphate (FTY720-P).
Overexpression of Sphk2 is associated with gefitinib resistance in non-small cell lung cancer.
Cai et al., Harbin, China. In Tumour Biol, Jan 2016
Recent studies have shown that sphingosine kinase 2 (SphK2) could promote tumor progression; however, whether SphK2 could affect the chemoresistance of NSCLC to chemotherapy remains unclear.
Hypoxic preconditioning protects cardiomyocytes against hypoxia/reoxygenation-induced cell apoptosis via sphingosine kinase 2 and FAK/AKT pathway.
Zhao et al., Shenyang, China. In Exp Mol Pathol, Dec 2015
SphK2 expression was determined by quantitative real-time PCR and Western blotting.
Bile acids and sphingosine-1-phosphate receptor 2 in hepatic lipid metabolism.
Zhou et al., Richmond, United States. In Acta Pharm Sin B, Mar 2015
CBA-induced activation of S1PR2 is a key regulator of sphingosine kinase 2 (SphK2) and hepatic gene expression.
Drugging sphingosine kinases.
Lynch et al., Blacksburg, United States. In Acs Chem Biol, Feb 2015
The transfer of the gamma phosphate from ATP to sphingosine (Sph) to generate a small signaling molecule, sphingosine 1-phosphate (S1P), is catalyzed by sphingosine kinases (SphK), which exist as two isoforms, SphK1 and SphK2.
Sphingolipids in pulmonary fibrosis.
Natarajan et al., Chicago, United States. In Adv Biol Regul, 2015
Microarray analysis of blood mononuclear cells from patients with IPF and SphK1-, SphK2- or S1PL-knockout mice and SphK inhibitor were used to assess the role of S1P in fibrogenesis.
Sphingosine Kinase 2 and Ceramide Transport as Key Targets of the Natural Flavonoid Luteolin to Induce Apoptosis in Colon Cancer Cells.
Riboni et al., Milano, Italy. In Plos One, 2014
The plant flavonoid luteolin exhibits different biological effects, including anticancer properties.
Sphingosine kinases signalling in carcinogenesis.
Di Stefano et al., Napoli, Italy. In Mini Rev Med Chem, 2014
Even, SphK2 may promote apoptosis and inhibit cell growth but its role has not yet been fully understood in pathologic conditions.
STAT3 and sphingosine-1-phosphate in inflammation-associated colorectal cancer.
Lin et al., United States. In World J Gastroenterol, 2014
In inflammatory response whereby interleukin (IL)-6 production is abundant, STAT3-mediated pathways were found to promote the activation of sphingosine kinases (SphK1 and SphK2) leading to the production of S1P.
Regulation of the hepatitis C virus RNA replicase by endogenous lipid peroxidation.
Lemon et al., Chapel Hill, United States. In Nat Med, 2014
Lipid peroxidation, regulated in part through sphingosine kinase-2, severely restricts HCV replication in Huh-7 cells and primary human hepatoblasts.
Sphingosine-1-phosphate links persistent STAT3 activation, chronic intestinal inflammation, and development of colitis-associated cancer.
Spiegel et al., Richmond, United States. In Cancer Cell, 2013
We show that sphingosine-1-phosphate (S1P) produced by upregulation of sphingosine kinase 1 (SphK1) links chronic intestinal inflammation to colitis-associated cancer (CAC) and both are exacerbated by deletion of Sphk2.
Junctional protein regulation by sphingosine kinase 2 contributes to blood-brain barrier protection in hypoxic preconditioning-induced cerebral ischemic tolerance.
Gidday et al., Saint Louis, United States. In J Cereb Blood Flow Metab, 2012
Junctional protein regulation by sphingosine kinase 2 contributes to blood-brain barrier protection in hypoxic preconditioning-induced cerebral ischemic tolerance.
Sphingosine-kinase 1 and 2 contribute to oral sensitization and effector phase in a mouse model of food allergy.
Rivera et al., Vienna, Austria. In Immunol Lett, 2012
contributes to oral sensitization and effector phase in a mouse model of food allergy
Sphingosine kinase 2 mediates cerebral preconditioning and protects the mouse brain against ischemic injury.
Waeber et al., United States. In Stroke, 2012
Applying genetic and pharmacological approaches, we demonstrate that neuronal SPK2 isoform plays an important role in cerebral preconditioning.
A novel role for mitochondrial sphingosine-1-phosphate produced by sphingosine kinase-2 in PTP-mediated cell survival during cardioprotection.
Lesnefsky et al., Richmond, United States. In Basic Res Cardiol, 2011
the mitochondrial Sphingosine-1-phosphate produced by SphK2 is required for the downstream protective modulation of mitochondrial permeability transition pore as an effector of preconditioning protection
The outs and the ins of sphingosine-1-phosphate in immunity.
Milstien et al., Richmond, United States. In Nat Rev Immunol, 2011
The potent lipid mediator sphingosine-1-phosphate (S1P) is produced inside cells by two closely related kinases, sphingosine kinase 1 (SPHK1) and SPHK2, and has emerged as a crucial regulator of immunity.
Loss of sphingosine kinase 1/S1P signaling impairs cell growth and survival of neurons and progenitor cells in the developing sensory ganglia.
Lee et al., Milwaukee, United States. In Plos One, 2010
The complete absence of Sphk1 and Sphk2 resulted in trigeminal and dorsal root ganglia with fewer neurons and progenitor cells. Sphk1/2 double mutants displayed an overall reduction in other sphingolipids.
Regulation of histone acetylation in the nucleus by sphingosine-1-phosphate.
Spiegel et al., Richmond, United States. In Science, 2009
Sphingosine kinase 2 (SphK2), one of the isoenzymes that generates S1P, was associated with histone H3 and produced S1P that regulated histone acetylation.
Division of labor: specialization of sphingosine kinases in mast cells.
Beaven, Bethesda, United States. In Immunity, 2007
Olivera et al. (2007) show that SphK2 regulates mast cell activation whereas SphK1 enhances susceptibility to antigen challenge in vivo.
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