Drugging sphingosine kinases.
Blacksburg, United States. In Acs Chem Biol, Feb 2015
The transfer of the gamma phosphate from ATP to sphingosine (Sph) to generate a small signaling molecule, sphingosine 1-phosphate (S1P), is catalyzed by sphingosine kinases (SphK), which exist as two isoforms, SphK1 and SphK2.
Sphingolipids in pulmonary fibrosis.
Chicago, United States. In Adv Biol Regul, 2015
Microarray analysis of blood mononuclear cells from patients with IPF and SphK1-, SphK2- or S1PL-knockout mice and SphK inhibitor were used to assess the role of S1P in fibrogenesis.
The outs and the ins of sphingosine-1-phosphate in immunity.
Richmond, United States. In Nat Rev Immunol, 2011
The potent lipid mediator sphingosine-1-phosphate (S1P) is produced inside cells by two closely related kinases, sphingosine kinase 1 (SPHK1) and SPHK2, and has emerged as a crucial regulator of immunity.