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Sphingosine kinase 1

sphingosine kinase, SphK1, sphingosine kinase 1, SphK
The protein encoded by this gene catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (S1P), a lipid mediator with both intra- and extracellular functions. Intracellularly, S1P regulates proliferation and survival, and extracellularly, it is a ligand for cell surface G protein-coupled receptors. This protein, and its product S1P, play a key role in TNF-alpha signaling and the NF-kappa-B activation pathway important in inflammatory, antiapoptotic, and immune processes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011] (from NCBI)
Papers using sphingosine kinase antibodies
Rho GTPase activation assays.
Supplier
Beaudoin Claude, In PLoS ONE, 2007
... Antibodies to BrdU [BU1/75 (ICR1)], M-cadherin, SphK1 and S1PR1 were purchased from Abcam (Cambridge, MA, USA) ...
Quantitative measurement of sphingosine 1-phosphate in biological samples by acylation with radioactive acetic anhydride.
Supplier
Neyrolles Olivier, In PLoS ONE, 1994
... Rabbit anti-mouse Sphingosine kinase-1 polyclonal antibody was purchased from Cayman chemicals (Hamburg, Germany) ...
Papers on sphingosine kinase
miR-124 inhibits cell proliferation in gastric cancer through down-regulation of SPHK1.
GeneRIF
Li et al., Guangzhou, China. In J Pathol, 2012
miR-124 inhibits cell proliferation in gastric cancer through down-regulation of SPHK1.
Low-density lipoprotein induced expression of connective tissue growth factor via transactivation of sphingosine 1-phosphate receptors in mesangial cells.
GeneRIF
Jaffa et al., Charleston, United States. In Mol Endocrinol, 2012
Data suggest that sphingosine 1-phosphate receptor 1 transactivation is dependent on SPHK1, is upstream of MAP kinase signaling system, and is required for LDL-regulated expression of connective tissue growth factor in mesangial cells.
Expression of sphingosine 1-phosphate receptor 4 and sphingosine kinase 1 is associated with outcome in oestrogen receptor-negative breast cancer.
GeneRIF
Edwards et al., Glasgow, United Kingdom. In Br J Cancer, 2012
findings highlight an important role for S1P(4) and SK1 in ER(-) breast cancer progression.
Rapid histamine-induced neutrophil recruitment is sphingosine kinase-1 dependent.
GeneRIF
Bonder et al., Adelaide, Australia. In Am J Pathol, 2012
These findings demonstrate a key role for sphingosine kinase-1 in histamine-induced rapid P-selectin up-regulation and associated leukocyte rolling, and suggest that endothelial SK-1 is an important contributor to allergic inflammation
The roles of antiapoptotic sphingosine kinase-1 and glucosylceramide genes in drug induced cell death of MCF-7 breast cancer cells.
GeneRIF
Baran et al., Urla, Turkey. In J Buon, 2011
Results that antineoplastic agents induce apoptosis in MCF-7 cells by downregulating the antiapoptotic SK-1 and GCS genes that may result in accumulation of apoptotic ceramides.
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