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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Sphingosine kinase 1

sphingosine kinase, SphK1, sphingosine kinase 1, SphK
The protein encoded by this gene catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (S1P), a lipid mediator with both intra- and extracellular functions. Intracellularly, S1P regulates proliferation and survival, and extracellularly, it is a ligand for cell surface G protein-coupled receptors. This protein, and its product S1P, play a key role in TNF-alpha signaling and the NF-kappa-B activation pathway important in inflammatory, antiapoptotic, and immune processes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011] (from NCBI)
Top mentioned proteins: V1a, Cdc7, SphK2, CAN, HAD
Papers using sphingosine kinase antibodies
Rho GTPase activation assays.
Beaudoin Claude, In PLoS ONE, 2007
... Antibodies to BrdU [BU1/75 (ICR1)], M-cadherin, SphK1 and S1PR1 were purchased from Abcam (Cambridge, MA, USA) ...
Quantitative measurement of sphingosine 1-phosphate in biological samples by acylation with radioactive acetic anhydride.
Neyrolles Olivier, In PLoS ONE, 1994
... Rabbit anti-mouse Sphingosine kinase-1 polyclonal antibody was purchased from Cayman chemicals (Hamburg, Germany) ...
Papers on sphingosine kinase
Cangrelor-Mediated Cardioprotection Requires Platelets and Sphingosine Phosphorylation.
Downey et al., Mobile, United States. In Cardiovasc Drugs Ther, Feb 2016
In rats treated with dimethylsphingosine to block sphingosine kinase, cangrelor was no longer protective.
From Sphingosine Kinase to Dihydroceramide Desaturase: A Structure-Activity Relationship (SAR) Study of the Enzyme Inhibitory and Anticancer Activity of 4-((4-(4-chlorophenyl)thiazol-2-ylamino)phenol (SKI-II).
Flynn et al., In J Med Chem, Feb 2016
UNASSIGNED: The sphingosine kinase (SK) inhibitor, SKI-II, has been employed extensively in biological investigations of the role of SK1 and SK2 in disease and has demonstrated impressive anticancer activity in vitro and in vivo.
Targeting colorectal cancer cells by a novel sphingosine kinase 1 inhibitor PF-543.
Fang et al., Hangzhou, China. In Biochem Biophys Res Commun, Feb 2016
UNASSIGNED: In this study, we showed that PF-543, a novel sphingosine kinase 1 (SphK1) inhibitor, exerted potent anti-proliferative and cytotoxic effects against a panel of established (HCT-116, HT-29 and DLD-1) and primary human colorectal cancer (CRC) cells.
Sphingosine kinase 1 dependent protein kinase C-δ activation plays an important role in acute liver failure in mice.
Luo et al., Hangzhou, China. In World J Gastroenterol, Jan 2016
Furthermore, sphingosine kinase 1 (SphK1) dependent PKC-δ activation played an important role in promoting NF-κB activation and inflammatory cytokine production in ALF.
Sphingosine Kinase 1 urothelial expression is increased in patients with neurogenic detrusor overactivity.
Game et al., Toulouse, France. In Int Braz J Urol, Nov 2015
UNLABELLED: To evaluate the expression of sphingosine kinase 1 (SPK1) in the bladder wall in patients with neurogenic lower urinary tract dysfunction and its association with clinical, urodynamic and pathological features.
Sphingosine-1-phosphate and estrogen signaling in breast cancer.
Spiegel et al., Richmond, United States. In Adv Biol Regul, Nov 2015
One of the enzymes that produce S1P, sphingosine kinase 1 (SphK1), is upregulated in breast cancer and its expression has been correlated with poor prognosis.
Bile acids and sphingosine-1-phosphate receptor 2 in hepatic lipid metabolism.
Zhou et al., Richmond, United States. In Acta Pharm Sin B, Mar 2015
CBA-induced activation of S1PR2 is a key regulator of sphingosine kinase 2 (SphK2) and hepatic gene expression.
Role of Ceramide from Glycosphingolipids and Its Metabolites in Immunological and Inflammatory Responses in Humans.
Takamori et al., Chiba, Japan. In Mediators Inflamm, 2014
Sphingosine is phosphorylated by sphingosine kinase to sphingosine-1-phosphate, which is involved in a wide range of cellular functions, including growth, differentiation, survival, chemotaxis, angiogenesis, and embryogenesis, in various types of cells.
Sphingosine kinase 1/sphingosine 1-phosphate signalling pathway as a potential therapeutic target of pulmonary hypertension.
Yang et al., Kunming, China. In Int J Clin Exp Med, 2014
Moreover, it has been reported recently that sphingosine kinase 1 and S1P2 inhibitors might be useful therapeutic agents in the treatment of empirical pulmonary hypertension.
Dengue Virus-Induced Inflammation of the Endothelium and the Potential Roles of Sphingosine Kinase-1 and MicroRNAs.
Carr et al., Adelaide, Australia. In Mediators Inflamm, 2014
Furthermore, we hypothesise roles for two factors, sphingosine kinase-1 and microRNAs (miRNAs), with a focus on several candidate miRNAs, which are known to control normal vascular function and inflammatory responses.
Regulation of the hepatitis C virus RNA replicase by endogenous lipid peroxidation.
Lemon et al., Chapel Hill, United States. In Nat Med, 2014
Lipid peroxidation, regulated in part through sphingosine kinase-2, severely restricts HCV replication in Huh-7 cells and primary human hepatoblasts.
Coupling between endocytosis and sphingosine kinase 1 recruitment.
De Camilli et al., New Haven, United States. In Nat Cell Biol, 2014
These tubules are intensely positive for sphingosine kinase 1 (SPHK1).
K63-linked polyubiquitination of transcription factor IRF1 is essential for IL-1-induced production of chemokines CXCL10 and CCL5.
Kordula et al., Richmond, United States. In Nat Immunol, 2014
In response to IL-1, cIAP2 and the sphingosine kinase SphK1 (the enzyme that generates S1P) formed a complex with IRF1, which led to its activation.
Sphingosine-1-phosphate links persistent STAT3 activation, chronic intestinal inflammation, and development of colitis-associated cancer.
Spiegel et al., Richmond, United States. In Cancer Cell, 2013
We show that sphingosine-1-phosphate (S1P) produced by upregulation of sphingosine kinase 1 (SphK1) links chronic intestinal inflammation to colitis-associated cancer (CAC) and both are exacerbated by deletion of Sphk2.
Sphingosine 1-phosphate is a missing link between chronic inflammation and colon cancer.
Pyne et al., Glasgow, United Kingdom. In Cancer Cell, 2013
In this issue of Cancer Cell, Liang and colleagues demonstrated that sphingosine kinase 1, the enzyme that catalyzes formation of the biologically active lipid sphingosine 1-phosphate, drives a malicious amplification loop involving sphingosine 1-phosphate receptor 1 and the NF-κB/IL-6/STAT3 pathway.
miR-124 inhibits cell proliferation in gastric cancer through down-regulation of SPHK1.
Li et al., Guangzhou, China. In J Pathol, 2012
miR-124 inhibits cell proliferation in gastric cancer through down-regulation of SPHK1.
Low-density lipoprotein induced expression of connective tissue growth factor via transactivation of sphingosine 1-phosphate receptors in mesangial cells.
Jaffa et al., Charleston, United States. In Mol Endocrinol, 2012
Data suggest that sphingosine 1-phosphate receptor 1 transactivation is dependent on SPHK1, is upstream of MAP kinase signaling system, and is required for LDL-regulated expression of connective tissue growth factor in mesangial cells.
Expression of sphingosine 1-phosphate receptor 4 and sphingosine kinase 1 is associated with outcome in oestrogen receptor-negative breast cancer.
Edwards et al., Glasgow, United Kingdom. In Br J Cancer, 2012
findings highlight an important role for S1P(4) and SK1 in ER(-) breast cancer progression.
Rapid histamine-induced neutrophil recruitment is sphingosine kinase-1 dependent.
Bonder et al., Adelaide, Australia. In Am J Pathol, 2012
These findings demonstrate a key role for sphingosine kinase-1 in histamine-induced rapid P-selectin up-regulation and associated leukocyte rolling, and suggest that endothelial SK-1 is an important contributor to allergic inflammation
The roles of antiapoptotic sphingosine kinase-1 and glucosylceramide genes in drug induced cell death of MCF-7 breast cancer cells.
Baran et al., Urla, Turkey. In J Buon, 2011
Results that antineoplastic agents induce apoptosis in MCF-7 cells by downregulating the antiapoptotic SK-1 and GCS genes that may result in accumulation of apoptotic ceramides.
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