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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

SPEG complex locus

SPEG, A PEG, APEG-1, aortic preferentially expressed gene-1
This gene encodes a protein with similarity to members of the myosin light chain kinase family. This protein family is required for myocyte cytoskeletal development. Studies have determined that a lack of this protein affected myocardial development. Multiple alternatively spliced transcript variants that encode different protein isoforms have been defined. [provided by RefSeq, Mar 2010] (from NCBI)
Top mentioned proteins: CAN, HAD, V1a, ACID, TUBE
Papers on SPEG
Encapsulation of PEGylated low-molecular-weight PEI polyplexes in hyaluronic acid hydrogels reduces aggregation.
New
Segura et al., Los Angeles, United States. In Acta Biomater, Dec 2015
The first approach reduces polyplex aggregation by utilizing polyethylene glycol modification of the gene carrier polymer polyethyleneimine (sPEG-PEI) to mitigate charge-charge interactions between polyplexes and the scaffold during gelation.
Evaluation of drug loading, pharmacokinetic behavior, and toxicity of a cisplatin-containing hydrogel nanoparticle.
New
DeSimone et al., Raleigh, United States. In J Control Release, May 2015
A PEG Mushroom conformation showed the best compromise between particle pharmacokinetic (PK) parameters and drug loading (16wt.%).
A novel polyamine allosteric site of SpeG from Vibrio cholerae is revealed by its dodecameric structure.
New
Anderson et al., Chicago, United States. In J Mol Biol, Apr 2015
Spermidine N-acetyltransferase, encoded by the gene speG, catalyzes the initial step in the degradation of polyamines and is a critical enzyme for determining the polyamine concentrations in bacteria.
Enteral tube feeding for dysphagic stroke patients.
Review
New
Rowat, Napier, New Zealand. In Br J Nurs, Mar 2015
A PEG tube is considered a more secure method of feeding stroke patients who require longer-term nutritional support, but it is an invasive procedure that can result in complications that are associated with an increased risk of morbidity and mortality after stroke.
How to optimize current therapy in hepatitis C virus genotype 1 patients. Predictors of response to interferon-based therapy with second wave direct acting antivirals.
Review
Serfaty, Paris, France. In Liver Int, 2015
In patients with HCV genotype 1 (HCV-1), a PEG-IFN/RBV-based regimen with sofosbuvir is highly effective but the presence of cirrhosis and the non-CC IFNL3 genotype have been associated with a poorer response.
Rescue of neonatal cardiac dysfunction in mice by administration of cardiac progenitor cells in utero.
Perrella et al., Boston, United States. In Nat Commun, 2014
Striated preferentially expressed gene (Speg) is a member of the myosin light chain kinase family.
An efficient PEGylated liposomal nanocarrier containing cell-penetrating peptide and pH-sensitive hydrazone bond for enhancing tumor-targeted drug delivery.
Wang et al., Beijing, China. In Int J Nanomedicine, 2014
A PEG derivative by conjugating PEG with STR via acid-degradable hydrazone bond (PEG2000-Hz-STR, PHS) was synthesized.
[Preparation and investigation of MRI-traceable Eudragit-E liquid embolic agent].
Fan et al., Beijing, China. In Beijing Da Xue Xue Bao, 2014
RESULTS: A PEG-SPIO concentration of 2 g/L was considered to be suitable for further studies.
SPEG interacts with myotubularin, and its deficiency causes centronuclear myopathy with dilated cardiomyopathy.
Beggs et al., Boston, United States. In Am J Hum Genet, 2014
Striated muscle preferentially expressed protein kinase (SPEG), the product of SPEG complex locus (SPEG), was identified as an MTM1-interacting protein, confirmed by immunoprecipitation and immunofluorescence studies.
In vitro and in vivo evaluation of a hydrogel reservoir as a continuous drug delivery system for inner ear treatment.
Scheper et al., Hannover, Germany. In Plos One, 2013
A PEG-based hydrogel made of reactive NCO-sP(EO-stat-PO) prepolymers was evaluated as a drug conveying and delivery system in vitro and in vivo.
Transcriptional profiles of Burkholderia pseudomallei reveal the direct and indirect roles of Sigma E under oxidative stress conditions.
Korbsrisate et al., Bangkok, Thailand. In Bmc Genomics, 2013
Importantly, we identified that the speG gene, encoding spermidine-acetyltransferase, is a novel member of the B. pseudomallei σE regulon.
Molecular and functional profiling of the polyamine content in enteroinvasive E. coli : looking into the gap between commensal E. coli and harmful Shigella.
Prosseda et al., Roma, Italy. In Plos One, 2013
A pathoadaptation process involving the speG gene and the cad operon has led to spermidine accumulation and loss of cadaverine.
Community-associated MRSA: what makes them special?
Review
Otto, Bethesda, United States. In Int J Med Microbiol, 2013
Finally, the exceptional epidemiological success of the USA300 CA-MRSA clone in particular may have been due to yet another gene acquisition, namely that of the speG gene, which is located on the arginine catabolic mobile element (ACME) and involved in detoxifying harmful host-derived polyamines.
Disruption of striated preferentially expressed gene locus leads to dilated cardiomyopathy in mice.
GeneRIF
Perrella et al., Boston, United States. In Circulation, 2009
Disruption of the striated preferentially expressed gene (Speg) locus leads to cardiac dysfunction and a phenotype consistent with dilated cardiomyopathy.
Acute deterioration of bulbar function after botulinum toxin treatment for sialorrhoea in amyotrophic lateral sclerosis.
Review
Zwarts et al., s-Hertogenbosch, Netherlands. In Am J Phys Med Rehabil, 2008
A PEG catheter was placed.
Systemic antimicrobial prophylaxis for percutaneous endoscopic gastrostomy.
Review
Lusardi et al., Pontypridd, United Kingdom. In Cochrane Database Syst Rev, 2005
A PEG is a feeding tube, placed surgically through the anterior abdominal wall, which delivers a liquid diet, or medication, via a clean or sterile delivery system.
Genomic rearrangements on VCAM1, SELE, APEG1and AIF1 loci in atherosclerosis.
GeneRIF
Spandidos et al., Irákleion, Greece. In J Cell Mol Med, 2005
Genomic rearrangement on APEG1 in arteriosclerosis was studied.
X-ray structure of engineered human Aortic Preferentially Expressed Protein-1 (APEG-1).
GeneRIF
Büssow et al., Berlin, Germany. In Bmc Struct Biol, 2004
the RGD motif might play a role not only in the adhesion of Aortic Preferentially Expressed Protein-1 and extracellular proteins but also in intracellular protein-protein interactions
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