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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

CDC42 small effector 2

SPEC2
Top mentioned proteins: Cdc42, HEC, HAD, V1a, Actin
Papers on SPEC2
Dual HER2 targeting impedes growth of HER2 gene-amplified uterine serous carcinoma xenografts.
Growdon et al., Boston, United States. In Clin Cancer Res, 2015
ARK1, ARK2, and SPEC2 cell lines were treated with trastuzumab or lapatinib.
Oncolytic vaccinia virotherapy for endometrial cancer.
Peng et al., Rochester, United States. In Gynecol Oncol, 2014
METHODS: Infectivity of VVNIS-C and VVNIS-W in type I (HEC1A, Ishikawa, KLE, RL95-2, and AN3 CA) and type II (ARK-1, ARK-2, and SPEC-2) human EC cell lines was evaluated.
Oncolytic measles and vesicular stomatitis virotherapy for endometrial cancer.
Bakkum-Gamez et al., Rochester, United States. In Gynecol Oncol, 2014
METHODS: Human EC cell lines (HEC-1-A, Ishikawa, KLE, RL95-2, AN3 CA, ARK-1, ARK-2, and SPEC-2) were infected with Edmonston strain MV expressing the thyroidal sodium iodide symporter, VSV expressing either human or murine IFN-β, or recombinant VSV with a methionine deletion at residue 51 of the matrix protein and expressing the sodium iodide symporter.
Acrp30 inhibits leptin-induced metastasis by downregulating the JAK/STAT3 pathway via AMPK activation in aggressive SPEC-2 endometrial cancer cells.
Wan et al., Shanghai, China. In Oncol Rep, 2012
We explored whether Acrp30 could reverse the leptin-induced metastasis phenotype in the SPEC-2 endometrial cancer cell line.
ACSL6 is associated with the number of cigarettes smoked and its expression is altered by chronic nicotine exposure.
Chen et al., Richmond, United States. In Plos One, 2010
We previously reported evidence for association of schizophrenia with SNPs and SNP haplotypes in a region of chromosome 5q containing the SPEC2, PDZ-GEF2 and ACSL6 genes.
High levels of Nrf2 determine chemoresistance in type II endometrial cancer.
Zhang et al., Tucson, United States. In Cancer Res, 2010
Likewise, the ESC-derived SPEC-2 cell line had a higher level of Nrf2 expression and was more resistant to the toxic effects of cisplatin and paclitaxel than the Ishikawa cell line, which was generated from EEC. Silencing of Nrf2 rendered SPEC-2 cells more susceptible to chemotherapeutic drugs, whereas it had a limited effect on Ishikawa cells.
EphA2 targeted chemotherapy using an antibody drug conjugate in endometrial carcinoma.
Sood et al., Houston, United States. In Clin Cancer Res, 2010
RESULTS: EphA2 was expressed in the Hec-1A and Ishikawa cells but was absent in the SPEC-2 cells.
Synuclein-gamma (SNCG) may be a novel prognostic biomarker in uterine papillary serous carcinoma.
Buttin et al., Chicago, United States. In Gynecol Oncol, 2009
METHODS: A focused, real time PCR array was performed comparing a papillary serous (SPEC2) and an endometrioid (Ishikawa) endometrial cancer cell line.
Is the histidine triad nucleotide-binding protein 1 (HINT1) gene a candidate for schizophrenia?
Chen et al., Richmond, United States. In Schizophr Res, 2008
However, the markers showing associations were in high LD to the SPEC2/PDZ-GEF2/ACSL6 locus reported previously in the same samples.
Biochemical characterization of distinct regions of SPEC molecules and their role in phagocytosis.
Burbelo et al., Washington, D.C., United States. In Exp Cell Res, 2007
Although the small Cdc42-binding proteins SPEC1 and SPEC2 play a role in F-actin accumulation in activated T lymphocytes, little is known about their precise activities in other cell types.
Haplotypes spanning SPEC2, PDZ-GEF2 and ACSL6 genes are associated with schizophrenia.
GeneRIF
Kendler et al., United States. In Hum Mol Genet, 2006
haplotypes underlying the SPEC2/PDZ-GEF2/acyl-CoA synthetase long-chain family member 6 region are associated with schizophrenia
The role of SPECs, small Cdc42-binding proteins, in F-actin accumulation at the immunological synapse.
GeneRIF
Burbelo et al., Washington, D.C., United States. In J Biol Chem, 2005
Recruitment of SPEC2 within Jurkat T cells to the antigen-presenting cell interface occurred following incubation with staphylococcal enterotoxin E superantigen-loaded B cells and colocalized there with F-actin and Cdc42. T cell receptor
SWEET-DB: an attempt to create annotated data collections for carbohydrates.
von der Lieth et al., Hildesheim, Germany. In Nucleic Acids Res, 2002
SWEET-DB (http://www.dkfz.de/spec2/sweetdb/) is an attempt to use modern web techniques to annotate and/or cross-reference carbohydrate-related data collections which allow glycoscientists to find important data for compounds of interest in a compact and well-structured representation.
The genomic structure of the human SPEC1 gene reveals complex splicing and close promoter proximity to the AF1q translocation gene.
Burbelo et al., Washington, D.C., United States. In Gene, 2001
In mammals, two genes, SPEC1 and SPEC2, encode proteins of 79 and 84 amino acid residues, respectively.
Development of a metastatic model for human endometrial carcinoma using orthotopic implantation in nude-mice.
Fidler et al., Birmingham, United States. In Int J Oncol, 1994
The human serous papillary endometrial carcinoma cell line SPEC-2 was injected into the subcutis (ectopic site) or uterine wall (orthotopic site) of athymic mice.
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