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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

ATPase, Ca++ transporting, type 2C, member 2

SPCA2, calcium-transporting ATPase, ATP2C2
Top mentioned proteins: ATPase, CAN, ACID, SERCA2, Orai1
Papers on SPCA2
The effect of TGF-beta-induced epithelial-mesenchymal transition on the expression of intracellular calcium-handling proteins in T47D and MCF-7 human breast cancer cells.
New
Feng et al., Beijing, China. In Arch Biochem Biophys, Nov 2015
The mRNA expression levels of SPCA1, SPCA2 and MCU were not influenced by TGF-β treatment, while NCX1 expression was decreased in T47D cells.
Language impairment and dyslexia genes influence language skills in children with autism spectrum disorders.
New
Gruen et al., New Haven, United States. In Autism Res, Apr 2015
There were associations with LI risk gene ATP2C2 and dyslexia risk gene MRPL19.
Proteome of the insulin-secreting Min6 cell porosome complex: involvement of Hsp90 in its assembly and function.
New
Jena et al., Detroit, United States. In J Proteomics, Mar 2015
Half maximal inhibition of Hsp90 using the specific inhibitor 17-demethoxy-17-(2-prophenylamino) geldanamycin, results in the loss of proteins, including the calcium-transporting ATPase type 2C and the potassium channel subfamily K member 2 from the Min6 porosome.
The expression of Ubc9 and the intensity of SERCA2a-SUMOylation were reduced in diet-induced obese rats and partially restored by trimetazidine.
Wu et al., Beijing, China. In J Cardiovasc Pharmacol, 2015
BACKGROUND: Reduced expression of sarcoplasmic reticulum calcium-transporting ATPase isoform 2a (SERCA2a) has been shown to play a significant role in the cardiac dysfunction of obese animal models.
Transcriptome Profiling of the Potato (Solanum tuberosum L.) Plant under Drought Stress and Water-Stimulus Conditions.
Song et al., Yinchuan, China. In Plos One, 2014
Among them, genes homologous to Protein Phosphatase 2C (PP2C), Aspartic protease in guard cell 1 (ASPG1), auxin-responsive protein, Arabidopsis pseudo response regualtor 2 (APRR2), GA stimulated transcripts in Arabidopsis 6 (GASA6), Calmodulin-like protein 19 (CML19), abscisic acid 8'-hydroxylases and calcium-transporting ATPase, et al. were related with drought-stress and water stimulus response.
Digital gene expression analysis of Microsporum canis exposed to berberine chloride.
Bao et al., Hangzhou, China. In Plos One, 2014
Besides, twenty-three GO terms were identified by Gene Ontology functional enrichment analysis, such as calcium-transporting ATPase activity, 2-oxoglutarate metabolic process, valine catabolic process, peroxisome and unfolded protein binding.
Effectiveness of gene delivery systems for pluripotent and differentiated cells.
Hajjar et al., New York City, United States. In Mol Ther Methods Clin Dev, 2014
Finally, adenoviral delivery of the calcium-transporting ATPase SERCA2a to hESC and hiPSC-derived cardiomyocytes successfully resulted in faster calcium reuptake.
Transcriptional responses in eastern honeybees (Apis cerana) infected with mites, Varroa destructor.
Shen et al., Taizhou, China. In Genet Mol Res, 2013
Among the upregulated unigenes in the Con2 colony, genes related to skeletal muscle movement (troponin and calcium-transporting ATPase), olfactory sensitivity (odorant binding proteins, and Down syndrome cell adhesion molecule gene) and transcription factors (cyclic adenosine monophosphate-responsive element-binding protein and transcription factor mblk-1) appeared to be involved in Varroa resistance.
New insights into store-independent Ca(2+) entry: secretory pathway calcium ATPase 2 in normal physiology and cancer.
Review
Rao et al., Chengdu, China. In Int J Oral Sci, 2013
Recent studies in secretory pathway calcium ATPases (SPCA) revealed novel functions of SPCA2 in interacting with store-operated Ca(2+) channel Orai1 and inducing Ca(2+) influx at the cell surface.
Decoding the genetics of speech and language.
Review
Fisher et al., Nijmegen, Netherlands. In Curr Opin Neurobiol, 2013
For example, rare protein-coding mutations of the FOXP2 transcription factor cause severe problems with sequencing of speech sounds, while common genetic risk variants of small effect size in genes like CNTNAP2, ATP2C2 and CMIP are associated with typical forms of language impairment.
Manganese and the brain.
Review
Clayton et al., London, United Kingdom. In Int Rev Neurobiol, 2012
While a number of proteins such as the divalent metal transporter 1, the transferrin/transferrin receptor complex, the ZIP family metal transporters ZIP-8 and ZIP-14, the secretory pathway calcium ATPases SPCA1 and SPCA2, ATP13A2, and ferroportin have been suggested to play a role in Mn transport, the degree that each of them contributes to Mn homeostasis has still to be determined.
Defining the genetic architecture of human developmental language impairment.
Review
Bartlett et al., Columbus, United States. In Life Sci, 2012
After review the evidence that genetic factors influence SLI, we discuss methods and findings from scans of the human chromosomes, including the main replicated regions on chromosomes 13, 16 and 19 and two identified genes, ATP2C2 and CMIP that appear to account for the language variation on chromosome 16.
SUMO1-dependent modulation of SERCA2a in heart failure.
Impact
Hajjar et al., New York City, United States. In Nature, 2011
The calcium-transporting ATPase ATP2A2, also known as SERCA2a, is a critical ATPase responsible for Ca(2+) re-uptake during excitation-contraction coupling.
Secretory pathway stress responses as possible mechanisms of disease involving Golgi Ca2+ pump dysfunction.
Review
Prasad et al., Cincinnati, United States. In Biofactors, 2011
In mammalian tissues, uptake of Ca(2+) and Mn(2+) by Golgi membranes is mediated by the secretory pathway Ca(2+) -ATPases, SPCA1 and SPCA2, encoded by the ATP2C1 and ATP2C2 genes.
MIST1 regulates the pancreatic acinar cell expression of Atp2c2, the gene encoding secretory pathway calcium ATPase 2.
GeneRIF
Pin et al., London, Canada. In Exp Cell Res, 2010
Atp2c2 transcription is regulated by MIST1
Store-independent activation of Orai1 by SPCA2 in mammary tumors.
Impact
GeneRIF
Rao et al., Baltimore, United States. In Cell, 2010
Findings reveal a signaling pathway in which the Orai1-SPCA2 complex elicits constitutive store-independent Ca(2+) signaling that promotes tumorigenesis.
CMIP and ATP2C2 modulate phonological short-term memory in language impairment.
GeneRIF
Monaco et al., Oxford, United Kingdom. In Am J Hum Genet, 2009
ATP2C2 modulates phonological short-term memory in language impairment.
Dissection of the functional differences between human secretory pathway Ca2+/Mn2+-ATPase (SPCA) 1 and 2 isoenzymes by steady-state and transient kinetic analyses.
GeneRIF
Wuytack et al., Leuven, Belgium. In J Biol Chem, 2006
analysis of SPCA1 and SPCA2 isoenzymes by steady-state and transient kinetic analyses
The secretory pathway Ca2+/Mn2+-ATPase 2 is a Golgi-localized pump with high affinity for Ca2+ ions.
GeneRIF
Wuytack et al., Leuven, Belgium. In J Biol Chem, 2005
hSPCA2 has the ability to transport Ca(2+) and Mn(2+); both its transport and Ca(2+)- and Mn(2+)-dependent phosphoprotein intermediate formation functions are insensitive to thapsigargin inhibition
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