GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 08 Dec 2016.
Serine threonine kinase 39
SPAK, PASK, PAS kinase, PASKIN, Ste20-like protein kinase
This gene encodes a serine/threonine kinase that is thought to function in the cellular stress response pathway. The kinase is activated in response to hypotonic stress, leading to phosphorylation of several cation-chloride-coupled cotransporters. The catalytically active kinase specifically activates the p38 MAP kinase pathway, and its interaction with p38 decreases upon cellular stress, suggesting that this kinase may serve as an intermediate in the response to cellular stress. [provided by RefSeq, Jul 2008] (from
... and promoters were obtained from the following sources: Ptrc from pTrc99A (Amersham Biosciences); PtetA from pASK-IBA3 (Sigma Genosys); lacI from pTrc99A; tetR from pcDNA6/TR (Invitrogen); egfp from pEGFP (BD Biosciences Clontech); ...
Rutter et al., Salt Lake City, United States. In Semin Cell Dev Biol, 2012
These data strongly suggest that PASK is required for normal nutrient partitioning and energy homeostasis in the mouse and that this activity is primarily carried out in a cell-autonomous fashion.[Review]
Hadchouel et al., Paris, France. In Hypertension, 2011
Findings uncover a vascular signaling pathway linking alpha(1)-adrenergic receptors and pressure to WNK1, SPAK, and NKCC1 and may, thus, significantly broaden the comprehension of the regulatory mechanisms of vascular tone in arterial hypertension.