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Serine threonine kinase 39

SPAK, PASK, PAS kinase, PASKIN, Ste20-like protein kinase
This gene encodes a serine/threonine kinase that is thought to function in the cellular stress response pathway. The kinase is activated in response to hypotonic stress, leading to phosphorylation of several cation-chloride-coupled cotransporters. The catalytically active kinase specifically activates the p38 MAP kinase pathway, and its interaction with p38 decreases upon cellular stress, suggesting that this kinase may serve as an intermediate in the response to cellular stress. [provided by RefSeq, Jul 2008] (from NCBI)
Papers using SPAK antibodies
Numerical Recipes. Cambridge: Cambridge University Press. 848 p
Huang Sui, In PLoS ONE, 1985
... and promoters were obtained from the following sources: Ptrc from pTrc99A (Amersham Biosciences); PtetA from pASK-IBA3 (Sigma Genosys); lacI from pTrc99A; tetR from pcDNA6/TR (Invitrogen); egfp from pEGFP (BD Biosciences Clontech); ...
Papers on SPAK
PAS kinase: integrating nutrient sensing with nutrient partitioning.
Rutter et al., Salt Lake City, United States. In Semin Cell Dev Biol, 2012
These data strongly suggest that PASK is required for normal nutrient partitioning and energy homeostasis in the mouse and that this activity is primarily carried out in a cell-autonomous fashion.[Review]
Kinases SPAK and OSR1 are upregulated by estradiol and activate NKCC1 in the developing hypothalamus.
McCarthy et al., Baltimore, United States. In J Neurosci, 2012
SPAK and oxidative stress response kinase (OSR1) may be critical factors in the regulation of depolarizing GABA-mediated processes in the developing brain.
Human mutation within Per-Arnt-Sim (PAS) domain-containing protein kinase (PASK) causes basal insulin hypersecretion.
Rutter et al., London, United Kingdom. In J Biol Chem, 2012
Per-Arnt-Sim (PAS) domain-containing protein kinase (PASK) has a role in insulin hypersecretion
WNK1 regulates vasoconstriction and blood pressure response to α 1-adrenergic stimulation in mice.
Hadchouel et al., Paris, France. In Hypertension, 2011
Findings uncover a vascular signaling pathway linking alpha(1)-adrenergic receptors and pressure to WNK1, SPAK, and NKCC1 and may, thus, significantly broaden the comprehension of the regulatory mechanisms of vascular tone in arterial hypertension.
The role of PAS kinase in PASsing the glucose signal.
Rutter et al., Provo, United States. In Sensors (basel), 2009
The role of PAS kinase in PASsing the glucose signal.
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