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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Sperm associated antigen 6

SPAG6, PF16, sperm-associated antigen 6
The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein expressed by this gene is recognized by anti-sperm antibodies from an infertile man. This protein localizes to the tail of permeabilized human sperm and contains eight contiguous armadillo repeats, a motif known to mediate protein-protein interactions. Studies in mice suggest that this protein is involved in sperm flagellar motility and maintenance of the structural integrity of mature sperm. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011] (from NCBI)
Top mentioned proteins: CAN, ACID, HAD, OUT, Armadillo
Papers on SPAG6
Spag6 Negatively Regulates Neuronal Migration During Mouse Brain Development.
Zhao et al., China. In J Mol Neurosci, Dec 2015
Sperm-associated antigen 6 (Spag6) is a Chlamydomonas reinhardtii PF16 homologous gene detected in the human testis and is crucial for sperm motility.
Identification of Reproduction-Related Gene Polymorphisms Using Whole Transcriptome Sequencing in the Large White Pig Population.
Sironen et al., Green, United States. In G3 (bethesda), Jul 2015
Seven genes (PGR, FRAS1, TCF4, ADAT1, SPAG6, PIWIL2, and DNAH8) with polymorphisms were highlighted as reproduction-related based on their biological function.
Expression of prestin in OHCs is reduced in Spag6 gene knockout mice.
Li et al., China. In Neurosci Lett, May 2015
Sperm-associated antigen 6 (Spag6) gene, which encodes an axonemal protein (SPAG6), ubiquitously expresses in tissue and organs containing ciliated cells.
Prospective validation of a new method of monitoring minimal residual disease in childhood acute myelogenous leukemia.
Gruhn et al., Ulm, Germany. In Clin Cancer Res, Apr 2015
EXPERIMENTAL DESIGN: The expression of seven leukemia-associated genes (WT1, PRAME, CCL23, GAGED2, MSLN, SPAG6, and ST18) was measured by TaqMan Low Density Arrays in 112 patients and 52 healthy controls.
SPAG6 silencing inhibits the growth of the malignant myeloid cell lines SKM-1 and K562 via activating p53 and caspase activation-dependent apoptosis.
Liu et al., Chongqing, China. In Int J Oncol, Feb 2015
SPAG6, which is a novel cancer-testis antigen, is overexpressed in myeloid malignancies.
De novo Assembly and Characterization of the Testis Transcriptome and Development of EST-SSR Markers in the Cockroach Periplaneta americana.
Jiang et al., Nanjing, China. In Sci Rep, 2014
Furthermore, the Spag6 gene was confirmed to be testes specific, and the fru and RPSA genes were related to the development of the testis.
Sperm Associated Antigen 6 (SPAG6) Regulates Fibroblast Cell Growth, Morphology, Migration and Ciliogenesis.
Zhang et al., Wuhan, China. In Sci Rep, 2014
Mammalian Spag6 is the orthologue of Chlamydomonas PF16, which encodes a protein localized in the axoneme central apparatus, and regulates flagella/cilia motility.
Gene cloning, sequence analysis and heterologous expression of a novel cold-active lipase from Pseudomonas sp. PF16.
Wei et al., In Technol Health Care, 2014
Based on morphology and 16S rRNA gene sequence analysis, the isolate which was named as PF16 was identified as a member of Pseudomonas.
Methylation of HOXA9 and ISL1 Predicts Patient Outcome in High-Grade Non-Invasive Bladder Cancer.
Farrell et al., Stoke-on-Trent, United Kingdom. In Plos One, 2014
The genes HOXA9, ISL1, NKX6-2, SPAG6, ZIC1 and ZNF154 were selected for investigation on the basis of previous reports and/or prognostic utility in low/intermediate-grade NMIBC.
Codon-based phylogenetics introduces novel flagellar gene markers to oomycete systematics.
André Lévesque et al., Ottawa, Canada. In Mol Phylogenet Evol, 2014
Here we report the use of two single-copy protein-coding flagellar genes, PF16 and OCM1, in oomycete systematics, showing their utility in phylogenetic reconstruction and species identification.
Otitis media in sperm-associated antigen 6 (Spag6)-deficient mice.
Wang et al., Jinan, China. In Plos One, 2013
Mammalian SPAG6 protein is localized to the axoneme central apparatus, and it is required for normal flagella and cilia motility.
Sperm-associated antigen 6 (SPAG6) deficiency and defects in ciliogenesis and cilia function: polarity, density, and beat.
Zhang et al., Wuhan, China. In Plos One, 2013
SPAG6, an axoneme central apparatus protein, is essential for function of ependymal cell cilia and sperm flagella.
Lineage-specific duplications of Muroidea Faim and Spag6 genes and atypical accelerated evolution of the parental Spag6 gene.
Wojnowski et al., Mainz, Germany. In J Mol Evol, 2013
Among those nine gene families are Fas apoptosis inhibitory molecule (Faim), implicated in apoptosis, and Sperm antigen 6 (Spag6), implicated in sperm mobility.
Sperm-associated antigen-17 gene is essential for motile cilia function and neonatal survival.
Strauss et al., Richmond, United States. In Am J Respir Cell Mol Biol, 2013
SPAG6 and SPAG16 (CP proteins that interact with SPAG17) were increased in tracheal tissue from SPAG17-deficient mice.
Transcriptional regulation of an axonemal central apparatus gene, sperm-associated antigen 6, by a SRY-related high mobility group transcription factor, S-SOX5.
Zhang et al., Richmond, United States. In J Biol Chem, 2010
SPAG6 is a S-SOX5 target gene, indicating a key role for S-SOX5 in the formation and function of motile cilia.
Tissue expression patterns identify mouse cilia genes.
Bergman et al., Lexington, United States. In Physiol Genomics, 2008
Spag6 is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia.
Accelerated mortality from hydrocephalus and pneumonia in mice with a combined deficiency of SPAG6 and SPAG16L reveals a functional interrelationship between the two central apparatus proteins.
Strauss et al., Richmond, United States. In Cell Motil Cytoskeleton, 2007
Accelerated mortality from hydrocephalus and pneumonia in mice with combined deficiency of Spag6 and Spag16L reveals a functional interrelationship between the two central apparatus proteins.
A sperm-associated WD repeat protein orthologous to Chlamydomonas PF20 associates with Spag6, the mammalian orthologue of Chlamydomonas PF16.
Strauss et al., Philadelphia, United States. In Mol Cell Biol, 2002
Data describe the cloning of human and mouse Pf20 proteins that interact with Spag6 protein.
Male infertility, impaired sperm motility, and hydrocephalus in mice deficient in sperm-associated antigen 6.
Strauss III et al., Philadelphia, United States. In Mol Cell Biol, 2002
Spag6 is essential for sperm flagellar motility and that it is important for the maintenance of the structural integrity of mature sperm. The occurrence of hydrocephalus in the mutant mice also implicates Spag6 in the motility of ependymal cilia.
The role of central apparatus components in flagellar motility and microtubule assembly.
Lefebvre et al., Saint Paul, United States. In Cell Motil Cytoskeleton, 1996
To date, the genes encoding four components of the central apparatus have been cloned, PF15, PF16, PF20 and KLP1.
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