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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Signal-induced proliferation-associated 1

SPA-1, Sipa1, SPAI
The product of this gene is a mitogen induced GTPase activating protein (GAP). It exhibits a specific GAP activity for Ras-related regulatory proteins Rap1 and Rap2, but not for Ran or other small GTPases. This protein may also hamper mitogen-induced cell cycle progression when abnormally or prematurely expressed. It is localized to the perinuclear region. Two alternatively spliced variants encoding the same isoform have been characterized to date. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: COPI, Rap1, HAD, ACID, Ubiquitin
Papers on SPA-1
Mutations in SIPA1L3 cause eye defects through disruption of cell polarity and cytoskeleton organization.
New
Jamieson et al., Sydney, Australia. In Hum Mol Genet, Nov 2015
Through germline genomic analyses in patients with lens and eye abnormalities, we discovered functional mutations in the Signal Induced Proliferation Associated 1 Like 3 (SIPA1L3) gene, which encodes a previously uncharacterized member of the Signal Induced Proliferation Associated 1 (SIPA1 or SPA1) family, with a role in Rap1 signalling.
Photoreceptor Specificity in the Light-Induced and COP1-Mediated Rapid Degradation of the Repressor of Photomorphogenesis SPA2 in Arabidopsis.
New
Hoecker et al., Köln, Germany. In Plos Genet, Sep 2015
The COP1/SPA complex consists of COP1 and members of the four-member SPA protein family (SPA1-SPA4).
High-level expression and phosphorylation of phytochrome B modulates flowering time in Arabidopsis.
New
Nagy et al., Szeged, Hungary. In Plant J, Sep 2015
Phytochrome A and cryptochrome photoreceptors stabilize CO in the evening by attenuating the activity of the CONSTITUTIVE PHOTOMORPHOGENIC 1-SUPPRESSOR OF PHYA-105 1 (COP1-SPA1) ubiquitin ligase complex, which promotes turnover of CO.
CUL4 forms an E3 ligase with COP1 and SPA to promote light-induced degradation of PIF1.
Huq et al., Austin, United States. In Nat Commun, 2014
Photomorphogenesis, a light-adapted programme is repressed in the dark by the synergistic actions of CUL4(COP1-SPA) E3 ubiquitin ligase and a subset of basic helix-loop-helix transcription factors called phytochrome interacting factors (PIFs).
Divergence of flowering genes in soybean.
Review
Lee et al., Seoul, South Korea. In J Biosci, 2012
ID 12398025, which contains the homeologous regions between chr 7 and chr 16, was redundant for the LHY/CCA1 and SPA1 homologs and the QTLs.
The action mechanisms of plant cryptochromes.
Review
Lin et al., Los Angeles, United States. In Trends Plant Sci, 2011
Two modes of CRY signal transduction have recently been discovered: the cryptochrome-interacting basic-helix-loop-helix 1 (CIB)-dependent CRY2 regulation of transcription; and the SUPPRESSOR OF PHYA1/CONSTITUTIVELY PHOTOMORPHOGENIC1 (SPA1/COP1)-dependent cryptochrome regulation of proteolysis.
Blue light-dependent interaction of CRY2 with SPA1 regulates COP1 activity and floral initiation in Arabidopsis.
GeneRIF
Lin et al., Changsha, China. In Curr Biol, 2011
SPA1 Is Required for the CRY2-Mediated Photoperiodic Regulation of Floral Initiation.
Arabidopsis cryptochrome 1 interacts with SPA1 to suppress COP1 activity in response to blue light.
GeneRIF
Lin et al., Beijing, China. In Genes Dev, 2011
results are consistent with a hypothesis that photoexcited CRY1 interacts with SPA1 to modulate COP1 activity and plant development.
Blue-light-dependent interaction of cryptochrome 1 with SPA1 defines a dynamic signaling mechanism.
GeneRIF
Yang et al., Shanghai, China. In Genes Dev, 2011
CRY1 interacts physically with SPA1 in a blue-light-dependent manner.
The Arabidopsis repressor of light signaling SPA1 acts in the phloem to regulate seedling de-etiolation, leaf expansion and flowering time.
GeneRIF
Hoecker et al., Köln, Germany. In Development, 2011
SPA1 acts in the phloem to regulate seedling de-etiolation, leaf expansion and flowering time.
MYC2, a bHLH transcription factor, modulates the adult phenotype of SPA1.
GeneRIF
Chattopadhyay et al., India. In Plant Signal Behav, 2010
demonstrated the genetic and molecular relationships of MYC2 and SPA1 in light and JA (jasmonic acid) signaling pathways. Here, we have further shown the genetic interactions between these two proteins in flowering time and lateral root development
Severe necrotizing fasciitis in a human immunodeficiency virus-positive patient caused by methicillin-resistant Staphylococcus aureus.
Review
Musser et al., Houston, United States. In J Clin Microbiol, 2008
Molecular analysis revealed that the strain had the USA300/spa1 genotype, now an abundant cause of community-acquired MRSA infection.
Dysplasia: a review.
Review
Vásárhelyi et al., Budapest, Hungary. In Pediatr Pulmonol, 2007
Indeed, carrier states of genetic variants of cytokines (IFNgamma T+874A), adhesion molecules (L-selectin-Pro213Ser), elements of renin-angiotensin system (ACE-I/D), antioxidant enzymes (GST-P1 Val105Ile), and surfactant proteins (SPA1, SPB intron 4) has been identified as risk factors to BPD.
Rap1 signal controls B cell receptor repertoire and generation of self-reactive B1a cells.
Impact
Minato et al., Kyoto, Japan. In Immunity, 2006
SPA-1(-/-) peritoneal B1 cells revealed the altered Vkappa gene repertoire, including skewed Vkappa4 usage and the significant Igkappa/Iglambda isotype inclusion indicative of extensive receptor editing.
Germline polymorphisms are potential metastasis risk and prognosis markers in breast cancer.
Review
Hunter et al., Bethesda, United States. In Breast Dis, 2005
Subsequent analysis identified Sipa1 as the most likely candidate for the observed linkage on Chr 19.
A bad rap: Rap1 signaling and oncogenesis.
Impact
Largaespada, Minneapolis, United States. In Cancer Cell, 2003
In the paper by Ishida et al. in this issue of Cancer Cell, the authors report the results of targeted inactivation of a Rap1-specific GTPase-activating protein (GAP) gene, called SPA-1, in mice.
Myeloproliferative stem cell disorders by deregulated Rap1 activation in SPA-1-deficient mice.
Impact
Minato et al., Kyoto, Japan. In Cancer Cell, 2003
SPA-1 (signal-induced proliferation-associated gene-1) is a principal Rap1 GTPase-activating protein in hematopoietic progenitors.
LAF1 ubiquitination by COP1 controls photomorphogenesis and is stimulated by SPA1.
Impact
Chua et al., New York City, United States. In Nature, 2003
The coiled-coil domain of SPA1, a negative regulator of phyA signalling, has no effect on COP1 auto-ubiquitination but facilitates LAF1 ubiquitination at low COP1 concentrations.
SPA1, a WD-repeat protein specific to phytochrome A signal transduction.
Impact
Quail et al., Berkeley, United States. In Science, 1999
Genetic analysis has identified a signaling pathway that is specifically activated by phytochrome A. A component in this pathway, SPA1 (for "suppressor of phyA-105"), functions in repression of photomorphogenesis and is required for normal photosensory specificity of phytochrome A. Molecular cloning of the SPA1 gene indicates that SPA1 is a WD (tryptophan-aspartic acid)-repeat protein that also shares sequence similarity with protein kinases.
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