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Selenium binding protein 1

sp56, SELENBP1, hSBP, selenium binding protein 1, lp56
This gene product belongs to the selenium-binding protein family. Selenium is an essential nutrient that exhibits potent anticarcinogenic properties, and deficiency of selenium may cause certain neurologic diseases. It has been proposed that the effects of selenium in preventing cancer and neurologic diseases may be mediated by selenium-binding proteins. The exact function of this gene is not known. [provided by RefSeq, Jul 2008] (from NCBI)
Papers on sp56
Inverse association between glutathione peroxidase activity and both selenium-binding protein 1 levels and Gleason score in human prostate tissue.
Diamond et al., Chicago, United States. In Prostate, 2012
Glutathione peroxidase (GPx)-1 enzyme activity is inversely correlated with selenium binding protein (SBP)-1 levels in prostate tissue, based on the Gleason score.
Function of the acrosomal matrix: zona pellucida 3 receptor (ZP3R/sp56) is not essential for mouse fertilization.
Gerton et al., Suita, Japan. In Biol Reprod, 2012
These results provide further evidence that either ZP3R is not involved in sperm-zona pellucida binding or this process might be functionally redundant, involving multiple proteins for gamete interactions.
Suppression of selenium-binding protein 1 in gastric cancer is associated with poor survival.
Tao et al., Hangzhou, China. In Hum Pathol, 2011
The 3-year survival rate of gastric cancer patients with high expression of selenium-binding protein 1 was significantly higher than that of patients with low expression
Structural and functional studies of the human selenium binding protein-1 and its involvement in hepatocellular carcinoma.
Costantini et al., Italy. In Biochim Biophys Acta, 2011
A reduced SELENBP1 expression by immunohistochemistry in liver tissues of patients with hepatocarcinoma (HCC), is reported.
The expression of selenium-binding protein 1 is decreased in uterine leiomyoma.
Lawrence et al., Providence, United States. In Diagn Pathol, 2009
Decreased expression of selenium-binding protein 1 in uterine leiomyoma may indicate a role of the protein in tumorigenesis.
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