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Selenium binding protein 1

sp56, SELENBP1, hSBP, selenium binding protein 1, lp56
This gene product belongs to the selenium-binding protein family. Selenium is an essential nutrient that exhibits potent anticarcinogenic properties, and deficiency of selenium may cause certain neurologic diseases. It has been proposed that the effects of selenium in preventing cancer and neurologic diseases may be mediated by selenium-binding proteins. The exact function of this gene is not known. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, HAD, ACID, CD45, AGE
Papers on sp56
Signatures of Evolutionary Adaptation in Quantitative Trait Loci Influencing Trace Element Homeostasis in Liver.
Bosch et al., Leipzig, Germany. In Mol Biol Evol, Dec 2015
Within the complete set of significant QTLs (which involved 30 SNPs and 20 gene regions), we identified 12 SNPs with extreme patterns of population differentiation (FST values in the top 5% percentile in at least one HapMap population pair) and significant evidence for selective sweeps involving QTLs at GPX1, SELENBP1, GPX3, SLC30A9, and SLC39A8.
Genomic predictors of remission to antidepressant treatment in geriatric depression using genome-wide expression analyses: a pilot study.
Lavretsky et al., Adelaide, Australia. In Int J Geriatr Psychiatry, Nov 2015
At baseline, we found three genes showing higher expression in all remitters versus non-remitters that satisfied the established level of significance: a fold change of 2 and p-value of 0.05 that included HLA-DRB5, SELENBP1, and LOC388588.
USP8/UBPy-regulated sorting and the development of sperm acrosome: the recruitment of MET.
Paiardi et al., Milano, Italy. In Reproduction, Jun 2015
The trafficking sorted by USP8/UBPy, an endosomal regulator recently described as a compelling candidate for male fertility gene, was investigated in comparison to that of SP56, a marker of the biosynthetic pathway.
Molecular profiling of peripheral blood is associated with circulating tumor cells content and poor survival in metastatic castration-resistant prostate cancer.
Mellado et al., Barcelona, Spain. In Oncotarget, May 2015
This analysis revealed a two-gene model (SELENBP1 and MMP9) with a high significant prognostic ability (HR 6; 95% CI 2.61 - 13.79; P<0.0001).
Selenoprotein and antioxidant genes and the risk of high-grade prostate cancer and prostate cancer recurrence.
Chan et al., San Francisco, United States. In Prostate, 2015
METHODS: We measured plasma selenium and genotyped 73 single nucleotide polymorphisms in TXNRD1, TXNRD2, GPX1, GPX3, GPX4, SEP15, SEPP1, SELENBP1, OGG1, and CAT among 568 men with non-metastatic prostate cancer who underwent radical prostatectomy.
Evidence that selenium binding protein 1 is a tumor suppressor in prostate cancer.
Diamond et al., Chicago, United States. In Plos One, 2014
Selenium-Binding Protein 1 (SBP1, SELENBP1, hSP56) is a selenium-associated protein shown to be at lower levels in tumors, and its lower levels are frequently predictive of a poor clinical outcome.
SELENBP1 expression in the prefrontal cortex of subjects with schizophrenia.
Everall et al., Melbourne, Australia. In Transl Psychiatry, 2014
Selenium binding protein 1 (SELENBP1) messenger RNA (mRNA) has previously been shown to be upregulated in the brain and blood from subjects with schizophrenia.
Inherited cancer predisposition sensitizes colonic mucosa to address Western diet effects and putative cancer-predisposing changes on mouse proteome.
Nyström et al., Helsinki, Finland. In J Nutr Biochem, 2014
Of these proteins, selenium binding protein 1 and galectin-4, which directly interact with MutL homolog 1, are underlined in neoplastic processes, suggesting that sensitivity to WD is increased by an Mlh1 mutation.
Decreased selenium-binding protein 1 mRNA expression is associated with poor prognosis in renal cell carcinoma.
Kim et al., Ch'ŏngju, South Korea. In World J Surg Oncol, 2013
BACKGROUND: The anticancer effects of selenium may be mediated by selenium-binding proteins, such as SELENBP1.
Inverse association between glutathione peroxidase activity and both selenium-binding protein 1 levels and Gleason score in human prostate tissue.
Diamond et al., Chicago, United States. In Prostate, 2012
Glutathione peroxidase (GPx)-1 enzyme activity is inversely correlated with selenium binding protein (SBP)-1 levels in prostate tissue, based on the Gleason score.
Function of the acrosomal matrix: zona pellucida 3 receptor (ZP3R/sp56) is not essential for mouse fertilization.
Gerton et al., Suita, Japan. In Biol Reprod, 2012
These results provide further evidence that either ZP3R is not involved in sperm-zona pellucida binding or this process might be functionally redundant, involving multiple proteins for gamete interactions.
Suppression of selenium-binding protein 1 in gastric cancer is associated with poor survival.
Tao et al., Hangzhou, China. In Hum Pathol, 2011
The 3-year survival rate of gastric cancer patients with high expression of selenium-binding protein 1 was significantly higher than that of patients with low expression
Structural and functional studies of the human selenium binding protein-1 and its involvement in hepatocellular carcinoma.
Costantini et al., Italy. In Biochim Biophys Acta, 2011
A reduced SELENBP1 expression by immunohistochemistry in liver tissues of patients with hepatocarcinoma (HCC), is reported.
The expression of selenium-binding protein 1 is decreased in uterine leiomyoma.
Lawrence et al., Providence, United States. In Diagn Pathol, 2009
Decreased expression of selenium-binding protein 1 in uterine leiomyoma may indicate a role of the protein in tumorigenesis.
Mammalian fertilization: the strange case of sperm protein 56.
Wassarman, New York City, United States. In Bioessays, 2009
Sperm protein 56 (sp56), a member of the C3/C4 superfamily of binding proteins, was identified nearly 20 years ago as a binding partner for mZP3 by photoaffinity cross-linking of acrosome-intact sperm.
Protein-carbohydrate interactions during fertilization.
Kölle et al., München, Germany. In Acta Anat (basel), 1997
Sperm surface proteins known to have specific ZP and carbohydrate-binding sites including the mouse beta1, 4-galactosyltransferase and sp56, the rabbit protein Sp17, a human mannose-binding protein and several members of the spermadhesin family are presented.
Molecules involved in mammalian sperm-egg interaction.
Saling et al., Durham, United States. In Int Rev Cytol, 1997
Galactosyltransferase, sp56, zona receptor kinase, and spermadhesins are thought to participate in the primary binding between sperm and zp and may initiate the exocytotic release of hydrolytic enzymes in the sperm head, the acrosome reaction.
The role of carbohydrate residues in mammalian fertilization.
Raz et al., Tel Aviv-Yafo, Israel. In Histol Histopathol, 1997
Several suggested complementary ZP3 binding proteins on the sperm are sp56, beta-1,4-galactosyltransferase and p95.
Tissue- and species-specific expression of sp56, a mouse sperm fertilization protein.
Bleil et al., Los Angeles, United States. In Science, 1995
A mouse sperm protein, sp56, was identified that has the characteristics expected of the sperm protein responsible for recognition of ZP3.
Mouse gamete adhesion molecules.
Wassarman, Nutley, United States. In Biol Reprod, 1992
A 56,000-Mr protein called sp56, which is located in plasma membrane surrounding acrosome-intact mouse sperm heads, is a putative primary egg-binding protein.
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