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SP140 nuclear body protein

Sp140, nuclear body protein SP140, LYSP100
Top mentioned proteins: Sp100, PML, ACID, Autoantigen, HAD
Papers on Sp140
Hypomethylation of TET2 Target Genes Identifies a Curable Subset of Acute Myeloid Leukemia.
Issa et al., Houston, United States. In J Natl Cancer Inst, Feb 2016
METHODS: We used bisulfite pyrosequencing to analyze the methylation status of four tet2-DMCs (SP140, MCCC1, EHMT1, and MTSS1) in a test group of 94 consecutive patients and a validation group of 92 consecutive patients treated with cytarabine-based chemotherapy.
A functional variant that affects exon-skipping and protein expression of SP140 as genetic mechanism predisposing to multiple sclerosis.
Alcina et al., Granada, Spain. In Hum Mol Genet, Nov 2015
Several variants in strong linkage disequilibrium (LD) at the SP140 locus have been associated with multiple sclerosis (MS), Crohn's disease (CD) and chronic lymphocytic leukemia (CLL).
Longitudinal analysis of 25 sequential sample-pairs using a custom multiple myeloma mutation sequencing panel (M(3)P).
Braggio et al., Scottsdale, United States. In Ann Hematol, Jul 2015
Mutation analysis revealed KRAS as the most commonly mutated gene (36 % in each time point), followed by NRAS (20 and 16 %), TP53 (16 and 16 %), DIS3 (16 and 16 %), FAM46C (12 and 16 %), and SP140 (12 and 12 %).
SP140L, an Evolutionarily Recent Member of the SP100 Family, Is an Autoantigen in Primary Biliary Cirrhosis.
Peterson et al., Tartu, Estonia. In J Immunol Res, 2014
The widely expressed SP100 and the leukocyte-specific proteins SP110 and SP140 have been associated with transcriptional regulation and various human diseases.
CD84 is markedly up-regulated in Kawasaki disease arteriopathy.
Rowley et al., Chicago, United States. In Clin Exp Immunol, 2014
Genes associated with cellular proliferation, motility and survival were also up-regulated in KD CA, and immune activation molecules MX2 and SP140 were up-regulated in chronic KD.
Structure of human Sp140 PHD finger: an atypical fold interacting with Pin1.
Musco et al., Milano, Italy. In Febs J, 2014
Sp140 is a nuclear leukocyte-specific protein involved in primary biliary cirrhosis and a risk factor in chronic lymphocytic leukemia.
Heterogeneity of genomic evolution and mutational profiles in multiple myeloma.
Munshi et al., Sanger, United States. In Nat Commun, 2013
We identify new candidate genes, including truncations of SP140, LTB, ROBO1 and clustered missense mutations in EGR1.
Genetic differences between Asian and Caucasian chronic lymphocytic leukemia.
Koeffler et al., Los Angeles, United States. In Int J Oncol, 2013
Further, we found amplification of IRF4 and deletion of the SP140/SP100 genes; these genes have been reported as CLL-associated genes by previous genome-wide-association study.
Effects of TET2 mutations on DNA methylation in chronic myelomonocytic leukemia.
Issa et al., Houston, United States. In Epigenetics, 2012
We found that two non-CpG island promoters, AIM2 and SP140, were hypermethylated in patients with mutant TET2.
Post-GWAS functional characterization of susceptibility variants for chronic lymphocytic leukemia.
Skibola et al., Berkeley, United States. In Plos One, 2011
Sixteen SNPs were identified that are linked to differential expression of SP140, a putative tumor suppressor gene previously associated with CLL/SLL.
Genetic susceptibility for chronic lymphocytic leukemia among Chinese in Hong Kong.
Rothman et al., Bethesda, United States. In Eur J Haematol, 2010
Polymorphisms in SP140 and ACOXL were also associated with risk of CLL.
PML nuclear body component Sp140 is a novel autoantigen in primary biliary cirrhosis.
Muratori et al., Bologna, Italy. In Am J Gastroenterol, 2010
A new PML NB protein, designated as Sp140, was identified using serum from a PBC patient.
A genome-wide association study identifies six susceptibility loci for chronic lymphocytic leukemia.
Houlston et al., United Kingdom. In Nat Genet, 2008
We identified six previously unreported CLL risk loci at 2q13 (rs17483466; P = 2.36 x 10(-10)), 2q37.1 (rs13397985, SP140; P = 5.40 x 10(-10)), 6p25.3 (rs872071, IRF4; P = 1.91 x 10(-20)), 11q24.1 (rs735665; P = 3.78 x 10(-12)), 15q23 (rs7176508; P = 4.54 x 10(-12)) and 19q13.32
[Identification of tumor-associated proteins in laryngeal squamous cell carcinoma by proteomics].
Li et al., Chongqing, China. In Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi, 2007
Such as cofilin-1, nuclear body protein SP140, GRP94, HSP 90, GSTP1-1, superoxide dismutase [Mn], cyclophilin A, proteasome activator complex subunit 2, apolipoprotein A-I precursor, CaM-like protein and so on.
Implication of the lymphocyte-specific nuclear body protein Sp140 in an innate response to human immunodeficiency virus type 1.
Kabat et al., Portland, United States. In J Virol, 2002
the nuclear body protein Sp140, was found specifically in all NP cells (n = 12 cell lines tested; P < or = 0.001), and HIV-1 infection induced its partial dispersal from nuclear bodies into cytosolic colocalization with Vif
Role and fate of PML nuclear bodies in response to interferon and viral infections.
Chelbi-Alix et al., Villejuif, France. In Oncogene, 2001
The NBs-associated proteins, PML, Sp100, Sp140, Sp110, ISG20 and PA28 are induced by IFN suggesting that nuclear bodies could play a role in IFN response.
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