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SP110 nuclear body protein

SP110, Ipr1, Intracellular pathogen resistance 1, Ifi75
The nuclear body is a multiprotein complex that may have a role in the regulation of gene transcription. This gene is a member of the SP100/SP140 family of nuclear body proteins and encodes a leukocyte-specific nuclear body component. The protein can function as an activator of gene transcription and may serve as a nuclear hormone receptor coactivator. In addition, it has been suggested that the protein may play a role in ribosome biogenesis and in the induction of myeloid cell differentiation. Alternative splicing has been observed for this gene and three transcript variants, encoding distinct isoforms, have been identified. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, Mtb, PML, Sp100, AGE
Papers on SP110
Characterization of promoter of the tuberculosis-resistant gene intracellular pathogen resistance 1.
Zhang et al., China. In Immunol Res, Dec 2015
Expression of the intracellular pathogen resistance 1 (Ipr1) gene could enhance the host resistance to mycobacterium.
Transgenic cattle produced by nuclear transfer of fetal fibroblasts carrying Ipr1 gene at a specific locus.
Zhang et al., China. In Theriogenology, Oct 2015
This study aimed to assess the effects of the intracellular pathogen resistance 1 (Ipr1) transgene on preventing infection of Mycobacterium bovis in cattle.
TALE nickase-mediated SP110 knockin endows cattle with increased resistance to tuberculosis.
Zhang et al., China. In Proc Natl Acad Sci U S A, May 2015
Here, we report site-specific knockin of the transcription activator-like effector (TALE) nickase-mediated SP110 nuclear body protein gene (SP110) via homologous recombination to produce tuberculosis-resistant cattle.
The effects of SP110's associated genes on fresh cavitary pulmonary tuberculosis in Han Chinese population.
Deng et al., Shanghai, China. In Clin Exp Med, Feb 2015
UNASSIGNED: SP110 is a promising anti-Mycobacterium tuberculosis (MTB) gene.
SP140L, an Evolutionarily Recent Member of the SP100 Family, Is an Autoantigen in Primary Biliary Cirrhosis.
Peterson et al., Tartu, Estonia. In J Immunol Res, 2014
The widely expressed SP100 and the leukocyte-specific proteins SP110 and SP140 have been associated with transcriptional regulation and various human diseases.
Effect of Ipr1 on expression levels of immune genes related to macrophage anti-infection of mycobacterium tuberculosis.
Li et al., Yantai, China. In Int J Clin Exp Med, 2014
BACKGROUND: Intracellular pathogen resistance 1 (Ipr1) has been found in macrophages and plays a pivotal role in fighting against Mycobacterium tuberculosis (Mtb) infection.
Identification of potential HIV restriction factors by combining evolutionary genomic signatures with functional analyses.
Telenti et al., Lausanne, Switzerland. In Retrovirology, 2014
Unexpectedly, over-expression of two factors (IL1A, SP110) significantly increased infectious HIV-1 production.
SP110 gene polymorphisms and tuberculosis susceptibility: a systematic review and meta-analysis based on 10 624 subjects.
Wang et al., Chongqing, China. In Infect Genet Evol, 2012
The SP110 (Speckled 110) gene, which is considered as a host genetic susceptibility to TB, has been widely studied in recent years, yet the results were somewhat contradictory and indeterminate.
Clinical, molecular, and cellular immunologic findings in patients with SP110-associated veno-occlusive disease with immunodeficiency syndrome.
Roscioli et al., Sydney, Australia. In J Allergy Clin Immunol, 2012
a range of mutations in SP110 that cause decreased SP110 protein levels and impaired late B-cell differentiation cause veno-occlusive disease with immunodeficiency syndrome.
Ipr1 gene mediates RAW 264.7 macrophage cell line resistance to Mycobacterium bovis.
Zhang et al., Taiwan. In Scand J Immunol, 2011
mediates RAW 264.7 macrophage cell line resistance to Mycobacterium bovis
Association of SP110 gene polymorphisms with susceptibility to tuberculosis in a Chinese population.
Xiao et al., Shanghai, China. In Infect Genet Evol, 2011
This study demonstrates that genotypes and haplotypes of SP110 might be associated with susceptibility to tuberculosis in Chinese population.
Genetic association study suggests a role for SP110 variants in lymph node tuberculosis but not pulmonary tuberculosis in north Indians.
Bose et al., Delhi, India. In Hum Immunol, 2011
the results might indicate a role of SP110 variants in extrapulmonary tuberculosis rather than PTB.
Identification of proteins interacting with human SP110 during the process of viral infections.
Chou et al., Shanghai, China. In Med Chem, 2011
identification of two proteins: the human remodeling and spacing factor 1 (RSF1) and the activating transcription factor 7 interacting protein (ATF7IP) that interact with human SP110 during the process of viral infections
Current findings, challenges and novel approaches in human genetic susceptibility to tuberculosis.
Hoal et al., Stellenbosch, South Africa. In Tuberculosis (edinb), 2010
In addition, numerous genes and pathways have been implicated in candidate gene association studies, with validation of polymorphisms in IFNG, NRAMP1, and NOS2A and equivocal results for IL10, CCL2, DC-SIGN, P2RX7, VDR, TLR2, TLR9 and SP110.
Genetic dissection of host resistance to Mycobacterium tuberculosis: the sst1 locus and the Ipr1 gene.
Kramnik, Boston, United States. In Curr Top Microbiol Immunol, 2007
Using a positional cloning approach, we have identified a novel host resistance gene, Ipr1, which is encoded within the sst1 locus and mediates innate immunity to the intracellular bacterial pathogens MTB and Listeria monocytogenes.
Hepatic Veno-Occlusive Disease with Immunodeficiency
Wong et al., Seattle, United States. In Unknown Journal, 2007
DIAGNOSIS/TESTING: Diagnosis is based on low serum concentrations of IgA, IgM, and IgG for age, normal lymphocyte numbers, normal CD4 and CD8 percentages, histologic examination of the liver (or hepatic ultrasonography and Doppler ultrasonography if hepatic biopsy is not possible), and molecular genetic testing of SP110, the only gene in which mutation is known to cause VODI.
An antigen produced by splicing of noncontiguous peptides in the reverse order.
Van den Eynde et al., Seattle, United States. In Science, 2006
description of a minor histocompatibility antigen created by a polymorphism in the SP110 gene; the antigenic peptide comprises 2 noncontiguous SP110 peptide segments spliced together in reverse order to that in which they occur in predicted SP110 protein
Mutations in the gene encoding the PML nuclear body protein Sp110 are associated with immunodeficiency and hepatic veno-occlusive disease.
Buckley et al., Sydney, Australia. In Nat Genet, 2006
reports the involvement of a Sp110 nuclear body protein in a human primary immunodeficiency and high-penetrance genetic mutations in hepatic veno-occlusive disease
Ipr1 gene mediates innate immunity to tuberculosis.
Kramnik et al., Boston, United States. In Nature, 2005
data indicate that the Ipr1 gene product might have a previously undocumented function in integrating signals generated by intracellular pathogens with mechanisms controlling innate immunity, cell death and pathogenesis
Role and fate of PML nuclear bodies in response to interferon and viral infections.
Chelbi-Alix et al., Villejuif, France. In Oncogene, 2001
The NBs-associated proteins, PML, Sp100, Sp140, Sp110, ISG20 and PA28 are induced by IFN suggesting that nuclear bodies could play a role in IFN response.
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