Current findings, challenges and novel approaches in human genetic susceptibility to tuberculosis.
Stellenbosch, South Africa. In Tuberculosis (edinb), 2010
In addition, numerous genes and pathways have been implicated in candidate gene association studies, with validation of polymorphisms in IFNG, NRAMP1, and NOS2A and equivocal results for IL10, CCL2, DC-SIGN, P2RX7, VDR, TLR2, TLR9 and SP110.
Hepatic Veno-Occlusive Disease with Immunodeficiency
Seattle, United States. In Unknown Journal, 2007
DIAGNOSIS/TESTING: Diagnosis is based on low serum concentrations of IgA, IgM, and IgG for age, normal lymphocyte numbers, normal CD4 and CD8 percentages, histologic examination of the liver (or hepatic ultrasonography and Doppler ultrasonography if hepatic biopsy is not possible), and molecular genetic testing of SP110, the only gene in which mutation is known to cause VODI.
Ipr1 gene mediates innate immunity to tuberculosis.
Boston, United States. In Nature, 2005
data indicate that the Ipr1 gene product might have a previously undocumented function in integrating signals generated by intracellular pathogens with mechanisms controlling innate immunity, cell death and pathogenesis