Autoimmune liver serology: current diagnostic and clinical challenges.
London, United Kingdom. In World J Gastroenterol, 2008
PBC is specified by antimitochondrial antibodies (AMA) reacting with enzymes of the 2-oxo-acid dehydrogenase complexes (chiefly pyruvate dehydrogenase complex E2 subunit) and disease-specific ANA mainly reacting with nuclear pore gp210 and nuclear body sp100.
Primary biliary cirrhosis and autoantibodies.
In Nihon Rinsho Meneki Gakkai Kaishi, 2008
The use of enzyme linked immunosorbent assays that utilize recombinant gp210 (an autoantigen of the nuclear envelope) and/or sp100 (a protein target represented by multiple nuclear dots) should be particularly considered in anti-mitochondrial antibody negative PBC sera.