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Pregnancy specific beta-1-glycoprotein 1

SP1, pregnancy-specific beta 1-glycoprotein
The human placenta is a multihormonal endocrine organ that produces hormones, enzymes, and other molecules that support fetal survival and development. Pregnancy-specific beta-1-glycoprotein (PSBG, PSG) is a major product of the syncytiotrophoblast, reaching concentrations of 100 to 290 mg/l at term in the serum of pregnant women (Horne et al., 1976 [PubMed 971765]). PSG is a member of the immunoglobulin (Ig) superfamily (Watanabe and Chou, 1988 [PubMed 3257488]; Streydio et al., 1988 [PubMed 3260773]).[supplied by OMIM, Oct 2009] (from NCBI)
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Top mentioned proteins: V1a, CAN, Sp3, ACID, miR
Papers using SP1 antibodies
Treatment of eccrine porocarcinoma with metastasis to the parotid gland using intensity-modulated radiation therapy: a case report
Supplier
Hoque Mohammad O., In PLoS ONE, 2009
... heat-induced epitope retrieval buffer, and primary antibodies against AR (M3562, 1∶50, Dako, Carpinteria, CA), ER (SP1, prediluted, Ventana Medical Systems, Tucson, AZ), PR (1E2, ...
MicroRNA-221/222 confers tamoxifen resistance in breast cancer by targeting p27(Kip1)
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Kerin Michael J et al., In Breast Cancer Research : BCR, 2007
... Immunohistochemistry was performed using a rabbit monoclonal antihuman ER antibody (clone SP1; Dako, Cambridgeshire, UK) and a polyclonal ...
Increasind expression of the pro-apoptotic Bcl2 family member PUMA is required for mitochondrial release of cytochrome C and the apoptosis associated with skeletal myoblast differentiation
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Jiang Bo et al., In Journal of Experimental & Clinical Cancer Research : CR, 2006
... Sp1 siRNA, control siRNA, siRNA Transfection reagent and siRNA Transfection Medium were purchased from Santa Cruz Biotechnology.
Fast regulation of AP-1 activity through interaction of lamin A/C, ERK1/2, and c-Fos at the nuclear envelope
Supplier
Andrés Vicente et al., In The Journal of Cell Biology, 2006
... ), pERK1/2 (sc-7383), Sp1 (sc-59-G), α-tubulin (sc-8035), anti-FLAG, and HRP-coupled secondary antibodies were purchased from Santa Cruz Biotechnology, Inc ...
Folate intake and risk of breast cancer characterized by hormone receptor status
Supplier
Giles G G et al., In British Journal of Cancer, 2004
... The following antibodies were used: ER (Labvision rabbit monoclonal SP1) at 1/250, PR (DAKO PGR636) at 1/1200 ...
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Papers on SP1
p53 coordinates base excision repair to prevent genomic instability.
New
Dianov et al., Novosibirsk, Russia. In Nucleic Acids Res, Feb 2016
Here we show that accumulation of unrepaired SSBs triggers a p53/Sp1-dependent downregulation of APE1, the endonuclease responsible for the DNA incision during BER.
Antenatal hypoxia induces epigenetic repression of glucocorticoid receptor and promotes ischemic-sensitive phenotype in the developing heart.
New
Zhang et al., Suzhou, China. In J Mol Cell Cardiol, Feb 2016
Functional cAMP-response elements (CREs) at -4408 and -3896 and Sp1 binding sites at -3425 and -3034 were identified at GR untranslated exon 1 promoters.
Characterization of the promoter region of the bovine long-chain acyl-CoA synthetase 1 gene: Roles of E2F1, Sp1, KLF15, and E2F4.
New
Zhang et al., China. In Sci Rep, Dec 2015
Mutational analysis and electrophoretic mobility shift assays demonstrated that E2F1, Sp1, KLF15 and E2F4 binding to the promoter region drives ACSL1 transcription.
The FHL2 regulation in the transcriptional circuitry of human cancers.
Review
New
Tsui et al., Hong Kong, Hong Kong. In Gene, Dec 2015
Fhl2, the gene that code for the protein, is transcriptionally regulated by diverse types of transcription factors, for example, p53, serum response factor (SRF), and specificity protein 1 (Sp1).
Nucleotides in neuroregeneration and neuroprotection.
Review
New
Perez-Sen et al., Madrid, Spain. In Neuropharmacology, Oct 2015
The expression of both receptors is transcriptionally regulated by Sp1 factor, which plays a key role in the startup of the transcription machinery to induce regeneration-associated genes expression.
Orphan nuclear receptor NR4A1 regulates transforming growth factor-β signaling and fibrosis.
New
Impact
Distler et al., Erlangen, Germany. In Nat Med, Feb 2015
NR4A1 recruits a repressor complex comprising SP1, SIN3A, CoREST, LSD1, and HDAC1 to TGF-β target genes, thereby limiting pro-fibrotic TGF-β effects.
First trimester serum tests for Down's syndrome screening.
Review
Alfirevic et al., Liverpool, United Kingdom. In Cochrane Database Syst Rev, 2014
We evaluated 78 test combinations formed from combinations of 18 different tests, with or without maternal age; ADAM12 (a disintegrin and metalloprotease), AFP (alpha-fetoprotein), inhibin, PAPP-A (pregnancy-associated plasma protein A, ITA (invasive trophoblast antigen), free βhCG (beta human chorionic gonadotrophin), PlGF (placental growth factor), SP1 (Schwangerschafts protein 1), total hCG, progesterone, uE3 (unconjugated oestriol), GHBP (growth hormone binding protein), PGH (placental growth hormone), hyperglycosylated hCG, ProMBP (proform of eosinophil major basic protein), hPL (human placental lactogen), (free αhCG, and free ßhCG to AFP ratio.
Anti-androgenic effects of flavonols in prostate cancer.
Review
Boam, Liverpool, United Kingdom. In Ecancermedicalscience, 2014
Mechanisms of flavonol action on the AR axis in PCa have been proposed to be inhibition of the 5α-reductase enzymes, direct androgen competition, suppression of the AR complex and transactivation by coregulators such as c-Jun, Sp1, and the PI3K/Akt pathway.
Diverse Mechanisms of Sp1-Dependent Transcriptional Regulation Potentially Involved in the Adaptive Response of Cancer Cells to Oxygen-Deficient Conditions.
Review
Miyagi et al., Yokohama, Japan. In Cancers (basel), 2014
Sp1 is a ubiquitously-expressed transcription factor that plays a vital role in the regulation of numerous genes required for normal cell function.
Cloning and Transcriptional Activity of the Mouse Omi/HtrA2 Gene Promoter.
Liu et al., Beijing, China. In Int J Mol Sci, 2014
Bioinformatics analysis suggested that the Omi/HtrA2 gene promoter contains a CpG island at -709~+37 bp, and eight heat shock transcription factor 1 (HSF1) sites, two Sp1 transcription factor (SP1)sites, one activator protein (AP) site, seven p53 sites, and four YY1 transcription factor(YY1) sites were predicted in the core areas.
Transcription Factor Sp1 Promotes the Expression of Porcine ROCK1 Gene.
Lei et al., Wuhan, China. In Int J Mol Sci, 2014
Site-directed mutagenesis indicated that the region from -604 to -554 bp contains responsive elements for Sp1.
Subcellular localization of coagulation factor II receptor-like 1 in neurons governs angiogenesis.
Impact
Chemtob et al., Montréal, Canada. In Nat Med, 2014
At the nucleus, F2rl1 facilitates recruitment of the transcription factor Sp1 to trigger Vegfa expression and, in turn, neovascularization.
p53-dependent Nestin regulation links tumor suppression to cellular plasticity in liver cancer.
Impact
Lowe et al., New York City, United States. In Cell, 2014
Here, we show that p53 restricts expression of the stem and progenitor-cell-associated protein nestin in an Sp1/3 transcription-factor-dependent manner and that Nestin is required for tumor initiation in vivo.
The combined hyperlipidemia caused by impaired Wnt-LRP6 signaling is reversed by Wnt3a rescue.
Review
Impact
Mani et al., New Haven, United States. In Cell Metab, 2014
Further investigation showed that LRP6(R611C) mutation triggers hepatic de novo lipogenesis, lipid and cholesterol biosynthesis, and apoB secretion by an Sp1-dependent activation of IGF1, AKT, and both mTORC1 and mTORC2.
An Sp1 transcription factor coordinates caspase-dependent and -independent apoptotic pathways.
Impact
Horvitz et al., Cambridge, United States. In Nature, 2013
Here we show that the Caenorhabditis elegans Sp1 transcription factor SPTF-3 specifies the programmed cell deaths of at least two cells-the sisters of the pharyngeal M4 motor neuron and the AQR sensory neuron-by transcriptionally activating both caspase-dependent and -independent apoptotic pathways.
Pregnancy-specific glycoprotein 1 induces endothelial tubulogenesis through interaction with cell surface proteoglycans.
GeneRIF
Dveksler et al., Bethesda, United States. In J Biol Chem, 2011
the presence of GAGs on the surface of endothelial cells was required for the ability of PSG1 to induce tube formation
Human pregnancy specific beta-1-glycoprotein 1 (PSG1) has a potential role in placental vascular morphogenesis.
GeneRIF
Dveksler et al., Bethesda, United States. In Biol Reprod, 2010
The aspartic acid at position 95 is not required for PSG1 activity but the amino acids implicated in the formation of a salt bridge within the N-domain are essential.
First trimester maternal serum pregnancy-specific beta-1-glycoprotein (SP1) as a marker of adverse pregnancy outcome.
GeneRIF
Christiansen et al., Copenhagen, Denmark. In Prenat Diagn, 2009
first trimester maternal serum marker of small-for-gestational age and preterm delivery
Pregnancy-specific {beta}-1-glycoprotein 1 and human leukocyte antigen-E mRNA in human sperm: differential expression in fertile and infertile men and evidence of a possible functional role during early development.
GeneRIF
Oehninger et al., Norfolk, United States. In Hum Reprod, 2009
The differential expression of HLA-E and PSG1 in the sperm of fertile and infertile men is discussed.
Human pregnancy-specific glycoprotein 1a (PSG1a) induces alternative activation in human and mouse monocytes and suppresses the accessory cell-dependent T cell proliferation.
GeneRIF
Bocco et al., Córdoba, Argentina. In J Leukoc Biol, 2002
Human PSG1a induces alternative activation in human & mouse monocytes & suppresses the accessory-cell-dependent T-cell proliferation. PSG1a contributes to immunomodulation during pregnancy, with opposite effects on maternal innate & adaptative systems.
More papers using SP1 antibodies
Body mass and mortality after breast cancer diagnosis
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Gonzalez-Perez R R et al., In British Journal of Cancer, 2004
... Antibodies for IL-1R tI, Ob-R-NH2, Ob-Rb-COOH, goat IgG2b, SP1 small interference (si) RNA and control siRNA-A were obtained from Santa Cruz Biotechnology, Inc ...
Characterization of human glycoprotein VI gene 5′ regulatory and promoter regions.
Supplier
Herman Christophe, In PLoS ONE, 2001
... Goat anti-human Ku80, goat anti-human PARP-1, rabbit anti-human Sp1, normal goat IgG and normal rabbit IgG were purchased from Santa Cruz Biotechnology (Santa Cruz, CA) ...
Phospholipase C-γ2 couples Bruton's tyrosine kinase to the NF-κB signaling pathway in B lymphocytes
Supplier
Kitamura Daisuke et al., In The Journal of Experimental Medicine, 2000
... , anti-Syk (LR), anti-IKKα/β (H-470), anti c-Rel (C), and anti-SP1 (PEP2) Abs were from Santa Cruz Biotechnology, Inc ...
Persistent activation of RelA by respiratory syncytial virus involves protein kinase C, underphosphorylated IkappaB-beta, and sequestration of protein phosphatase 2A by the viral phosphoprotein
Supplier
Barik Sailen et al., In BMC Microbiology, 1997
... Antibodies against the following antigens were obtained from commercial sources: p65, Sp1 (Santa Cruz Biotechnology); phospho-AKT, caspases-3, -6, -7, ...
Components of the human SWI/SNF complex are enriched in active chromatin and are associated with the nuclear matrix.
Supplier
Blagosklonny Mikhail V., In PLoS ONE, 1996
... from Santa-cruz, mouse β-actin and mouse α-tubulin from Sigma, mouse Histone H1 from Roche, mouse SP1 from Abcam.
Cancer cell cycles.
Supplier
Damania Blossom, In PLoS Pathogens, 1995
... Mouse antibodies to Cyclin D1 (DSC-6) and Sp1 (1C6), and rabbit antibody to Ub (FL-76) were from Santa Cruz Biotechnology, Inc (Santa Cruz, CA) ...
Characterization of promoter elements required for cell-specific expression of the neurotensin/neuromedin N gene in a human endocrine cell line.
Supplier
Dent Paul, In PLoS ONE, 1994
... Mouse anti-NFATc3 antibody, the NFATc, NFATc mutant, Sp1, and ETS oligonucleotides were from Santa Cruz Biotechnology (Santa Cruz, CA) ...
Regulation of α2integrin gene expression in cells with megakaryocytic features: a common theme of three necessary elements
Supplier
Clark Richard A.F. et al., In The Journal of Cell Biology, 1993
... Polyclonal antibodies against NF-κB p65, p50, c-Rel, RelB, Iκ-Bα, and monoclonal antibody against Sp1 were purchased from Santa Cruz Biotechnology ...
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