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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Surfactant protein D

SP-D, Pulmonary Surfactant-Associated Protein D, surfactant protein D, HOXD13
binds carbohydrates; may play a role in defense response in the lung [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: SP-A, CAN, HAD, MUC1, AGE
Papers using SP-D antibodies
NLRP3 inflammasome is required in murine asthma in the absence of aluminum adjuvant
Lang Carol J. et al., In Journal of Allergy, 2010
... goat Abs to caspase-1 P10 and P20 active subunits; and mouse monoclonal Ab (mAb) to SP-D were from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...
Papers on SP-D
Variable expressivity of the phenotype in two families with brachydactyly type E, craniofacial dysmorphism, short stature and delayed bone age caused by novel heterozygous mutations in the PTHLH gene.
Latos-Bieleńska et al., Poznań, Poland. In J Hum Genet, Feb 2016
Isolated brachydactyly type E (BDE), which is characterized by shortened metacarpals and/or metatarsals, results in a small proportion of patients from HOXD13 or PTHLH mutations, although in the majority of cases molecular lesion remains unknown.
PUMA promotes apoptosis of hematopoietic progenitors driving leukemic progression in a mouse model of myelodysplasia.
Curtis et al., Melbourne, Australia. In Cell Death Differ, Feb 2016
Using the NUP98-HOXD13 (NHD13) transgenic mouse model of MDS, we previously reported that overexpression of the anti-apoptotic protein BCL2, blocked apoptosis and improved cytopenias, paradoxically, delaying leukemic progression.
Association between the surfactant protein D (SFTPD) gene and subclinical carotid artery atherosclerosis.
Holmskov et al., Odense, Denmark. In Atherosclerosis, Jan 2016
We hypothesized that plasma SP-D (pSP-D) and SP-D gene (SFTPD) single nucleotide polymorphisms (SNPs) are risk factors for atherosclerosis.
Intraoperative cell salvage during cardiac surgery is associated with reduced postoperative lung injury.
de Vries et al., Utrecht, Netherlands. In Interact Cardiovasc Thorac Surg, Jan 2016
METHODS: Serial measurements of systemic plasma concentrations of interleukin-6 (IL-6), myeloperoxidase, elastase, surfactant protein D (SP-D), Clara cell 16 kD protein (CC16) and soluble receptor for advanced glycation endproducts (sRAGEs) were performed on blood samples from 195 patients who underwent cardiac surgery with the use of a cell salvage (CS) device (CS, n = 99) or without (CONTROL, n = 96).
Identification of genomic aberrations in hemangioblastoma by droplet digital PCR and SNP microarray highlights novel candidate genes and pathways for pathogenesis.
Toren et al., Tel Aviv-Yafo, Israel. In Bmc Genomics, Dec 2015
CONCLUSIONS: Our findings provide the first high-resolution genome-wide view of chromosomal changes in hemangioblastoma and identify 23 candidate genes: EGFR, PRDM16, PTPN11, HOXD11, HOXD13, FLT3, PTCH, FGFR1, FOXP1, GPC3, HOXC13, HOXC11, MKL1, CHEK2, IRF4, GPHN, IKZF1, RB1, HOXA9, and micro RNA, such as hsa-mir-196a-2 for hemangioblastoma pathogenesis.
Inflammatory Diseases of the Lung Induced by Conventional Cigarette Smoke: A Review.
Hwang et al., In Chest, Dec 2015
In particular, metalloproteases 9 and 12, surfactant protein D, antimicrobial peptides (LL-37 and human β defensin 2), and IL-1, IL-6, IL-8, and IL-17 have been found in higher quantities in the lungs of smokers with ongoing inflammation.
Murine models of Aspergillosis: Role of collectins in host defense.
Sarma et al., In Indian J Exp Biol, Nov 2015
Collectins, namely surfactant protein A (SP-A), surfactant protein D (SP-D) and mannan binding lectin (MBL), are pattern recognition molecules regulating both innate and adaptive immune response against pathogens.
The Role of Surfactant in Lung Disease and Host Defense against Pulmonary Infections.
Mallampalli et al., Chi-lung, Taiwan. In Ann Am Thorac Soc, May 2015
Surfactant is enriched with a relatively unique phospholipid, termed dipalmitoylphosphatidylcholine, and four surfactant-associated proteins, SP-A, SP-B, SP-C, and SP-D.
[Significance of surfactant proteins in the diagnosis of therapeutic diseases].
Voevoda et al., In Ter Arkh, 2014
The hydrophilic proteins SP-A and SP-D are responsible for the regulation of the latter.
Childhood asthma: causes, risks, and protective factors; a role of innate immunity.
Floros et al., United States. In Swiss Med Wkly, 2013
Aside from the Th cell responses the role of innate immunity in the context of alveolar macrophages, dendritic cells, and surfactant protein A (SP-A) and SP-D is discussed.
Hox genes regulate digit patterning by controlling the wavelength of a Turing-type mechanism.
Ros et al., Santander, Spain. In Science, 2013
We showed that the progressive reduction in Hoxa13 and Hoxd11-Hoxd13 genes (hereafter referred to as distal Hox genes) from the Gli3-null background results in progressively more severe polydactyly, displaying thinner and densely packed digits.
A NUP98-HOXD13 leukemic fusion gene leads to impaired class switch recombination and antibody production.
Caudell et al., Blacksburg, United States. In Exp Hematol, 2012
findings show that expression of NUP98-HOXD13 impairs class switch recombination and reduces the antibody-mediated immune response, in addition to its role in leukemia
Surfactant protein D facilitates Cryptococcus neoformans infection.
Wright et al., Durham, United States. In Infect Immun, 2012
Mice lacking SP-D were partially protected during Cryptococcus neoformans infection; they displayed a longer mean time to death and decreased fungal burden at several time points postinfection than wild-type mice.
Surfactant protein D (Sp-D) binds to membrane-proximal domain (D3) of signal regulatory protein α (SIRPα), a site distant from binding domain of CD47, while also binding to analogous region on signal regulatory protein β (SIRPβ).
Parkos et al., Atlanta, United States. In J Biol Chem, 2012
Surfactant protein D (Sp-D) binds to membrane-proximal domain (D3) of signal regulatory protein alpha (SIRPalpha), a site distant from binding domain of CD47, while also binding to analogous region on signal regulatory protein beta (SIRPbeta).
Surfactant protein d deficiency in mice is associated with hyperphagia, altered fat deposition, insulin resistance, and increased basal endotoxemia.
Sørensen et al., Odense, Denmark. In Plos One, 2011
The data suggest SP-D as a regulator of energy intake and body composition and an inhibitor of metabolic endotoxemia. SP-D may play a causal role at the crossroads of inflammation, obesity, and insulin resistance.
SP-D polymorphisms and the risk of COPD.
Shakoori et al., Lahore, Pakistan. In Dis Markers, 2011
Polymorphism at rs721917 is associated with reduced serum SP-D levels and risk of Chronic Obstructive Pulmonary Disease.
Immunoregulatory functions of surfactant proteins.
Wright, Durham, United States. In Nat Rev Immunol, 2005
In this article, I review the structure and functions of the surfactant proteins SP-A and SP-D in regulating host immune defence and in modulating inflammatory responses.
A dual role for Hox genes in limb anterior-posterior asymmetry.
Duboule et al., Genève, Switzerland. In Science, 2004
By using an inversion of and a large deficiency in the mouse HoxD cluster, we found that a perturbation in the early collinear expression of Hoxd11, Hoxd12, and Hoxd13 in limb buds led to a loss of asymmetry.
By binding SIRPalpha or calreticulin/CD91, lung collectins act as dual function surveillance molecules to suppress or enhance inflammation.
Henson et al., Denver, United States. In Cell, 2003
Surfactant proteins A and D (SP-A and SP-D) are lung collectins composed of two regions, a globular head domain that binds PAMPs and a collagenous tail domain that initiates phagocytosis.
Collections and ficolins: humoral lectins of the innate immune defense.
Jensenius et al., Denmark. In Annu Rev Immunol, 2002
The human collectins, mannan-binding lectin (MBL) and surfactant protein A and D (SP-A and SP-D), are oligomeric proteins composed of carbohydrate-recognition domains (CRDs) attached to collagenous regions and are thus structurally similar to the ficolins, L-ficolin, M-ficolin, and H-ficolin.
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