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SRY-box containing gene 8

Sox8
This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins. This protein may be involved in brain development and function. Haploinsufficiency for this protein may contribute to the mental retardation found in haemoglobin H-related mental retardation (ART-16 syndrome). [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Sox, CAN, SRY, AMH, SET
Papers using Sox8 antibodies
The high mobility group transcription factor Sox8 is a negative regulator of osteoblast differentiation
Supplier
Amling Michael et al., In The Journal of Cell Biology, 1998
... Col1a1-Sox8 transgenic mice were obtained by ...
Papers on Sox8
Search for regulatory factors of the pituitary-specific transcription factor PROP1 gene.
New
Kato et al., Japan. In J Reprod Dev, Jan 2016
Reporter assays for another 39 factors using the 3 kb upstream regions in CHO cells ultimately revealed that 8 factors, MSX2, PAX6, PIT1, PITX1, PITX2, RPF1, SOX8 and SOX11, but not RBP-J, regulate Prop1 expression.
Gonadal Identity in the Absence of Pro-Testis Factor SOX9 and Pro-Ovary Factor Beta-Catenin in Mice.
New
Yao et al., United States. In Biol Reprod, Aug 2015
To identify the genes responsible for the initial events of masculinization and to determine how the genetic context (XX vs. XY) affects this process, we compared the transcriptomes of Sox9/beta-catenin mutant gonads and found that early molecular changes underlying the XY-specific masculinization involve the expression of Sry and 21 SRY direct target genes, such as Sox8 and Cyp26b1.
Long-term expandable SOX9+ chondrogenic ectomesenchymal cells from human pluripotent stem cells.
New
Nakayama et al., Houston, United States. In Stem Cell Reports, May 2015
They maintained normal karyotype for at least 10 passages and expressed genes representing embryonic progenitors (SOX4/12, LIN28A/B), cranial mesenchyme (ALX1/3/4), and chondroprogenitors (SOX9, COL2A1) of neural crest origin (SOX8/9, NGFR, NES).
Sexual cell-fate reprogramming in the ovary by DMRT1.
New
Zarkower et al., Minneapolis, United States. In Curr Biol, Apr 2015
DMRT1 can silence Foxl2 even in the absence of the testis-determining genes Sox8 and Sox9.
The requirement of histone modification by PRDM12 and Kdm4a for the development of pre-placodal ectoderm and neural crest in Xenopus.
New
Michiue et al., Tokyo, Japan. In Dev Biol, Apr 2015
ChIP-qPCR analyses indicated that PRDM12 promoted the occupancy of the trimethylated histone H3K9 (H3K9me3) on the Foxd3, Slug, and Sox8 promoters.
SOXE transcription factors form selective dimers on non-compact DNA motifs through multifaceted interactions between dimerization and high-mobility group domains.
Jauch et al., Guangzhou, China. In Sci Rep, 2014
The SOXE transcription factors SOX8, SOX9 and SOX10 are master regulators of mammalian development directing sex determination, gliogenesis, pancreas specification and neural crest development.
Transcriptome analysis of cattle muscle identifies potential markers for skeletal muscle growth rate and major cell types.
Dalrymple et al., Nanjing, China. In Bmc Genomics, 2014
However, some exceptions were identified: expression of SOX8 previously attributed to muscle satellite cells was correlated with angiogenesis.
Genome wide chromatin occupancy of mrhl RNA and its role in gene regulation in mouse spermatogonial cells.
Rao et al., Portugal. In Rna Biol, 2013
Wnt3a ligand treatment of Gc1-Spg cells down regulated mrhl RNA expression and also perturbed expression of these 27 GRPAM genes that included genes regulating Wnt signaling pathway and spermatogenesis, one of them being Sox8, a developmentally important transcription factor.
The SOX gene family: function and regulation in testis determination and male fertility maintenance.
Review
Yang et al., Hangzhou, China. In Mol Biol Rep, 2013
Besides, researchers have found that Sox8 and Sox9 have functions in the male fertility maintenance after birth.
Genes promoting and disturbing testis development.
Review
Jiménez et al., Armilla, Spain. In Histol Histopathol, 2012
Others can be considered testis-promoting, differentaition and/or maintenance genes: these include SRY, SOX9, FGF9, PTGDS, SOX8, SOX3, NR0B1, PDGFRa, DMRT1, AMH, NGF, NTF3 and NGFR as the most important examples.
Mechanisms of peripheral neuropathy associated with bortezomib and vincristine in patients with newly diagnosed multiple myeloma: a prospective analysis of data from the HOVON-65/GMMG-HD4 trial.
Impact
Sonneveld et al., Rotterdam, Netherlands. In Lancet Oncol, 2010
Significant genes in myeloma plasma cells from patients that were associated with early-onset bortezomib-induced peripheral neuropathy were the enzyme coding genes RHOBTB2 (upregulated by 1·59 times; p=4·5×10(-5)), involved in drug-induced apoptosis, CPT1C (1·44 times; p=2·9×10(-7)), involved in mitochondrial dysfunction, and SOX8 (1·68 times; p=4·28×10(-13)), involved in development of peripheral nervous system.
Evolutionary conserved sequence elements with embryonic enhancer activity in the vicinity of the mammalian Sox8 gene.
GeneRIF
Wegner et al., Erlangen, Germany. In Int J Biochem Cell Biol, 2010
Seven regions near the Sox8 gene as potential enhancers, were identified.
SoxE factors as multifunctional neural crest regulatory factors.
Review
LaBonne et al., Evanston, United States. In Int J Biochem Cell Biol, 2010
Neural crest cells are the primary innovation that led to evolution of the vertebrates, and transcription factors of the SoxE family (Sox8, Sox9 and Sox10) are among the central players regulating the development of these cells.
SOX E genes: SOX9 and SOX8 in mammalian testis development.
Review
Scherer et al., Freiburg, Germany. In Int J Biochem Cell Biol, 2010
The group E SOX proteins consist of SOX8, SOX9 and SOX10.
SoxE function in vertebrate nervous system development.
Review
Wegner et al., Erlangen, Germany. In Int J Biochem Cell Biol, 2010
Sox8, Sox9, and Sox10 as transcription factors of subgroup E of the Sox protein family are essential for many aspects of nervous system development.
Adult-onset degeneration of adipose tissue in mice deficient for the Sox8 transcription factor.
GeneRIF
Wegner et al., Erlangen, Germany. In J Lipid Res, 2009
Data suggest a precursor-intrinsic role of Sox8 during replenishment of the adipocyte pool in adult mice and assume that disturbance of this function significantly contributes to adipose tissue degeneration in Sox8-deficient mice.
Differential expression of SOX2 and SOX17 in testicular germ cell tumors.
GeneRIF
Nonaka, New York City, United States. In Am J Clin Pathol, 2009
SOX2 and SOX17 expression patterns can distinguish between seminoma and embryonal carcinoma, and this distinction may be diagnostically useful.
Testis cord differentiation after the sex determination stage is independent of Sox9 but fails in the combined absence of Sox9 and Sox8.
GeneRIF
Scherer et al., Freiburg, Germany. In Dev Biol, 2009
This study shows that testis cord differentiation is independent of Sox9, and that concerted Sox9 and Sox8 function in post E14.0 Sertoli cells is essential for the maintenance of testicular function.
Downstream genes of Sox8 that would affect adult male fertility.
GeneRIF
Mishina et al., United States. In Sex Dev, 2008
Downstream genes of Sox8 that would affect male fertility are reported.
Importance of SoxE in neural crest development and the evolution of the pharynx.
Impact
Bronner-Fraser et al., Pasadena, United States. In Nature, 2006
To understand neural crest evolution, we explored molecular mechanisms underlying craniofacial development in the basal jawless vertebrate, sea lamprey (Petromyzon marinus), focusing on the SoxE (Sox8, Sox9 and Sox10) gene family.
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