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SRY-box containing gene 7

Sox7
This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. The protein may play a role in tumorigenesis. A similar protein in mice is involved in the regulation of the wingless-type MMTV integration site family (Wnt) pathway. [provided by RefSeq, Jul 2008] (from NCBI)
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Top mentioned proteins: Sox, SOX18, CAN, GATA4, SRY
Papers on Sox7
Overexpression of miR-664 is associated with enhanced osteosarcoma cell migration and invasion ability via targeting SOX7.
New
Chen et al., Guangzhou, China. In Clin Exp Med, Nov 2015
The effect of miR-664 on SOX7 was determined by luciferase assays and Western blot assay.
Inside the 8p23.1 duplication syndrome; eight microduplications of likely or uncertain clinical significance.
New
Wynn et al., Oslo, Norway. In Am J Med Genet A, Sep 2015
This MRO spans 776 kb (chr8:10,167,881-10,943,836 hg19) and contains SOX7 and seven of the other 32 core 8p23.1 DS genes.
Suppression of SOX7 by DNA methylation and its tumor suppressor function in acute myeloid leukemia.
New
Leung et al., Hong Kong, Hong Kong. In Blood, Jul 2015
SOX7 belongs to the SOX (Sry-related high-mobility group [HMG] box) gene family, a group of transcription factors containing in common a HMG box domain.
Sox7 controls arterial specification in conjunction with hey2 and efnb2 function.
New
Schulte-Merker et al., Utrecht, Netherlands. In Development, Jun 2015
SoxF family members have been linked to arterio-venous specification events and human pathological conditions, but in contrast to Sox17 and Sox18, a detailed in vivo analysis of a Sox7 mutant model is still lacking.
SOX7 interferes with β-catenin activity to promote neuronal apoptosis.
New
Yu et al., Xiamen, China. In Eur J Neurosci, May 2015
SOX7 mediates various developmental processes.
UV exposure modulates hemidesmosome plasticity, contributing to long-term pigmentation in human skin.
New
Hearing et al., Bethesda, United States. In J Pathol, May 2015
The attenuated expression of SOX7 and other hemidesmosomal components (integrin α6β4 and plectin) leads to increased melanosome uptake by keratinocytes and points to a spatial regulation within the epidermis.
MiR-492 contributes to cell proliferation and cell cycle of human breast cancer cells by suppressing SOX7 expression.
New
Xu et al., Guangzhou, China. In Tumour Biol, Mar 2015
Bioinformatics analysis further revealed sex-determining region Y-box 7 (SOX7), a putative tumor suppressor, as a potential target of miR-492.
The SOX transcription factors as key players in pluripotent stem cells.
Review
Kolatkar et al., Doha, Qatar. In Stem Cells Dev, 2014
Although, SOX2 has attracted special attention as a critical factor in maintaining PSCs characteristics and as an integral component that is required to reprogram somatic cells into pluripotency, new reports widely appreciated that other SOX TFs, such as SOX1, SOX3, or reengineered SOX7 and SOX17, can compensate for the absence of SOX2 and thus play a fundamental role during the reprogramming process and maintaining pluripotency.
[Analysis of 22 patients with congenital cleft lip and palate using high-resolution chromosome microarray].
Liao et al., Guangzhou, China. In Zhonghua Yi Xue Yi Chuan Xue Za Zhi, 2014
MYST4, MACROD2 and SOX7 genes are likely the causative genes.
[Analysis of genomic copy number variations in two unrelated neonates with 8p deletion and duplication associated with congenital heart disease].
Huang et al., Shanghai, China. In Zhonghua Er Ke Za Zhi, 2014
Case 1 had serious cardiac abnormalities whose GATA4 was located in the duplication segment and the copy number increased while SOX7 was located in the deletion segment and the copy number decreased.
SOX7: from a developmental regulator to an emerging tumor suppressor.
Review
Sui et al., Winston-Salem, United States. In Histol Histopathol, 2014
SOX7 belongs to the SOX (SRY-related HMG-box) family of transcription factors that have been shown to regulate multiple biological processes, such as hematopoiesis, vasculogenesis and cardiogenesis during embryonic development.
8p23.1 duplication syndrome: narrowing of critical interval to 1.80 Mbp.
Müller et al., Gießen, Germany. In Mol Cytogenet, 2013
DISCUSSION: The case indicates that genes within this interval, in particular dosage sensitive genes SOX7 and TNKS1, and possibly MIR124-1 and MIR598 as well suffice to cause the pathognomonic features of the 8p23.1 duplication syndrome.
Reduced expression of SOX7 in ovarian cancer: a novel tumor suppressor through the Wnt/β-catenin signaling pathway.
Liu et al., In J Ovarian Res, 2013
One of the members, SOX7, is associated with the development of a variety of cancers as a tumor suppression factor, but its relevance with ovarian cancer was unclear.
SOX7 regulates the expression of VE-cadherin in the haemogenic endothelium at the onset of haematopoietic development.
GeneRIF
Kouskoff et al., Manchester, United Kingdom. In Development, 2012
SOX7 regulates the expression of VE-cadherin in the haemogenic endothelium at the onset of haematopoietic development.
SOX7 is involved in aspirin-mediated growth inhibition of human colorectal cancer cells.
GeneRIF
Zhang et al., Changchun, China. In World J Gastroenterol, 2011
Data show that SOX7 is upregulated by aspirin and is involved in aspirin-mediated growth inhibition of human colorectal cancer SW480 cells.
Sox factors transcriptionally regulate ROBO4 gene expression in developing vasculature in zebrafish.
GeneRIF
Ramchandran et al., Milwaukee, United States. In J Biol Chem, 2011
Sox7 and Sox18-mediated transcriptional regulation of Robo4 is important in the developing embryonic vasculature
[Transcriptomic regulation and molecular mechanism of polygenic tumor at different stages].
Review
Li et al., Changsha, China. In Zhong Nan Da Xue Xue Bao Yi Xue Ban, 2011
Genes including SPLUNC1, LTF, BRD7, NOR1, BRCA1/2, PALB2, AF1Q, SOX17, NGX6, SOX7, and LRRC4 have been identified as the key transcriptional regulation genes during the stage of tumor initiation and invasion.
Sox7-sustained expression alters the balance between proliferation and differentiation of hematopoietic progenitors at the onset of blood specification.
GeneRIF
Kouskoff et al., Manchester, United Kingdom. In Blood, 2009
Sox7-sustained expression in the earliest committed hematopoietic precursors promotes the maintenance of their multipotent and self-renewing status.
Sox7 and Sox17 are strain-specific modifiers of the lymphangiogenic defects caused by Sox18 dysfunction in mice.
GeneRIF
Koopman et al., Brisbane, Australia. In Development, 2009
SOX7 and SOX17 are not normally expressed during lymphatic development, excluding a conventional redundancy mechanism with SOX18. Instead, these genes are activated specifically in the absence of SOX18 function, and only in certain strains.
Establishment of endoderm progenitors by SOX transcription factor expression in human embryonic stem cells.
Impact
GeneRIF
Rossant et al., Toronto, Canada. In Cell Stem Cell, 2008
stable endoderm progenitors can be established from human ES cells by constitutive expression of SOX7 producing extraembryonic endoderm progenitors
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