PSCA acts as a tumor suppressor by facilitating the nuclear translocation of RB1CC1 in esophageal squamous cell carcinoma.
Hong Kong, Hong Kong. In Carcinogenesis, Feb 2016
Here, we reported decreased expression of PSCA in 188/218 (86.2%) of primary ESCC cases and was negatively regulated by its transcription factor SOX5 which was significantly associated with the poor differentiation (p = 0.003), increased lymph node metastasis (p < 0.0001), advanced stage (p = 0.007) and disease-specific survival (p < 0.0001), but not associated with the recently reported transcrible rs2294008 (C>T) polymorphism in ESCC.
Novel genetic causes for cerebral visual impairment.
Nijmegen, Netherlands. In Eur J Hum Genet, Oct 2015
In addition, in 11 patients (44%) with CVI, variants in one or more candidate genes were identified (ACP6, AMOT, ARHGEF10L, ATP6V1A, DCAF6, DLG4, GABRB2, GRIN1, GRIN2B, KCNQ3, KCTD19, RERE, SLC1A1, SLC25A16, SLC35A2, SOX5, UFSP2, UHMK1, ZFP30).
Screening feature genes of lung carcinoma with DNA microarray analysis.
Wuhan, China. In Int J Clin Exp Med, 2014
The transcription biding site analysis showed that these genes were regulated by LHX3, HNF3B, CDP, HFH1, FOXO4, STAT, SOX5, MEF2, FOXO3 and SRY.
Sox proteins in melanocyte development and melanoma.
Bethesda, United States. In Pigment Cell Melanoma Res, 2010
Since then, we have discovered that SOX5, SOX9, SOX10 and SOX18 all participate as transcription factors that affect key melanocytic genes in both regulatory and modulatory fashions.
Genome-wide association study of PR interval.
München, Germany. In Nat Genet, 2010
Six of the loci were near cardiac developmental genes, including CAV1-CAV2, NKX2-5 (CSX1), SOX5, WNT11, MEIS1, and TBX5-TBX3, providing pathophysiologically interesting candidate genes.
Molecular mechanism of osteochondroprogenitor fate determination during bone formation.
Århus, Denmark. In Adv Exp Med Biol, 2005
Sox9, together with L-Sox5 and Sox6, of the Sox family is required for chondrogenic differentiation commitment, while Runx2/Cbfa 1, a member of runt family and Osterix/Osx, a novel zinc finger-containing transcription factor play a pivotal role in osteoblast differentiation decision and hypertrophic chondrocyte maturation.
Transcriptional mechanisms of chondrocyte differentiation.
Houston, United States. In Matrix Biol, 2000
Two other members of the Sox family, L-Sox5 and Sox6, also bind to the 48-bp Col2a1 enhancer and together with Sox9 activate this enhancer as well as the endogenous Col2a1 and aggrecan genes.