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SRY-box containing gene 1

This intronless gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins. In mice, a similar protein regulates the gamma-crystallin genes and is essential for lens development. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, Sox, Sox2, HAD, SOX3
Papers on Sox1
The stabilization of hypoxia inducible factor modulates differentiation status and inhibits the proliferation of mouse embryonic stem cells.
Pacherník et al., Brno, Czech Republic. In Chem Biol Interact, Feb 2016
Identification, molecular characterization and gene expression analysis of sox1a and sox1b genes in Japanese flounder, Paralichthys olivaceus.
Zhang et al., Qingdao, China. In Gene, Jan 2016
The transcription factor, Sox1 has been implicated in neural determination and differentiation as well as in the maintenance of neural progenitor cell status in mammals.
Efficient Generation of Induced Pluripotent Stem and Neural Progenitor Cells From Acutely Harvested Dura Mater Obtained During Ventriculoperitoneal Shunt Surgery.
Waldau et al., Sacramento, United States. In World Neurosurg, Nov 2015
One clone underwent targeted neural differentiation and formed neural rosettes as well as TuJ1/SOX1-positive neural progenitor cells.
Prospective separation and transcriptome analyses of cortical projection neurons and interneurons based on lineage tracing by Tbr2 (Eomes)-GFP/Dcx-mRFP reporters.
Lu et al., Suita, Japan. In Dev Neurobiol, Sep 2015
Expression profiling documented cell-specific genes including differentially expressed transcriptional regulators that might be involved in cellular specifications, for instance, our data found that SOX1 and SOX2, which were known for important functions in neural stem/progenitor cells, continued to be expressed by interneurons but not by projection neurons.
Prognostic significance of SOX-1 expression in human hepatocelluar cancer.
Chen et al., Nanjing, China. In Int J Clin Exp Pathol, 2014
Sex-determining region Y (SRY)-box 1 (SOX1) as a member of the SOX gene superfamily is reported to function as a tumor suppressor in hepatocelluar cancer (HCC).
Self-renewal of human embryonic stem cells on defined synthetic electrospun nanofibers.
Forsyth et al., Stoke-on-Trent, United Kingdom. In Biomed Mater, 2014
Retention of pluripotentiality was confirmed by expression of Alkaline phosphatase, OCT-3/4 and Nanog expression on PCL scaffolds and the expression of transcripts representative of mesoderm (ACTC1), ectoderm (SOX1) and endoderm (AFP) during subsequent spontaneous in vitro differentiation.
Triage of high-risk human papillomavirus-positive women by methylated POU4F3.
Lai et al., Taipei, Taiwan. In Clin Epigenetics, 2014
Five genes, POU4F3, HS3ST2, AJAP1, PAX1, and SOX1, were prioritized for the clinical performance to triage hrHPV-positive women.
Rapid, efficient, and simple motor neuron differentiation from human pluripotent stem cells.
Okada et al., Japan. In Mol Brain, 2014
Treatment with GSK3β inhibitors during the initial phase of differentiation in combination with dual SMAD inhibition was sufficient to induce PAX6 (+) and SOX1 (+) neural progenitors within 1 week, and subsequent treatment with retinoic acid (RA) and purmorphamine, which activates sonic hedgehog (SHH) signaling, resulted in the highly efficient induction of HB9(+) and ISL-1(+) motor neurons within 2 weeks.
The SOX transcription factors as key players in pluripotent stem cells.
Kolatkar et al., Doha, Qatar. In Stem Cells Dev, 2014
Although, SOX2 has attracted special attention as a critical factor in maintaining PSCs characteristics and as an integral component that is required to reprogram somatic cells into pluripotency, new reports widely appreciated that other SOX TFs, such as SOX1, SOX3, or reengineered SOX7 and SOX17, can compensate for the absence of SOX2 and thus play a fundamental role during the reprogramming process and maintaining pluripotency.
Encephalitis and GABAB receptor antibodies: novel findings in a new case series of 20 patients.
Graus et al., Barcelona, Spain. In Neurology, 2013
Five patients with SCLC had additional onconeuronal antibodies (Ri, amphiphysin, or SOX1), and 2 without tumor had GAD65 and NMDAR antibodies, respectively.
SOX1 antibodies in Lambert-Eaton myasthenic syndrome and screening for small cell lung carcinoma.
Titulaer et al., Leiden, Netherlands. In Ann N Y Acad Sci, 2012
SOX1 antibodies are a specific marker for SCLC-LEMS but they are also found in SCLC patients without paraneoplastic neurological syndromes.
Interaction of Sox1, Sox2, Sox3 and Oct4 during primary neurogenesis.
Casey et al., Washington, D.C., United States. In Dev Biol, 2011
Continuous expression of Sox1 and Sox2 in transgenic embryos represses neuron differentiation and inhibits anterior development while increasing cell proliferation.
Sox1 maintains the undifferentiated state of cortical neural progenitor cells via the suppression of Prox1-mediated cell cycle exit and neurogenesis.
Remboutsika et al., Greece. In Stem Cells, 2011
Sox1 regulates the size of the cortical neural progenitor pool via suppression of neurogenic cell divisions.
Sox1 is required for the specification of a novel p2-derived interneuron subtype in the mouse ventral spinal cord.
Malas et al., Nicosia, Cyprus. In J Neurosci, 2010
Transgenic interneuron diversification in the p2 domain is more complex than previously thought and directly implicates Sox1 in this process.
Upregulation of SOX2, NOTCH1, and ID1 in supratentorial primitive neuroectodermal tumors: a distinct differentiation pattern from that of medulloblastomas.
Kim et al., Seoul, South Korea. In J Neurosurg Pediatr, 2010
Supratentorial PNETs expressed significantly higher levels of SOX2, NOTCH1, ID1, and ASCL-1 transcripts.
[Lambert-Eaton myasthenic syndrome (LEMS)].
Suzuki, Tokyo, Japan. In Brain Nerve, 2010
In addition, autoantibodies to synaptotagmin, an M1-type muscarinic acetylcholine receptor and SOX1 are also found in the sera of patients with LEMS.
Dynamic distribution and stem cell characteristics of Sox1-expressing cells in the cerebellar cortex.
Sottile et al., Nottingham, United Kingdom. In Cell Res, 2009
Our results show that the Bergmann glia population expresses Sox1 during cerebellar development, and that these cells can be isolated and show stem cell characteristics in vitro, suggesting that they could hold a broader potential than previously thought.
SOX antibodies in small-cell lung cancer and Lambert-Eaton myasthenic syndrome: frequency and relation with survival.
Verschuuren et al., Leiden, Netherlands. In J Clin Oncol, 2009
Data show that SOX antibodies have diagnostic value in discriminating SCLC-LEMS from nontumor LEMS, but have no relation to survival in patients with SCLC.
SOX-1 autoantibodies in patients with paraneoplastic neurological syndromes.
Blaes et al., Gießen, Germany. In Autoimmun Rev, 2009
Recently, autoantibodies against cerebellar Bergmann glia were found in patients with paraneoplastic Lambert-Eaton myasthenic syndrome and other paraneoplastic neurological syndromes associated with small cell lung cancer, and SOX1 has been identified as the corresponding antigen.
Expression of alpha- and beta-globin genes occurs within different nuclear domains in haemopoietic cells.
Fisher et al., London, United Kingdom. In Nat Cell Biol, 2001
beta-globin loci, in common with several inactive genes studied here (human c-fms and SOX-1) and previously (mouse lambda5, CD4, CD8alpha, RAGs, TdT and Sox-1), were associated with pericentric heterochromatin in a high proportion of cycling lymphocytes.
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