Rapid, efficient, and simple motor neuron differentiation from human pluripotent stem cells.
Japan. In Mol Brain, 2014
Treatment with GSK3β inhibitors during the initial phase of differentiation in combination with dual SMAD inhibition was sufficient to induce PAX6 (+) and SOX1 (+) neural progenitors within 1 week, and subsequent treatment with retinoic acid (RA) and purmorphamine, which activates sonic hedgehog (SHH) signaling, resulted in the highly efficient induction of HB9(+) and ISL-1(+) motor neurons within 2 weeks.
The SOX transcription factors as key players in pluripotent stem cells.
Doha, Qatar. In Stem Cells Dev, 2014
Although, SOX2 has attracted special attention as a critical factor in maintaining PSCs characteristics and as an integral component that is required to reprogram somatic cells into pluripotency, new reports widely appreciated that other SOX TFs, such as SOX1, SOX3, or reengineered SOX7 and SOX17, can compensate for the absence of SOX2 and thus play a fundamental role during the reprogramming process and maintaining pluripotency.
[Lambert-Eaton myasthenic syndrome (LEMS)].
Tokyo, Japan. In Brain Nerve, 2010
In addition, autoantibodies to synaptotagmin, an M1-type muscarinic acetylcholine receptor and SOX1 are also found in the sera of patients with LEMS.
SOX-1 autoantibodies in patients with paraneoplastic neurological syndromes.
Gießen, Germany. In Autoimmun Rev, 2009
Recently, autoantibodies against cerebellar Bergmann glia were found in patients with paraneoplastic Lambert-Eaton myasthenic syndrome and other paraneoplastic neurological syndromes associated with small cell lung cancer, and SOX1 has been identified as the corresponding antigen.