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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Sorting nexin 9

sorting nexin 9, SNX9, WISP, SH3PX1
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members, but does contain a SH3 domain near its N-terminus. This protein interacts with the cytoplasmic domains of the precursor but not the processed forms of a disintegrin and metalloprotease domain 9 and 15. This protein binds the beta-appendage domain of adaptor protein 2 and may function to assist adaptor protein 2 in its role at the plasma membrane. This protein interacts with activated Cdc42-associated kinase-2 to regulate the degradation of epidermal growth factor receptor protein. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: WISP-1, Wnt1, CAN, Cyr61, Actin
Papers on sorting nexin 9
BAR-SH3 sorting nexins are conserved interacting proteins of Nervous wreck that organize synapses and promote neurotransmission.
New
O'Connor-Giles et al., Madison, United States. In J Cell Sci, Feb 2016
To study the role of BAR-SH3 sorting nexins in vivo, we took advantage of the lack of genetic redundancy in Drosophila and employed CRISPR-based genome engineering to generate null and endogenously tagged alleles of SH3PX1.
Impaired SNX9 Expression in Immune Cells during Chronic Inflammation: Prognostic and Diagnostic Implications.
New
Baniyash et al., Jerusalem, Israel. In J Immunol, Feb 2016
In searching for new biomarkers that could validate the impaired host immune status under chronic inflammatory conditions, we discovered that sorting nexin 9 (SNX9), a protein that participates in early stages of clathrin-mediated endocytosis, is downregulated as well under such conditions.
Thymosin β4 Prevents Angiotensin II-Induced Cardiomyocyte Growth by Regulating Wnt/WISP Signaling.
New
Gupta et al., Beijing, China. In J Cell Physiol, Jan 2016
Cell size, hypertrophy marker gene expression and Wnt signaling components, β-catenin and Wnt-induced secreted protein-1 (WISP-1) were evaluated by quantitative real-time PCR, Western blotting and fluorescent microscopy.
CCN4/WISP-1 positively regulates chondrogenesis by controlling TGF-β3 function.
New
Kuboki et al., Okayama, Japan. In Bone, Dec 2015
UNASSIGNED: The CCN family of proteins plays important roles in development and homeostasis of bone and cartilage.
Dual 4- and 5-phosphatase activities regulate SopB-dependent phosphoinositide dynamics to promote bacterial entry.
New
Zhou et al., West Lafayette, United States. In Cell Microbiol, Dec 2015
We found that the 5-phosphatase activity of SopB is likely responsible for generating PtdIns(3,4)P2 and subsequent recruitment of SNX9, an actin modulating protein.
Effect of siRNA on Wisp-1 gene expression, proliferation, migration and adhesion of mouse hepatocellular carcinoma cells.
New
Ren et al., China. In Asian Pac J Trop Med, Oct 2015
OBJECTIVE: To study the inhibition effect of siRNA on the expression of Wisp-1 gene in Hca-F of mouse hepatocellular carcinoma cells strain and also its effect on the proliferation, migration and adhesion of hepatocellular carcinoma cells.
Novel applications of trophic factors, Wnt and WISP for neuronal repair and regeneration in metabolic disease.
Review
New
Maiese, Newark, United States. In Neural Regen Res, Apr 2015
Diabetes mellitus affects almost 350 million individuals throughout the globe resulting in significant morbidity and mortality.
Depletion or over-expression of Sh3px1 results in dramatic changes in cell morphology.
Gonsalvez et al., Augusta, United States. In Biol Open, 2014
The mammalian Sorting Nexin 9 (Snx9) family consists of three paralogs: Snx9, Snx18 and Snx33.
Role of WNT1-inducible-signaling pathway protein 1 in etoposide resistance in lung adenocarcinoma A549 cells.
Lu et al., Shanghai, China. In Int J Clin Exp Med, 2014
OBJECT: The aim of this study was to explore the role of WNT1-inducible-signaling Pathway Protein 1 (WISP-1) in etoposide resistance in lung adenocarcinoma A549 cells.
High expression of WISP-1 correlates with poor prognosis in pancreatic ductal adenocarcinoma.
Sun et al., Shanghai, China. In Am J Transl Res, 2014
WNT1 inducible signaling pathway protein 1 (WISP-1) is a member of the CCN family of growth factors and reported to possess an important role in tumorigenesis by triggering downstream events via integrin signaling.
Input of microenvironmental regulation on colorectal cancer: role of the CCN family.
Review
Kuo et al., Taipei, Taiwan. In World J Gastroenterol, 2014
Many studies have shown that CCN members, such as CCN1, CCN2, CCN3, Wnt-induced secreted protein (WISP)-1, WISP-2, and WISP-3, are dysregulated in CRC, which implies potential diagnostic markers or therapeutic targets clinically.
Wnt1 inducible signalling pathway protein-2 (WISP‑2/CCN5): roles and regulation in human cancers (review).
Review
Jiang et al., Beijing, China. In Oncol Rep, 2014
Recent results suggest that WISP-2 is relevant to tumorigenesis and malignant transformation, particularly in breast cancer, colorectal cancer and hepatocarcinoma.
Spatiotemporal control of endocytosis by phosphatidylinositol-3,4-bisphosphate.
Impact
Haucke et al., Berlin, Germany. In Nature, 2013
Timed formation of PI(3,4)P2 by PI(3)K C2α is required for selective enrichment of the BAR domain protein SNX9 at late-stage endocytic intermediates.
Specific amino acids in the BAR domain allow homodimerization and prevent heterodimerization of sorting nexin 33.
GeneRIF
Lichtenthaler et al., München, Germany. In Biochem J, 2011
study identifies critical amino acids within the BAR domains of SNX9 and SNX33 as determinants for the specificity of BAR domain-mediated interactions and suggests that SNX9 and SNX33 have distinct molecular functions.
E. coli secreted protein F promotes EPEC invasion of intestinal epithelial cells via an SNX9-dependent mechanism.
GeneRIF
Hecht et al., Chicago, United States. In Cell Microbiol, 2010
Findings suggest that EspF promotes EPEC invasion of intestinal epithelial cells by harnessing the membrane-deforming activity of SNX9.
The E3 ubiquitin ligase Itch regulates sorting nexin 9 through an unconventional substrate recognition domain.
GeneRIF
Lévy et al., Lausanne, Switzerland. In Febs J, 2010
The interaction with SNX9 is mediated by the proline-rich domain (PRD) of Itch, a domain distinct from the conventional WW recognition domain, and the SH3 domain of SNX9.
To seek shelter from the WNT in osteoarthritis? WNT-signaling as a target for osteoarthritis therapy.
Review
van den Berg et al., Nijmegen, Netherlands. In Curr Drug Targets, 2010
Alternatively, identifying more down stream Wnt signaling effector molecules, like WISP-1, for more specific therapy promises to be a safer and more efficient approach to find a treatment for this disease that heavily constrains millions of people each year.
Mechanism of aldolase control of sorting nexin 9 function in endocytosis.
GeneRIF
Izard et al., Jupiter, United States. In J Biol Chem, 2010
SNX9 binding to aldolase is structurally precluded by the binding of substrate to the active site.
Role of CCN, a vertebrate specific gene family, in development.
Review
Yamaguchi et al., Tokyo, Japan. In Dev Growth Differ, 2009
CCN4, CCN5, and CCN6 were formerly reported to be in the Wisp family, but they are now integrated into CCN due to the resemblance of their four principal modules: insulin like growth factor binding protein, von Willebrand factor type C, thrombospondin type 1, and carboxy-terminal domain.
Structure and plasticity of Endophilin and Sorting Nexin 9.
GeneRIF
Sondermann et al., Ithaca, United States. In Structure, 2008
Tip-to-tip interactions between the BAR domains in a trigonal crystal form of Snx9(PX-BAR) reminiscent of functionally important interactions described for F-BAR domains.
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