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Sorbitol dehydrogenase

sorbitol dehydrogenase, L-Iditol 2-Dehydrogenase
Sorbitol dehydrogenase (SORD; EC 1.1.1.14) catalyzes the interconversion of polyols and their corresponding ketoses, and together with aldose reductase (ALDR1; MIM 103880), makes up the sorbitol pathway that is believed to play an important role in the development of diabetic complications (summarized by Carr and Markham, 1995 [PubMed 8535074]). The first reaction of the pathway (also called the polyol pathway) is the reduction of glucose to sorbitol by ALDR1 with NADPH as the cofactor. SORD then oxidizes the sorbitol to fructose using NAD(+) cofactor.[supplied by OMIM, Jul 2010] (from NCBI)
Top mentioned proteins: SDH, ACID, HAD, CAN, V1a
Papers on sorbitol dehydrogenase
Sorbitol dehydrogenase inhibitor protects the liver from ischemia/reperfusion-induced injury via elevated glycolytic flux and enhanced sirtuin 1 activity.
New
Liu et al., Taizhou, China. In Mol Med Report, 21 Nov 2014
UNLABELLED: Sorbitol dehydrogenase (SDH), a key enzyme of the polyol pathway, has recently been demonstrated to have an important role in mediating tissue ischemia/reperfusion (I/R) injury.
Enhanced production of L-sorbose from D-sorbitol by improving the mRNA abundance of sorbitol dehydrogenase in Gluconobacter oxydans WSH-003.
New
Chen et al., In Microb Cell Fact, 18 Nov 2014
The sldhAB gene, which encodes the sorbitol dehydrogenase (SLDH), was overexpressed in an industrial strain G. oxydans WSH-003 with a strong promoter, P tufB .
Effect of Temperature and Storage Time on Sorbitol Dehydrogenase Activity in Sprague-Dawley Rat Serum and Plasma.
New
Travlos et al., United States. In Toxicol Pathol, 16 Nov 2014
UNLABELLED: Sorbitol dehydrogenase (SDH) is a liver-specific enzyme sensitive to the detection of acute hepatocellular injury in rats; however, its usefulness has been questioned as being a highly labile enzyme.
Evaluation of imidacloprid-induced neurotoxicity in male rats: a protective effect of curcumin.
New
Telang et al., Bareilly, India. In Neurochem Int, 23 Oct 2014
Acetylcholinestaerase, ATPase and serum biochemicals such as creatine kinase, lactate dehydrogenase, sorbitol dehydrogenase and alkaline phosphatase levels were significantly decreased (p<0.05) as result of IMI exposure and these enzyme levels were reversed in groups treated with the Cur in IMI treatments.
Effects of ursolic acid on glucose metabolism, the polyol pathway and dyslipidemia in non-obese type 2 diabetic mice.
New
Lee et al., In Indian J Exp Biol, Jul 2014
Renal aldose reductase activity was higher, whereas sorbitol dehydrogenase activity was lower in the diabetic control group than in the non-diabetic group.
Grape seed extract and zinc containing nutritional food supplement prevents onset and progression of age-related cataract in wistar rats.
New
Lalit Vaishnav et al., India. In J Nutr Health Aging, May 2014
The extent of tissue damage caused by the selenite was assessed biochemically by measurements of the levels of reduced glutathione, glutathione peroxidase, glucose-6-phosphate dehydrogenase, protein thiol, catalase, superoxide dismutase, malondialdehyde, aldose reductase, sorbitol dehydrogenase and adenosine triphosphate in the isolated lenses.
Protective effect of quercetin on atrazine-induced oxidative stress in the liver, kidney, brain, and heart of adult wistar rats.
New
Abarikwu, Nigeria. In Toxicol Int, May 2014
RESULTS: Q10 but not Q5 attenuated ATZ-induced increase in the levels of serum enzyme markers sorbitol dehydrogenase (SDH), acid phosphatase (ACP), alkaline phosphatase (ALP), and aspartate aminotransferase (AST).
Drug therapy of neuropathic pain: current developments and future perspectives.
Review
New
Ramesh et al., Patiāla, India. In Curr Drug Targets, Feb 2014
The review also gives an insight into various pharmacological agents with potential neuropathic pain attenuating properties in experimental models that include NSAIDs, corticosteroids, ion channel blockers (Ca(2+), Na(+), K(+), and TRP channel); ion exchange modulators (NCE and NHE); ion/molecule transport modulators (NKCC-1 and glycine); receptor modulators (kinin, histamine, 5-HT1A, dopamine, alpha & beta adrenergic, purinergic, excitatory amino acid, sigma, ORL1, endothelin, melanocortin, ephrin and PAR); enzyme inhibitors (cytosolic kinase, metalloproteinase, protease, vasopeptidase, D-amino acid oxidase, fatty acid amide hydrolase, aldose reductase and sorbitol dehydrogenase); other ligands (AGE, RAGEs, neuropeptides, neurotrophic factor, complement cascade, cytokine, glial cell & gap junction, nitrous oxide, growth factor, cell adhesion molecule and neuronal sprouting molecule).
Evaluation of plasma muscle enzyme activity as an indicator of lesion characteristics and prognosis in horses undergoing celiotomy for acute gastrointestinal pain.
New
Hackett et al., In Bmc Vet Res, Dec 2013
Evaluation of preoperative plasma aspartate aminotransferase (AST), creatine kinase (CK), sorbitol dehydrogenase (SDH), and gamma-glutamyltransferase (GGT) activities, fibrinogen and glucose concentrations, and hematocrit (HCT) and their association with gastrointestinal lesion characteristics and survival was performed.
Benign elevations in serum aminotransferases and biomarkers of hepatotoxicity in healthy volunteers treated with cholestyramine.
New
Watkins et al., United States. In Bmc Pharmacol Toxicol, Dec 2013
Significant elevations were noted in mean levels of necrosis biomarkers sorbitol dehydrogenase (8.1 fold), cytokeratin 18 (2.1 fold) and HMGB1 (1.7 fold).
The course of toxicity in the pregnant mouse after exposure to the cyanobacterial toxin cylindrospermopsin: clinical effects, serum chemistries, hematology, and histopathology.
New
Hill et al., United States. In J Toxicol Environ Health A, Dec 2013
The onset of symptoms was rapid, producing reductions in weight gain in GD8-12 animals, bleeding in the vaginal area in GD13-17 animals, and significant increases in sorbitol dehydrogenase (SDH) in both groups after a single dose.
Primary and secondary metabolism in the sun-exposed peel and the shaded peel of apple fruit.
Review
New
Cheng et al., China. In Physiol Plant, May 2013
This was related to lower sorbitol dehydrogenase activity and higher activities of sorbitol oxidase, neutral invertase and acid invertase in the sun-exposed peel.
Sorbitol dehydrogenase expression is regulated by androgens in the human prostate.
GeneRIF
Vaarala et al., Oulu, Finland. In Oncol Rep, 2010
The expression of SORD is regulated by androgens in human prostate. In prostate cancer, increased immunostaining was associated with high Gleason patterns and high serum PSA concentrations.
ZAC1 is up-regulated by hypertonicity and decreases sorbitol dehydrogenase expression, allowing accumulation of sorbitol in kidney cells.
GeneRIF
Berl et al., Aurora, United States. In J Biol Chem, 2009
The zinc-finger protein ZAC1 is up-regulated under hypertonic stress and negatively regulates expression of sorbitol dehydrogenase, allowing for accumulation of sorbitol as a compatible organic osmolyte.
The current state of serum biomarkers of hepatotoxicity.
Review
Schomaker et al., United States. In Toxicology, 2008
In contrast, the enzymatic markers sorbitol dehydrogenase, glutamate dehydrogenase, paraxonase, malate dehydrogenase, and purine nucleoside phosphorylase are all readily measured by photometric methods and use reagents that work across preclinical species and humans and are commercially available.
Pyridine nucleotide redox abnormalities in diabetes.
Review
Ido, Boston, United States. In Antioxid Redox Signal, 2007
Our studies suggest that cytosolic NADH reductive stress under high glucose is largely caused by increased flux of glucose through polyol (sorbitol) pathway consisting of aldose reductase and sorbitol dehydrogenase.
Catalytic mechanism of Zn2+-dependent polyol dehydrogenases: kinetic comparison of sheep liver sorbitol dehydrogenase with wild-type and Glu154-->Cys forms of yeast xylitol dehydrogenase.
GeneRIF
Nidetzky et al., Graz, Austria. In Biochem J, 2007
Results compare the catalytic mechanism of liver sorbitol dehydrogenase with wild-type and Glu154-->Cys forms of yeast xylitol dehydrogenase.
Role of exosomes in sperm maturation during the transit along the male reproductive tract.
Review
Frenette et al., Canada. In Blood Cells Mol Dis, 2005
These include two enzymes involved in the polyol pathway: an aldose reductase and a sorbitol dehydrogenase.
Sorbitol dehydrogenase: structure, function and ligand design.
Review
GeneRIF
Chung et al., Australia. In Curr Med Chem, 2004
Sorbitol dehydrogenase (SDH), a member of the medium-chain dehydrogenase/reductase protein family and the second enzyme of the polyol pathway of glucose metabolism, converts sorbitol to fructose strictly using NAD(+) as coenzyme.
Expression, purification and preliminary crystallographic analysis of human sorbitol dehydrogenase.
GeneRIF
El-Kabbani et al., Australia. In Acta Crystallogr D Biol Crystallogr, 2003
crystals of sorbitol dehydrogenase belong to the monoclinic C2 space group, with unit-cell parameters a = 145.9, b = 52.3, c = 169.0 A, beta = 101.8 degrees
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