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Sorbitol dehydrogenase

sorbitol dehydrogenase, L-Iditol 2-Dehydrogenase
Sorbitol dehydrogenase (SORD; EC catalyzes the interconversion of polyols and their corresponding ketoses, and together with aldose reductase (ALDR1; MIM 103880), makes up the sorbitol pathway that is believed to play an important role in the development of diabetic complications (summarized by Carr and Markham, 1995 [PubMed 8535074]). The first reaction of the pathway (also called the polyol pathway) is the reduction of glucose to sorbitol by ALDR1 with NADPH as the cofactor. SORD then oxidizes the sorbitol to fructose using NAD(+) cofactor.[supplied by OMIM, Jul 2010] (from NCBI)
Top mentioned proteins: SDH, ACID, HAD, CAN, V1a
Papers on sorbitol dehydrogenase
Fibroblast growth factor 21 protects mouse brain against D-galactose induced aging via suppression of oxidative stress response and advanced glycation end products formation.
Ren et al., Harbin, China. In Pharmacol Biochem Behav, 11 May 2015
The expression of aldose reductase (AR), sorbitol dehydrogenase (SDH) and member-anchored receptor for AGEs (RAGE) declined significantly after FGF21 treatment.
Evaluation of ameliorative effect of curcumin on imidacloprid-induced male reproductive toxicity in wistar rats.
Telang et al., India. In Environ Toxicol, 10 Apr 2015
Activities of gamma-glutamyl transpeptidase, lactate dehydrogenase-x, and sorbitol dehydrogenase were significantly increased (p < 0.05), while, 3β-HSD and 17β-HSD enzymatic activity along with testosterone concentration in testis and plasma were decreased significantly (p < 0.05) in IM-treated rats.
Modulatory potential of α-amyrin against hepatic oxidative stress through antioxidant status in Wistar albino rats.
Gupta et al., Jaipur, India. In J Ethnopharmacol, 23 Mar 2015
Hepatomodulatory potential was assessed by using the serum- markers like γ-glutamyl transpeptidase (GGT), aspartate and alanine transaminases (AST, ALT), lactate dehydrogenase (LDH), alkaline phosphatase (ALP), acid phosphatase (ACP), sorbitol dehydrogenase (SDH), glutamate dehydrogenase (GDH), and total bilirubin, total protein, glutathione reduced (GSH), ceruloplasmin, β-carotene, vitamin C and vitamin E in serum concomitantly with the hepatic-antioxidants like superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR), glutathione-s-transferase (GST), and 5´-nucleotidase, acid ribonuclease, glucose-6-phosphatase, succinic dehydrogenase and cytochrome-P-450 in liver tissue whereas lipid peroxidation (LPO) was estimated in both serum and liver contents.
Uptake and metabolism of fructose by rat neocortical cells in vivo and by isolated nerve terminals in vitro.
Rise et al., Oslo, Norway. In J Neurochem, 23 Mar 2015
The genes encoding aldose reductase and sorbitol dehydrogenase, enzymes of the polyol pathway that forms glucose from fructose, were expressed in rat neocortex.
Non-climacteric ripening and sorbitol homeostasis in plum fruits.
Blumwald et al., Davis, United States. In Plant Sci, Feb 2015
These changes were highly correlated with decreased activity and expression of NAD(+)-dependent sorbitol dehydrogenase and sorbitol oxidase and increased sorbitol-6-phosphate dehydrogenase activity, suggesting an enhanced sorbitol synthesis in non-climacteric fruits.
H2S donors attenuate diabetic nephropathy in rats: Modulation of oxidant status and polyol pathway.
Abdelsalam et al., Cairo, Egypt. In Pharmacol Rep, Feb 2015
Activities of myeloperoxidase and sorbitol dehydrogenase were not altered by STZ or any of the treatments.
Vitamin U, a novel free radical scavenger, prevents lens injury in rats administered with valproic acid.
Yanardag et al., İstanbul, Turkey. In Hum Exp Toxicol, Jan 2015
Lens lipid peroxidation levels and aldose reductase and sorbitol dehydrogenase activities were increased in VPA group.
Spermine alleviates drought stress in white clover with different resistance by influencing carbohydrate metabolism and dehydrins synthesis.
Yan et al., Chengdu, China. In Plos One, Dec 2014
Spm induced a significant increase in sucrose phosphate synthase (SPS) or sorbitol dehydrogenase (SDH) activity, but decrease in sucrose synthetase (SS) activity when two cultivars were subjected to drought.
Polyol specificity of recombinant Arabidopsis thaliana sorbitol dehydrogenase studied by enzyme kinetics and in silico modeling.
Handford et al., Santiago, Chile. In Front Plant Sci, Dec 2014
Nicotinamide adenine dinucleotide(+)-dependent SORBITOL DEHYDROGENASE (SDH, E. C.
Drug therapy of neuropathic pain: current developments and future perspectives.
Ramesh et al., Patiāla, India. In Curr Drug Targets, Feb 2014
The review also gives an insight into various pharmacological agents with potential neuropathic pain attenuating properties in experimental models that include NSAIDs, corticosteroids, ion channel blockers (Ca(2+), Na(+), K(+), and TRP channel); ion exchange modulators (NCE and NHE); ion/molecule transport modulators (NKCC-1 and glycine); receptor modulators (kinin, histamine, 5-HT1A, dopamine, alpha & beta adrenergic, purinergic, excitatory amino acid, sigma, ORL1, endothelin, melanocortin, ephrin and PAR); enzyme inhibitors (cytosolic kinase, metalloproteinase, protease, vasopeptidase, D-amino acid oxidase, fatty acid amide hydrolase, aldose reductase and sorbitol dehydrogenase); other ligands (AGE, RAGEs, neuropeptides, neurotrophic factor, complement cascade, cytokine, glial cell & gap junction, nitrous oxide, growth factor, cell adhesion molecule and neuronal sprouting molecule).
[The biochemical markers of hepatobiliary function in children under environmental pollution].
In Wiad Lek, 2013
Among the investigated enzymes the high frequency of abnormal levels of gamma-glutamyltransferase (54.6%) alkaline phosphatase (36.1%), sorbitol dehydrogenase (28.6%) were detected in children from ecologically unfavorable districts which may indicate that these markers were helpful for the early diagnosis of environmentally triggered hepatobiliary disease.
Primary and secondary metabolism in the sun-exposed peel and the shaded peel of apple fruit.
Cheng et al., China. In Physiol Plant, 2013
This was related to lower sorbitol dehydrogenase activity and higher activities of sorbitol oxidase, neutral invertase and acid invertase in the sun-exposed peel.
Sorbitol dehydrogenase expression is regulated by androgens in the human prostate.
Vaarala et al., Oulu, Finland. In Oncol Rep, 2010
The expression of SORD is regulated by androgens in human prostate. In prostate cancer, increased immunostaining was associated with high Gleason patterns and high serum PSA concentrations.
ZAC1 is up-regulated by hypertonicity and decreases sorbitol dehydrogenase expression, allowing accumulation of sorbitol in kidney cells.
Berl et al., Aurora, United States. In J Biol Chem, 2009
The zinc-finger protein ZAC1 is up-regulated under hypertonic stress and negatively regulates expression of sorbitol dehydrogenase, allowing for accumulation of sorbitol as a compatible organic osmolyte.
The current state of serum biomarkers of hepatotoxicity.
Schomaker et al., United States. In Toxicology, 2008
In contrast, the enzymatic markers sorbitol dehydrogenase, glutamate dehydrogenase, paraxonase, malate dehydrogenase, and purine nucleoside phosphorylase are all readily measured by photometric methods and use reagents that work across preclinical species and humans and are commercially available.
Pyridine nucleotide redox abnormalities in diabetes.
Ido, Boston, United States. In Antioxid Redox Signal, 2007
Our studies suggest that cytosolic NADH reductive stress under high glucose is largely caused by increased flux of glucose through polyol (sorbitol) pathway consisting of aldose reductase and sorbitol dehydrogenase.
Catalytic mechanism of Zn2+-dependent polyol dehydrogenases: kinetic comparison of sheep liver sorbitol dehydrogenase with wild-type and Glu154-->Cys forms of yeast xylitol dehydrogenase.
Nidetzky et al., Graz, Austria. In Biochem J, 2007
Results compare the catalytic mechanism of liver sorbitol dehydrogenase with wild-type and Glu154-->Cys forms of yeast xylitol dehydrogenase.
Role of exosomes in sperm maturation during the transit along the male reproductive tract.
Frenette et al., Canada. In Blood Cells Mol Dis, 2005
These include two enzymes involved in the polyol pathway: an aldose reductase and a sorbitol dehydrogenase.
Sorbitol dehydrogenase: structure, function and ligand design.
Chung et al., Australia. In Curr Med Chem, 2004
Sorbitol dehydrogenase (SDH), a member of the medium-chain dehydrogenase/reductase protein family and the second enzyme of the polyol pathway of glucose metabolism, converts sorbitol to fructose strictly using NAD(+) as coenzyme.
Expression, purification and preliminary crystallographic analysis of human sorbitol dehydrogenase.
El-Kabbani et al., Australia. In Acta Crystallogr D Biol Crystallogr, 2003
crystals of sorbitol dehydrogenase belong to the monoclinic C2 space group, with unit-cell parameters a = 145.9, b = 52.3, c = 169.0 A, beta = 101.8 degrees
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