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Sorbitol dehydrogenase
sorbitol dehydrogenase, L-Iditol 2-Dehydrogenase
Sorbitol dehydrogenase (SORD; EC 1.1.1.14) catalyzes the interconversion of polyols and their corresponding ketoses, and together with aldose reductase (ALDR1; MIM 103880), makes up the sorbitol pathway that is believed to play an important role in the development of diabetic complications (summarized by Carr and Markham, 1995 [PubMed 8535074]). The first reaction of the pathway (also called the polyol pathway) is the reduction of glucose to sorbitol by ALDR1 with NADPH as the cofactor. SORD then oxidizes the sorbitol to fructose using NAD(+) cofactor.[supplied by OMIM, Jul 2010] (from
NCBI)
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Papers on
sorbitol dehydrogenase
Reagentless D-sorbitol biosensor based on D-sorbitol dehydrogenase immobilized in a sol-gel carbon nanotubes-poly(methylene green) composite.
New
Villers-lès-Nancy, France. In Anal Bioanal Chem, 06 Apr 2013
A reagentless D-sorbitol biosensor based on NAD-dependent D-sorbitol dehydrogenase (DSDH) immobilized in a sol-gel carbon nanotubes-poly(methylene green) composite has been developed.
Aldo-keto reductase and sorbitol dehydrogenase enzymes in Egyptian diabetic patients with and without proliferative diabetic retinopathy.
New
Buraydah, Saudi Arabia. In Clin Exp Optom, 04 Apr 2013
The sorbitol dehydrogenase (SDH) level in diabetic patients showed a significant decrease compared with the normal control level.
Protective effect of ascorbic acid against ethanol-induced reproductive toxicity in male guinea pigs.
New
Thiruvananthapuram, India. In Br J Nutr, 21 Feb 2013
Animals treated with ethanol showed a significant decline in sperm quality (P< 0·001), decreased activity of steroidogenic enzymes (P< 0·05) and reduced serum testosterone (P< 0·05), luteinising hormone and follicle-stimulating hormone levels, decrease in the activity of testicular succinate dehydrogenase, adenosine triphosphatase, sorbitol dehydrogenase and reduction in fructose content (P< 0·05).
Field studies using fish biomarker--how many fish are enough?
New
Perth, Australia. In Mar Pollut Bull, Dec 2012
The numbers of fish to collect are reported for ethoxyresorufin-o-deethylase (EROD); ethoxycoumarin-o-deethylase (ECOD), serum sorbitol dehydrogenase (sSDH), stress proteins, gonadosomatic index, liver somatic index, condition factor, and biliary metabolites of polycyclic aromatic hydrocarbons.
Direct oxidation and covalent binding of isoniazid to rodent liver and human hepatic microsomes: humans are more like mice than rats.
New
Toronto, Canada. In Chem Res Toxicol, Dec 2012
The alanine transaminase assay (ALT) is inhibited by INH, and other assays such as glutamate and sorbitol dehydrogenase (SDH) were better biomarkers of INH-induced liver injury.
Primary and secondary metabolism in the sun-exposed peel and the shaded peel of apple fruit.
New
China. In Physiol Plant, Oct 2012
This was related to lower sorbitol dehydrogenase activity and higher activities of sorbitol oxidase, neutral invertase, and acid invertase in the sun-exposed peel.
Antioxidant and schistosomicidal effect of Allium sativum and Allium cepa against Schistosoma mansoni different stages.
New
Al Jīzah, Egypt. In Eur Rev Med Pharmacol Sci, Jul 2012
METHODS: In the present work, the in vivo effects of A. sativum and A. cepa on lipid peroxide and some antioxidant enzymes; thioredoxin reductase (TrxR), sorbitol dehydrogenase (SDH), superoxide dismutase (SOD), catalase (CAT) and glutathione reductase (GR) (as they have a crucial role in host protection against invading parasite) were also studied.
Mechanism of Antidiabetic Action of Compound GII Purified from Fenugreek (Trigonella foenum graecum) Seeds.
Delhi, India. In Indian J Clin Biochem, 2011
Serum total cholesterol (TC), triglycerides (TG), LDL + VLDL cholesterol [(LDL + VLDL)C], HDL cholesterol [(HDL)C], total tissue lipids, glycogen and enzymes of carbohydrate metabolism (glycolysis, gluconeogenesis, polyol pathway) hexokinase, glucokinase, pyruvate kinase, malic enzyme, glucose-6-phosphatase, glucose-6-phosphate dehydrogenase, aldose reductase and sorbitol dehydrogenase and antioxidant enzymes glutathione peroxidase, glutathione reductase and superoxide dismutase were estimated.
Sorbitol dehydrogenase expression is regulated by androgens in the human prostate.
GeneRIF
Oulu, Finland. In Oncol Rep, 2010
The expression of SORD is regulated by androgens in human prostate. In prostate cancer, increased immunostaining was associated with high Gleason patterns and high serum PSA concentrations.
ZAC1 is up-regulated by hypertonicity and decreases sorbitol dehydrogenase expression, allowing accumulation of sorbitol in kidney cells.
GeneRIF
Aurora, United States. In J Biol Chem, 2009
The zinc-finger protein ZAC1 is up-regulated under hypertonic stress and negatively regulates expression of sorbitol dehydrogenase, allowing for accumulation of sorbitol as a compatible organic osmolyte.
The current state of serum biomarkers of hepatotoxicity.
Review
United States. In Toxicology, 2008
In contrast, the enzymatic markers sorbitol dehydrogenase, glutamate dehydrogenase, paraxonase, malate dehydrogenase, and purine nucleoside phosphorylase are all readily measured by photometric methods and use reagents that work across preclinical species and humans and are commercially available.
Pyridine nucleotide redox abnormalities in diabetes.
Review
Boston, United States. In Antioxid Redox Signal, 2007
Our studies suggest that cytosolic NADH reductive stress under high glucose is largely caused by increased flux of glucose through polyol (sorbitol) pathway consisting of aldose reductase and sorbitol dehydrogenase.
Catalytic mechanism of Zn2+-dependent polyol dehydrogenases: kinetic comparison of sheep liver sorbitol dehydrogenase with wild-type and Glu154-->Cys forms of yeast xylitol dehydrogenase.
GeneRIF
Graz, Austria. In Biochem J, 2007
Results compare the catalytic mechanism of liver sorbitol dehydrogenase with wild-type and Glu154-->Cys forms of yeast xylitol dehydrogenase.
Biochemical activity of selenium and glutathione on country made liquor (CML) induced hepatic damage in rats.
Nāmakkal, India. In Indian J Clin Biochem, 2007
There was a significant increase in several serum enzyme levels (viz., aspartate transaminase, alanine transaminase, alkaline phosphatase, sorbitol dehydrogenase, glutamate dehydrogenase, bilirubin) and decrease in various hepatic enzymes (Succinic dehydrogenase, Glucose 6-phosphatase, 5'Nucleotiease, Acid phosphatase, Acid ribonuclease, Cytochrome P-450) due to repeated administration of CML (2ml/100g of body weight).
Role of exosomes in sperm maturation during the transit along the male reproductive tract.
Review
Canada. In Blood Cells Mol Dis, 2005
These include two enzymes involved in the polyol pathway: an aldose reductase and a sorbitol dehydrogenase.
Sorbitol dehydrogenase: structure, function and ligand design.
Review
GeneRIF
Australia. In Curr Med Chem, 2004
Sorbitol dehydrogenase (SDH), a member of the medium-chain dehydrogenase/reductase protein family and the second enzyme of the polyol pathway of glucose metabolism, converts sorbitol to fructose strictly using NAD(+) as coenzyme.
Contribution of polyol pathway to diabetes-induced oxidative stress.
Review
Hong Kong, Hong Kong. In J Am Soc Nephrol, 2003
The first enzyme in the pathway, aldose reductase (AR), reduces glucose to sorbitol, which is then converted to fructose by sorbitol dehydrogenase (SDH).
Expression, purification and preliminary crystallographic analysis of human sorbitol dehydrogenase.
GeneRIF
Australia. In Acta Crystallogr D Biol Crystallogr, 2003
crystals of sorbitol dehydrogenase belong to the monoclinic C2 space group, with unit-cell parameters a = 145.9, b = 52.3, c = 169.0 A, beta = 101.8 degrees
Studies on some serum enzyme levels in various liver diseases.
Mangalore, India. In Indian J Clin Biochem, 2000
aldolase (ALD) (EC 4.1.2.13) and sorbitol dehydrogenase (SDH) (EC 1.1.1.14)
