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Sorbitol dehydrogenase

sorbitol dehydrogenase, L-Iditol 2-Dehydrogenase
Sorbitol dehydrogenase (SORD; EC catalyzes the interconversion of polyols and their corresponding ketoses, and together with aldose reductase (ALDR1; MIM 103880), makes up the sorbitol pathway that is believed to play an important role in the development of diabetic complications (summarized by Carr and Markham, 1995 [PubMed 8535074]). The first reaction of the pathway (also called the polyol pathway) is the reduction of glucose to sorbitol by ALDR1 with NADPH as the cofactor. SORD then oxidizes the sorbitol to fructose using NAD(+) cofactor.[supplied by OMIM, Jul 2010] (from NCBI)
Top mentioned proteins: SDH, ACID, HAD, CAN, V1a
Papers on sorbitol dehydrogenase
Inhibitory effects and actions of pentacyclic triterpenes upon glycation.
Yin, Wuxue, China. In Biomedicine (taipei), 30 Sep 2015
The impact of these triterpenes upon the activity and protein expression of enzymes involved in polyol pathway including aldose reductase and sorbitol dehydrogenase has been examined, and positive results are reported.
Glyphosate herbicide induces genotoxic effect and physiological disturbances in Bulinus truncatus snails.
Abd El-Atti et al., Al Jīzah, Egypt. In Pestic Biochem Physiol, 30 Sep 2015
The activities of superoxide dismutase (SOD), catalase (CAT) and glutathione reductase (GR), thioredoxin reductase (TrxR), glycogen phosphorylase (GP), glucose-6-phosphatase (G-6-Pase), succinic dehydrogenase (SDH) and lactic dehydrogenase (LDH) enzymes in homogenate of snail's tissues were reduced in response to the treatment with the herbicide, while lipid peroxide (LP), sorbitol dehydrogenase (SDH) and transaminases (GOT and GPT) activity increased (P < 0.001).
A novel carboxymethylated mercaptotriazinoindole inhibitor of aldose reductase interferes with the polyol pathway in streptozotocin-induced diabetic rats.
Stefek et al., Bratislava, Slovakia. In Physiol Res, 20 Sep 2015
In addition, the effect of CMTI on aldose reductase back reaction and on sorbitol dehydrogenase was determined.
TiO2 Nanoparticle Exposure Decreases Spermatogenesis via Biochemical Dysfunctions in the Testis of Male Mice.
Zhang et al., Nanjing, China. In J Agric Food Chem, 12 Sep 2015
Furthermore, TiO2 NP exposure with 2.5, 5, or 10 mg/kgbw decreased activities of lactate dehydrogenase (-11.59% to -39.84%), sorbitol dehydrogenase (-23.56% to -57.33%), succinate dehydrogenase (-27.04% to -57.85%), glucose-6-phosphate dehydrogenase (-28.3% to -56.42%), Na(+)/K(+)-ATPase (-15.59% to -53.11%), Ca(2+)-ATPase (-12.44% to -55.41%), and Ca(2+)/Mg(2+)-ATPase (-28.25% to -65.72%), and elevated activities of acid phosphatase (+10.48% to +40.0%), alkaline phosphatase (+20.65% to +64.07%), and total nitric oxide synthase (+0.68- to +2.3-fold) in the testes of mice, respectively.
A fiber-optic sorbitol biosensor based on NADH fluorescence detection toward rapid diagnosis of diabetic complications.
Mitsubayashi et al., Tokyo, Japan. In Analyst, 05 Sep 2015
The biosensor used a sorbitol dehydrogenase from microorganisms of the genus Flavimonas with high substrate specificity and detected the fluorescence of reduced nicotinamide adenine dinucleotide (NADH) by the enzymatic reaction.
The identification of proteomic markers of sperm freezing resilience in ram seminal plasma.
de Graaf et al., Sydney, Australia. In J Proteomics, 03 Sep 2015
26S proteasome complex, acylamino acid releasing enzyme, alpha mannosidase class 2C, heat shock protein 90, tripeptidyl-peptidase 2, TCP-1 complex, sorbitol dehydrogenase and transitional endoplasmic reticulum ATPase were found to be positively correlated (r(2)>0.7)
Xylose fermentation by Saccharomyces cerevisiae using endogenous xylose-assimilating genes.
Uemura et al., Yokohama, Japan. In Biotechnol Lett, 31 Aug 2015
RESULTS: An endogenous gene cassette composed of aldose reductase (GRE3), sorbitol dehydrogenase (SOR1) and xylulose kinase (XKS1) with a PGK1 promoter and a terminator was introduced into two S. cerevisiae strains, a laboratory strain (CEN.PK2-1C) and an industrial strain (Kyokai No. 7).
Enhanced production of L-sorbose in an industrial Gluconobacter oxydans strain by identification of a strong promoter based on proteomics analysis.
Zhou et al., Wuxi, China. In J Ind Microbiol Biotechnol, 31 Jul 2015
Overexpression of D-sorbitol dehydrogenase (sldh) by P B932_2000 in G. oxydans WSH-003 enhanced the titer and productivity of L-sorbose synthesis from D-sorbitol by 12.0 % and 33.3 %, respectively.
Genome-Wide Analysis of Sorbitol Dehydrogenase (SDH) Genes and Their Differential Expression in Two Sand Pear (Pyrus pyrifolia) Fruits.
Xu et al., Hangzhou, China. In Int J Mol Sci, Dec 2014
Through RNA-seq of a mixed fruit sample, fourteen expressed sorbitol dehydrogenase (SDH) genes have been identified from sand pear (Pyrus pyrifolia Nakai).
Drug therapy of neuropathic pain: current developments and future perspectives.
Ramesh et al., Patiāla, India. In Curr Drug Targets, Feb 2014
The review also gives an insight into various pharmacological agents with potential neuropathic pain attenuating properties in experimental models that include NSAIDs, corticosteroids, ion channel blockers (Ca(2+), Na(+), K(+), and TRP channel); ion exchange modulators (NCE and NHE); ion/molecule transport modulators (NKCC-1 and glycine); receptor modulators (kinin, histamine, 5-HT1A, dopamine, alpha & beta adrenergic, purinergic, excitatory amino acid, sigma, ORL1, endothelin, melanocortin, ephrin and PAR); enzyme inhibitors (cytosolic kinase, metalloproteinase, protease, vasopeptidase, D-amino acid oxidase, fatty acid amide hydrolase, aldose reductase and sorbitol dehydrogenase); other ligands (AGE, RAGEs, neuropeptides, neurotrophic factor, complement cascade, cytokine, glial cell & gap junction, nitrous oxide, growth factor, cell adhesion molecule and neuronal sprouting molecule).
[Activity of the marker liver enzymes under the conditions of toxic hepatitis and alimentary deprivation of protein].
Buchkovskaia et al., In Eksp Klin Gastroenterol, 2013
The activity of the sorbitoldehydrogenase (SDH), alanine aminotransferase (ALT) and alkaline phosphatase (ALP) in the blood serum of rats with acetaminophen-induced hepatitis under the conditions of alimentary deprivation of protein was studied.
Primary and secondary metabolism in the sun-exposed peel and the shaded peel of apple fruit.
Cheng et al., China. In Physiol Plant, 2013
This was related to lower sorbitol dehydrogenase activity and higher activities of sorbitol oxidase, neutral invertase and acid invertase in the sun-exposed peel.
Sorbitol dehydrogenase expression is regulated by androgens in the human prostate.
Vaarala et al., Oulu, Finland. In Oncol Rep, 2010
The expression of SORD is regulated by androgens in human prostate. In prostate cancer, increased immunostaining was associated with high Gleason patterns and high serum PSA concentrations.
ZAC1 is up-regulated by hypertonicity and decreases sorbitol dehydrogenase expression, allowing accumulation of sorbitol in kidney cells.
Berl et al., Aurora, United States. In J Biol Chem, 2009
The zinc-finger protein ZAC1 is up-regulated under hypertonic stress and negatively regulates expression of sorbitol dehydrogenase, allowing for accumulation of sorbitol as a compatible organic osmolyte.
The current state of serum biomarkers of hepatotoxicity.
Schomaker et al., United States. In Toxicology, 2008
In contrast, the enzymatic markers sorbitol dehydrogenase, glutamate dehydrogenase, paraxonase, malate dehydrogenase, and purine nucleoside phosphorylase are all readily measured by photometric methods and use reagents that work across preclinical species and humans and are commercially available.
Pyridine nucleotide redox abnormalities in diabetes.
Ido, Boston, United States. In Antioxid Redox Signal, 2007
Our studies suggest that cytosolic NADH reductive stress under high glucose is largely caused by increased flux of glucose through polyol (sorbitol) pathway consisting of aldose reductase and sorbitol dehydrogenase.
Catalytic mechanism of Zn2+-dependent polyol dehydrogenases: kinetic comparison of sheep liver sorbitol dehydrogenase with wild-type and Glu154-->Cys forms of yeast xylitol dehydrogenase.
Nidetzky et al., Graz, Austria. In Biochem J, 2007
Results compare the catalytic mechanism of liver sorbitol dehydrogenase with wild-type and Glu154-->Cys forms of yeast xylitol dehydrogenase.
Role of exosomes in sperm maturation during the transit along the male reproductive tract.
Frenette et al., Canada. In Blood Cells Mol Dis, 2005
These include two enzymes involved in the polyol pathway: an aldose reductase and a sorbitol dehydrogenase.
Sorbitol dehydrogenase: structure, function and ligand design.
Chung et al., Australia. In Curr Med Chem, 2004
Sorbitol dehydrogenase (SDH), a member of the medium-chain dehydrogenase/reductase protein family and the second enzyme of the polyol pathway of glucose metabolism, converts sorbitol to fructose strictly using NAD(+) as coenzyme.
Expression, purification and preliminary crystallographic analysis of human sorbitol dehydrogenase.
El-Kabbani et al., Australia. In Acta Crystallogr D Biol Crystallogr, 2003
crystals of sorbitol dehydrogenase belong to the monoclinic C2 space group, with unit-cell parameters a = 145.9, b = 52.3, c = 169.0 A, beta = 101.8 degrees
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