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Sorbitol dehydrogenase

sorbitol dehydrogenase, L-Iditol 2-Dehydrogenase
Sorbitol dehydrogenase (SORD; EC 1.1.1.14) catalyzes the interconversion of polyols and their corresponding ketoses, and together with aldose reductase (ALDR1; MIM 103880), makes up the sorbitol pathway that is believed to play an important role in the development of diabetic complications (summarized by Carr and Markham, 1995 [PubMed 8535074]). The first reaction of the pathway (also called the polyol pathway) is the reduction of glucose to sorbitol by ALDR1 with NADPH as the cofactor. SORD then oxidizes the sorbitol to fructose using NAD(+) cofactor.[supplied by OMIM, Jul 2010] (from NCBI)
Top mentioned proteins: SDH, ACID, HAD, CAN, V1a
Papers on sorbitol dehydrogenase
Uptake and metabolism of fructose by rat neocortical cells in vivo and by isolated nerve terminals in vitro.
New
Rise et al., Oslo, Norway. In J Neurochem, 23 Mar 2015
The genes encoding aldose reductase and sorbitol dehydrogenase, enzymes of the polyol pathway that forms glucose from fructose, were expressed in rat neocortex.
Modulatory potential of α-amyrin against hepatic oxidative stress through antioxidant status in wistar albino rats.
New
Gupta et al., Jaipur, India. In J Ethnopharmacol, 23 Mar 2015
Hepatomodulatory potential was assessed by using the serum- markers like γ-glutamyl transpeptidase (GGT), aspartate and alanine transaminases (AST, ALT), lactate dehydrogenase (LDH), alkaline phosphatase (ALP), acid phosphatase (ACP), sorbitol dehydrogenase (SDH), glutamate dehydrogenase (GDH), and total bilirubin, total protein, glutathione reduced (GSH), ceruloplasmin, β-carotene, vitamin C and vitamin E in serum concomitantly with the hepatic-antioxidants like superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR), glutathione-s-transferase (GST), and 5´-nucleotidase, acid ribonuclease, glucose-6-phosphatase, succinic dehydrogenase and cytochrome-P-450 in liver tissue whereas lipid peroxidation (LPO) was estimated in both serum and liver contents.
H2S donors attenuate diabetic nephropathy in rats: Modulation of oxidant status and polyol pathway.
New
Abdelsalam et al., Cairo, Egypt. In Pharmacol Rep, 28 Feb 2015
Activities of myeloperoxidase and sorbitol dehydrogenase were not altered by STZ or any of the treatments.
Non-climacteric ripening and sorbitol homeostasis in plum fruits.
New
Blumwald et al., Davis, United States. In Plant Sci, 28 Feb 2015
These changes were highly correlated with decreased activity and expression of NAD(+)-dependent sorbitol dehydrogenase and sorbitol oxidase and increased sorbitol-6-phosphate dehydrogenase activity, suggesting an enhanced sorbitol synthesis in non-climacteric fruits.
Polyols in grape berry: transport and metabolic adjustments as a physiological strategy for water-deficit stress tolerance in grapevine.
New
Gerós et al., Braga, Portugal. In J Exp Bot, 28 Feb 2015
mannitol) and mature berry mesocarps (K m=79mM) was, like sorbitol dehydrogenase activity, strongly inhibited (50-75%) by water-deficit stress.
Sorbitol dehydrogenase inhibitor protects the liver from ischemia/reperfusion-induced injury via elevated glycolytic flux and enhanced sirtuin 1 activity.
New
Liu et al., Taizhou, China. In Mol Med Report, Jan 2015
Sorbitol dehydrogenase (SDH), a key enzyme of the polyol pathway, has recently been demonstrated to have an important role in mediating tissue ischemia/reperfusion (I/R) injury.
Vitamin U, a novel free radical scavenger, prevents lens injury in rats administered with valproic acid.
New
Yanardag et al., İstanbul, Turkey. In Hum Exp Toxicol, Jan 2015
Lens lipid peroxidation levels and aldose reductase and sorbitol dehydrogenase activities were increased in VPA group.
Protective effect of Satureja montana extract on cyclophosphamide-induced testicular injury in rats.
New
AbdelMohsen et al., Cairo, Egypt. In Chem Biol Interact, Dec 2014
Oral daily administration of S.montana extract (50mg/kg/day) for 7days before and 7days after an intraperitoneal injection of cyclophosphamide (200mg/kg) restored the reduced relative testicular weight, serum testosterone level and testicular alkaline phosphatase activity, raised the lowered testicular sorbitol dehydrogenase and acid phosphatase activities, and decreased the elevated testicular hemoglobin absorbance.
Enhanced production of L-sorbose from D-sorbitol by improving the mRNA abundance of sorbitol dehydrogenase in Gluconobacter oxydans WSH-003.
New
Chen et al., In Microb Cell Fact, Nov 2014
The sldhAB gene, which encodes the sorbitol dehydrogenase (SLDH), was overexpressed in an industrial strain G. oxydans WSH-003 with a strong promoter, P tufB .
Effect of Temperature and Storage Time on Sorbitol Dehydrogenase Activity in Sprague-Dawley Rat Serum and Plasma.
New
Travlos et al., United States. In Toxicol Pathol, Nov 2014
Sorbitol dehydrogenase (SDH) is a liver-specific enzyme sensitive to the detection of acute hepatocellular injury in rats; however, its usefulness has been questioned as being a highly labile enzyme.
Drug therapy of neuropathic pain: current developments and future perspectives.
Review
New
Ramesh et al., Patiāla, India. In Curr Drug Targets, Feb 2014
The review also gives an insight into various pharmacological agents with potential neuropathic pain attenuating properties in experimental models that include NSAIDs, corticosteroids, ion channel blockers (Ca(2+), Na(+), K(+), and TRP channel); ion exchange modulators (NCE and NHE); ion/molecule transport modulators (NKCC-1 and glycine); receptor modulators (kinin, histamine, 5-HT1A, dopamine, alpha & beta adrenergic, purinergic, excitatory amino acid, sigma, ORL1, endothelin, melanocortin, ephrin and PAR); enzyme inhibitors (cytosolic kinase, metalloproteinase, protease, vasopeptidase, D-amino acid oxidase, fatty acid amide hydrolase, aldose reductase and sorbitol dehydrogenase); other ligands (AGE, RAGEs, neuropeptides, neurotrophic factor, complement cascade, cytokine, glial cell & gap junction, nitrous oxide, growth factor, cell adhesion molecule and neuronal sprouting molecule).
Primary and secondary metabolism in the sun-exposed peel and the shaded peel of apple fruit.
Review
Cheng et al., China. In Physiol Plant, 2013
This was related to lower sorbitol dehydrogenase activity and higher activities of sorbitol oxidase, neutral invertase and acid invertase in the sun-exposed peel.
Sorbitol dehydrogenase expression is regulated by androgens in the human prostate.
GeneRIF
Vaarala et al., Oulu, Finland. In Oncol Rep, 2010
The expression of SORD is regulated by androgens in human prostate. In prostate cancer, increased immunostaining was associated with high Gleason patterns and high serum PSA concentrations.
ZAC1 is up-regulated by hypertonicity and decreases sorbitol dehydrogenase expression, allowing accumulation of sorbitol in kidney cells.
GeneRIF
Berl et al., Aurora, United States. In J Biol Chem, 2009
The zinc-finger protein ZAC1 is up-regulated under hypertonic stress and negatively regulates expression of sorbitol dehydrogenase, allowing for accumulation of sorbitol as a compatible organic osmolyte.
The current state of serum biomarkers of hepatotoxicity.
Review
Schomaker et al., United States. In Toxicology, 2008
In contrast, the enzymatic markers sorbitol dehydrogenase, glutamate dehydrogenase, paraxonase, malate dehydrogenase, and purine nucleoside phosphorylase are all readily measured by photometric methods and use reagents that work across preclinical species and humans and are commercially available.
Pyridine nucleotide redox abnormalities in diabetes.
Review
Ido, Boston, United States. In Antioxid Redox Signal, 2007
Our studies suggest that cytosolic NADH reductive stress under high glucose is largely caused by increased flux of glucose through polyol (sorbitol) pathway consisting of aldose reductase and sorbitol dehydrogenase.
Catalytic mechanism of Zn2+-dependent polyol dehydrogenases: kinetic comparison of sheep liver sorbitol dehydrogenase with wild-type and Glu154-->Cys forms of yeast xylitol dehydrogenase.
GeneRIF
Nidetzky et al., Graz, Austria. In Biochem J, 2007
Results compare the catalytic mechanism of liver sorbitol dehydrogenase with wild-type and Glu154-->Cys forms of yeast xylitol dehydrogenase.
Role of exosomes in sperm maturation during the transit along the male reproductive tract.
Review
Frenette et al., Canada. In Blood Cells Mol Dis, 2005
These include two enzymes involved in the polyol pathway: an aldose reductase and a sorbitol dehydrogenase.
Sorbitol dehydrogenase: structure, function and ligand design.
Review
GeneRIF
Chung et al., Australia. In Curr Med Chem, 2004
Sorbitol dehydrogenase (SDH), a member of the medium-chain dehydrogenase/reductase protein family and the second enzyme of the polyol pathway of glucose metabolism, converts sorbitol to fructose strictly using NAD(+) as coenzyme.
Expression, purification and preliminary crystallographic analysis of human sorbitol dehydrogenase.
GeneRIF
El-Kabbani et al., Australia. In Acta Crystallogr D Biol Crystallogr, 2003
crystals of sorbitol dehydrogenase belong to the monoclinic C2 space group, with unit-cell parameters a = 145.9, b = 52.3, c = 169.0 A, beta = 101.8 degrees
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