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Epoxide hydrolase 2, cytoplasmic

soluble epoxide hydrolase, sEH, epoxide hydratase, cytosolic epoxide hydrolase, EPHX2
This gene encodes a member of the epoxide hydrolase family. The protein, found in both the cytosol and peroxisomes, binds to specific epoxides and converts them to the corresponding dihydrodiols. Mutations in this gene have been associated with familial hypercholesterolemia. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2012] (from NCBI)
Top mentioned proteins: ACID, CAN, HAD, V1a, Cyp
Papers on soluble epoxide hydrolase
Transcriptome profiling in oral cavity and esophagus tissues from (S)-N'-nitrosonornicotine-treated rats reveals candidate genes involved in human oral cavity and esophageal carcinogenesis.
Kassie et al., Richmond, United States. In Mol Carcinog, Feb 2016
The most significant impact of exposure to (S)-NNN was alteration of genes involved in immune regulation (Aire, Ctla4, and CD80), inflammation (Ephx2 and Inpp5d) and cancer (Cdkn2a, Dhh, Fetub B, Inpp5d, Ly6E, Nr1d1, and Wnt6).
Inhibition of Chronic Pancreatitis and Murine Pancreatic Intraepithelial Neoplasia by a Dual Inhibitor of c-RAF and Soluble Epoxide Hydrolase in LSL-KrasG12D/Pdx-1-Cre Mice.
Yang et al., Chicago, United States. In Anticancer Res, Jan 2016
In the process of long-standing chronic inflammation, aberrant metabolites of arachidonic acid play a crucial role in promoting carcinogenesis, in which the soluble epoxide hydrolase (sEH), as a pro-inflammatory enzyme, generally inactivates anti-inflammatory epoxyeicosatrienoic acids (EETs).
Cyclooxygenase- and cytochrome P450-derived eicosanoids in stroke.
Wang et al., Guangzhou, China. In Prostaglandins Other Lipid Mediat, Jan 2016
Several elegant studies have contributed to defining the importance of stabilizing the levels of epoxyeicosatrienoic acids (EETs), by inhibiting or deleting soluble epoxide hydrolase (sEH), in stroke research.
Inhibition of mutant Kras(G12D)-initiated murine pancreatic carcinoma growth by a dual c-Raf and soluble epoxide hydrolase inhibitor t-CUPM.
Yang et al., Chicago, United States. In Cancer Lett, Jan 2016
The soluble epoxide hydrolase (sEH), a pro-inflammatory enzyme, generally inactivates anti-inflammatory and anti-pain epoxyeicosatrienoic acids (EETs).
Soluble Epoxide Hydrolase: A Potential Target for Metabolic Diseases.
Ai et al., Tianjin, China. In J Diabetes, Jan 2016
EETs can be further hydrolyzed to less active diols by the enzyme soluble epoxide hydrolase (sEH).
Renal Ischemia/Reperfusion Injury in Soluble Epoxide Hydrolase-Deficient Mice.
Schunck et al., Berlin, Germany. In Plos One, Dec 2015
EETs are rapidly metabolized to dihydroxyeicosatrienoic acids (DHETs) by the soluble epoxide hydrolase (sEH).
A multimodal disease modifying approach to treat neuropathic pain - inhibition of soluble epoxide hydrolase (sEH).
Khanna et al., United States. In Drug Discov Today, Nov 2015
Here we review evidence that inhibition of soluble epoxide hydrolase (sEH), the enzyme that degrades epoxyeicosatrienoic acids (EETs), has potential to be a multimodal, disease modifying approach to treat NP: (1) EET actions involve both endogenous opioid system and the GABAergic systems thus provide superior pain relief compared to morphine or gabapentin, (2) EETs are directly anti-inflammatory and inhibit expression of inflammatory cytokines and adhesion molecules thus can prevent continued nerve damage; and (3) EETs promote nerve regeneration in cultured neurons.
New approaches in the treatment of hypertension.
Schmieder et al., Jishou, China. In Circ Res, Apr 2015
New drug classes, eg, inhibitors of vasopeptidases, aldosterone synthase and soluble epoxide hydrolase, agonists of natriuretic peptide A and vasoactive intestinal peptide receptor 2, and a novel mineralocorticoid receptor antagonist are in phase II/III of development, while inhibitors of aminopeptidase A, dopamine β-hydroxylase, and the intestinal Na(+)/H(+) exchanger 3, agonists of components of the angiotensin-converting enzyme 2/angiotensin(1-7)/Mas receptor axis and vaccines directed toward angiotensin II and its type 1 receptor are in phase I or preclinical development.
Reprogramming: A Preventive Strategy in Hypertension Focusing on the Kidney.
Joles et al., Kao-hsiung, Taiwan. In Int J Mol Sci, 2014
Furthermore, a significantly increased expression of gene Ephx2 (soluble epoxide hydrolase) was noted in both genetic and acquired animal models of hypertension.
Proteomics and bioinformatics analysis of mouse hypothalamic neurogenesis with or without EPHX2 gene deletion.
Li et al., Beijing, China. In Int J Clin Exp Pathol, 2014
The aim of this study was to identify differently expressed proteins in the presence and absence of EPHX2 gene in mouse hypothalamus using proteomics profiling and bioinformatics analysis.
The pharmacology of the cytochrome P450 epoxygenase/soluble epoxide hydrolase axis in the vasculature and cardiovascular disease.
Fleming, Frankfurt am Main, Germany. In Pharmacol Rev, 2014
Moreover, inhibitors of the soluble epoxide hydrolase that increase epoxide but decrease diol levels have potential for the treatment of the metabolic syndrome.
Impact of soluble epoxide hydrolase and epoxyeicosanoids on human health.
Hammock et al., Davis, United States. In Annu Rev Pharmacol Toxicol, 2012
The presence of epoxyeicosatrienoic acids (EETs) in tissues and their metabolism by soluble epoxide hydrolase (sEH) to 1,2-diols were first reported 30 years ago.
Genetic disruption of soluble epoxide hydrolase is protective against streptozotocin-induced diabetic nephropathy.
Wang et al., Wuhan, China. In Am J Physiol Endocrinol Metab, 2012
investigation of role of cytoplasmic Ephx2 in diabetic nephropathy using gene disruption techniques: Streptozotocin-induced diabetic nephropathy is attenuated in Ephx2-deficient mice relative to wild-type controls.
Soluble epoxide hydrolase: sex differences and role in endothelial cell survival.
Alkayed et al., Portland, United States. In Arterioscler Thromb Vasc Biol, 2012
Endothelial cells isolated from female cerebral microvessels are more resistant to ischemic injury, in part, because of lower sEH expression.
Role of soluble epoxide hydrolase phosphatase activity in the metabolism of lysophosphatidic acids.
Hammock et al., Davis, United States. In Biochem Biophys Res Commun, 2012
These findings also underline possible cellular mechanisms by which both activities of sEH (EH and phosphatase) may have complementary or opposite roles.
Homocysteine upregulates soluble epoxide hydrolase in vascular endothelium in vitro and in vivo.
Zhu et al., Shantou, China. In Circ Res, 2012
ATF6 activation and DNA demethylation may coordinately contribute to Hcy-induced sEH expression and endothelial activation.
N-terminal domain of soluble epoxide hydrolase negatively regulates the VEGF-mediated activation of endothelial nitric oxide synthase.
Lee et al., Taipei, Taiwan. In Cardiovasc Res, 2012
overexpressing the phosphatase domain of Ephx2 prevented the VEGF-mediated NO production and eNOS phosphorylation at Ser617, Ser635, and Ser1179
Epoxides and soluble epoxide hydrolase in cardiovascular physiology.
Imig, Milwaukee, United States. In Physiol Rev, 2012
The contribution of EETs to vascular and cardiac function is further influenced by soluble epoxide hydrolase (sEH) that degrades EETs to diols.
Soluble epoxide hydrolase as a therapeutic target for cardiovascular diseases.
Hammock et al., Milwaukee, United States. In Nat Rev Drug Discov, 2009
These endogenous lipid mediators are broken down into diols by soluble epoxide hydrolase (sEH), and so inhibiting this enzyme would be expected to enhance the beneficial cardiovascular properties of EETs.
Soluble epoxide hydrolase is a susceptibility factor for heart failure in a rat model of human disease.
Hubner et al., Berlin, Germany. In Nat Genet, 2008
Linkage analyses with genome-wide expression profiling identified Ephx2 as a heart failure susceptibility gene in SHHF rats.
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