Gap junctions are essential for murine primordial follicle assembly immediately before birth.
Beijing, China. In Reproduction, Feb 2016
In addition, the expression of ovarian somatic cell (OSC)-specific genes, such as Notch2, Foxl2 and Irx3, was negatively affected by GJC blockers, whereas oocyte-related genes, such as Ybx2, Nobox and Sohlh1, were hardly affected, implying that the establishment of GJC during this period may be more important to OSCs than to oocytes.
Transcriptional control of spermatogonial maintenance and differentiation.
San Diego, United States. In Semin Cell Dev Biol, 2014
Several transcription factors have been identified that promote spermatogonial differentiation (DMRT1, NGN3, SOHLH1, SOHLH2, SOX3, and STAT3); some of these may influence the decision of an SSC to commit to differentiate while others may promote later spermatogonial differentiation steps.
Transcriptional control of KIT gene expression during germ cell development.
Roma, Italy. In Int J Dev Biol, 2012
Variable mechanisms, involving different germ cell-specific transcription factors, are operating in the various developmental stages: SOX2 and SOHLH1/2 act as direct positive regulators in PGCs and in postnatal spermatogonia, respectively, whereas PLZF suppresses KIT expression in spermatogonial stem cells.
Oocyte-specific genes affect folliculogenesis, fertilization, and early development.
Bethesda, United States. In Semin Reprod Med, 2007
Mouse transgenesis has been particularly useful in defining germ-cell specific genes and their roles in folliculogenesis (e.g., DAZLA, FIGLA, NOBOX, SOHLH1, YBX2, CPEB1, GDF9), fertilization (e.g., ZP1, ZP2, ZP3), and preimplantation embryonic development (e.g., NPM2, ZAR1, NALP5, DPPA3).