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BCL2-associated athanogene 4

SODD, BAG-4
The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. This protein was found to be associated with the death domain of tumor necrosis factor receptor type 1 (TNF-R1) and death receptor-3 (DR3), and thereby negatively regulates downstream cell death signaling. The regulatory role of this protein in cell death was demonstrated in epithelial cells which undergo apoptosis while integrin mediated matrix contacts are lost. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Mar 2011] (from NCBI)
Papers on SODD
Silencer of death domains (SODD) inhibits skeletal muscle and kidney enriched inositol 5-phosphatase (SKIP) and regulates phosphoinositide 3-kinase (PI3K)/Akt signaling to the actin cytoskeleton.
GeneRIF
Mitchell et al., Australia. In J Biol Chem, 2011
Silencer of death domains (SODD) inhibits skeletal muscle and kidney enriched inositol 5-phosphatase (SKIP) and regulates phosphoinositide 3-kinase (PI3K)/Akt signaling to the actin cytoskeleton.
[Effects of SODD and survivin on leukemia cell apoptosis induced by chemotherapeutic drugs].
GeneRIF
Hu et al., Wuhan, China. In Zhongguo Shi Yan Xue Ye Xue Za Zhi, 2007
Vincristine induces Jurkat cell apoptosis by downregulating expression of SODD protein and priming the death receptor pathway.
A genome-wide linkage scan for cleft lip and cleft palate identifies a novel locus on 8p11-23.
GeneRIF
Murray et al., Iowa City, United States. In Am J Med Genet A, 2007
results of analysis of the genome-wide scan data was a 20 cM region at 8p11-23 in which markers had LODs > or =1.0. Linkage and association analyses of these SNPs yield suggestive results for markers in FGFR1 and BAG4.
Multiple interacting oncogenes on the 8p11-p12 amplicon in human breast cancer.
GeneRIF
Ethier et al., Ann Arbor, United States. In Cancer Res, 2007
Gene induces transformed phenotype when overexpressed in a cancer breast cell line.
Constitutive androstane receptor (CAR) ligand, TCPOBOP, attenuates Fas-induced murine liver injury by altering Bcl-2 proteins.
GeneRIF
Gores et al., Rochester, United States. In Hepatology, 2006
The proapoptotic proteins Bak (Bcl-2 antagonistic killer) and Bax (Bcl-2-associated X protein) were depleted in livers from TCPOBOP-treated CAR+/+ mice.
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