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Superoxide dismutase 1, soluble

SOD, SOD1, Cu/Zn superoxide dismutase
The protein encoded by this gene binds copper and zinc ions and is one of two isozymes responsible for destroying free superoxide radicals in the body. The encoded isozyme is a soluble cytoplasmic protein, acting as a homodimer to convert naturally-occuring but harmful superoxide radicals to molecular oxygen and hydrogen peroxide. The other isozyme is a mitochondrial protein. Mutations in this gene have been implicated as causes of familial amyotrophic lateral sclerosis. Rare transcript variants have been reported for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: catalase, Ros, CAN, ACID, V1a
Papers using SOD antibodies
Crocetin reduces the oxidative stress induced reactive oxygen species in the stroke-prone spontaneously hypertensive rats (SHRSPs) brain
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Yamamoto Yorihiro et al., In Journal of Clinical Biochemistry and Nutrition, 2010
... Superoxide dismutase (SOD) and 2,2,6,6-tetramethy-4-piperidone-N-oxyl (4-oxo-TEMPO) were purchased from Sigma Aldrich (St ...
Circulating mitochondrial DAMPs cause inflammatory responses to injury
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Lotze Michael T. et al., In The Journal of Cell Biology, 2009
... The SOD activity assay kit was also obtained from Abcam.
Relationship between the Measured Friction Coefficient and Tread Groove Depth on Footwear Pad under Different Floor and Surface Conditions.
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Stadler Krisztian, In PLoS ONE, 2008
... The kits for other determinations included SOD and TBARS from Cayman (Michigan, USA), the rat ...
Lupeol, a novel anti-inflammatory and anti-cancer dietary triterpene
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Lin Yu-Chin et al., In Evidence-based Complementary and Alternative Medicine : eCAM, 2008
... The SOD, GPx, GRd, COX, TNF-α, and NF-κB enzyme-link immunosorbent assay (ELISA) Development Kits were purchased from Cayman Chemical Company (Michigan, USA) ...
Dual role of JNK1-mediated phosphorylation of Bcl-2 in autophagy and apoptosis regulation.
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Fimia Gian Maria, In PLoS ONE, 2007
... Superoxide dismutase (SOD) was purchased from Calbichem (Merck KGaA, Darmstadt, Germany) ...
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Papers on SOD
Mutant SOD1 mediated pathogenesis of Amyotrophic Lateral Sclerosis.
Review
New
Rashid et al., India. In Gene, Mar 2016
ALS is caused by multiple factors including mutation in any one of a number of specific genes, one of the most frequently affected is superoxide dismutase (SOD) 1. Alterations in SOD 1 have been linked with several variants of familial ALS.
Protective effect of melatonin on myenteric neuron damage in experimental colitis in rats.
New
Dong et al., Xi'an, China. In Fundam Clin Pharmacol, Feb 2016
Myeloperoxidase (MPO), superoxide dismutase (SOD) and malondialdehyde (MDA) levels were detected to evaluate the inflammatory and oxidative stress status.
Therapeutic evaluation of HIV transduction basic domain-conjugated superoxide dismutase solution on suppressive effects of the formation of peroxynitrite and expression of COX-2 in murine skin.
New
Chen et al., Taipei, Taiwan. In J Biomed Sci, Dec 2015
The involvement of superoxide dismutase (SOD) in restoring the antioxidant capacity can then neutralize the inflammatory response.
Pulsatile Hyperglycaemia Induces Vascular Oxidative Stress and GLUT 1 Expression More Potently than Sustained Hyperglycaemia in Rats on High Fat Diet.
New
Raun et al., Copenhagen, Denmark. In Plos One, Dec 2015
We hypothesized that liver's ability to regulate the glucose homeostasis under varying states of hyperglycaemia may indirectly affect oxidative stress status in aorta despite the amount of glucose challenged with.
Green Tea Polyphenols Attenuated Glutamate Excitotoxicity via Antioxidative and Antiapoptotic Pathway in the Primary Cultured Cortical Neurons.
New
Qin et al., Beijing, China. In Oxid Med Cell Longev, Dec 2015
Green tea polyphenols were then showed to inhibit the glutamate induced ROS release and SOD activity reduction in the neurons.
Berberine Attenuates Myocardial Ischemia/Reperfusion Injury by Reducing Oxidative Stress and Inflammation Response: Role of Silent Information Regulator 1.
New
Yu et al., Xi'an, China. In Oxid Med Cell Longev, Dec 2015
BBR treatment also reduced myocardium superoxide generation, gp91(phox) expression, malondialdehyde (MDA) level, and cardiac inflammatory markers and increased myocardium superoxide dismutase (SOD) level.
Nothing Boring About Boron.
Review
New
Pizzorno, Seattle, United States. In Integr Med (encinitas), Aug 2015
As the current article shows, boron has been proven to be an important trace mineral because it (1) is essential for the growth and maintenance of bone; (2) greatly improves wound healing; (3) beneficially impacts the body's use of estrogen, testosterone, and vitamin D; (4) boosts magnesium absorption; (5) reduces levels of inflammatory biomarkers, such as high-sensitivity C-reactive protein (hs-CRP) and tumor necrosis factor α (TNF-α); (6) raises levels of antioxidant enzymes, such as superoxide dismutase (SOD), catalase, and glutathione peroxidase; (7) protects against pesticide-induced oxidative stress and heavy-metal toxicity; (8) improves the brains electrical activity, cognitive performance, and short-term memory for elders; (9) influences the formation and activity of key biomolecules, such as S-adenosyl methionine (SAM-e) and nicotinamide adenine dinucleotide (NAD(+)); (10) has demonstrated preventive and therapeutic effects in a number of cancers, such as prostate, cervical, and lung cancers, and multiple and non-Hodgkin's lymphoma; and (11) may help ameliorate the adverse effects of traditional chemotherapeutic agents.
Copper transport and trafficking at the host-bacterial pathogen interface.
Impact
Giedroc et al., Bloomington, United States. In Acc Chem Res, 2015
Recent highlights of copper chemistry at the host-microbial pathogen interface include the first high resolution structures and functional characterization of a Cu(I)-effluxing P1B-ATPase, a new class of bacterial copper chaperone, a fungal Cu-only superoxide dismutase SOD5, and the discovery of a small molecule Cu-bound SOD mimetic.
Golgi Fragmentation in ALS Motor Neurons. New Mechanisms Targeting Microtubules, Tethers, and Transport Vesicles.
Review
Rabouille et al., Marseille, France. In Front Neurosci, 2014
Here, we present the different mechanisms that may underlie Golgi fragmentation in animal and cellular models of ALS linked to mutations in SOD1, TARDBP (TDP-43), VAPB, and C9Orf72 and we propose a novel one based on findings in progressive motor neuronopathy (pmn) mice.
ALS Patient Stem Cells for Unveiling Disease Signatures of Motoneuron Susceptibility: Perspectives on the Deadly Mitochondria, ER Stress and Calcium Triad.
Review
Sareen et al., Los Angeles, United States. In Front Cell Neurosci, 2014
Mutations in superoxide dismutase-1 (SOD1), TAR DNA-binding protein 43 (TARDBP/TDP-43) and C9orf72, have been identified in subsets of familial and sporadic patients.
Cholesterol and metal ions in Alzheimer's disease.
Review
Impact
Lim et al., Ann Arbor, United States. In Chem Soc Rev, 2014
For example, (a) cholesterol has been shown to be misregulated in AD-afflicted brains, and the aberrant activity of proteins (particularly, apolipoprotein E (ApoE) and 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR)) has been linked to cholesterol-related AD exacerbation; (b) dyshomeostasis of metal ions associated with misfolded proteins (i.e., amyloid-β (Aβ) aggregates) found in the brains of AD patients is shown to promote oxidative stress leading to the malfunction of multiple proteins, including cytochrome c oxidase (CcO), and Cu/Zn superoxide dismutase (SOD1); (c) metal ion misregulation has also been observed to disrupt the activity of proteins (e.g., HMGR, low-density lipoproteins (LDL)), required for cholesterol production and regulation.
Insight into the structure and mechanism of nickel-containing superoxide dismutase derived from peptide-based mimics.
Impact
Shearer, Reno, United States. In Acc Chem Res, 2014
Unlike the other known SODs (MnSOD, FeSOD, and (CuZn)SOD), which utilize "typical" biological nitrogen and oxygen donors, NiSOD utilizes a rather unexpected ligand set.
Pathways disrupted in human ALS motor neurons identified through genetic correction of mutant SOD1.
Impact
Eggan et al., United States. In Cell Stem Cell, 2014
Although many distinct mutations in a variety of genes are known to cause Amyotrophic Lateral Sclerosis (ALS), it remains poorly understood how they selectively impact motor neuron biology and whether they converge on common pathways to cause neuronal degeneration.
Modeling ALS with iPSCs reveals that mutant SOD1 misregulates neurofilament balance in motor neurons.
Impact
Zhang et al., Wuhan, China. In Cell Stem Cell, 2014
Using induced pluripotent cells (iPSCs) from patients with mutation in the Cu/Zn superoxide dismutase (SOD1) gene, we show that spinal MNs, but rarely non-MNs, exhibited neurofilament (NF) aggregation followed by neurite degeneration when glia were not present.
Role of Oxidative Stress in HIV-1-Associated Neurocognitive Disorder and Protection by Gene Delivery of Antioxidant Enzymes.
Review
Strayer et al., Philadelphia, United States. In Antioxidants (basel), 2013
We used SV40 vectors for gene delivery of antioxidant enzymes, Cu/Zn superoxide dismutase (SOD1), or glutathione peroxidase (GPx1) into the rat caudate putamen (CP).
Transformation from a neuroprotective to a neurotoxic microglial phenotype in a mouse model of ALS.
GeneRIF
Appel et al., Changsha, China. In Exp Neurol, 2012
During the early slowly progressing phase of disease in transgenic mice, the adult mSOD1 microglia display a neuroprotective M2 phenotype whereas in the rapidly progressing phase of disease, adult mSOD1 microglia adopt an M1 neurotoxic phenotype.
Human superoxide dismutase 1 (hSOD1) maturation through interaction with human copper chaperone for SOD1 (hCCS).
GeneRIF
Zovo et al., Sesto Fiorentino, Italy. In Proc Natl Acad Sci U S A, 2012
analysis of human superoxide dismutase 1 (hSOD1) maturation through interaction with human copper chaperone for SOD1 (hCCS)
Ataxin-3 regulates aggresome formation of copper-zinc superoxide dismutase (SOD1) by editing K63-linked polyubiquitin chains.
GeneRIF
Wang et al., Suzhou, China. In J Biol Chem, 2012
the sequestration of misfolded SOD1 into aggresomes, which is driven by ataxin-3, plays an important role in attenuating protein misfolding-induced cell toxicity.
Redox properties of the disulfide bond of human Cu,Zn superoxide dismutase and the effects of human glutaredoxin 1.
GeneRIF
Outten et al., Columbia, United States. In Biochem J, 2012
the differences in the GSH/glutaredoxin 1 reaction rate with normal compared with amyotrophic lateral sclerosis mutant SOD1 may contribute to the greater pathogenicity of the amyotrophic lateral sclerosis mutant SOD1
Relation of CuZnSOD activity with renal insufficiency in hypertensive diabetic patients.
GeneRIF
Korac et al., Belgrade, Serbia. In Indian J Biochem Biophys, 2012
the activity of copper zinc superoxide dismutase (CuZnSOD) in the erythrocytes of hypertensive diabetic patients with or without renal insufficiency
More papers using SOD antibodies
Presymptomatic biochemical changes in hindlimb muscle of G93A human Cu/Zn superoxide dismutase 1 transgenic mouse model of amyotrophic lateral sclerosis
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Milligan Carol et al., In Neurology Research International, 2007
... For histological analysis of NMJ denervation and glial activation 5 treated, 13 nontreated SOD1, and 10 non-transgenic littermates (wild type (WT)) ...
Inhibition of lipid synthesis through activation of AMP kinase: an additional mechanism for the hypolipidemic effects of berberine.
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Xu Aimin, In PLoS ONE, 2005
... Antibody raised against SOD was obtained from Santa Cruz Biotechnology Inc (Santa Cruz, CA) ...
Receptor for advanced glycation end products and its ligands: a journey from the complications of diabetes to its pathogenesis
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Ushio-Fukai Masuko, In PLoS ONE, 2004
... The antibodies used in the present study included: VEGFR2 (55B11), β-actin, Beclin-1, LC3B, SOD1, and peroxidase conjugated secondary antibodies (Cell Signaling, Danvers, MA); VEGFR2 (Flk-1:A-3), ...
Regulation of longevity in Caenorhabditis elegans by heat shock factor and molecular chaperones.
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Orr Harry, In PLoS Genetics, 2003
... The SOD1 transgenic strains were created by ...
A role for NF-kappa B subunits p50 and p65 in the inhibition of lipopolysaccharide-induced shock
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Zhang Ming et al., In Journal of Inflammation Research, 2003
... Transgenic mice strains overexpressing SOD1Two independently generated strains of transgenic (tg) mice overexpressing the ...
Effects of Lentinus edodes mycelia on dietary-induced atherosclerotic involvement in rabbit aorta
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Lu Han-Lin et al., In The Scientific World Journal, 2001
Moreover, the anti-rat SOD and GPx antibodies to measure hepatic SOD and GPx proteins were purchased from Biodesign (Saco, ME, USA) ...
The luminal domain of ATF6 senses endoplasmic reticulum (ER) stress and causes translocation of ATF6 from the ER to the Golgi
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Horke S et al., In Cell Death & Disease, 2001
... Staurosporine, tunicamycin, actinomycin D, antimycin A, polyethylene glycol (PEG)-conjugated SOD (PEG-SOD), doxorubicin, -acetyl-cysteine, imatinib, and SP600125 were purchased from Sigma; Mito-HE was from Molecular Probes (Invitrogen / Life Technologies); TRAIL and TNF ...
Dorfin ubiquitylates mutant SOD1 and prevents mutant SOD1-mediated neurotoxicity
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Hara Hideaki et al., In Scientific Reports, 2001
... Disease mechanisms revealed by transcription profiling in SOD1-G93A transgenic mouse spinal cord ...
Muscle activity and muscle agrin regulate the organization of cytoskeletal proteins and attached acetylcholine receptor (AChR) aggregates in skeletal muscle fibers
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Abe Koji et al., In Neurology International, 2000
... For histological studies and Western blot analysis, SOD1G93A mice and non-transgenic mice were deeply anesthetized ...
Analysis of relative gene expression data using real-time quantitative PCR and the 2-ΔΔCT method
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Gurtu Sunil et al., In Oxidative Medicine and Cellular Longevity, 2000
... SOD and GPx assay kits were purchased from Cayman (MI, USA) ...
The p38 signal transduction pathway: activation and function.
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Liu Ping et al., In Molecular Vision, 1999
... Anti-JNK, anti-phosphorylation of JNK (p-JNK), anti- phosphorylation of P38 (p-p38) (Thr180/Tyr182), anti-p38, anti-catalase, anti-SOD-1, and anti-HO-1 antibodies were purchased from Santa Cruz Biotechnology Inc ...
Involvement of Onuf's nucleus in amyotrophic lateral sclerosis.
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Gillingwater Thomas H., In PLoS ONE, 1996
... month-old) and aged (22 to 28-month-old) C57BL/6 mice from the National Institute of Aging and SOD-G93A transgenic mice from the Jackson ...
Neurofilaments and orthograde transport are reduced in ventral root axons of transgenic mice that express human SOD1 with a G93A mutation
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Fisher Elizabeth M. C. et al., In Disease Models & Mechanisms, 1996
... Effect of transgene copy number on survival in the G93A SOD1 transgenic mouse model of ALS ...
Bcl-2: prolonging life in a transgenic mouse model of familial amyotrophic lateral sclerosis
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Pasinelli Piera et al., In Human Molecular Genetics, 1996
... CuZn superoxide dismutase (SOD1) accumulates in vacuolated mitochondria in transgenic mice expressing amyotrophic lateral ...
Isolation of a candidate gene for Menkes disease and evidence that it encodes a copper-transporting ATPase
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González Mauricio et al., In Environmental Health Perspectives, 1992
... Division, Abbott Park, IL, USA); zinc–Cu superoxide dismutase (SOD) activity in erythrocytes measured by a Bioxytech SOD-525 Assay (OXIS International Inc, Portland, OR, ...
Cerebral blood flow, the cerebrospinal fluid, and brain metabolism
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Chio Chung-Ching et al., In Journal of Biomedicine and Biotechnology, 1990
... The SOD and catalase activity were performed with a SOD activity commercial kit (Oxis Research, Portland, USA) and ...
Exudation primes human and guinea pig PMNs for subsequent responsiveness to the chemotactic peptide N-formylmethionylleucylphenylalainine and increases complement component C3bi receptor expression
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Kubes Paul et al., In The Journal of Cell Biology, 1985
... Cell shortening measurements were performed in myocytes from WT (C57BL6) or SOD overexpressing transgenic mice in the presence ...
Chemical effects of ultrasound on aqueous solutions. Evidence for •OH and •H by spin trapping
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Kohno Masahiro et al., In Journal of Clinical Biochemistry and Nutrition, 1981
... -oxyl (TEMPOL), 4-oxo-2,2,6,6-tetramethyl-1-piperidinyloxy (4-oxo-TEMPO), DPIBF, hypoxanthine (HPX), sodium azide and superoxide dismutase (SOD) from Sigma Aldrich (St ...
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