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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Suppressor of cytokine signaling 4

SOCS7, SOCS4, SOCS6, suppressor of cytokine signaling 7
The protein encoded by this gene contains a SH2 domain and a SOCS BOX domain. The protein thus belongs to the suppressor of cytokine signaling (SOCS), also known as STAT-induced STAT inhibitor (SSI), protein family. SOCS family members are known to be cytokine-inducible negative regulators of cytokine signaling. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CIs, SOCS3, cis-2, CAN, Insulin
Papers on SOCS7
Convergent evolution of SOCS4 between yak and Tibetan antelope in response to high-altitude stress.
Qiu et al., Lanzhou, China. In Gene, Dec 2015
We found that one gene, SOCS4, which is involved in the regulation of HIF-1α, showed a signature of convergent evolution.
SOCS4 is dispensable for an efficient recall response to influenza despite being required for primary immunity.
Nicholson et al., Australia. In Immunol Cell Biol, Nov 2015
Mice lacking functional SOCS4 are hypersusceptible to primary infection with influenza A virus (IAV), displaying dysregulated pro-inflammatory cytokine and chemokine production in the lungs, delayed viral clearance and impaired trafficking of influenza-specific CD8(+) T cells to the site of infection.
Cortical Layer Inversion and Deregulation of Reelin Signaling in the Absence of SOCS6 and SOCS7.
Voss et al., Melbourne, Australia. In Cereb Cortex, Nov 2015
Using mice that are single or double deficient, we discovered that combined loss of the suppressors of cytokine signaling, SOCS6 and SOCS7, recapitulated the cortical layer inversion seen in mice lacking reelin and led to a dramatic increase in the reelin signaling molecule disabled (DAB1) in the cortex.
MiR-21 and miR-183 can simultaneously target SOCS6 and modulate growth and invasion of hepatocellular carcinoma (HCC) cells.
Jia et al., Zaozhuang, China. In Eur Rev Med Pharmacol Sci, Sep 2015
This study aimed to explore the regulative role of miR-21 and miR-183 over suppressors of cytokine signaling 6 (SOCS6), a negative regulator of cytokine receptor signaling.
Maternal organism and embryo biosensoring: insights from ruminants.
Charpigny et al., Jouy-le-Moutier, France. In J Reprod Immunol, Apr 2015
MiR-142-3p Suppresses SOCS6 Expression and Promotes Cell Proliferation in Nasopharyngeal Carcinoma.
Tian et al., In Cell Physiol Biochem, 2014
Suppressor of cytokine signaling 6 (SOCS6) was identified as a direct target of miR-142-3p, and miR- 142-3p down-regulated the expression of SOCS6 by directly binding to its 3′untranslated region (UTR).
Targeted Analysis Reveals an Important Role of JAK-STAT-SOCS Genes for Milk Production Traits in Australian Dairy Cattle.
Williamson et al., Sydney, Australia. In Front Genet, 2014
Gene expression studies using qRT-PCR revealed differential expression of SOCS2, SOCS4, and SOCS5 genes across the lactation cycle in dairy cows.
Interleukin-23 Facilitates Thyroid Cancer Cell Migration and Invasion by Inhibiting SOCS4 Expression via MicroRNA-25.
Tao et al., Wuhan, China. In Plos One, 2014
Additional data demonstrate that SOCS4 negatively regulates IL-23-mediated migration and invasion.
MiRNA-155 mediates TAM resistance by modulating SOCS6-STAT3 signalling pathway in breast cancer.
Wang et al., Jinan, China. In Am J Transl Res, 2014
Further, we identified SOCS6 as a new direct target of miR-155.
SOCS6 is a selective suppressor of receptor tyrosine kinase signaling.
Kazi et al., Barisāl, Bangladesh. In Tumour Biol, 2014
SOCS6 is one of eight members of the SOCS family of proteins.
How does Reelin control neuronal migration and layer formation in the developing mammalian neocortex?
Nakajima et al., Tokyo, Japan. In Neurosci Res, 2014
Reelin is also involved in the termination of neuronal migration by degrading Dab1 via the SOCS7-Cullin5-Rbx2 system, and Reelin has been found to induce the birth-date-dependent neuronal aggregation in vivo.
LNCaP prostate cancer cells with autocrine interleukin-6 expression are resistant to IL-6-induced neuroendocrine differentiation due to increased expression of suppressors of cytokine signaling.
You et al., New Orleans, United States. In Prostate, 2012
LNCaP-S17 cells are resistant to exogenous IL-6-induced neuroendocrine differentiation due to increased levels of CIS/SOCS7 that block activation of JAK2-STAT3 pathways.
Suppressor of cytokine signaling 4 (SOCS4): moderator of ovarian primordial follicle activation.
McLaughlin et al., Newcastle, Australia. In J Cell Physiol, 2012
Negative regulation of the JAK/STAT pathway is controlled by SOCS4, which target members of negative feedback loops, to suppress follicle growth and development.
The N-terminal domains of SOCS proteins: a conserved region in the disordered N-termini of SOCS4 and 5.
Norton et al., Australia. In Proteins, 2012
Identified is a conserved region of about 70 residues in the N-terminal domains of Socs4 and 5 that is predicted to be more ordered than the surrounding sequence.
Suppressor of cytokine signaling 4 detected as a novel gastric cancer suppressor gene using double combination array analysis.
Nakao et al., Nagoya, Japan. In World J Surg, 2012
The expression of SOCS4 seems to be controlled epigenetically and is often weakly expressed in gastric cancer tissue and cell lines. SOCS4 methylation status could be a predictor of gastric cancer prognosis.
Regulation of epidermal growth factor receptor signalling by inducible feedback inhibitors.
Alemà et al., Roma, Italy. In J Cell Sci, 2011
In mammalian cells, four EGFR inducible feedback inhibitors (IFIs), namely LRIG1, RALT (also known as MIG6 and ERRFI1), SOCS4 and SOCS5, have been discovered recently.
Suppressor of cytokine signalling-6 promotes neurite outgrowth via JAK2/STAT5-mediated signalling pathway, involving negative feedback inhibition.
Banerjee et al., New Delhi, India. In Plos One, 2010
Findings define a molecular mechanism for Jak2/Stat5 mediated Suppressor of cytokine signalling-6 (SOCS6) signalling.
Steatosis and insulin resistance in hepatitis C: a way out for the virus?
Romero-Gómez et al., Sevilla, Spain. In World J Gastroenterol, 2009
The HCV core protein interferes with in vitro insulin signalling by genotype-specific mechanisms, where the role of suppressor of cytokine signal 7 (SOCS-7) in genotype 3a and mammalian target of rapamycin (mTOR) in genotype 1 in IRS-1 downregulation play key roles.
Septins regulate actin organization and cell-cycle arrest through nuclear accumulation of NCK mediated by SOCS7.
Macara et al., Charlottesville, United States. In Cell, 2007
Demonstrate connection between septins/SOCS7/NCK signaling and the DNA damage response.
Connecting the dots between septins and the DNA damage checkpoint.
Takeda et al., Kyoto, Japan. In Cell, 2007
In this issue of Cell, Kremer et al. (2007) link septins to DNA damage in mammalian cells by identifying a new signaling pathway that includes the adaptors SOCS7 and NCK.
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