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Sorting nexin 7

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region like some family members, and its exact function is unknown. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 11. [provided by RefSeq, Jun 2010] (from NCBI)
Top mentioned proteins: PrP, GnRH receptor, FLIP, FLIP, DAAM2
Papers on SNX7
A genome-wide association study of kynurenic acid in cerebrospinal fluid: implications for psychosis and cognitive impairment in bipolar disorder.
Landén et al., Stockholm, Sweden. In Mol Psychiatry, Jan 2016
After replication in an independent cohort, we linked this genetic variant-associated with reduced SNX7 expression-to positive psychotic symptoms and executive function deficits in bipolar disorder.
[Expression, purification and phosphoinositide binding specifity of recombinant human SNX7 expressed in Escherichia coli].
Xu et al., In Sheng Wu Gong Cheng Xue Bao, 2014
SNX7, a member of SNXs family, contains a PX domain and a BAR domain.
Genetic variants contribute to gene expression variability in humans.
Cai et al., College Station, United States. In Genetics, 2013
Using a data set of gene expression in lymphoblastoid cell lines (LCLs) derived from 210 HapMap individuals, we identify cis-acting evQTL involving 218 distinct genes, among which 8 genes, ADCY1, CTNNA2, DAAM2, FERMT2, IL6, PLOD2, SNX7, and TNFRSF11B, are cross-validated using an extra expression data set of the same LCLs.
An antiapoptotic role of sorting nexin 7 is required for liver development in zebrafish.
Shu et al., Beijing, China. In Hepatology, 2012
In this study, we demonstrated that SNX7 was essential for embryonic liver development.
Do GnRH analogues directly affect human endometrial epithelial cell gene expression?
Oehninger et al., Norfolk, United States. In Mol Hum Reprod, 2010
The specific aims were: (i) to study the modulatory effect of GnRH analogues by RT-PCR [in the absence and presence of E(2) and P4, and cyclic adenosine monophosphate (cAMP)] on mRNA expression of genes modulated during the window of implantation in GnRH analogues/rFSH-treated assisted reproductive technology cycles including OPTINEURIN (OPTN), CHROMATIN MODIFYING PROTEIN (CHMP1A), PROSAPOSIN (PSAP), IGFBP-5 and SORTING NEXIN 7 (SNX7), and (ii) to analyze the 5'-flanking regions of such genes for the presence of putative steroid-response elements [estrogen-response elements (EREs) and P4-response element (PREs)].
High definition cytogenetics and oligonucleotide aCGH analyses of cisplatin-resistant ovarian cancer cells.
Squire et al., Toronto, Canada. In Genes Chromosomes Cancer, 2008
Cryptic genomic aberrations associated with concurrent localized changes of specific gene expression included a homozygous deletion of 0.38 Mb at 1p21.3 adjacent to SNX7, and an insertional transposition of 0.85 Mb from 13q12.12 into chromosome 22.
New locus for hereditary spastic paraplegia maps to chromosome 1p31.1-1p21.1.
Bernardi et al., Roma, Italy. In Ann Neurol, 2005
Sequencing of one candidate gene in the region (sorting nexin 7, SNX7), involved in several stages of intracellular trafficking and protein transport, showed no disease-causing mutations.
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