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Sorting nexin 6

SNX6, sorting nexin 6, TRAF4-associated factor 2, TFAF2
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein associates with the long isoform of the leptin receptor, the transforming growth factor-beta family of receptor serine-threonine kinases, and with receptor tyrosine kinases for platelet-derived growth factor, insulin, and epidermal growth factor. This protein may form oligomeric complexes with family member proteins through interactions of both the PX domain and the coiled coil regions of the molecules. Translocation of this protein from the cytoplasm to the nucleus occurs after binding to proviral integration site 1 protein. This gene results in two transcripts encoding two distinct isoforms. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: SNX5, SNX1, SNX2, V1a, Vps26
Papers on SNX6
Fbxo3-Dependent Fbxl2 Ubiquitination Mediates Neuropathic Allodynia through the TRAF2/TNIK/GluR1 Cascade.
New
Peng et al., Taipei, Taiwan. In J Neurosci, Jan 2016
In contrast, intrathecal administration of BC-1215 (N1,N2-Bis[[4-(2-pyridinyl)phenyl]methyl]-1,2-ethanediamine) (a novel Fbxo3 inhibitor) prevented SNL-induced Fbxl2 ubiquitination and subsequent TFAF2 de-ubiquitination to ameliorate behavioral allodynia via antagonizing TRAF2/TNIK/GluR1 signaling.
Rapid mapping of interactions between Human SNX-BAR proteins measured in vitro by AlphaScreen and single-molecule spectroscopy.
Gambin et al., Australia. In Mol Cell Proteomics, 2014
SNX2, SNX4, SNX6, and SNX8 show a promiscuous ability to bind other SNX-BAR proteins and we also observe a novel interaction with the SNX3 protein which lacks the BAR domain structure.
Isoform 5 of PIPKIγ regulates the endosomal trafficking and degradation of E-cadherin.
Anderson et al., Madison, United States. In J Cell Sci, 2014
Additionally, we show that the endosomal trafficking proteins SNX5 and SNX6 associate with PIPKIγi5 and inhibit PIPKIγi5-mediated E-cadherin degradation.
Computational evaluation of new homologous down regulators of Translationally Controlled Tumor Protein (TCTP) targeted for tumor reversion.
Wishard et al., Indore, India. In Interdiscip Sci, 2013
The present investigation is a novel protein-protein docking approach to target TCTP by a set of proteins similar to the protein: sorting nexin 6 (SNX6) which is an established down regulator of TCTP.
Sorting nexin 6 enhances lamin a synthesis and incorporation into the nuclear envelope.
Andrés et al., Madrid, Spain. In Plos One, 2013
Here, we demonstrate that trafficking of lamin A, but not lamin B1, and its assembly into the nuclear envelope are regulated by sorting nexin 6 (SNX6), a major component of the retromer that targets proteins and other molecules to specific subcellular locations.
PtdIns(4)P regulates retromer-motor interaction to facilitate dynein-cargo dissociation at the trans-Golgi network.
Impact
Liu et al., Beijing, China. In Nat Cell Biol, 2013
We report that phosphotidylinositol-4-phosphate (PtdIns(4)P), a Golgi-enriched phosphoinositide, negatively regulates the protein-protein interaction between the p150(Glued) subunit of dynein-dynactin and the retromer component SNX6.
Identification of candidate genes and mutations in QTL regions for chicken growth using bioinformatic analysis of NGS and SNP-chip data.
Marklund et al., Uppsala, Sweden. In Front Genet, 2012
The candidate mutations were identified within the GCG, IGFBP2, GRB14, CRIM1, FGF16, VEGFR-2, ALG11, EDN1, SNX6, and BIRC7 genes.
14q13.1-21.1 deletion encompassing the HPE8 locus in an adolescent with intellectual disability and bilateral microphthalmia, but without holoprosencephaly.
Corsello et al., Palermo, Italy. In Am J Med Genet A, 2012
The deletion of the potential HPE candidate genes NPAS3, EAPP, SNX6, and TULIP1, raises doubts about their pathologic role in determining HPE.
Identification of VHY/Dusp15 as a regulator of oligodendrocyte differentiation through a systematic genomics approach.
Hooft van Huijsduijnen et al., Genève, Switzerland. In Plos One, 2011
Finally, we identified PDGFR-beta and SNX6 as novel and specific Dusp15 substrates, providing an indication as to how this PTP might exert control over OL differentiation.
Brain proteome alterations of Atlantic cod (Gadus morhua) exposed to PCB 153.
Goksøyr et al., Bergen, Norway. In Aquat Toxicol, 2011
The last three of these six proteins (deltex, Rab14 and sorting nexin 6) may preliminarily identify involvement of the Notch signaling pathway and endosomal function in PCB 153-induced neurotoxicity.
The structure of BRMS1 nuclear export signal and SNX6 interacting region reveals a hexamer formed by antiparallel coiled coils.
Bravo et al., Valencia, Spain. In J Mol Biol, 2011
We present here the first structural report derived from breast cancer metastasis suppressor 1 (BRMS1), a member of the metastasis suppressor protein group, which, during recent years, have drawn much attention since they suppress metastasis without affecting the growth of the primary tumor.
A SNX3-dependent retromer pathway mediates retrograde transport of the Wnt sorting receptor Wntless and is required for Wnt secretion.
Impact
Korswagen et al., Utrecht, Netherlands. In Nat Cell Biol, 2011
Here, we report that Wls recycling is mediated through a retromer pathway that is independent of the retromer sorting nexins SNX1-SNX2 and SNX5-SNX6.
Sorting nexin 6 interacts with breast cancer metastasis suppressor-1 and promotes transcriptional repression.
GeneRIF
Bravo et al., Madrid, Spain. In J Cell Biochem, 2011
Study observed that SNX6 increases BRMS1-dependent transcriptional repression. Moreover, over-expression of SNX6 was capable of diminishing trans-activation in a dose-dependent manner.
Proteomic identification of sorting nexin 6 as a negative regulator of BACE1-mediated APP processing.
GeneRIF
Kim et al., New York City, United States. In Faseb J, 2010
SNX6 modulates the retrograde trafficking and basal levels of BACE1, thereby regulating BACE1-mediated APP processing and Abeta biogenesis
The retromer component SNX6 interacts with dynactin p150(Glued) and mediates endosome-to-TGN transport.
GeneRIF
Liu et al., Beijing, China. In Cell Res, 2009
These observations indicate that in addition to SNX1/2, SNX6 in association with the dynein/dynactin complex drives the formation and movement of tubular retrograde intermediates.
An epidermal growth factor (EGF) -dependent interaction between GIT1 and sorting nexin 6 promotes degradation of the EGF receptor.
GeneRIF
Berk et al., Rochester, United States. In Faseb J, 2008
These data demonstrate an endosomal, EGF-regulated interaction between SNX6 and GIT1 that enhances degradation of the EGFR, and thereby alters EGFR signaling.
Retromer.
Review
Hurley et al., Bethesda, United States. In Curr Opin Cell Biol, 2008
The mammalian retromer complex comprises a sorting nexin dimer composed of a still undefined combination of SNX1, SNX2, SNX5 and SNX6, and a cargo-recognition trimer composed of Vps26, Vps29 and Vps35.
A loss-of-function screen reveals SNX5 and SNX6 as potential components of the mammalian retromer.
GeneRIF
Cullen et al., Bristol, United Kingdom. In J Cell Sci, 2007
SNX5 and SNX6 may constitute functional equivalents of Vps17p in mammalian retromer
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