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Sorting nexin 4

SNX4, Snx4p, Sorting nexin 4, ATG24
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein associated with the long isoform of the leptin receptor and with receptor tyrosine kinases for platelet-derived growth factor, insulin, and epidermal growth factor in cell cultures, but its function is unknown. This protein may form oligomeric complexes with family members. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: V1a, Transferrin, SNX1, CAN, SNX2
Papers using SNX4 antibodies
The adaptor complex AP-2 regulates post-endocytic trafficking through the non-clathrin Arf6-dependent endocytic pathway.
Supplier
Rappoport Joshua Z., In PLoS ONE, 2007
... Antibodies used in this study were anti-SNX4 (E-18; Santa Cruz Biotechnology, Santa Cruz, CA for ...
Papers on SNX4
ATG24 Represses Autophagy and Differentiation and Is Essential for Homeostasy of the Flagellar Pocket in Trypanosoma brucei.
Michels et al., Brussels, Belgium. In Plos One, 2014
We therefore characterized T. brucei ATG24, the T. brucei ortholog of yeast Atg24 and mammalian SNX4, and found it to have a regulatory role in autophagy and differentiation as well as endocytic trafficking.
Rapid mapping of interactions between Human SNX-BAR proteins measured in vitro by AlphaScreen and single-molecule spectroscopy.
Gambin et al., Australia. In Mol Cell Proteomics, 2014
SNX2, SNX4, SNX6, and SNX8 show a promiscuous ability to bind other SNX-BAR proteins and we also observe a novel interaction with the SNX3 protein which lacks the BAR domain structure.
α-Taxilin interacts with sorting nexin 4 and participates in the recycling pathway of transferrin receptor.
Shirataki et al., Mibu, Japan. In Plos One, 2013
α-Taxilin was immunoprecipitated with sorting nexin 4 (SNX4), which is involved in the recycling of TfnR.
Atg24-assisted mitophagy in the foot cells is necessary for proper asexual differentiation in Magnaporthe oryzae.
Naqvi et al., Singapore, Singapore. In Autophagy, 2013
We show that loss of MoAtg24, a sorting nexin related to yeast Snx4, disrupts mitophagy and consequently leads to highly reduced conidiation, suggesting that mitophagy in the foot cells plays an important role during asexual development in Magnaporthe.
Reggies/flotillins interact with Rab11a and SNX4 at the tubulovesicular recycling compartment and function in transferrin receptor and E-cadherin trafficking.
Stuermer et al., Konstanz, Germany. In Mol Biol Cell, 2013
We find that reggie-1 and -2 associate with the Rab11a, SNX4, and EHD1-decorated tubulovesicular recycling compartment in HeLa cells and that reggie-1 directly interacts with Rab11a and SNX4.
Microtubule motors mediate endosomal sorting by maintaining functional domain organization.
Stephens et al., Bristol, United Kingdom. In J Cell Sci, 2013
Endosomal domains labelled with SNX1, SNX4 and SNX8 couple to discrete combinations of dynein and kinesin motors.
Qualitative and quantitative characterization of protein-phosphoinositide interactions with liposome-based methods.
Kühnel et al., Göttingen, Germany. In Autophagy, 2013
Besides the PROPPINs there are other PtdIns3P binding proteins with a link to autophagy, which includes the FYVE-domain containing proteins ZFYVE1/DFCP1 and WDFY3/ALFY and the PX-domain containing proteins Atg20 and Snx4/Atg24.
PtdIns(4)P regulates retromer-motor interaction to facilitate dynein-cargo dissociation at the trans-Golgi network.
Impact
Liu et al., Beijing, China. In Nat Cell Biol, 2013
PtdIns(4)P also regulates SNX4-mediated retrograde vesicular trafficking to the endocytic recycling compartment by modulating its interaction with dynein.
Using multifocal plane microscopy to reveal novel trafficking processes in the recycling pathway.
Ward et al., Dallas, United States. In J Cell Sci, 2013
Significantly, TCs with different itineraries can be identified by associations with distinct complements of Rab GTPases, APPL1 and SNX4.
The role of snx41-based pexophagy in magnaporthe development.
Naqvi et al., Singapore, Singapore. In Plos One, 2012
Besides its role in selective autophagy, Atg20/Snx42 is also involved in an autophagy-independent endosomal retrieval trafficking, in cooperation with two other sorting nexins, Snx41 and Snx4.
[Study on gene differential expressions of substance and energy metabolism in chronic superficial gastritis patients of Pi deficiency syndrome and of pi-wei hygropyrexia syndrome].
Wang et al., Guangzhou, China. In Zhongguo Zhong Xi Yi Jie He Za Zhi, 2012
Genes correlated to protein metabolism included ASRGL1, AARSD1, EBNA1BP2, PUM2, MRPL52, C120RF65, PSMB8, PSME2, UBA7, RNF11, FBXO44, ZFYVE26, CHMP2A, SSR4, SNX4, RAB3B, RABL2A, GOLGA2, KDELR1, PHPT1, ACPP, PTPRF, CRKL, HDAC7, ADPRHL2, B3GNT1, ST8SIA4, DDOST, and FUT9, mainly involved in the biosynthesis processes of protein, ubiquitination, targeted transport and post-translation modification.
SNX-BAR-mediated endosome tubulation is co-ordinated with endosome maturation.
GeneRIF
Cullen et al., Bristol, United Kingdom. In Traffic, 2012
SNX4, but not SNX1 and SNX8, is associated with the Rab11-recycling endosomes and that a high frequency of SNX4-mediated tubule formation is observed as endosomes undergo Rab4-to-Rab11 transition.
Two novel WD40 domain-containing proteins, Ere1 and Ere2, function in the retromer-mediated endosomal recycling pathway.
Emr et al., Ithaca, United States. In Mol Biol Cell, 2011
Using a chemical-genetic screen in yeast, we show that the arginine transporter Can1 is recycled back to the cell surface via two independent pathways mediated by the sorting nexins Snx4/41/42 and the retromer complex, respectively.
Mutational evolution in a lobular breast tumour profiled at single nucleotide resolution.
Impact
Aparicio et al., Vancouver, Canada. In Nature, 2009
Five of the 32 mutations (in ABCB11, HAUS3, SLC24A4, SNX4 and PALB2) were prevalent in the DNA of the primary tumour removed at diagnosis 9 years earlier, six (in KIF1C, USP28, MYH8, MORC1, KIAA1468 and RNASEH2A) were present at lower frequencies (1-13%), 19 were not detected in the primary tumour, and two were undetermined.
SNX4 in complex with clathrin and dynein: implications for endosome movement.
GeneRIF
Sandvig et al., Oslo, Norway. In Plos One, 2008
clathrin serving as a regulator of SNX4-dependent transport; upon clathrin release, dynein may bind SNX4 and mediate retrograde movement
SNX4 coordinates endosomal sorting of TfnR with dynein-mediated transport into the endocytic recycling compartment.
Impact
GeneRIF
Cullen et al., Bristol, United Kingdom. In Nat Cell Biol, 2007
by driving membrane tubulation, SNX4 coordinates iterative, geometric-based sorting of the TfnR with the long-range transport of carriers from early endosomes to the ERC
Phosphoinositide-regulated retrograde transport of ricin: crosstalk between hVps34 and sorting nexins.
GeneRIF
Sandvig et al., Oslo, Norway. In Traffic, 2007
study indicates that hVps34 and its product PI(3)P are involved in endosome to Golgi transport of ricin, and that SNX2 and SNX4 are likely to be effectors in this pathway
Sorting nexin 4 and amphiphysin 2, a new partnership between endocytosis and intracellular trafficking.
GeneRIF
Camonis et al., Paris, France. In J Cell Sci, 2003
Sorting nexin 4 and amphiphysin 2 have roles in endocytosis and intracellular trafficking
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