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Sorting nexin 3

SNX3, sorting nexin 3, Grd19
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like most family members. This protein interacts with phosphatidylinositol-3-phosphate, and is involved in protein trafficking. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: SNX1, SNX5, SNX2, Transferrin, Epidermal Growth Factor
Papers on SNX3
Retromer Ensures the Degradation of Autophagic Cargo by Maintaining Lysosome Function in Drosophila.
New
Sass et al., Budapest, Hungary. In Traffic, Oct 2015
Finally, we find that Snx3 and Snx6 are also required for proper autolysosomal degradation in Drosophila larval fat body cells.
Secondary structure and (1)H, (13)C, (15)N resonance assignments of the endosomal sorting protein sorting nexin 3.
New
Lenoir et al., Genève, Switzerland. In Biomol Nmr Assign, Oct 2015
Sorting nexin 3 (SNX3) belongs to a sub-family of sorting nexins that primarily contain a single Phox homology domain capable of binding phosphoinositides and membranes.
Vaccinia Virus Infection Requires Maturation of Macropinosomes.
New
Mercer et al., Zürich, Switzerland. In Traffic, Aug 2015
The vacuoles first acquired markers of early endosomes [Rab5, early endosome antigen 1 and phosphatidylinositol(3)P]. Prior to release of virus cores into the cytoplasm, they contained markers of late endosomes and lysosomes (Rab7a, lysosome-associated membrane protein 1 and sorting nexin 3).
[The morphological changes of SW620 cells induced by over-expression of human sorting nexin 3].
New
Guo et al., Chongqing, China. In Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi, Aug 2015
OBJECTIVE: To explore the effect of human sorting nexin 3 (hSNX3) on the morphology and migration of colorectal cancer cells through over-expression of hSNX3 in SW620 cells.
Rapid mapping of interactions between Human SNX-BAR proteins measured in vitro by AlphaScreen and single-molecule spectroscopy.
Gambin et al., Australia. In Mol Cell Proteomics, 2014
SNX2, SNX4, SNX6, and SNX8 show a promiscuous ability to bind other SNX-BAR proteins and we also observe a novel interaction with the SNX3 protein which lacks the BAR domain structure.
A mechanism for retromer endosomal coat complex assembly with cargo.
Burd et al., New Haven, United States. In Proc Natl Acad Sci U S A, 2014
We show that membrane recruitment of retromer is mediated by bivalent recognition of an effector of PI3K, SNX3, and the RAB7A GTPase, by the VPS35 retromer subunit.
Inhibition of late endosomal maturation restores Wnt secretion in Caenorhabditis elegans vps-29 retromer mutants.
Korswagen et al., Utrecht, Netherlands. In Cell Signal, 2014
It has recently been shown that this is mediated by an alternative retromer pathway in which the sorting nexin SNX3 interacts with the cargo-selective subcomplex of the retromer to sort Wls into a retrieval pathway that is morphologically distinct from the classical SNX-BAR dependent retromer pathway.
SNX15 links clathrin endocytosis to the PtdIns3P early endosome independently of the APPL1 endosome.
Cullen et al., Bristol, United Kingdom. In J Cell Sci, 2013
In designing an RNAi-mediated loss-of-function screen, we establish that of 30 human SNXs only SNX3, SNX5, SNX9, SNX15 and SNX21 appear to regulate EGF receptor degradative sorting.
SNX3 recruits to phagosomes and negatively regulates phagocytosis in dendritic cells.
Wong et al., Singapore, Singapore. In Immunology, 2013
We hypothesized that SNX3, a small sorting nexin that contains a single PI3P lipid-binding PX domain as its only protein domain, localizes to phagosomes and regulates phagocytosis in DC.
Snx3 regulates recycling of the transferrin receptor and iron assimilation.
Impact
Paw et al., Boston, United States. In Cell Metab, 2013
Here we report that sorting nexin 3 (Snx3) facilitates the recycling of transferrin receptor (Tfrc) and thus is required for the proper delivery of iron to erythroid progenitors.
Identification of Alzheimer disease-associated variants in genes that regulate retromer function.
Farrer et al., Boston, United States. In Neurobiol Aging, 2012
We obtained significant evidence of association with KIAA1033 (VEGAS p = 0.025), SNX1 (VEGAS p = 0.035), SNX3 (p = 0.0057), and RAB7A (VEGAS p = 0.018).
SNX3-dependent regulation of epidermal growth factor receptor (EGFR) trafficking and degradation by aspirin in epidermoid carcinoma (A-431) cells.
GeneRIF
Wong et al., Singapore, Singapore. In Cell Mol Life Sci, 2012
SNX3 and SNX5 play essential roles in the aspirin-mediated accumulation of endocytosed-TfnR at the early/sorting endosome
SNX12 role in endosome membrane transport.
Gruenberg et al., Genève, Switzerland. In Plos One, 2011
SNX12 is a member of the PX domain-containing sorting nexin family and shares high homology with SNX3, which plays a central role in the formation of intralumenal vesicles within multivesicular endosomes.
A SNX3-dependent retromer pathway mediates retrograde transport of the Wnt sorting receptor Wntless and is required for Wnt secretion.
Impact
Korswagen et al., Utrecht, Netherlands. In Nat Cell Biol, 2011
We have found that the unrelated sorting nexin, SNX3, has an evolutionarily conserved function in Wls recycling and Wnt secretion and show that SNX3 interacts directly with the cargo-selective subcomplex of the retromer to sort Wls into a morphologically distinct retrieval pathway.
The SNXy flavours of endosomal sorting.
Impact
Wunder et al., In Nat Cell Biol, 2011
The sorting nexin SNX3 is required for the retrograde trafficking of Wntless, but not of other retrograde cargo proteins, revealing that the cargo specificity of retromer is provided by the sorting nexins.
Developmental expression of sorting nexin 3 in the mouse central nervous system.
GeneRIF
Tanoue et al., Tokyo, Japan. In Gene Expr Patterns, 2011
Snx3 mRNA is expressed during neural development and in adult neural tissues, suggesting that SNX3 may play an important role in the development and function of the central nervous system.
Sorting nexin 3 (SNX3) is a component of a tubular endosomal network induced by Salmonella and involved in maturation of the Salmonella-containing vacuole.
GeneRIF
Brumell et al., Toronto, Canada. In Cell Microbiol, 2010
SNX3 plays a significant role in regulating the maturation of Salmonella containing vacuoles.
Sorting nexin 3, a protein upregulated by lithium, contains a novel phosphatidylinositol-binding sequence and mediates neurite outgrowth in N1E-115 cells.
GeneRIF
Tanoue et al., Tokyo, Japan. In Cell Signal, 2009
SNX3 promotes neurite outgrowth even in the presence of serum and that its short basic C-terminal sequence, as well as the PX domain, binds to phosphatidylinositol monophosphates.
Opposing activities of the Snx3-retromer complex and ESCRT proteins mediate regulated cargo sorting at a common endosome.
GeneRIF
Burd et al., Philadelphia, United States. In Mol Biol Cell, 2008
In the presence and absence of iron, Fet3-Ftr1 transits an endosomal compartment where a subunit of the multivesicular body sorting receptor (Vps27), Snx3/Grd19, and retromer proteins colocalize.
SNX3 regulates endosomal function through its PX-domain-mediated interaction with PtdIns(3)P.
Impact
Hong et al., Singapore, Singapore. In Nat Cell Biol, 2001
We show that SNX3 is associated with the early endosome through a novel motif (PX domain) capable of interaction with phosphatidylinositol-3-phosphate (PtdIns(3)P).
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